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<ul><li><p>EDITOR IN CHIEF</p><p>William C. Roberts, MDBaylor Heart &amp; Vascular InstituteBaylor University Medical CenterWadley Tower No. 4573600 Gaston AvenueDallas, Texas 75246(214)826-8252Fax: (214)826-2855</p><p>ASSOCIATE EDITORS</p><p>Vincent E. FriedewaldPaul A. GrayburnASSISTANT EDITORSRobert C. KowalJeffrey M. Schussler</p><p>EDITORIAL BOARDCARDIOVASCULARMEDICINEIn AdultsAntonio AbbateJ. Dawn AbbottGeorge S. AbelaJamil AboulhosnJoseph S. AlpertMartin A. AlpertEzra A. AmsterdamJeffrey L. AndersonEvan AppelbaumRichard W. AsingerPablo AvanzasGary John BaladyEric BatesJeroen J. BaxGeorge A. BellerWilliam E. BodenMonty M. BodenheimerRobert O. BonowJeffrey S. BorerMartial G. BourassaEugene BraunwaldJeffrey A. BrinkerDavid L. BrownMichael E. CainRichard O. Cannon IIIBernard R. ChaitmanKanu ChatterjeeJohn S. ChildRobert J. CodyLawrence S. CohenMarc CohenC. Richard ContiMichael H. CrawfordJames P. DaubertGregory J. DehmerJames A. de LemosAnthony N. DeMariaPablo DenesGeorge A. DiamondJohn P. DiMarcoAllen DollarMichael J. DomanskiGerald DorrosUri ElkayamKenneth A. EllenbogenMyrvin H. EllestadStephen G. EllisToby R. EngelAndrew E. EpsteinN. A. Mark Estes, IIIMichael Ezekowitz</p><p>Rodney H. FalkJohn A. FarmerDavid P. FaxonTed FeldmanJack FerlinzJerome L. FlegGerald F. FletcherJoseph A. FranciosaGary S. FrancisW. Bruce FyeWilliam H. GaaschJulius M. GardinBernard J. GershS. David GertzMihai GheorghiadeD. Luke GlancyStephen P. GlasserMichael R. GoldSamuel Z. GoldhaberRobert E. GoldsteinSidney GoldsteinSteven A. GoldsteinJ. Anthony GomesAntonio M. Gotto, Jr.K. Lance GouldDonald C. HarrisonPhilip D. HenryL. David HillisDavid R. Holmes, Jr.Mun K. HongWilliam G. HundleyAmi S. IskandrianAllan S. JaffeHani JneidGreg L. KaluzaJoel S. KarlinerJohn A. KastorSanjiv KaulEllen C. KeeleyKenneth M. KentRichard E. KerberDean J. KereiakesMorton J. KernSpencer B. King IIIRobert E. KleigerGeorge J. KleinLloyd W. KleinPaul KligfieldRobert A. KlonerJohn B. KostisCharles LandauRichard L. LangeCarl J. LavieCarl V. LeierB. T. Liang</p><p>Joseph Lindsay, Jr.Gregory Y.H. LipFrancisco Lopez-JimenezJoseph LoscalzoG.B. John ManciniFrancis E. MarchlinskiFrank I. MarcusBarry J. MaronMartin S. MaronRandolph P. MartinAttilo MaseriCharles MaynardMichael D. McGoonDarren K. McGuireRaymond G. McKayJawahar L. MehtaBernard MeierFranz H. MesserliEric L. MichelsonRichard V. MilaniAlan B. MillerWayne L. MillerGary S. MintzFred MoradyLori MoscaArthur J. MossJames E. MullerGerald B. NaccarelliNavin C. NandaRobert A. ORourkeErik Magnus OhmanRichard L. PageSebastian T. PalmeriSeung-Yung ParkEugene R. PassamaniAlan S. PearlmanCarl J. PepineJoseph K. PerloffBertram PittPhilip J. PodridDon PoldermansArshed A. QuyyumiCharles E. RackleyC. Venkata RamNathaniel ReichekRobert RobertsJennifer G. RobinsonLynda E. RosenfeldMelvin M. ScheinmanDavid J. SchneiderJohn S. SchroederPatrick Washington SerruysPravin M. ShahPrediman K. ShahJamshid Shirani</p><p>Robert J. SiegelMarc A. SilverRoss J. Simpson, Jr.Steven N. SinghBurton E. SobelJohn C. SombergDavid H. SpodickLynne W. StevensonGregory W. StoneJohn R. StrattonJonathan M. TobisEric J. TopolByron F. VandenbergHector O. VenturaGeorge W. VetrovecRobert A. VogelRon WaksmanDavid D. WatersNanette K. WengerRobert WilenskyJames T. WillersonClyde W. YancyBarry L. ZaretDouglas P. ZipesIn Infants and ChildrenHugh D. AllenBruce S. AlpertStanley J. GoldbergWarren G. GuntherothHoward P. GutgesellJohn D. KuglerJames E. LockJohn W. MooreLowell W. PerryDavid J. SahnRichard M. SchiekenCARDIOVASCULAR SURGERYEugene H. BlackstoneLawrence I. BonchekLawrence H. CohnJohn A. ElefteriadesHartzel V. SchaffRELATED SPECIALISTSL. Maximilian BujaJean-Pierre DespresMichael EmmettGiovanni FilardoBarry A. FranklinCharles B. HigginsJeffrey E. SaffitzRenu Virmani</p><p>A5</p></li><li><p>CONTENTS THE AMERICAN JOURNAL OF CARDIOLOGYVOL. 107, NO. 4 FEBRUARY 15, 2011Coronary Artery Disease</p><p>An Early and Simple Predictor of Severe Left Mainand/or Three-Vessel Disease in Patients WithNonST-Segment Elevation Acute CoronarySyndrome ......................................................495Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi,Satoshi Morita, Mitsuaki Endo, Nobuhiki Maejima,Noriaki Iwahashi, Kozo Okada, Toshiyuki Ishikawa,Satoshi Umemura, and Kazuo Kimura</p><p>Reperfusion by Primary Percutaneous CoronaryIntervention in Patients With ST-Segment ElevationMyocardial Infarction Within 12 to 24 Hours of theOnset of Symptoms (from a Prospective NationalObservational Study [PL-ACS]) .........................501Marek Gierlotka, Mariusz Gasior, Krzysztof Wilczek,Michal Hawranek, Janusz Szkodzinski, Piotr Paczek,Andrzej Lekston, Zbigniew Kalarus, Marian Zembala,and Lech Polonski</p><p>ReviewPercutaneous Coronary Intervention for NonST-Elevation Acute Coronary Syndromes: Which,When and How? ............................................509Robert K. Riezebos, Jan G.P. Tijssen,Freek W.A. Verheugt, and Gerrit J. Laarman</p><p>Coronary Artery DiseaseLong-Term Follow-Up of Patients With First-TimeChest Pain Having 64-Slice ComputedTomography ...................................................516Fabiola B. Sozzi, Filippo Civaia, Philippe Rossi,Jean-Francois Robillon, Stephane Rusek,Frederic Berthier, Francois Bourlon, Laura Iacuzio,Gilles Dreyfus, and Vincent Dor</p><p>Usefulness of Cooling and Coronary Catheterizationto Improve Survival in Out-of-Hospital CardiacArrest ............................................................522Dion Stub, Christopher Hengel, William Chan,Damon Jackson, Karen Sanders, Anthony M. Dart,Andrew Hilton, Vincent Pellegrino, James A. Shaw,Stephen J. Duffy, Stephen Bernard, and David M. Kaye</p><p>Two-Year Safety and Effectiveness of Sirolimus-Eluting Stents (from a Prospective Registry) .......528Bimmer E. Claessen, Roxana Mehran, Martin B. Leon,Eric A. Heller, Giora Weisz, George Syros,Gary S. Mintz, Theresa Franklin-Bond,Irene Apostolidou, Jose P.S. Henriques,Gregg W. Stone, Jeffrey W. Moses, andGeorge D. Dangas</p><p>Comparison of Morbidity and Mortality in DiabeticsVersus Nondiabetics Having Isolated CoronaryBypass Versus Coronary Bypass plus ValveOperations Versus Isolated Valve Operations ....535Serenella Castelvecchio, Lorenzo Menicanti,Ekaterina Baryshnikova, Carlo de Vincentiis,Alessandro Frigiola, and Marco Ranucci, for theSurgical and Clinical Outcome Research (SCORE)Group</p><p>Heart Failure</p><p>Relation of Bundle Branch Block to Long-Term(Four-Year) Mortality in Hospitalized Patients WithSystolic Heart Failure ......................................540Alon Barsheshet, Ilan Goldenberg, Moshe Garty,Shmuel Gottlieb, Amir Sandach,Avishag Laish-Farkash, Michael Eldar, andMichael Glikson</p><p>Characteristics of Depression Remission and ItsRelation With Cardiovascular Outcome AmongPatients With Chronic Heart Failure (from theSADHART-CHF Study) ......................................545Wei Jiang, Ranga Krishnan, Maragatha Kuchibhatla,Michael S. Cuffe, Carolyn Martsberger,Rebekka M. Arias, and Christopher M. OConnor, forthe SADHART-CHF Investigators</p><p>Warfarin Use and Outcomes in Patients WithAdvanced Chronic Systolic Heart Failure WithoutAtrial Fibrillation, Prior Thromboembolic Events, orProsthetic Valves .............................................552Marjan Mujib, Abu-Ahmed Z. Rahman, Ravi V. Desai,Mustafa I. Ahmed, Margaret A. Feller,Inmaculada Aban, Thomas E. Love, Michel White,Prakash Deedwania, Wilbert S. Aronow,Gregg Fonarow, and Ali Ahmed</p><p>Editorial</p><p>The Risk of Thromboembolism in Heart Failure:Does It Merit Anticoagulation Therapy? ............558Eduard Shantsila and Gregory Y.H. Lip</p><p>Heart Failure</p><p>Trials on the Effect of Cardiac Resynchronization onArterial Blood Pressure in Patients With HeartFailure ...........................................................561Sameer Ather, Sripal Bangalore, Srinath Vemuri,Long B. Cao, Biykem Bozkurt, and Franz H. Messerli</p><p>A6 THE AMERICAN JOURNAL OF CARDIOLOGY VOL. 107 FEBRUARY 15, 2011</p></li><li><p>Patient Perception Versus Medical Record Entry ofHealth-Related Conditions Among Patients WithHeart Failure ..................................................569Adnan S. Malik, Grigorios Giamouzis,Vasiliki V. Georgiopoulou, Lucy V. Fike,Andreas P. Kalogeropoulos, Catherine R. Norton,Dan Sorescu, Sidra Azim, Sonjoy R. Laskar,Andrew L. Smith, Sandra B. Dunbar, and Javed Butler</p><p>Effectiveness of Serial Increases in Amino-TerminalProB-Type Natriuretic Peptide Levels to Indicate theNeed for Mechanical Circulatory Support inChildren With Acute Decompensated HeartFailure ...........................................................573Derek T.H. Wong, Kristen George, Judith Wilson,Cedric Manlhiot, Brian W. McCrindle, Khosrow Adeli,and Paul F. Kantor</p><p>Arrhythmias and ConductionDisturbances</p><p>Relation of Obesity to Recurrence Rate and Burdenof Atrial Fibrillation .........................................579Maya Guglin, Kuldeep Maradia, Ren Chen, andAnne B. Curtis</p><p>Roundtable Discussion (CME)</p><p>The Editors Roundtable: Implantable Cardioverter-Defibrillators in Primary Prevention of SuddenCardiac Death and Disparity-Related Barriers toImplementation ...............................................583Vincent E. Friedewald, Gregg C. Fonarow,Brian Olshansky, Clyde W. Yancy, andWilliam C. Roberts</p><p>Valvular Heart Disease</p><p>Comparison of the Effectiveness and Safety of Low-Molecular Weight Heparin Versus UnfractionatedHeparin Anticoagulation After Heart ValveSurgery ..........................................................591Claudia Bucci, William H. Geerts, Andrew Sinclair,and Stephen E. Fremes</p><p>Congenital Heart Disease</p><p>Seeking Optimal Relation Between OxygenSaturation and Hemoglobin Concentration in AdultsWith Cyanosis from Congenital Heart Disease ...595Craig S. Broberg, Ananda R. Jayaweera,Gerhard P. Diller, Sanjay K. Prasad, Swee Lay Thein,Bridget E. Bax, John Burman, andMichael A. Gatzoulis</p><p>Cardiomyopathy</p><p>Relation of Pulse Pressure to Blood PressureResponse to Exercise in Patients With HypertrophicCardiomyopathy .............................................600Kevin S. Heffernan, Martin S. Maron,Eshan A. Patvardhan, Richard H. Karas, andJeffrey T. Kuvin, the Vascular Function Study Group</p><p>Editorial</p><p>Clinical Challenges of Genotype Positive()Phenotype Negative () Family Members inHypertrophic Cardiomyopathy .........................604Barry J. Maron, Laura Yeates, andChristopher Semsarian</p><p>Miscellaneous</p><p>Usefulness of Repeated N-Terminal Pro-B-TypeNatriuretic Peptide Measurements as IncrementalPredictor for Long-Term Cardiovascular OutcomeAfter Vascular Surgery ....................................609Dustin Goei, Jan-Peter van Kuijk, Willem-Jan Flu,Sanne E. Hoeks, Michel Chonchol,Hence J.M. Verhagen, Jeroen J. Bax, andDon Poldermans</p><p>Usefulness of At Rest and Exercise Hemodynamicsto Detect Subclinical Myocardial Disease in Type 2Diabetes Mellitus .............................................615Christine L. Jellis, Tony Stanton, Rodel Leano,Jennifer Martin, and Thomas H. Marwick</p><p>Specific Characteristics of Sudden Death in aMediterranean Spanish Population ...................622M. Teresa Subirana, Josep O. Juan-Babot,Teresa Puig, Joaqun Lucena, Antonio Rico,Manuel Salguero, Juan C. Borondo, Jorge Ordoez,Josep Arimany, Rafael Vazquez, Lina Badimon,Gaetano Thiene, and Antonio Bayes de Luna</p><p>Clinical and Prognostic Relevance ofEchocardiographic Evaluation of Right VentricularGeometry in Patients With Idiopathic PulmonaryArterial Hypertension ......................................628Stefano Ghio, Anna Sara Pazzano, Catherine Klersy,Laura Scelsi, Claudia Raineri, Rita Camporotondo,Andrea DArmini, and Luigi Oltrona Visconti</p><p>Clinically Significant Incidental Findings AmongHuman Immunodeficiency Virus-Infected MenDuring Computed Tomography for Determination ofCoronary Artery Calcium .................................633Nancy Crum-Cianflone, James Stepenosky,Sheila Medina, Dylan Wessman, David Krause, andGilbert Boswell</p><p>CONTENTS A11</p></li><li><p>Case Report</p><p>Self-Terminated Ventricular Fibrillation andRecurrent Syncope ..........................................638Yuval Konstantino, Angela Morello,Peter J. Zimetbaum, and Mark E. Josephson</p><p>Readers Comments</p><p>Comparison of 600 Versus 300-mg ClopidogrelLoading Dose in Patients With ST-Segment ElevationMyocardial Infarction Undergoing PrimaryCoronary Angioplasty .....................................641</p><p>Long-Term Follow Up of Atrioventricular Block inTranscatheter Aortic Valve Implantation ............641</p><p>Instructions to Authors can be found at the AJCwebsite: www.AJConline.org</p><p>Classifieds on pages A10, A37</p><p>Full Text: www.ajconline.org</p><p>A18 THE AMERICAN JOURNAL OF CARDIOLOGY VOL. 107 FEBRUARY 15, 2011</p></li><li><p>An Early and Simple Predictor of Severe Left Main and/orThree-Vessel Disease in Patients With NonST-Segment</p><p>oroD, K</p><p>, Noemu</p><p>possCS)</p><p>presensel dil facthy. Ssis inepicangs: nD (n</p><p>d to nmultedicto</p><p>evel (oed sev98%</p><p>R onith N</p><p>oing aallow early CABG. 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:</p><p>shono(NinccomigioproCAcanreqheanWcowoACstupre</p><p>Yoscr</p><p>000doi495500)</p><p>Dual antiplatelet therapy with clopidogrel and aspirinuld be initiated as soon as possible in patients with</p><p>nST-segment elevation acute coronary syndromeSTE-ACS).1,2 However, such combination therapy canrease perioperative bleeding in patients undergoing early</p><p>ronary artery bypass grafting (CABG).37 Therefore, oneght consider with-holding clopidogrel until coronary an-graphy and definition of the coronary anatomy.8 Theportion of patients with NSTE-ACS who undergoBG during hospitalization is 9% to 21%.4,5,812 CABGoften be deferred for several days, and few patients</p><p>uire urgent CABG. Ideally, clopidogrel should be with-ld in the minority of patients who urgently require CABGd should be given to the remaining majority of patients.e previously examined clinical factors related to left mainronary artery and/or 3-vessel disease (LM/3VD) thatuld most likely lead to CABG in patients with NSTE-S but did not evaluate severity of coronary lesions in thatdy.13 In the present study, we assessed the ability todict severe LM/3VD, which would most likely to</p><p>require urgent CABG, using only clinical factors on admis-sion in patients with NSTE-ACS.</p><p>MethodsWe studied 572 consecutive patients (mean age 67 11</p><p>years, range 30 to 92, 397 men and 175 women) who wereadmitted to Yokohama City University Medical Center(Yokohama, Japan) coronary care unit and fulfilled thefollowing criteria: (1) typical chest discomfort attributed tocardiac ischemia, lasting 5 minutes, occurring within 24hours before hospital admission, and involving an unstablepattern of pain including pain at rest, new onset, severe orfrequent angina, or accelerating angina14; (2) no conditionsprecluding evaluation ST-segment changes on electrocar-diogram (ECG) such as left or right bundle branch block,left ventricular hypertrophy, or ventricular pacing; (3) fullyassessable ECGs on admission; and (4) fully assessableangiographic data during hospitalization. We excluded pa-tients with nonischemic or atypical pain, persistent newST-segment elevation in leads other than lead aVR, recent(6 months) percutaneous coronary intervention, or previ-ous CABG. All patient...</p></li></ul>