the aging brain the brain changes with age the frontal cortex & hippocampus are critical to...
TRANSCRIPT
The Aging Brain
• The brain changes with age• The frontal cortex & hippocampus are critical to learning,
memory, planning and other cognitive activities, shrink in size
• Changes in neuron communication • Neuron damage & death• Reduced blood flow to the brain• Change = reduced brain function
Age-Associated Memory Impairment (AAMI)
• A condition characterized by mild cognitive & memory decline that occurs as part of the normal aging process
• It is believed to be the result of chemical changes in the brain, as well as reduced brain volume
• It affects close to 1 in 3 people aged 60 to 78
• AAMI is a condition related to normal aging, while Alzheimer’s disease (AD) is associated with serious neuro-degeneration
Age-Associated Memory Impairment (AAMI)
What are the signs of AAMI?
• Difficulties in memory such as misplacing
objects or forgetting names/words
• Trouble communicating
• Delayed reaction time
• Impaired ability to multi-task
• 50 years of age or older
• Absence of dementia
What Causes Cognitive Decline-Part1?
Excess Accumulation of Toxic Amyloid-beta (Ab) Protein:
• “Strangles” neurons within the brain • Neurons malfunction and die• Impairs “communication” in the brain which causes
memory and cognitive decline
What Causes Cognitive Decline-Part 2?
Hippocampus Shrinkage
• The Hippocampus is a structure in the brain that is involved in memory, learning and spatial navigation
• Neuron death causes a decrease in the size of the hippocampus and overall brain size
• Loss of hippocampus size is associated with lower scores on memory tests
Hippocampus
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Age (years)
• By the age of 25, cognitive performance has reached it’s peak and declines rapidly after the age of 40
Decline In Hippocampus Volume Accelerates Around Age 40
• Poor diet (excess sugar, nutrient deficiency, processed food)
• Lack of physical activity• Excess body weight• Chronic Inflammation• Social Isolation• High stress• Declining hormone levels
Factors Associated with Cognitive Decline
• Bacopa-Powerful protective effects on the brain and nervous system
• Citicoline-Enhances neurotransmitter balance in the brain
• Curcumin-Identified as one of the compounds responsible for low rates of Alzheimer’s disease in India
• GABA-Prevents overstimulation of the brain
• Ginkgo Biloba-Increases blood flow to the brain
• Homotaurine- Prevents shrinkage of the Hippocampus and neuron death
• Lion’s Mane-Calms the nervous system to improve memory and concentration
• Phosphatidylserine-Plays an essential role in brain cell membrane structure
• R-Lipoic Acid-Protects neurons from damage
Brain Nutrients
• Homotaurine is an amino acid discovered in marine red algae
• VIVImind™ is supported by over $200 million and 15 years of scientific research, including 16 clinical studies with over 2000 individuals in Canada, USA and Europe
• The first nutraceutical to undergo Phase III clinical research in large, state-of-the-art, clinical trials in the field of cognition
• It is Clinically proven to prevent Hippocampus volume loss by 68%!
Why VIVImind™?
How Does VIVImind™ Work?
Homotaurine crosses the blood-brain barrier and Inhibits the Formation of Amyloid Tangles to
Protect Against Neuron Death
VIVImind™ Clinical Trial Results
• 1052 patients diagnosed with mild to moderate Alzheimer’s disease received a placebo or Homotaurine for 18 months
• 33% improvement in cognitive performance with Homotaurine• 68% reduction in Hippocampus shrinkage with Homotaurine
VIVImind™ Clinical Trial Results
• Results were even more effective in patients with the Apoe4 gene
Homotaurine and Alzheimer's Disease
AD is a model of accelerated cerebral and cognitive aging• Common cognitive domains affected• Common neurological contributing factors• Exacerbating effect of Aβ
VIVImind™
• Reduces Aβ-induced toxicity• Protects memory throughout the aging process as
demonstrated in patients diagnosed with AD
How to Use VIVImind™
Dosage adults (50 years and older) :2 capsules(50 mg), twice daily with food• Start with 1 capsule at bedtime for one week and progress to 1
capsule twice daily for an additional week before starting normal dosage
• Do not crush, blend or mix the capsules. Swallow whole.
Duration :• Efficacy is dependant on Long-term use. Use for a minimum of 6
months for beneficial effects.
VIVImind™ Safety
• Safe and well tolerated upon chronic use
• Does not bind to plasma proteins
• Does not interfere with liver enzyme (CYP450) activity
• Does not interfere with Warfarin
VIVImind™
Supports the Memory Centre of the Brain
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