tca cycle tri carboxylic acid cycle : is called so because several of its metabolites have three...
DESCRIPTION
TCA cycle Primary function of this cycle is energy production and final metabolites are CO2 and H 2 O. Pyrovate which is the end product of glycolytic pathway is converted to acetyl coA as in the reaction pyruvate dehydrogenas + FAD Pyruvate Acetyl coA +CoA-SH +CO2 +NADH +NAD Primary function of this cycle is energy production and final metabolites are CO2 and H 2 O. Pyrovate which is the end product of glycolytic pathway is converted to acetyl coA as in the reaction pyruvate dehydrogenas + FAD Pyruvate Acetyl coA +CoA-SH +CO2 +NADH +NADTRANSCRIPT
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TCA cycleTCA cycle Tri carboxylic acid cycle : is called so
because several of its metabolites have three carboxyl group (citrate ,cis-aconitate ,isocitrate) .
Also called Kreb-cycle
Cycle of energy production, central cycle in the metabolisim of CHO, fatty acid and amino acid.
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TCA cyclePrimary function of this cycle is energy production and final metabolites are CO2 and H2O .
Pyrovate which is the end product of glycolytic pathway is converted to acetyl coA as in the reaction pyruvate dehydrogenas + FAD
Pyruvate Acetyl coA +CoA-SH +CO2 +NADH
+NAD
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TCA cycleSteps of TCA cycle Citrate synthetase Oxaloacetate Citrate + acetyl CoA CH2COOH | HO-COOH | CH2COOH
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TCA cycle Aconitase Citrate Cis-aconitate H2O CH2COOH | C- COOH || CH-
COOH
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TCA cycle
Aconitase Cis-aconitate Iso-citrate H2O CH2COOH | CH-COOH | HO-CH-COOH
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TCA cycle
Isocitrate dehydrogenase Isocitrate Oxalosuccinate
+ NAD + NADH
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TCA cycle
Isocitrate dehydrogenase Oxalosuccinate α-
ketoglutyrate CO2
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TCA cycle
α-ketoglutyrate dehydrogenase complex α-ketoglutyrate succinyl CoA + CoA-SH CO2 + NAD + NADH
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TCA cycle
Succinate Thiokinase Succinyl CoA Succinate Mg CoA-SH +ADP + ATP
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TCA cycle
Succinate dehydrogenase
Succinate Fumerate + FAD + FADH
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TCA cycle
Fumarase Fumarate Malate H2O
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TCA cycle
Malate dehydrogenase Malate Oxaloacetate + NAD + NADH