tat in risk detection and prevention of cardiovascular disease

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TAT IN RISK DETECTION AND PREVENTION OF CARDIOVASCULAR DISEASE

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Page 1: TAT in risk detection and prevention of cardiovascular disease

TAT IN RISKDETECTION ANDPREVENTION OFCARDIOVASCULARDISEASE

Page 2: TAT in risk detection and prevention of cardiovascular disease

TELOMERE LENGTH INDEPENDENT RISKFACTOR FOR CVD

TELOMERE MEASUREMENT CAN IDENTIFY HIGH RISK INDIVIDUALS WITH SHORT TELOMERES

TAT ( TELOMERE ANALYSIS TEST) USED TO COMPLEMENT TRADITIONAL CARDIOVASCULARTESTS IN ORDER TO PROVIDE MORE COMPREHENSIVE ANALYSIS AND  IDENTIFY THE RISKSOF DEVELOPING CARDIOVASCULAR PROBLEMS AT AN EARLIER STAGE

Page 3: TAT in risk detection and prevention of cardiovascular disease

REDUCED TELOMERE LENGTHS ARE FOUND IN PATIENTS

WITH CARDIOVASCULAR RISK FACTORS SUCH AS:

ATHEROSCLEROSIS

HYPERTENSION

OBESITY

DIABETES (ESPECIALLY TYPE 2)

SMOKING

PHYSICAL INACTIVITY

STRESS

CHRONIC INFECTIONS

Page 4: TAT in risk detection and prevention of cardiovascular disease

A positive effect on telomere length is found with increased

physical activity, statin treatment, and higher blood levels of

omega­3 fatty acids

Page 5: TAT in risk detection and prevention of cardiovascular disease

Statins may extend lives by not only lowering cholesterol levels but also protectingagainst telomere shortening, thus reducing the risk of cardiovascular disease and

other age­associated diseases

A) All individuals

B) Individuals on

pravastatin

treatment

(grey) or placebo

(orange)