Table S1, SDC. Common deregulated genes between WS and S (L1 vs. L2)

Symbol Entrez Gene Name Group S

(Probesets)

S (Fold-

change)

Group WS (Probesets)

WS (Fold-

change)

ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1

203504_s_at -1.4 203505_at -1.3

ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4

203196_at -1.4 203196_at -1.5

ABCD3 ATP-binding cassette, sub-family D (ALD), member 3

202850_at -1.4 202850_at -1.2

ADCY1 adenylate cyclase 1 (brain) 213245_at -2.0 213245_at -2.1 ADM adrenomedullin 202912_at 2.4 202912_at 2.0 ADORA3 adenosine A3 receptor 206171_at -1.6 206171_at -1.4 ADRB2 adrenoceptor beta 2, surface 206170_at 2.4 206170_at 2.2

AGO1 argonaute RISC catalytic component 1

218287_s_at -1.3 218287_s_at -1.3

ANAPC5 anaphase promoting complex subunit 5

208722_s_at -1.3 211036_x_at -1.3

APOLD1 apolipoprotein L domain containing 1

221031_s_at 2.8 221031_s_at 3.2

AREG amphiregulin 205239_at 4.7 205239_at 4.7

ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

218098_at -1.7 218098_at -1.4

ARIH1 ariadne RBR E3 ubiquitin protein ligase 1

201878_at 1.4 201878_at 1.3

ARL2 ADP-ribosylation factor-like 2 202564_x_at -1.2 202564_x_at -1.3

ARL4C ADP-ribosylation factor-like 4C

202207_at 1.5 202207_at 1.7

ARMC8 armadillo repeat containing 8 203486_s_at -1.2 203486_s_at -1.3 ARRB1 arrestin, beta 1 43511_s_at -1.2 221861_at -1.1 ATF3 activating transcription factor 3 202672_s_at 11.9 202672_s_at 10.8 ATXN1 ataxin 1 203232_s_at -1.4 203232_s_at -1.5 AVL9 AVL9 homolog (S. cerevisiase) 212474_at -1.5 212474_at -1.4 BAG3 BCL2-associated athanogene 3 217911_s_at 3.3 217911_s_at 3.0 BCL2A1 BCL2-related protein A1 205681_at 4.5 205681_at 2.9 BCL3 B-cell CLL/lymphoma 3 204908_s_at 2.2 204908_s_at 1.8

BHLHE40 basic helix-loop-helix family, member e40

201170_s_at 3.0 201170_s_at 2.9

BIRC3 baculoviral IAP repeat containing 3

210538_s_at 7.3 210538_s_at 4.6

BMP2 bone morphogenetic protein 2 205290_s_at 2.1 205289_at 2.0

BTG2 BTG family, member 2 201236_s_at 2.5 201235_s_at 1.6 BTG3 BTG family, member 3 205548_s_at 1.9 205548_s_at 1.6

C14orf132 chromosome 14 open reading frame 132

218820_at -1.6 218820_at -1.7

CAD

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

202715_at -1.2 202715_at -1.5

CBX5 chromobox homolog 5 212126_at -1.6 212126_at -1.5

CCDC121 coiled-coil domain containing 121

220321_s_at -1.3 220321_s_at -1.3

CCDC93 coiled-coil domain containing 93

209688_s_at -1.5 209688_s_at -1.9

CCL20 chemokine (C-C motif) ligand 20

205476_at 10.8 205476_at 5.6

CCL3 chemokine (C-C motif) ligand 3

205114_s_at 4.5 205114_s_at 5.2

CCL4 chemokine (C-C motif) ligand 4

204103_at 7.5 204103_at 7.2

CD160 CD160 molecule 207840_at -1.5 207840_at -1.3

CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

201925_s_at 2.2 201925_s_at 1.5

CD59 CD59 molecule, complement regulatory protein

212463_at -1.3 212463_at -1.4

CD83 CD83 molecule 204440_at 3.0 204440_at 2.6

CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)

202284_s_at 2.7 202284_s_at 2.0

CEBPB CCAAT/enhancer binding protein (C/EBP), beta

212501_at 1.5 212501_at 1.4

CEBPD CCAAT/enhancer binding protein (C/EBP), delta

203973_s_at 2.0 203973_s_at 1.9

CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

207980_s_at 2.2 207980_s_at 2.9

CKS2 CDC28 protein kinase regulatory subunit 2

204170_s_at 2.7 204170_s_at 3.1

CLCN3 chloride channel, voltage-sensitive 3

201732_s_at -1.5 201735_s_at -1.5

CLMN calmin (calponin-like, transmembrane)

213839_at -2.4 213839_at -2.4

CLTC clathrin, heavy chain (Hc) 200614_at -1.5 200614_at -1.4 COPB1 coatomer protein complex, 201359_at -1.4 201359_at -1.3

subunit beta 1 CPD carboxypeptidase D 201941_at -1.3 201941_at -1.3 CUL3 cullin 3 201370_s_at -1.4 201371_s_at -1.4

CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

204470_at 4.6 204470_at 2.9

CXCL3 chemokine (C-X-C motif) ligand 3

207850_at 5.0 207850_at 3.6

CXCL8 chemokine (C-X-C motif) ligand 8

202859_x_at 12.2 202859_x_at 7.5

CXCR4 chemokine (C-X-C motif) receptor 4

217028_at 2.4 209201_x_at 1.6

CYR61 cysteine-rich, angiogenic inducer, 61

201289_at 3.1 201289_at 3.6

DCP2 decapping mRNA 2 212919_at -1.7 212919_at -2.0

DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32

218198_at -1.2 218198_at -1.2

DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1

200666_s_at 3.8 200666_s_at 4.3

DPH5 diphthamide biosynthesis 5 222360_at -1.2 219590_x_at -1.2 DUSP10 dual specificity phosphatase 10 215501_s_at 2.0 215501_s_at 2.6 DUSP2 dual specificity phosphatase 2 204794_at 2.1 204794_at 1.8 DUSP3 dual specificity phosphatase 3 201536_at -1.3 201536_at -1.3 DUSP5 dual specificity phosphatase 5 209457_at 3.4 209457_at 4.0 EGR1 early growth response 1 201693_s_at 3.6 201693_s_at 3.6 EGR2 early growth response 2 205249_at 4.6 205249_at 4.5

EIF1 eukaryotic translation initiation factor 1

212130_x_at 1.3 212227_x_at 1.3

ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )

210827_s_at 2.4 210827_s_at 2.2

ELL elongation factor RNA polymerase II

204096_s_at 1.2 204096_s_at 1.2

ELL2 elongation factor, RNA polymerase II, 2

214446_at 1.7 214446_at 1.5

ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2

201329_s_at 2.3 201329_s_at 2.1

FAM172A family with sequence similarity 172, member A

212936_at -1.7 212936_at -1.7

FAM178A family with sequence similarity 178, member A

203482_at -1.5 203482_at -1.5

FAM46A family with sequence similarity 46, member A

221766_s_at 2.6 221766_s_at 1.8

FAM46C family with sequence similarity 220306_at 1.7 220306_at 1.6

46, member C

FANCC Fanconi anemia, complementation group C

205189_s_at -1.4 205189_s_at -1.4

FEM1C fem-1 homolog c (C. elegans) 213341_at 1.6 213341_at 1.8

FOS FBJ murine osteosarcoma viral oncogene homolog

209189_at 5.6 209189_at 5.5

FOSL2 FOS-like antigen 2 218880_at 2.8 218880_at 2.5 FZD4 frizzled class receptor 4 218665_at -1.5 218665_at -1.3

GADD45A growth arrest and DNA-damage-inducible, alpha

203725_at 1.9 203725_at 1.7

GADD45B growth arrest and DNA-damage-inducible, beta

209305_s_at 4.4 209305_s_at 4.5

GALNT10 polypeptide N-acetylgalactosaminyltransferase 10

212256_at -1.4 207357_s_at -1.2

GCLM glutamate-cysteine ligase, modifier subunit

203925_at 1.2 203925_at 1.3

GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)

212139_at -1.5 212139_at -1.5

GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2

208914_at -1.4 208914_at -1.3

GLUL glutamate-ammonia ligase 200648_s_at 1.5 200648_s_at 1.5 GPR183 G protein-coupled receptor 183 205419_at 3.3 205419_at 2.8

GTDC1 glycosyltransferase-like domain containing 1

219770_at -1.2 219770_at -1.2

GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

210164_at 1.8 210164_at 1.7

GZMK granzyme K (granzyme 3; tryptase II)

206666_at -1.6 206666_at -1.3

HBA1/HBA2 hemoglobin, alpha 1 217414_x_at 2.4 217414_x_at 2.7

HBEGF heparin-binding EGF-like growth factor

203821_at 2.5 203821_at 2.2

HCAR3 hydroxycarboxylic acid receptor 3

205220_at 3.3 205220_at 2.8

HDAC4 histone deacetylase 4 204225_at -1.3 204225_at -1.7

HILPDA hypoxia inducible lipid droplet-associated

218507_at 1.6 218507_at 1.4

HSPA1A/HSPA1B heat shock 70kDa protein 1A 202581_at 12.6 202581_at 11.4

HSPH1 heat shock 105kDa/110kDa protein 1

206976_s_at 2.7 208744_x_at 2.4

HTT huntingtin 202389_s_at -1.2 202390_s_at -1.2 ICAM1 intercellular adhesion molecule 202638_s_at 4.5 202638_s_at 3.1

1 IER2 immediate early response 2 202081_at 2.9 202081_at 2.1 IER3 immediate early response 3 201631_s_at 3.5 201631_s_at 2.2 IER5 immediate early response 5 218611_at 2.6 218611_at 2.1 IL1B interleukin 1, beta 39402_at 3.3 39402_at 3.1

IL1RN interleukin 1 receptor antagonist

212657_s_at 5.4 212657_s_at 5.0

IL6 interleukin 6 205207_at 2.8 205207_at 2.0 INHBA inhibin, beta A 210511_s_at 1.5 210511_s_at 1.5 IPO5 importin 5 211954_s_at -1.5 211954_s_at -1.4

ITPKC inositol-trisphosphate 3-kinase C

213076_at 1.9 213076_at 1.4

IVNS1ABP influenza virus NS1A binding protein

206245_s_at 1.6 206245_s_at 1.8

JMJD6 jumonji domain containing 6 212723_at 1.8 212722_s_at 1.6 JUN jun proto-oncogene 201466_s_at 5.4 201466_s_at 6.1 JUNB jun B proto-oncogene 201473_at 2.5 201473_at 2.1 JUND jun D proto-oncogene 203752_s_at 2.8 203752_s_at 3.4

KCNE4 potassium voltage-gated channel, Isk-related family, member 4

222379_at 2.1 222379_at 1.6

KHNYN KH and NYN domain containing

212356_at -1.4 212356_at -1.6

KIAA0100 KIAA0100 201729_s_at -1.8 201728_s_at -1.5 KLF2 Kruppel-like factor 2 219371_s_at 2.3 219371_s_at 2.2 KLF4 Kruppel-like factor 4 (gut) 221841_s_at 3.4 221841_s_at 3.1 KLF6 Kruppel-like factor 6 208961_s_at 4.0 208961_s_at 4.6 KLF9 Kruppel-like factor 9 203542_s_at 1.6 203542_s_at 1.7 KLHDC10 kelch domain containing 10 209256_s_at -1.8 209256_s_at -1.5

KRAS Kirsten rat sarcoma viral oncogene homolog

214352_s_at 1.3 214352_s_at 1.3

LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)

205269_at 1.7 205270_s_at 1.3

LINC00341 long intergenic non-protein coding RNA 341

219563_at -1.9 219563_at -2.1

LOC102724428/SIK1 salt-inducible kinase 1 208078_s_at 3.4 208078_s_at 4.2

LOC103344931 uncharacterized LOC103344931

213739_at -1.2 213739_at -1.3

LRPPRC leucine-rich pentatricopeptide repeat containing

211615_s_at -1.3 211615_s_at -1.3

LRRC37A3 (includes others)

leucine rich repeat containing 37, member A3

221740_x_at -1.4 221740_x_at -1.6

MAFF v-maf avian 36711_at 8.0 36711_at 5.0

musculoaponeurotic fibrosarcoma oncogene homolog F

MAN1A2 mannosidase, alpha, class 1A, member 2

217922_at -1.4 217922_at -1.3

MAP2K3 mitogen-activated protein kinase kinase 3

215498_s_at 1.5 215499_at 1.3

MAP3K8 mitogen-activated protein kinase kinase kinase 8

205027_s_at 2.8 205027_s_at 3.0

MAP3K9 mitogen-activated protein kinase kinase kinase 9

213927_at -1.3 213927_at -1.5

MARCKS myristoylated alanine-rich protein kinase C substrate

201670_s_at 1.5 201670_s_at 1.9

METTL3 methyltransferase like 3 209265_s_at -1.4 209265_s_at -1.3

MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase

212098_at -1.2 212098_at -1.5

MIEF1 mitochondrial elongation factor 1

204594_s_at -1.6 204594_s_at -1.5

MORF4L1 mortality factor 4 like 1 217982_s_at -1.1 217982_s_at -1.1

MRPL3 mitochondrial ribosomal protein L3

208787_at -1.2 208787_at -1.2

MTDH metadherin 212248_at -1.4 212248_at -1.2

MYC v-myc avian myelocytomatosis viral oncogene homolog

202431_s_at 3.8 202431_s_at 3.7

NAMPT nicotinamide phosphoribosyltransferase

217739_s_at 1.5 217739_s_at 1.4

NF2 neurofibromin 2 (merlin) 218915_at -1.3 218915_at -1.3

NFIL3 nuclear factor, interleukin 3 regulated

203574_at 2.8 203574_at 2.6

NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

201502_s_at 2.3 201502_s_at 2.1

NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)

218133_s_at -1.3 218133_s_at -1.2

NOTCH2 notch 2 202443_x_at -1.6 202443_x_at -1.6

NR4A2 nuclear receptor subfamily 4, group A, member 2

216248_s_at 5.6 216248_s_at 7.1

NRBF2 nuclear receptor binding factor 2

221803_s_at 1.4 221803_s_at 1.5

OPA1 optic atrophy 1 (autosomal dominant)

212214_at -1.5 212214_at -1.4

PDK3 pyruvate dehydrogenase kinase, isozyme 3

206347_at -1.3 221957_at -1.2

PDXK pyridoxal (pyridoxine, vitamin 218019_s_at -1.8 218019_s_at -2.2

B6) kinase

PELI1 pellino E3 ubiquitin protein ligase 1

218319_at 2.3 218319_at 1.8

PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

202464_s_at 3.2 202464_s_at 2.5

PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta

201080_at -1.4 201081_s_at -1.2

PLAUR plasminogen activator, urokinase receptor

210845_s_at 3.1 210845_s_at 1.9

PLK2 polo-like kinase 2 201939_at 3.0 201939_at 2.6

PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1

204285_s_at 2.9 204285_s_at 3.2

PNRC1 proline-rich nuclear receptor coactivator 1

209034_at 1.8 209034_at 1.6

POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

201803_at -1.4 201803_at -1.4

PPAP2B phosphatidic acid phosphatase type 2B

209355_s_at 1.6 212226_s_at 1.4

PPARD peroxisome proliferator-activated receptor delta

37152_at 1.6 37152_at 1.4

PPP1R15A protein phosphatase 1, regulatory subunit 15A

37028_at 2.0 37028_at 1.9

PPP1R7 protein phosphatase 1, regulatory subunit 7

201213_at -1.3 201213_at -1.3

PREPL prolyl endopeptidase-like 212217_at -1.8 212216_at -1.5

PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit

209799_at 1.3 209799_at 1.2

PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

204748_at 7.3 204748_at 5.7

PTP4A1 protein tyrosine phosphatase type IVA, member 1

200730_s_at 2.1 200730_s_at 3.0

RARS arginyl-tRNA synthetase 201330_at -1.2 201330_at -1.2

RASSF1 Ras association (RalGDS/AF-6) domain family member 1

204346_s_at 1.3 204346_s_at 1.4

RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2

216215_s_at -1.5 216215_s_at -1.4

RGS2 regulator of G-protein signaling 2

202388_at 2.9 202388_at 2.4

RHOB ras homolog family member B 212099_at 1.9 212099_at 2.2

RIPK2 receptor-interacting serine-threonine kinase 2

209545_s_at 1.8 209545_s_at 1.5

RND1 Rho family GTPase 1 210056_at 6.5 210056_at 4.4 RNF14 ring finger protein 14 201824_at -1.4 201824_at -1.4

RYBP RING1 and YY1 binding protein

201846_s_at 1.6 201846_s_at 1.5

SBNO1 strawberry notch homolog 1 (Drosophila)

218737_at -1.3 218737_at -1.3

SEC14L1 SEC14-like 1 (S. cerevisiae) 202083_s_at 1.5 202082_s_at 1.3 SEPHS1 selenophosphate synthetase 1 208940_at -1.3 208940_at -1.2 SEPT2 septin 2 200015_s_at -1.2 200015_s_at -1.2

SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

202627_s_at 4.7 202627_s_at 5.3

SGPL1 sphingosine-1-phosphate lyase 1

212321_at -1.6 212321_at -1.3

SKP1 S-phase kinase-associated protein 1

200719_at -1.2 200719_at -1.3

SLC20A1 solute carrier family 20 (phosphate transporter), member 1

201920_at 2.6 201920_at 2.3

SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14

216236_s_at 2.4 216236_s_at 1.6

SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3

202499_s_at 4.4 202499_s_at 2.8

SLC30A5 solute carrier family 30 (zinc transporter), member 5

218989_x_at -1.4 218989_x_at -1.3

SLCO4A1 solute carrier organic anion transporter family, member 4A1

219911_s_at 1.5 219911_s_at 1.2

SMG5 SMG5 nonsense mediated mRNA decay factor

34868_at -1.3 212147_at -1.3

SOD2 superoxide dismutase 2, mitochondrial

215078_at 9.0 215078_at 9.1

SPRY2 sprouty homolog 2 (Drosophila)

204011_at 1.7 204011_at 1.5

SPSB1 splA/ryanodine receptor domain and SOCS box containing 1

219677_at 2.0 219677_at 1.7

ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5

203217_s_at -1.2 203217_s_at -1.2

STK17B serine/threonine kinase 17b 205214_at 2.6 205214_at 1.7

TBC1D13 TBC1 domain family, member 13

44696_at -1.4 44696_at -1.3

TBC1D16 TBC1 domain family, member 222116_s_at -1.8 222116_s_at -1.9

16

TGIF1 TGFB-induced factor homeobox 1

203313_s_at 2.7 203313_s_at 2.6

TGIF2 TGFB-induced factor homeobox 2

218724_s_at 1.5 218724_s_at 1.4

TIPARP TCDD-inducible poly(ADP-ribose) polymerase

212665_at 2.9 212665_at 2.6

TMEM62 transmembrane protein 62 218776_s_at -1.2 218776_s_at -1.2

TNFAIP3 tumor necrosis factor, alpha-induced protein 3

202643_s_at 6.5 202643_s_at 6.0

TP53BP2 tumor protein p53 binding protein 2

203120_at 1.8 203120_at 1.7

TRAF3 TNF receptor-associated factor 3

221571_at -1.3 221571_at -1.6

TRAK2 trafficking protein, kinesin binding 2

202125_s_at -1.3 202125_s_at -1.3

TRIB1 tribbles pseudokinase 1 202241_at 3.2 202241_at 3.4

TSC22D2 TSC22 domain family, member 2

204094_s_at 3.2 204094_s_at 2.2

TTC23 tetratricopeptide repeat domain 23

219838_at -1.2 219838_at -1.2

TYMP thymidine phosphorylase 217497_at 1.8 217497_at 1.5

UBE2H ubiquitin-conjugating enzyme E2H

221962_s_at 1.6 221962_s_at 1.6

UBR5 ubiquitin protein ligase E3 component n-recognin 5

208883_at -1.6 208883_at -1.5

UGCG UDP-glucose ceramide glucosyltransferase

204881_s_at 1.6 221765_at 1.7

UNC119B unc-119 homolog B (C. elegans)

202365_at -2.1 202365_at -2.5

UNC13B unc-13 homolog B (C. elegans) 202893_at -1.4 202893_at -1.5 USP46 ubiquitin specific peptidase 46 203870_at -1.5 203870_at -1.3 VNN3 vanin 3 220528_at 2.7 220528_at 2.2 WDR37 WD repeat domain 37 211383_s_at -1.4 211383_s_at -1.6 WDR5B WD repeat domain 5B 219538_at -1.3 219538_at -1.5 WEE1 WEE1 G2 checkpoint kinase 212533_at 2.8 215711_s_at 2.3

WSB2 WD repeat and SOCS box containing 2

201760_s_at -1.4 201760_s_at -1.4

XK X-linked Kx blood group 206698_at -1.4 206698_at -1.4

ZBTB14 zinc finger and BTB domain containing 14

209724_s_at -1.4 209724_s_at -1.3

ZBTB43 zinc finger and BTB domain containing 43

204180_s_at 1.6 204180_s_at 1.4

ZC3H12A zinc finger CCCH-type 218810_at 3.0 218810_at 2.2

containing 12A

ZFAND5 zinc finger, AN1-type domain 5

217741_s_at 2.4 217741_s_at 2.6

ZFP36 ZFP36 ring finger protein 201531_at 2.9 201531_at 2.6

ZFYVE26 zinc finger, FYVE domain containing 26

213073_at -1.4 213073_at -1.4

ZHX3 zinc fingers and homeoboxes 3 217367_s_at -1.8 217367_s_at -1.6 ZNF331 zinc finger protein 331 219228_at 2.3 219228_at 2.5

ZSCAN26 zinc finger and SCAN domain containing 26

213218_at -1.3 213218_at -1.4

Table S2, SDC. Significant canonical pathways for common deregulated genes

Ingenuity Canonical Pathways z-score Molecules Glucocorticoid Receptor Signaling -- JUN,ADRB2,KRAS,HSPA1A/HSPA1B,CCL3,IL1B,P

RKAA1,IL6,NFKBIA,CXCL8,POLR2B,FOS,IL1RN,CEBPB,PTGS2,CDKN1A,CXCL3,SERPINE1,ICAM1

HGF Signaling 1.134 FOS,JUN,KRAS,MAP3K8,PTGS2,CDKN1A,IL6,ELF3,MAP3K9,ETS2

CD40 Signaling 0.816 FOS,JUN,TNFAIP3,PTGS2,MAP2K3,TRAF3,NFKBIA,ICAM1

IL-6 Signaling 3.162 FOS,JUN,KRAS,IL1RN,IL1B,CEBPB,MAP2K3,IL6,NFKBIA,CXCL8

NRF2-mediated Oxidative Stress Response

1.667 FOS,JUN,SOD2,KRAS,JUND,ABCC4,DNAJB1,MAP2K3,GCLM,CUL3,MAFF,JUNB

HMGB1 Signaling 3.000 FOS,JUN,KRAS,IL1B,RHOB,MAP2K3,SERPINE1,IL6,ICAM1,CXCL8

PPAR Signaling -2.333 FOS,JUN,PPARD,KRAS,IL1RN,IL1B,PTGS2,NFKBIA,CITED2

Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis

-- JUN,KRAS,CEBPD,IL1B,IL6,TRAF3,NFKBIA,FZD4,CXCL8,FOS,MYC,IL1RN,CEBPB,MAP2K3,ICAM1

IL-17 Signaling -- JUN,KRAS,PTGS2,CEBPB,CXCL1,MAP2K3,IL6,CXCL8

Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

-- CCL3,IL1B,CXCL1,CCL4,IL6

IL-17A Signaling in Fibroblasts -- FOS,JUN,CEBPD,CEBPB,IL6,NFKBIA Role of IL-17A in Arthritis -- PTGS2,CXCL1,CCL20,MAP2K3,CXCL3,NFKBIA,C

XCL8 Acute Phase Response Signaling 3.317 FOS,JUN,SOD2,KRAS,IL1RN,IL1B,CEBPB,MAP2K

3,SERPINE1,IL6,NFKBIA Role of Tissue Factor in Cancer -- HBEGF,KRAS,CYR61,IL1B,PLAUR,CXCL1,EGR1,

CXCL8,ARRB1 TGF-β Signaling 2.449 FOS,JUN,KRAS,INHBA,TGIF1,MAP2K3,SERPINE1

,BMP2 IL-17A Signaling in Gastric Cells -- FOS,JUN,CXCL1,CCL20,CXCL8 Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

-- CCL3,IL1RN,IL1B,CCL4,IL6,CXCL8

Role of IL-17A in Psoriasis -- CXCL1,CCL20,CXCL3,CXCL8 IL-10 Signaling -- FOS,JUN,IL1RN,IL1B,MAP2K3,IL6,NFKBIA TNFR2 Signaling 1.000 FOS,JUN,TNFAIP3,NFKBIA,BIRC3 Toll-like Receptor Signaling 1.633 FOS,JUN,IL1RN,IL1B,TNFAIP3,MAP2K3,NFKBIA TREM1 Signaling 2.646 CD83,CCL3,IL1B,CXCL3,IL6,ICAM1,CXCL8

Cholecystokinin/Gastrin-mediated Signaling

2.828 FOS,JUN,KRAS,IL1RN,IL1B,RHOB,PTGS2,MAP2K3

CD27 Signaling in Lymphocytes -- FOS,JUN,MAP3K8,MAP2K3,NFKBIA,MAP3K9 Granulocyte Adhesion and Diapedesis

-- CXCR4,CCL3,IL1RN,IL1B,CXCL1,CCL20,CXCL3,CCL4,ICAM1,CXCL8

PPARα/RXRα Activation -1.265 JUN,ADCY1,KRAS,IL1B,PRKAA1,ABCA1,MAP2K3,BCL3,IL6,NFKBIA

Hereditary Breast Cancer Signaling

-- POLR2B,KRAS,FANCC,CDKN1A,GADD45B,GADD45A,HDAC4,WEE1

Agranulocyte Adhesion and Diapedesis

-- CXCR4,CCL3,IL1RN,IL1B,CXCL1,CCL20,CXCL3,CCL4,ICAM1,CXCL8

ATM Signaling -- JUN,CBX5,CDKN1A,GADD45B,GADD45A,NFKBIA

Communication between Innate and Adaptive Immune Cells

-- CD83,CCL3,IL1RN,IL1B,CCL4,IL6,CXCL8

Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

-- CCL3,IL1B,CXCL1,CCL4

GNRH Signaling 1.414 FOS,JUN,ADCY1,KRAS,MAP3K8,MAP2K3,EGR1,MAP3K9

NF-κB Signaling 1.000 KRAS,IL1RN,IL1B,TNFAIP3,MAP3K8,BMP2,TRAF3,NFKBIA,PELI1

Role of IL-17F in Allergic Inflammatory Airway Diseases

-- IL1B,CXCL1,CCL4,IL6,CXCL8

JAK/Stat Signaling 1.633 FOS,JUN,KRAS,CEBPB,CDKN1A,IL6 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis

-- FOS,JUN,IL1RN,IL1B,MAP2K3,BMP2,IL6,NFKBIA,FZD4,BIRC3

TNFR1 Signaling 1.000 FOS,JUN,TNFAIP3,NFKBIA,BIRC3 Cell Cycle: G2/M DNA Damage Checkpoint Regulation

2.000 CDKN1A,SKP1,GADD45A,CKS2,WEE1

IL-8 Signaling 3.000 FOS,JUN,HBEGF,KRAS,RHOB,PTGS2,CXCL1,ICAM1,CXCL8

Molecular Mechanisms of Cancer -- JUN,KRAS,BMP2,NFKBIA,FZD4,BIRC3,FOS,ADCY1,MYC,RHOB,CDKN1A,MAP2K3,PMAIP1

Colorectal Cancer Metastasis Signaling

1.265 FOS,JUN,ADCY1,KRAS,MYC,RHOB,PTGS2,IL6,FZD4,ARRB1

Unfolded protein response -- HSPA1A/HSPA1B,CEBPD,CEBPB,PPP1R15A,HSPH1

ErbB Signaling -- FOS,JUN,HBEGF,KRAS,AREG,MAP2K3 PKCθ Signaling in T Lymphocytes -- FOS,JUN,KRAS,LCP2,MAP3K8,NFKBIA,MAP3K9 RANK Signaling in Osteoclasts -- FOS,JUN,MAP3K8,NFKBIA,MAP3K9,BIRC3 p53 Signaling -- JUN,TP53BP2,CDKN1A,GADD45B,GADD45A,PM

AIP1 Telomerase Signaling 2.000 KRAS,MYC,CDKN1A,HDAC4,ELF3,ETS2

IL-17A Signaling in Airway Cells -- CXCL1,CCL20,CXCL3,IL6,NFKBIA April Mediated Signaling -- FOS,JUN,TRAF3,NFKBIA B Cell Receptor Signaling -- JUN,KRAS,BCL2A1,MAP3K8,MAP2K3,EGR1,NFK

BIA,MAP3K9 Cardiac Hypertrophy Signaling 1.667 JUN,ADCY1,ADRB2,KRAS,RHOB,MAP3K8,MAP2

K3,IL6,MAP3K9 B Cell Activating Factor Signaling -- FOS,JUN,TRAF3,NFKBIA Neurotrophin/TRK Signaling 1.342 FOS,JUN,KRAS,SPRY2,MAP2K3 GADD45 Signaling -- CDKN1A,GADD45B,GADD45A LPS-stimulated MAPK Signaling 2.236 FOS,JUN,KRAS,MAP2K3,NFKBIA Pyridoxal 5'-phosphate Salvage Pathway

-- PRKAA1,MAP3K8,MAP2K3,PDXK,MAP3K9

MIF Regulation of Innate Immunity

2.000 FOS,JUN,PTGS2,NFKBIA

Chemokine Signaling 2.236 FOS,JUN,KRAS,CXCR4,CCL4 Prolactin Signaling 2.000 FOS,JUN,KRAS,MYC,CEBPB VDR/RXR Activation -- PPARD,CEBPB,CDKN1A,GADD45A,KLF4 CXCR4 Signaling 2.449 FOS,JUN,ADCY1,KRAS,CXCR4,RHOB,EGR1 Graft-versus-Host Disease Signaling

-- IL1RN,IL1B,IL6,GZMB

Atherosclerosis Signaling -- CXCR4,IL1RN,IL1B,IL6,ICAM1,CXCL8 Bladder Cancer Signaling -- KRAS,MYC,RASSF1,CDKN1A,CXCL8 HIPPO signaling -- NF2,RASSF1,TP53BP2,PPP1R7,SKP1 Adipogenesis pathway -- CEBPD,CEBPB,EGR2,HDAC4,BMP2,FZD4 Xenobiotic Metabolism Signaling -- KRAS,IL1B,MAP3K8,MAP2K3,HDAC4,IL6,CUL3,

MAP3K9,CITED2 Hepatic Cholestasis -- JUN,ADCY1,IL1RN,IL1B,IL6,NFKBIA,CXCL8 Role of Cytokines in Mediating Communication between Immune Cells

-- IL1RN,IL1B,IL6,CXCL8

Airway Pathology in Chronic Obstructive Pulmonary Disease

-- CXCL3,CXCL8

IL-1 Signaling 1.342 FOS,JUN,ADCY1,MAP2K3,NFKBIA SAPK/JNK Signaling -0.447 JUN,DUSP10,KRAS,GADD45A,MAP3K9 Thrombopoietin Signaling 2.000 FOS,JUN,KRAS,MYC Production of Nitric Oxide and Reactive Oxygen Species in Macrophages

1.890 FOS,JUN,RHOB,MAP3K8,PPP1R7,NFKBIA,MAP3K9

ILK Signaling 1.890 FOS,JUN,MYC,RHOB,PTGS2,BMP2,PPAP2B Pathogenesis of Multiple Sclerosis -- CCL3,CCL4 ERK/MAPK Signaling 1.890 FOS,KRAS,MYC,PPP1R7,ELF3,DUSP2,ETS2 PCP pathway 1.000 JUN,JUND,FZD4,JUNB T Cell Receptor Signaling -- FOS,JUN,KRAS,LCP2,NFKBIA Aryl Hydrocarbon Receptor Signaling

1.633 FOS,JUN,MYC,IL1B,CDKN1A,IL6

Activation of IRF by Cytosolic Pattern Recognition Receptors

--

JUN,IL6,TRAF3,NFKBIA

ERK5 Signaling 2.000 FOS,KRAS,MYC,MAP3K8 Cell Cycle: G1/S Checkpoint Regulation

-- MYC,CDKN1A,SKP1,HDAC4

Glioblastoma Multiforme Signaling

0.816 KRAS,MYC,NF2,RHOB,CDKN1A,FZD4

TWEAK Signaling -- TRAF3,NFKBIA,BIRC3 Hepatic Fibrosis / Hepatic Stellate Cell Activation

-- IL1B,KLF6,CXCL3,SERPINE1,IL6,ICAM1,CXCL8

Protein Ubiquitination Pathway -- ANAPC5,USP46,HSPA1A/HSPA1B,UBE2H,DNAJB1,SKP1,HSPH1,BIRC3

Erythropoietin Signaling -- FOS,JUN,KRAS,NFKBIA G-Protein Coupled Receptor Signaling

-- ADCY1,ADRB2,KRAS,HCAR3,MAP3K8,RGS2,ADORA3,NFKBIA

Germ Cell-Sertoli Cell Junction Signaling

-- KRAS,RHOB,MAP3K8,MAP2K3,MAP3K9,PPAP2B

CCR5 Signaling in Macrophages -- FOS,JUN,CCL3,CCL4 Small Cell Lung Cancer Signaling -- MYC,PTGS2,TRAF3,NFKBIA STAT3 Pathway -- KRAS,MYC,CDKN1A,MAP3K9 p38 MAPK Signaling 1.342 DUSP10,MYC,IL1RN,IL1B,MAP2K3 Role of PKR in Interferon Induction and Antiviral Response

-- MAP2K3,TRAF3,NFKBIA

Corticotropin Releasing Hormone Signaling

-- FOS,JUN,ADCY1,JUND,PTGS2

Thyroid Cancer Signaling -- KRAS,MYC,CXCL1 Cyclins and Cell Cycle Regulation -- CDKN1A,SKP1,HDAC4,WEE1 Protein Kinase A Signaling -- DUSP10,ADCY1,ANAPC5,DUSP5,DUSP3,PTP4A1,

PTGS2,PPP1R7,NFKBIA,DUSP2 UVC-Induced MAPK Signaling -- FOS,JUN,KRAS Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes

-- FOS,JUN,KRAS,NFKBIA

LXR/RXR Activation -1.342 IL1RN,IL1B,PTGS2,ABCA1,IL6 PI3K/AKT Signaling 1.342 KRAS,MAP3K8,PTGS2,CDKN1A,NFKBIA PDGF Signaling 2.000 FOS,JUN,KRAS,MYC Dendritic Cell Maturation -- CD83,IL1RN,IL1B,IL6,NFKBIA,ICAM1 P2Y Purigenic Receptor Signaling Pathway

1.342 FOS,JUN,ADCY1,KRAS,MYC

Huntington's Disease Signaling -- JUN,POLR2B,HSPA1A/HSPA1B,HTT,DNAJB1,CLTC,HDAC4

RAR Activation -- FOS,JUN,ADCY1,PNRC1,BMP2,CITED2 iNOS Signaling -- FOS,JUN,NFKBIA PI3K Signaling in B Lymphocytes -- FOS,JUN,KRAS,NFKBIA,ATF3 Altered T Cell and B Cell -- IL1RN,IL1B,IL6,TRAF3

Signaling in Rheumatoid Arthritis Endothelin-1 Signaling 2.449 FOS,JUN,ADCY1,KRAS,MYC,PTGS2 Sertoli Cell-Sertoli Cell Junction Signaling

-- JUN,KRAS,MAP3K8,MAP2K3,MAP3K9,PPAP2B

UVA-Induced MAPK Signaling -- FOS,JUN,TIPARP,KRAS Apoptosis Signaling -1.000 KRAS,BCL2A1,NFKBIA,BIRC3 IL-12 Signaling and Production in Macrophages

-- FOS,JUN,MAP3K8,CEBPB,JMJD6

Neuregulin Signaling 2.000 HBEGF,KRAS,AREG,MYC Chronic Myeloid Leukemia Signaling

-- KRAS,MYC,CDKN1A,HDAC4

IL-2 Signaling -- FOS,JUN,KRAS IGF-1 Signaling -- FOS,JUN,KRAS,CYR61 Lymphotoxin β Receptor Signaling -- CXCL1,TRAF3,NFKBIA ErbB2-ErbB3 Signaling -- JUN,KRAS,MYC Glioma Invasiveness Signaling -- KRAS,RHOB,PLAUR CDK5 Signaling 1.000 ADCY1,KRAS,PPP1R7,EGR1 Polyamine Regulation in Colon Cancer

-- KRAS,MYC

Induction of Apoptosis by HIV1 -- CXCR4,NFKBIA,BIRC3 Tumoricidal Function of Hepatic Natural Killer Cells

-- ICAM1,GZMB

Estrogen-mediated S-phase Entry -- MYC,CDKN1A Pancreatic Adenocarcinoma Signaling

2.000 HBEGF,KRAS,PTGS2,CDKN1A

Aldosterone Signaling in Epithelial Cells

-- KRAS,HSPA1A/HSPA1B,DNAJB1,PIP4K2B,HSPH1

Type I Diabetes Mellitus Signaling -- IL1B,MAP2K3,NFKBIA,GZMB Role of BRCA1 in DNA Damage Response

-- FANCC,CDKN1A,GADD45A

Salvage Pathways of Pyrimidine Ribonucleotides

-- PRKAA1,MAP3K8,MAP2K3,MAP3K9

Hypoxia Signaling in the Cardiovascular System

-- JUN,UBE2H,NFKBIA

Systemic Lupus Erythematosus Signaling

-- FOS,JUN,KRAS,IL1RN,IL1B,IL6

Gαs Signaling -- ADCY1,ADRB2,HCAR3,RGS2 Mitotic Roles of Polo-Like Kinase -- ANAPC5,PLK2,WEE1 Estrogen-Dependent Breast Cancer Signaling

-- FOS,JUN,KRAS

IL-15 Signaling -- KRAS,IL6,CXCL8 Renin-Angiotensin Signaling 1.000 FOS,JUN,ADCY1,KRAS Signaling by Rho Family GTPases -- FOS,JUN,RHOB,PIP4K2B,SEPT2,MAP3K9 IL-3 Signaling -- FOS,JUN,KRAS Role of MAPK Signaling in the -- KRAS,PTGS2,MAP2K3

Pathogenesis of Influenza GDNF Family Ligand-Receptor Interactions

-- FOS,JUN,KRAS

PEDF Signaling -- SOD2,KRAS,NFKBIA Role of NFAT in Regulation of the Immune Response

2.000 FOS,JUN,KRAS,LCP2,NFKBIA

CD28 Signaling in T Helper Cells -- FOS,JUN,LCP2,NFKBIA Renal Cell Carcinoma Signaling -- FOS,JUN,KRAS 4-1BB Signaling in T Lymphocytes

-- JUN,NFKBIA

Regulation of the Epithelial-Mesenchymal Transition Pathway

-- KRAS,MAP2K3,EGR1,NOTCH2,FZD4

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

-- IL1B,RIPK2,IL6,CXCL8

HER-2 Signaling in Breast Cancer -- KRAS,AREG,CDKN1A Phospholipase C Signaling 2.000 ADCY1,KRAS,LCP2,RHOB,HDAC4,MARCKS Role of NFAT in Cardiac Hypertrophy

1.342 ADCY1,KRAS,MAP2K3,HDAC4,IL6

Acute Myeloid Leukemia Signaling

-- KRAS,MYC,MAP2K3

BMP signaling pathway -- JUN,KRAS,BMP2 Ovarian Cancer Signaling -- KRAS,PTGS2,FZD4,ARRB1 Coagulation System -- PLAUR,SERPINE1 MIF-mediated Glucocorticoid Regulation

-- PTGS2,NFKBIA

Ceramide Signaling -- FOS,JUN,KRAS Complement System -- CD59,CD55 Prostate Cancer Signaling -- KRAS,CDKN1A,NFKBIA Relaxin Signaling -- FOS,JUN,ADCY1,NFKBIA OX40 Signaling Pathway -- JUN,TRAF3,NFKBIA Glutamine Biosynthesis I -- GLUL AMPK Signaling 2.000 ADRB2,PFKFB3,PRKAA1,MAP2K3 Death Receptor Signaling -- TIPARP,NFKBIA,BIRC3 Superpathway of Inositol Phosphate Compounds

-- DUSP10,PIP4K2B,PPP1R7,ITPKC,DUSP2

Melanoma Signaling -- KRAS,CDKN1A Virus Entry via Endocytic Pathways

-- KRAS,CLTC,CD55

Mouse Embryonic Stem Cell Pluripotency

-- KRAS,MYC,FZD4

Role of RIG1-like Receptors in Antiviral Innate Immunity

-- TRAF3,NFKBIA

Docosahexaenoic Acid (DHA) Signaling

-- IL1B,BCL2A1

Superoxide Radicals Degradation -- SOD2 G Beta Gamma Signaling -- ADCY1,HBEGF,KRAS cAMP-mediated signaling -0.447 ADCY1,ADRB2,HCAR3,RGS2,ADORA3 LPS/IL-1 Mediated Inhibition of RXR Function

2.000 JUN,IL1RN,ABCC4,IL1B,ABCA1

HIF1α Signaling -- JUN,KRAS,SLC2A3 Hematopoiesis from Pluripotent Stem Cells

-- IL6,CXCL8

3-phosphoinositide Biosynthesis -- DUSP10,PIP4K2B,PPP1R7,DUSP2 Rac Signaling -- JUN,KRAS,PIP4K2B Wnt/β-catenin Signaling -- JUN,PPARD,MYC,FZD4 Semaphorin Signaling in Neurons -- RHOB,RND1 UVB-Induced MAPK Signaling -- FOS,JUN Glutathione Biosynthesis -- GCLM Endometrial Cancer Signaling -- KRAS,MYC Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency

-- KRAS,BMP2,FZD4

NGF Signaling -- KRAS,MAP3K8,MAP3K9 Actin Nucleation by ARP-WASP Complex

-- KRAS,RHOB

Androgen Signaling -- JUN,POLR2B,DNAJB1 Diphthamide Biosynthesis -- DPH5 NAD Biosynthesis III -- NAMPT Fc Epsilon RI Signaling -- KRAS,LCP2,MAP2K3 Myc Mediated Apoptosis Signaling

-- KRAS,MYC

Gα12/13 Signaling -- JUN,KRAS,NFKBIA 14-3-3-mediated Signaling -- FOS,JUN,KRAS EGF Signaling -- FOS,JUN EIF2 Signaling -- KRAS,AGO1,PPP1R15A,EIF1 Gαi Signaling -- ADCY1,KRAS,ADORA3 GM-CSF Signaling -- KRAS,BCL2A1 Prostanoid Biosynthesis -- PTGS2 Synaptic Long Term Potentiation -- ADCY1,KRAS,PPP1R7 Estrogen Receptor Signaling -- POLR2B,KRAS,RBFOX2 Breast Cancer Regulation by Stathmin1

-- ADCY1,KRAS,PPP1R7,CDKN1A

Granzyme B Signaling -- GZMB Glycogen Degradation II -- TYMP Selenocysteine Biosynthesis II (Archaea and Eukaryotes)

-- SEPHS1

Antiproliferative Role of Somatostatin Receptor 2

-- KRAS,CDKN1A

Angiopoietin Signaling -- KRAS,NFKBIA D-myo-inositol (1,4,5,6)- -- DUSP10,PPP1R7,DUSP2

Tetrakisphosphate Biosynthesis D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis

-- DUSP10,PPP1R7,DUSP2

Agrin Interactions at Neuromuscular Junction

-- JUN,KRAS

Non-Small Cell Lung Cancer Signaling

-- KRAS,RASSF1

Glycogen Degradation III -- TYMP Type II Diabetes Mellitus Signaling

-- PRKAA1,CEBPB,NFKBIA

Basal Cell Carcinoma Signaling -- BMP2,FZD4 Human Embryonic Stem Cell Pluripotency

-- INHBA,BMP2,FZD4

RAN Signaling -- IPO5 Uridine-5'-phosphate Biosynthesis -- CAD Fatty Acid α-oxidation -- PTGS2 Caveolar-mediated Endocytosis Signaling

-- CD55,COPB1

NF-κB Activation by Viruses -- KRAS,NFKBIA Cardiomyocyte Differentiation via BMP Receptors

-- BMP2

Salvage Pathways of Pyrimidine Deoxyribonucleotides

-- TYMP

Vitamin-C Transport -- SLC2A3 GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell

-- ADCY1,ADRB2

Regulation of eIF4 and p70S6K Signaling

-- KRAS,AGO1,EIF1

D-myo-inositol-5-phosphate Metabolism

-- DUSP10,PPP1R7,DUSP2

3-phosphoinositide Degradation -- DUSP10,PPP1R7,DUSP2 VEGF Family Ligand-Receptor Interactions

-- FOS,KRAS

eNOS Signaling -- ADCY1,HSPA1A/HSPA1B,PRKAA1 Gαq Signaling -- RHOB,RGS2,NFKBIA Melanocyte Development and Pigmentation Signaling

-- ADCY1,KRAS

Role of JAK family kinases in IL-6-type Cytokine Signaling

-- IL6

D-myo-inositol (1,3,4)-trisphosphate Biosynthesis

-- ITPKC

CTLA4 Signaling in Cytotoxic T Lymphocytes

-- LCP2,CLTC

Antiproliferative Role of TOB in T -- SKP1

Cell Signaling Crosstalk between Dendritic Cells and Natural Killer Cells

-- CD83,IL6

IL-15 Production -- IL6 1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian)

-- ITPKC

TR/RXR Activation -- BCL3,KLF9 Factors Promoting Cardiogenesis in Vertebrates

-- BMP2,FZD4

Dopamine Receptor Signaling -- ADCY1,PPP1R7 Regulation of Actin-based Motility by Rho

-- RHOB,PIP4K2B

γ-glutamyl Cycle -- GCLM α-Adrenergic Signaling -- ADCY1,KRAS VEGF Signaling -- KRAS,EIF1 Glioma Signaling -- KRAS,CDKN1A Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells

-- GZMB

Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism

-- ITPKC

CREB Signaling in Neurons -- ADCY1,POLR2B,KRAS Antioxidant Action of Vitamin C -- SLC2A3,NFKBIA IL-9 Signaling -- BCL3 Oncostatin M Signaling -- KRAS Circadian Rhythm Signaling -- BHLHE40 Cell Cycle Regulation by BTG Family Proteins

-- BTG2

Nucleotide Excision Repair Pathway

-- POLR2B

Amyotrophic Lateral Sclerosis Signaling

-- GLUL,BIRC3

Retinoate Biosynthesis I -- BMP2 D-myo-inositol (1,4,5)-Trisphosphate Biosynthesis

-- PIP4K2B

Notch Signaling -- NOTCH2 iCOS-iCOSL Signaling in T Helper Cells

-- LCP2,NFKBIA

Sphingosine-1-phosphate Signaling

-- ADCY1,RHOB

mTOR Signaling -- KRAS,RHOB,PRKAA1 Inhibition of Angiogenesis by TSP1

-- JUN

Natural Killer Cell Signaling -- KRAS,LCP2 fMLP Signaling in Neutrophils -- KRAS,NFKBIA

Thrombin Signaling -- ADCY1,KRAS,RHOB PTEN Signaling -- KRAS,CDKN1A RhoA Signaling -- PIP4K2B,SEPT2 FcγRIIB Signaling in B Lymphocytes

-- KRAS

Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

-- ETS2

Triacylglycerol Biosynthesis -- PPAP2B Assembly of RNA Polymerase II Complex

-- POLR2B

Autoimmune Thyroid Disease Signaling

-- GZMB

Pyrimidine Ribonucleotides De Novo Biosynthesis

-- CAD

CNTF Signaling -- KRAS FXR/RXR Activation -- IL1RN,IL1B Insulin Receptor Signaling -- KRAS,PPP1R7 Serotonin Receptor Signaling -- ADCY1 Cardiac β-adrenergic Signaling -- ADCY1,PPP1R7 Role of CHK Proteins in Cell Cycle Checkpoint Control

-- CDKN1A

Regulation of Cellular Mechanics by Calpain Protease

-- KRAS

Epithelial Adherens Junction Signaling

-- KRAS,NOTCH2

Wnt/Ca+ pathway -- FZD4 ErbB4 Signaling -- KRAS Role of JAK1 and JAK3 in γc Cytokine Signaling

-- KRAS

Axonal Guidance Signaling -- KRAS,CXCR4,BMP2,FZD4,RND1 Glutamate Receptor Signaling -- GLUL Tec Kinase Signaling -- FOS,RHOB Retinoic acid Mediated Apoptosis Signaling

-- TIPARP

Role of PI3K/AKT Signaling in the Pathogenesis of Influenza

-- NFKBIA

Macropinocytosis Signaling -- KRAS Tight Junction Signaling -- FOS,JUN Gap Junction Signaling -- ADCY1,KRAS Cdc42 Signaling -- FOS,JUN PXR/RXR Activation -- IL6 T Helper Cell Differentiation -- IL6 Growth Hormone Signaling -- FOS GABA Receptor Signaling -- ADCY1 FLT3 Signaling in Hematopoietic -- KRAS

Progenitor Cells Ephrin B Signaling -- CXCR4 Dopamine-DARPP32 Feedback in cAMP Signaling

-- ADCY1,PPP1R7

Melatonin Signaling -- MAP2K3 Ephrin Receptor Signaling -- KRAS,CXCR4 Leptin Signaling in Obesity -- ADCY1 IL-4 Signaling -- KRAS RhoGDI Signaling -- RHOB,PIP4K2B Reelin Signaling in Neurons -- MAP3K9 Role of Wnt/GSK-3β Signaling in the Pathogenesis of Influenza

-- FZD4

Eicosanoid Signaling -- PTGS2 tRNA Charging -- RARS Clathrin-mediated Endocytosis Signaling

-- CLTC,ARRB1

Allograft Rejection Signaling -- GZMB FGF Signaling -- MAP2K3 FAK Signaling -- KRAS PAK Signaling -- KRAS GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells

-- ADCY1