t pa flight plan - smchealth.org · t‐pa flight plan door to needle time < 60 minutes...
TRANSCRIPT
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t‐PA Flight PlanDoor to Needle Time < 60 minutes
Presented by:Sunil Bhopale, MD, FACEP
Emergency DepartmentSheryll Domingo, RN
Stroke Program Coordinator
San Mateo County 4th Annual Stroke Conference
November 30, 2012
REDWOOD CITY MEDICAL CENTER
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2 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Presentation overview:
Objectives
Stroke 101
Stroke Care Evolution in the Emergency Department
Data
Door to Needle time < 60 minute strategies
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3 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Objectives:
Review stroke physiology
Discuss available stroke treatments
Describe challenges with stroke diagnosis and treatments
Understand the importance of individual roles during acute stroke management
Identify opportunities for improved stroke care in the Emergency Department
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4 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Stroke 101: Quick Overview
Ischemic StrokesCardioembolic StrokeThrombotic StrokesLacunar StrokesCryptogenic Strokes
Hemorrhagic StrokesIntracerebral Hemorrhage (ICH) or Intraparenchymal Hemorrhage (IPH)Subarachnoid Hemorrhage (SAH)
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5 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Acute Medical Treatments
Ischemic Strokes:– t-PA– Other blood thinners– Neuroprotectants– Endovascular treatment
Hemorrhagic Strokes– Blood “thickeners” and
treat cause– Lower brain pressure
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6 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Acute Ischemic Stroke Medical Treatments
Blood pressure managementAntiplatelet therapyIV thrombolysisEndovascular treatment
– Merci clot removal (“corkscrew device”)– Intra-arterial t-PA– Intra-arterial t-PA with mechanical thrombectomy– 2008 Penumbra device (“vacuum cleaner”)– Early 2012 Solitaire Stent Retrieval Device– 2012 TREVO device
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7 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Stroke Care Evolution in the ED
1995 - NINDS trial showed benefit of t-PA– Benefit of t-PA – 30% of patients will show a significant improvement in
neurological function at 3 months after event instead of 20%
1999 Cleveland Trial – t-PA had no benefit and resulted in increased intracranial hemorrhagesEarly 2000s – t-PA use plummeted2003-4 – t-PA now with some benefit
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NINDS TPA Stroke Trial
8 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Excellent outcome at 3 months on all scales
N Engl J Med 1995;333:1581-7
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Timing of Stroke Interventions
Patients have far better outcomes the earlier they receive treatmentIntravenous thrombolysis is still considered first-line therapy for acute strokeIn 2011 for Kaiser Redwood City, less than 50% of patients got t-PA within 60 minutes of arrival
9 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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IV Thrombolysis and Stroke
10 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Number Needed to Treat to Benefit from IV TPA Across Full Range of Functional Outcomes
Outcome NNTNormal/Near Normal 8.3Improved 3.1
For every 100 patients treated with tPA,32 benefit, 3 harmed
From Target: Stroke, 2009
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Challenges with Stroke Identification
Is the patient having a stroke or stroke mimic?– Depends on history, exam, lab, and imaging data
Key points with:– History: Last known well time, seizure-like activity, waxing/waning symptoms– Exam: Focal deficit– Labs: Blood sugar, platelet count, coagulation profile– Imaging: Hemorrhage or infarct, vascular anatomy
11 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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12 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Door to Needle times Strategies
EMS Pre-notificationRapid Triage ProtocolSingle Call ActivationStroke ToolsRapid Brain Imaging
Rapid Lab TestingPremix t-PARapid Access to t-PATeam-Based ApproachPrompt Data Feedback
Source – Target: Stroke 2009
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“Flight” Plan:Door to Needle time < 60 minutes
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14 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
What is a “Flight” Plan?
Mutual Goal Established– Drill Down analysis– Data
Multiple Meetings: agreement from various disciplinesProcess Flow changes “Flight” planTest of ChangeFeedback to team
Performance Improvement Initiative
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15 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Goal: Improve our door to needle time within 60 minutes or less in 50% of our
cases
Performance Improvement Initiative:IV t-Pa Door to Needle Time (DTN) within 60 minutes
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Current t‐PA Administration:KP NCAL vs Overall National
16 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
2-5% nationally for all stroke patientsKaiser NCAL: Range 1-20%, average 10%KP door-to-needle time <60 minutes: average = 50% since October 2011
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Drill Down Summary
17 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
Analysis showed that we have a greatest opportunity for improvement from Code Gray activation to t-PA ordered time frame
t-Pa administration
t-PA OrderedCode Gray
ActivatedPatient Arrival
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Patient arrive via EMS or NON EMS
Radiologist call back with NON‐CON Head CT result
Door to Needle Time ≤ 60 Minutes
Activate code gray within 5 minutes
Review t‐PA exclusion list
Discuss case with neurologist
Assent for IV t‐PA
Enter weight in KPHC
Obtain/confirm 2 IVs
Call Pharmacy x5524 : provide pt weight, name and MRN
Draw and send labs
Transport patient to radiology for CT/CTA
Green Light:
•Inform CN/RN
•Enter KPHC order for t‐PA
Red Light: Document Reason and time
RN/CN calculates IV t‐PA dose while in CT
Calculate IV t‐PA bolus and infusion dose
ED Clerk
Call back with results x1406
Green Light: Call pharmacy at x5524Track
response time
EMS provide “flight plan” information
Ensure IV pump and IV tubing prepared
CN/RN final double check IV TPA dose
Set monitor to take VS q15 min
Place pt on monitor, Weigh pt, Place NPO sign
Deliver IV t‐PA bolus and infusion
IV t‐PA bolus given over 1 minute
Time is brain! The sooner t‐PA is given the better the outcome, and the fewer the complications.
Perform and document m‐NIHSS & VS q 15 min from time initial bolus given, then q 30min for 6h, then q 1h for 16h
Insert foley and NGT prn prior to IV t‐PA bolus
ED Physician
Primary RN
Charge Nurse (CN)
Radiology
Laboratory
Pharmacy
ED Technician
Register pt in KPHC
Print generic labels and affix label to lab requisition
RN/CN calculate IV TPA dose while in CT
Prepare CT suite
Confirm weight in KPHC
RN/CN final double check IV t‐PA dose
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Name: Code 3 (circle): Yes No__________________________
Last seen normal time : ___________________________
Name of Family Contact: ___________________________
Best Contact number: _____________________________
Glucose (fingerstick) : _____________________________
Medications - any evidence that patient on anyanticoagulant? (circle)
Warfarin (Coumadin) Dabigatran (Pradaxa)Heparin SQ Fondaparinux (Arixtra)Enoxaparin (Lovenox) Aspirin/Plavix
Prenotify
EMERGENCY MEDICAL SERVICES DOOR TO NEEDLE TIME “FLIGHT PLAN”
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20 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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21 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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E2012 IV TPA DOOR TO NEEDLE TIME WITHIN 60 MINUTES: "FLIGHT PLAN"
Project :"Brainstorm"Kick Off Meeting
"Flight Plan": education intiated
Project :"Brainstorm"Kick Off Meeting
"Flight Plan": education initiated
"Flight Plan" launched 08.06.12
Goal: 60 min
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ED Stroke Volume
22 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
# of Stroke/TIA
ED only
# of code gray activated(sx onset ≤ 7
hours)
#of ischemic stroke with
sx onset < 4.5 hours
# of IV TPA given
# of endovascular
stroke treatment
cases2010 276 145
+8 (IP)58
+3 (IP)12
3 (IP)4N=1 failed IVTPAN=3 >3-4.5 hrs
2011 282 157+10 (IP)
42+1 (IP)
81 (IP)
3N=3 IV TPA ContraindicatedN=1 (IP Code Gray- no TPA-direct to INR)
2012 Jan- Oct
207 135+5 (IP)
48+ 1(IP)
13 10N= 1 No IV TPA INR 1.7N= 3 arrived > 4.5 hrsN=1 Recent SDHN= 5 s/p TPA
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IV t-Pa Utilization in the ED for Ischemic Stroke Patients arriving with sx onset < 4.5 hours
23 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
2010 2011 2012Jan to Oct
Number of Ischemic Stroke Patients
58 42 48
Number of IV TPA given in ED
12 8 13
Percentage of IV TPA utilization in ED
21% 19% 34%
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Critical Steps to Reduce Door-to-Needle Times
Early ED physician MD involvementGetting patient weight into chart and making sure patient is NPOHaving early discussion with patient/family re: risks/benefits/alternatives to IV t-PAPrenotification of pharmacy about potential t-PA patientRegular drill-downs of every stroke alert with ED nursing, lab, radiology, and neurology
24 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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Importance of ED Physician Feedback
Drill-downs of every stroke alertPhysicians and staff congratulated when timeframes metOne ED physician needs to be the stroke championClose collaboration between ED physicians and Neurology
25 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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Importance of ED Physician Feedback
Form e-mail from ED MD stroke champion reviewing key issues:– Delay in stroke activation– Not obtaining CT angiogram– Reasons why t-PA were not given were not explicitly stated– Lack of NIHSS score documentation– No stroke education with discharge instructions– Delay in administration of t-PA
Having a command in electronic medical record to include pertinent stroke data
26 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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Results of ED Physician and Staff Feedback
ED physicians reminded of key timeframe parametersED physicians took ownership of driving stroke evaluation and candidacy for t-PABetter charting for QA/QI purposes
Net result: Improved door-to-needle times
27 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012
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Questions?
28 | © 2011 Kaiser Foundation Health Plan, Inc. For internal use only.November 29, 2012