Systematic reviews: planning the literature search 9 2016

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<p>PowerPoint Presentation</p> <p>Clara FowlerResearch Services &amp; Assessment MangerResearch Medical LibrarySystematic Reviews: Planning the Literature Search</p> <p>1</p> <p>EXPERIENCE?What is your experience with literature searching?</p> <p>I search EMBASE or CINAHL or CENTRAL frequentlyI search MEDLINE using the Ovid interface frequentlyI search PubMed frequentlyIve searched one or more of these databases infrequentlyIve heard of these databases, but never searched them</p> <p>Create a Searchable Question</p> <p>Preliminary Searching Strategies</p> <p>Search, Organize &amp; Report Results</p> <p>AGENDA</p> <p>Systematic Reviews</p> <p>High-quality systematic reviews seek to: Identify all relevant published evidence through systematic searching of multiple literature databaseshttp://www.medicine.ox.ac.uk/bandolier/painres/download/whatis/syst-review.pdf</p> <p>Create a Searchable QuestionUse PICO format.Create list of KEY CONCEPTS.Identify SYNONYMS &amp; ACRONYMS.</p> <p>Approximately 5%-30% of the population age 50 and older suffers from dry eye disease impacting visual acuity, social and physical functioning, and workplace productivity. Patients incur medical costs through frequent visits to health care professionals, as well as from prescription and over-the-counter therapies.</p> <p>The first line of treatment includes artificial tears and environmental coping strategies (frequent blinking and using humidifiers). </p> <p>There are multiple secondary treatments including topical glucocorticoids, omega-3 fatty acids, acupuncture, and surgery. A new drug, Xiidra, was approved by the FDA in 2016 to treat dry eye disease.Clinical Scenario</p> <p>In patients with dry eye disease, does Xiidra improve patient-relevant outcomes over nonprescription artificial tears?</p> <p>P (Patient): Dry Eye DiseaseI (Intervention): XiidraC (Comparison): artificial tearsO (Outcome(s)): improvement in ocular discomfort, eye dryness, and visual impairmentCreate the PICO question</p> <p>What are the most important elements of this search?</p> <p>How can you make sure that your search is comprehensive?.</p> <p>P (Patient): Dry Eye DiseasesInclude conditions that would create dry eye disease as well as synonyms for dry eye</p> <p>Dry eye disease: dry eye syndrome, dysfunctional tear syndrome, keratoconjunctivitis sicca, Sjgren's syndrome, aqueous tear-deficient dry eye, lacrimal dysfunction, lacrimal ductal obstruction, reduced reflex sensory tear secretion, decreased tear production, tear film evaporation, ocular surface irritation, chronic eye irritation, excessive tearing, blepharitis, blink rateIdentify SYNONYMS</p> <p>I (Intervention): XiidraCreate a search for the drug using all name variants</p> <p>Brand: XiidraScientific: LifitegrastExperimental: SAR 1118, SAR1118, SAR-1118Class: lymphocyte function-associated antigen 1 (LFA-1) antagonist</p> <p>Identify SYNONYMS</p> <p>Artificial tears</p> <p>How many synonyms can you think of to use for this concept?</p> <p>SearchExperience</p> <p>C (Comparison): artificial tears</p> <p>Lubricant eye drops, artificial tear drops, lubricating eye-drops, </p> <p>Nonprescription drugs, non-prescription, over the counter, OTC, over-the-counter</p> <p>Identify SYNONYMS</p> <p>Scoping SearchIs this a new question?</p> <p>Is there enough data available to complete a systematic review?</p> <p>How much time will it take to complete?</p> <p>Search PubMed Clinical Queries &amp; Cochrane Library to see if there are exisiting systematic reviews</p> <p>Search PROSPERO for registered systematic reviews</p> <p>Select DatabasesTo Search</p> <p>Cochrane LibraryCampbell LibraryMEDLINEEMBASEWeb of ScienceCINAHLPsycINFOCENTRALOthers?</p> <p>Publication TypesJOURNAL ARTICLESMEETING ABSTRACTSCLINICAL TRIALSWEBSITES</p> <p>Create a comprehensive list of keywords with alternate spellings</p> <p>Use truncationdecreas* tear* irritat*</p> <p>Use adjacencylacrimal adj3 (dysfunction* OR obstruct*)</p> <p>Keywords</p> <p>Most databases have a thesaurus or list of subject headings</p> <p>MeSH MEDLINEEMTREE EMBASECINAHL Headlines</p> <p>Look up all the relevant subject headings for each concept in your search</p> <p>Selectively explode terms</p> <p>Subject Headings</p> <p>Draft Strategy</p> <p>Create MEDLINE Strategy and review line-by-line with co-authors</p> <p>Use PRESS checklist to review all key search methods</p> <p>PRESSCHECKLIST</p> <p>REVIEW SEARCH STRATEGIES</p> <p>SearchExperience</p> <p>TranslateSearch Strategy into Other Databases</p> <p>Cochrane LibraryMEDLINEEMBASEWeb of ScienceCINAHLPsycINFOPubMedOthers?</p> <p>EMBASE</p> <p>Try translating the MEDLINE strategy into the EMBASE database</p> <p>SearchExperience</p> <p>IDENTIFICATION</p> <p>Records identified through database searching</p> <p>PRISMA</p> <p>Hand SearchingGrey LiteratureContacting ExpertsProceedingsClinicaltrials.govCited Reference Searchingpubstatusaheadofprint</p> <p>Unpublished Literature</p> <p>IDENTIFICATION</p> <p>Records identified through database searching</p> <p>Additional records identified through other sources</p> <p>PRISMA</p> <p>TipsRun the final searches within 24 hours</p> <p>Save search strategy in database as well as in a .txt file</p> <p>Last update search should be done within 6-months of submission for publication</p> <p>Exporting to EndNote</p> <p>Organizing Search Results</p> <p>De-duplication with EndNote</p> <p>Citation Management</p> <p>Search Tracking Spreadsheet</p> <p>PRISMA Flow Diagram</p> <p>Documentation</p> <p>IDENTIFICATION</p> <p>Records identified through database searching</p> <p>Additional records identified through other sources</p> <p>SCREENING</p> <p>Records after duplicates removed</p> <p>PRISMA</p> <p>Writing the SearchMethodology</p> <p>List databases and other resources searched and include date search endedDescribe search strategies and filters and number of resultsInclude other searching methods hand searching, reference searching, requesting data and articlesProvide a copy of the MEDLINE search for the appendixDiscussion Section: Include level of confidence that all available studies were located. Address whether search limits may have blocked retrieval of results or if other sources could have been searched.http://eahil.eu/wp-content/uploads/2015/09/3-7-Foster.pdf</p> <p>QUESTIONS?</p> <p>Icons from The Noun Project </p> <p>Created by Gregory Sujkowski</p> <p>Created byMickey GodfreyCreated byEric BirdCreated byOlivier GuillardCreated byiconsmind.comCreated byCallum TaylorCreated byCreative Stall</p> <p>icon attributesTemplate created by April Aultman Becker</p>

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