SYMPOSIUM

. "StatusAsthmaticus"Sheraton-Boston HotelBoston, Mass.

Friday & SaturdayJune 3&4,1977

Sponsors:•

The Massachusetts Thoracic Society•

The Lung Associations throughout Massachusetts•

T e Office of Continuing EducationTufts University School of Medicine

Supported by an Educational Grant from :

NT

Astra Pharmaceutical Products, Inc .

:r LiL i!!;,ced '

Ur

eeStatusAsthmaticus"Sheraton-Boston HotelBoston, Mass.Friday & Saturday June 3& 4,1977

PURPOSEThis symposium is designed to reviewthe newer and fundamental conceptsin the causes and mechanisms of Statusthmati u and to present the important

advances in diagnosis and treatrnent1

The program is oriented to the specialistin pulmonary medicine . allergy, generalpractice, respiratory therapy, and relatedco-profe ions1

Chairman : Earle B . Weis, M .D .

Sponsors :. The Massachusetts Thoracic Society•

The Lung Associations throughout Massachusetts•

The Office of Continuing EducationTufts University School of Medicine

Supported bar an Educational Grant from :

Ir k Astra Pharmaceutical Products, Ino,Framingham, MA

This Continuing Medical Education offering meetsthe criteria for 1 hours in Category I for thePhysician's Recognition Award of the A.M..

PROGRAM

FRIDAY, June 3 , 1977

MOP I N SESSION-Republic Ballroom

7:45-8:20REGISTRATION

8:20-8:30WELCOME

Earle B. Weiss, .D. General Chairman

FUNDAMENTALS•

Chairman : Ar end Bouhuys, M .D., Ph .D .

8:30 .9 :00DEFINITION, CRITERIA FOR DIAGNOSIS(including differential diagnosis)and CLINICAL CAUSES

uri S . Segal, MD .

EPIDEMIOLOGY AND MORTALITYPATTERNS

Frank E . Sp i r, M.D .

9:15-9:45PATHOLOGY F STATUS ASTHMATICUS(including immunopathology)WM . Thurlbe l , 1 .D,

9:45-1 0:15MECHANISMS F ASTHMA IN RELATIONT STATUS (immune. biochemical .cholinergic)Stephen I . Wass rman, MD .

RECESS

10:30-10:PHARMACOLOGICAL BASIS FORREFRACTORINESSAr end Bouhuys, M.D., Ph.D .

10 :

-11 :MUCUS AS A CONTRIBUTING ELEMENTLynne 1 . Reid, M .D.

11 :20-11 :45DISCUSSION

1 1 :4512:45LUNCH

AFTERNOON SSS ION

PATHOPHYSIOLOGY AND DIAGNOSIS∎ Chairman : Cordon L . Snider, M.D.

12 :45-1 :30OVERVIEW F PATHOPHYSIOLOGY .SPIROMETRIC AND LUN VOLUMECHANGESWarren R. Summer, M .D .

1 :30-2 :00SPECTRUM of GAS EXCHANGE DEFECTSAND ACID-BASE PROFILE

Hor a noun Ka rni, ICI . D .

ADRENOCORTICAL AND HPA FUNCTIONIN STATUS (including steroid resistance)Stuart M . Brooks , MD.

SIGNIFICANCE F THE EOSINOPHILRESPONSE; IMPLICATIONS FOR THERAPY

Albert L. Sh ff r, MD{

RECESS

3:00-3:20CHARACTERISTICS F THE RISK PATIENTAND FEATURES of THE PRODROME STATEAnthony S . R buck, 1 .D .

STAGING CLINICAL SEVERITY TTHERAPEUTIC SCHEDULESGordon L. Snider, M .D .

3 :45-4:15DISCUSSION

EVENING-Liberty Complex

MEETTHE FACULTYCocktail hour for all registered participants

SATURDAY, June 4,1 977

MORNING SESSION Indep ndenc Room

THERAPY∎ Chairman : f ron Stein, M .D .

8:30-9 :00SPUTUM : OBSERVATIONS I N STATUSAND THERAPY

Satr f rd Chodo h, II,D,

THEOPHYLLINE : PHARMACOKINETICSAND CLINICAL APPLICATION

Ralph P . Miech, M .D . . Phil

9:35-10:10-ADRENERGIC AGENTS : PHARMACO-

KINETICS, CLINICAL APPLICATION,INCLUDING ADVANCES IN LV THERAPYAND ADVERSE REACTIONSDomingo M . A iado, .D .

10:10-10:30p2-SELECTIVE AGENTS AND ROLE I1STATUSJoseph J . I

Phillip , Ph.D .

10 :30-10:45RECESS

10:45-11 :15COAT IC TERCIDS (mechanisms) ANDTHERAPEUTIC SCHEDULESJohn V. Collins, M .D .

11 :15-11 :30ANTIBIOTICS AND SEDATIVES

L. Jack Faling, MD .

11 :30. 11 :45ROLE F IPPB

ron Stein. MID .

11 :45-12:15OXYGENATION AND VENTILATORYSUPPORT

Thomas L, Petty, M . D .

12:15-12 :30BRONCHOSCOPY, LAVAGE

Daniel IIA . o mart, MD .

DISCUSSION

LUNCH

AFTERNOON SESSION

SPECIAL PROBLEMS∎ Chairman : Gus#aye A . Laurenzi, M .D .

2:00-2 :35CHILDHOOD STATUS

Elliot F . Ellis, II1,D .

2:35-2 :50PREGNANCYSheldon intz, M .D .

2:50-3 :10CAUSES F COMPLICATIONS ANDMORTALITY-IN AND OUT F HOSPITALC u to v A. Lour n i, 1 . D,

3:10-3:25METHOD CF PROPHYLAXISSheldon Spector+ . D,

3:25-3:40RECESS

3:40-4:00CORTICOSTEROID WEANING ANDMAINTENANCE SCHEDULES (oral andaerosol)

fll . Henr Willi r

,

f,

4:00-4:15PSYCHOLOGICAL PRPROBLEMS

Peter H . Knapp, .D .

441 5-4:45DFSCU I N

4:45ADJOURNMENT

FACULTYDomingo M. Aviado, M .D .

Professor of PharmacologyUniversity of Pennsylvania School of MedicinePhiladelphia, Pennsylvania

Arend Bouhuys, M.D., Ph.D.Professor of Medicine and EpidemiologyDirector, Lung Research CenterYale University School of MedicineNew Haven, Connecticut

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Coauthor: Richard L . RdoJtson, M.D.Vos~doCto ralAssociafein M9diciriaYa1B UnivBr3ify SChO01 of MEd1CiReNew Haven . Connacdcul

Stuart M. Brooks, M .D.Associate Professor andChief, Clinical Studies DivisionDepartment of Enuironmentaf Health and MedicineUniversity otCircirrntiCincinnati, Ohio

John Y Collins, M.D .Consultant PhysicianBrompton HospitalLondon. England

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Coauthor: D. Jones. M.D.Cl+n+caf Research FellowBromptor HospitalLondon. England

Sanford Chodaah, M .O.Associate Professor of MedicineBoston University5choof of MedicineDirector, Sputum LaboratoryBoston City Hasp ftalBoston, Massachusetts

Elliot F. Ellis, M .D .Professor and Cha+rmanDepartment of PediatricsState University of New York at BuffaloPediatrician-in-ChiefChildren's Hospital at BuffaloBuffalo, New York

L. Jack haling, M.D.Assistant Professor of MedicineTufts University School of MedicinePulmonary ServiceVeterans Administration HospitalBoston, Massachusetts

I-loma oun azemi .D .Associate Professor of MedicineHarvard Medical SchoolChief, Pulmonary UnitMassachusetts General HospitalBoston, Massachusetts

. Coauthor: David,. anorakD.Iss+sranrProfessor of Med+canHarvard Medroar SchoolAsststenr in MedlctneMassachusetts er,erai F osp~ralBoston, Massachusetts

Peter H. Knapp, M.D .Professor and Associate ChairmanDivision of PsychiatryBoston UniverSitySchaol of MedicineBoston, Massachusetts

S Coauthor: Loris VdChof7

D.Also para Professorot Ps ctr~atry8osrori nihers+ty Schao of Med~crr~egosronp Massact usetrs

Daniel M . Kavnat, M .D .Assistant Professor of MedicineBoston University School of MedicineMedical Director, Respiratory Care ServiceBrockton HospitalBrockton . Massachusetts

Gustave A. Laurenzi, M .D.Clinical Professor of MedicineTufts University School of MedicineDirectvrof Pulmonary DiseasesNewton-Wellesley HospitalNewton Lower Falls, Massachusetts

Joseph J . MGPhillipa, Ph.D .Associate Medical DirectorAstra Pharmaceutical Products, Inc .Framingham, Massachusetts

Ralph P . Miech, M.D., Ph.D.Associate Professor of Medical SciencesDivision of Biological and Medical SciencesBrown UniversityProvidence, Rhode Island

Sheldon M+ntx, M .D.Assistant ProfessorDepartment of MedicineUniversity of TorontoAssociate DirectorGage Research InstituteToronto, OntarioCanada

Thomas L. Petty, M .D.Professor of MedicineHead, Division of Pulmonary SciencesU niversity of ColoradoDenver, Colorado

Anthony 5. Rehuck, M .D.Associate Professarvf MedicineUniversity of TorontoToronto . OntarioCanada

Lynne M. Reid, M .D .S . Burt Wolbach Professor of PathologyHarvard Medical SchoolPathologist-in-ChiefChildren's Hospital Medial CenterBoston, Massachusetts

Maurice S . Segal, M.D.Emeritus Professor of MedicineTufts

University School of MedicineDirector, Foundation for Research inBronchial Asthma and Related DiseasesCambridge, Massachusetts

Albert L . 5heffer, M .O.Associate Clinical ProfessorHarvard Medical SchoolDirector . Allergy ClinicPeter Bent Brigham HospitalBoston, Massachusetts

Sheldon Spector, M .O.Head, Allergy and Clinical EmmunologyNational Jewish Hospital and Research CenterDenver, Colorado

Frank E. 5peizer, M .D.Associate Professor in MedicineHarvard Medical SchoolChief. Division of Clinical EpidemiologyChanning LaboratoryBoston, Massachusetts

Gordon L . Snider, M .D.Professor of Medicine and HeadPulmonary SectionEoston University School of MedicineChief, Pulmonary disease sectionVeteranSAdrninistration HospitalBoston. Massachusetts

Myron Stein, M.D.Professor of Clinical MedicineLiniversiry of Cal iforn is at Los AngelesCo-Director. PuimonaryMedicineDavid M. Brotman Memorial HospitalGulver City, California

Warren R. Summer, M.D.Assistant Professorof Medicine andClinical DirectorDivision of Respiratory DiseasesThe Johns Hopkins UniversitySchonl of MedicineBaltimore, Maryland

William M. Thurlheck, M.D .Professor and HeadDepartment of PathologyUniversityof ManitobaWinnipeg, ManitobaCanada

Stephen I. Wasssrman, M.O.Assistant Professor of MedicineHarvard Medical SchoolAssistant PhysicianRobert Breck and Peter Bent Brigham HospitalsBoston, Massachusetts

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Coauthors :davidM_ Center, M.A.Research Fflow in MiceI-larverp Medical Schoo'Assistant PhysicianPeter 9enf 8ri$hem HpspifalBoston. Messachuselts

M. Henry Williams, M .O.Professor of MedicineAlbert Einstein College of MedicineDirector, Chest ServicesBronx Municipal Hospital CenterBronx . New York

1f. Frank A ustenr .D.Professor of Modi ineHarvard Me#caJ SchoolFhysrdan-irr-ChiefRobert Br k 8rfghar tospAafBoston, Massachusetts

Earle B. Weiss, M.D.Professor of MedicineUniversityof Massachusetts Medical SchoolDirector, Department of Respiratory DiseasesThe St. Vincent HospitalWorcester, Massachusetts