Switching to Single-Use, Single-LayerFluoropolymers for BioprocessingIn biopharmaceutical production, each instance where materials or productsin development must be stored, handled, or transported presents a risk forbreakage, contamination, and expensive product loss. Entegris Aramus™single-layer fluoropolymer bag assemblies eliminate these risks. Here’s how:

In a modern, decentralized biopharmaceutical production line, materials andproducts must be kept frozen to ensure product safety, consistency, and shelflife, and then they are stored, handled, and shipped at cold temperatures manytimes in many facilities.

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COLD STORAGE AND HANDLING REQUIREMENTS

DESIGNED FOR YOUR PROCESSES AND TOOLS

Entegris AramusSingle-use Bag

Assembly

CRO/CMOUpstream

Production

BulkBiopharmaceutical

Manufacture

Final FillAnd Finish

MaterialTransport

ProductTransport

BulkTransport

DownstreamProduction

STORAGE

UNCAPPING BOTTLES

HANDLING CONTAMINATION

Bottles must be uncapped and recapped in costlycleanroom environments to prevent contamination.

CONNECTING ARAMUS BAGSAramus bag assemblies have built-in connectors madeof high-purity materials, eliminating the need to uncapor recap when connecting to process tools.

CUSTOM DESIGNEDEach Aramus bag assembly is custom-designed to meetyour specific bulk drug substance filling needs and tightdelivery timelines.

The Entegris Aramus single-use bag assembly is made from a single layer of high-grade, gamma-stable fluoropolymer film that ensures product remains inert, and they are custom designed to fit seamlessly into your process, and can even improve your bottom line.

200°C

-196°C

Bottle materials can also begin leaching chemicals into the valuable productsthey contain. Aramus assemblies are made from chemically-resistant fluoropolymerfilm that doesnot contaminatethe product.

Bottle materials are susceptible to costly breakage if dropped.Aramus bag assembliesare thoroughly drop-tested to ensurereliability.

Many vital cell-baseddrugs must be stored at or below -85°C. Aramus bag assemblies stay resilient whereas other materials become brittle.

Failure in any part ofthe product life cyclecan result in market opportunity losses and unacceptable risk to patient health, timelydrug development, and product yields.Careful bag selectioncan mitigate theserisks and help maintainproduct quality, purity, and e�cacy.