surgical pharmacology and anesthesia
DESCRIPTION
Pharmacology Pharmacology: Study of drugs and their actions Drug: Diagnosis, treatment, cure, mitigation (lessen), or prevention of disease or a condition Prophylaxis: Treatment to prevent disease: treatment such as vaccination that prevents disease or stops it spreading © 2004 by Delmar Learning, a division of Thomson Learning, Inc. All Rights Reserved.TRANSCRIPT
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Surgical Pharmacology and
Anesthesia
Chapter 9
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Pharmacology
• Pharmacology: Study of drugs and their actions
• Drug: Diagnosis, treatment, cure, mitigation (lessen), or prevention of disease or a condition
• Prophylaxis: Treatment to prevent disease: treatment such as vaccination that prevents disease or stops it spreading
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Drug Sources
• Drugs are derived from 5 main sources:
• Plants• Animals• Minerals• Laboratory synthesis• Biotechnology
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Drug Sources
• certain plants and plant parts may contain medicinal properties
• Ex: digitalis
• Plants
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Drug Sources
• Essential hormones are derived from animal (including human ) sources
• Bovine• Porcine • EX: Bovine
insulin
• Animals
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Drug Sources
• Variety of applications
• from the earth• EX: gold, iron,
magnesium, silver, and zinc
• Minerals and mineral salts
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Drug Sources
• manufactured in a lab in 1 of 2 methods:
• Synthetic• Semisynthetic
• Laboratory Synthesis
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Drug Sources
• Synthetic: Drugs manufactured totally from lab chemicals EX: Meperdine Sulfate (Demerol)
• Semisynthetic: Drugs which begin with a natural substance which begins with a natural substance that is then chemically altered
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Drug Sources
• Biotechnology• genetic engineering• also called recombinant DNA
technology
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Drug Sources
• Recombinant DNA technology
• DNA is made artificially• introduces foreign DNA into the
DNA of a specific organism. • 2 DNA types combine• new DNA/specific proteins are
replicated in the daughter cells of an organism
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Drug Sources
• Recombinant DNA technology
• Cell reproduction occurs rapidly
• provides large amounts of the desired protein for use in the manufacture of certain drugs
• EX: Hepatitis B vaccine
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Pharmacodynamics
• The interaction of drug molecules with the target cells
• resulting action is biochemical and physiological
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Pharmacokinetics
• The entire process of the drug within the body:
• absorption• distribution• bio-transformation
(metabolism)• excretion
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Indication
• Reason to perform a specific procedure or prescribe a certain drug
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Contraindication
• Reason why a specific procedure or drug may be undesirable or improper in a particular situation
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Drug Forms
• Drugs are prepared for administration in several different forms
• the type of form in which the drug is made available will determine the route of administration as well as the pharmacodynamics and pharmacokinetics
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Drug Nomenclature
• 3 names are assigned to each drug
• chemical name• generic name• Trade or brand name
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Drug Nomenclature
• Chemical name:• precise chemical composition
and• precise molecular structure of
a drug• complex• difficult to use
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Drug Nomenclature
• Generic name:• nonproprietary name for a drug • often the shortened version of
the chemical name• may include a reference to the
intended use• Advocated in the health care
setting to avoid confusion
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Drug Nomenclature
• Trade or Brand name:• Drug name selected and
copyrighted by the manufacturer for marketing purposes
• Name of drug is capitalized and may be followed by the trademark sign
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Route of Administration
• Oral/enteral• PO• Ingest
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Route of Administration
• Buccal• between the cheek and teeth• dissolved or absorbed• (considered topical)
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Route of Administration
• Sublingual• placed under tongue until
dissolved or absorbed• (considered topical)
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Route of Administration
• Topical• applied to skin or mucous
membrane• provides a localized or
systemic effect
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Route of Administration
• Inhalation• Direct administration via
respiratory tract
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Route of Administration
• Parenteral• other than enteral - by injection
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Route of Administration
• Dermal• between the layers of the skin
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Route of Administration
• Subcutaneous (SC or SQ)• Under the skin, into the
adipose tissue
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Route of Administration
• Intramuscular (IM)• Within a muscle
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Route of Administration
• Intravenous (IV)• Into a vein
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Route of Administration
• Intra-articular• Within a joint
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Route of Administration
• Intrethecal• Into the subarachnoid space
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Route of Administration
• Intracardiac• into the heart
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Drug Classifications
• Keeps drugs organized• classifications overlap, or have
several sub-classifications• drugs for sale are classified in
2 ways:• OTC• Require prescription
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Drug Classifications
• Controlled Substance Act 1970
• designates certain drugs as controlled substances and defines 5 classifications or schedules:
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Drug Classifications
• Schedule I• EX: heroin,
LSD, other hallucinogens and certain opiates and opium derivatives
• High abuse potential
• no current approved medical use
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Drug Classifications
• Schedule II • High abuse potential
• high ability to produce
• physical / and or
• psychological dependence
• there is current approved or acceptable medical use
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Drug Classifications
• Schedule III • Less potential for abuse
• current approval for medical use
• contain limited quantities of codeine
• anabolic steroids
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Drug Classifications
• Schedule IV • Relatively low abuse potential
• current medical use
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Drug Classifications
• Schedule V • antitussives• antidiarrheals
• Contains limited amounts of certain narcotic drugs for use
• limited quantities can be purchased without prescription (>18)
• must be purchased from a pharmacist
• state laws vary
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Drug Classifications
• Drugs are also classified according to:
• chemical type (barbituate)• body system affected
(neurologic agent)• physiological action (CNS
depression)• therapeutic action
(anticonvulsant)
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Pharmacokinetics
• Term used to describe the entire process of the drug within the body which involves:
• absorption• distribution• biotransformation
(metabolism)• excretion
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Pharmacokinetics
• Absorption• must be absorbed to produce
an effect• occurs at the site of
administration• substance is taken into the
bloodstream by the capillaries - passive transport
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Pharmacokinetics
• Absorption• passive transport - drug
substance is transferred from a an area of high concentration to an area of lower concentration until the concentration on both sides of the cell membrane is equal
• requires no energy• most drugs are transported this
way
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Pharmacokinetics
• Absorption• Active transport required for
limited number of drugs (glucose, amino acids)
• energy source in the form of a cation (ion that has a + charge)(sodium) carries the substance from a lower concentration to a higher concentration
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Pharmacokinetics
• Absorption• rate of absorption affects final
drug action (pharmacodynamics) of a substance
• influenced by several factors- drug type, dosage, route of administration, patient’s condition
• a vasoconstrictor may be added to the drug prep to slow absorption
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Pharmacokinetics
• Distribution• transport of the drug substance
that occurs once it enters the circulatory system
• distributed to target cells for action or to the liver for biotransformation
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Pharmacokinetics
• Distribution• affected by the rate of
absorption, systemic circulation (cardiovascular function) and regional blood flow to the target organ or tissue.
• Drug is carried to all parts of the body
• effects other than those that are intended may be noted
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Pharmacokinetics
• Distribution• also affected by plasma protein
binding, tissue binding, certain barriers established by the body (blood - brain barrier)
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Pharmacokinetics
• Biotransformation• metabolism• most often occurs in the liver
and may involve other tissues (intestinal mucosa, lungs, kidneys, blood plasma)
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Pharmacokinetics
• Biotransformation• a few drugs are converted into
ac active substance by the liver, but the main function is to breakdown of drug molecules with enzymes for excretion
• the breakdown of metabolism are called metabolites - less active or inactive substances
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Pharmacokinetics
• Biotransformation• the hepatic first pass effect
must be considered when planning drug dosage and administration route
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Pharmacokinetics
• Excretion• drug’s effect continues until it is
biotransformed and/or excreted• drugs are physiologically
removed from the target organ or tissue through the circulatory system in the intact or biotransformed (changed or inactivated) state
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Pharmacokinetics
• Excretion• The kidneys are primarily
responsible for excretion• also may be excreted through
feces, sweat, saliva, or exhaled, also through breast milk
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Pharmacodynamics
• Describes the interaction of drug molecules with the target cells
• action of substance causes an alteration in physiological activity but is incapable of initiating a new function
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Pharmacodynamics
• Drug actions include inhibition or destruction of foreign agents, supplementation or replacement of specific hormones, vitamins, or enzymes
• increasing/decreasing speed of physiological function
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Pharmacodynamics
• Drugs are administered to produce an expected or therapeutic effect
• there are 3 time and action related aspects of pharmacodynamics:
• onset• peak effect• duration of action
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Pharmacodynamics
• Onset• time it takes from
administration of the drug for it’s action to become evident
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Pharmacodynamics
• Peak effect• period of time during which the
drug is at it’s maximum effectiveness
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Pharmacodynamics
• Duration of action• time between the onset of
action to the cessation of action
• timing of future doses of drug will depend on time of onset, peak effect, and duration of action
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The Five R’s of Drug Handling
• Right patient• Right drug• Right dose• Right route of administration• Right time and frequency
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Drug Identification on the Sterile Field
• Labeled immediately• Policies and procedures of the
facility• Some medications require
different handling procedures
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Balanced Anesthesia
• Hypnosis• Anesthesia• Amnesia• Muscle relaxation
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Phases of General Anesthesia
• Induction • Maintenance • Emergence• Recovery
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Laryngospasm and Bronchospasm
• Spasm or rigidity of upper respiratory tract
• Inability of patient to breathe• Inability of anesthesia provider
to move air and waste gases in and out of the lungs
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Malignant Hyperthermia
• Potentially fatal• Genetically transmitted• Stop anesthetic gases• Administer 100% 02 • Chilled IV fluids• Chilled saline lavage of body
cavities• Dantrolene
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Anesthetic Agents
• Inhalation agents• IV agents• Local/regional agents
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Monitoring Devices
• Electrocardiogram• Blood pressure monitor• Temperature monitor• Pulse oximeter
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Types of Anesthesia
• Local– Monitored anesthesia care
(MAC)
• Regional– Nerve plexus block– Bier block– Spinal block