Supporting Your Innate Immunity

Mark Lange, PhD

DisclaimerThese statements have not been evaluated by the Food and Drug

Administration. This product is not intended to diagnose, treat, cure or

prevent any disease.

The Hygiene Hypothesis▪The shift from dirty to sterile has changed our immune response.

▪The idea that sterile is good, sterile is healthy, is being questioned.

Our Urban Lifestyle Attempts to Eliminate Naturally-Occurring Microbes, Yeasts and Molds

Exposure to Dirt/Microbes Might Actually Upregulate Immune

Response▪Children going to daycare have fewer asthma and allergies as they grow up.

▪Children living on farms less likely to have asthma and allergies.

▪Growing up in large family gives exposure to viruses and microbes.

▪Breast-fed babies have fewer allergies than bottle-fed.

Is Getting Dirty the Best Way to Support Natural Immune

Response?

How Your Immune System Works

▪Creates a barrier that prevents bacteria and viruses from entering body.

▪Your innate (meaning “present from birth”) immune system detects and destroys without needing to be trained to identify the intruders. (FAST)

▪Your adaptive immune system learns. (SLOWER)

Cells of the Innate Immune System▪Neutrophils are very abundant.▪Attack in large numbers.▪They are the first responders; within minutes.▪Survive only 1-2 days.

Cells of the Innate Immune System▪Macrophages (“big eaters”) ▪Hang out in lung, gut, mucosal tissue.▪Either “eat” (phagocytize) invaders or▪Give an external oxidative burst to kill invaders.

Complement▪Is like a chemical red flag, marking pathogens as being “non-self.”

▪Acts as an attractant to innate immune cells, such as neutrophils.

▪Complement also enhances the binding of the pathogen for phagocytosis, enhancing the antimicrobial activities of neutrophils.

Supporting a Healthy Immune System

Wellmune®

▪Derived from a proprietary strain of yeast.▪Generally Recognized as Safe (GRAS) and non-allergenic.

▪Effectiveness proven in clinical trials.▪Source of beta glucans, which act as complement to neutrophils.

How Wellmune® WorksAfter ingestion, Wellmune is absorbed in the GI tract through Peyer’s patches.

Macrophages Digest Wellmune

Wellmune Wellmune Active Fragments

Enzymes

Slowly released

Engulfing a Bacterium

Neutrophil

Bacterium flagged with complement

Receptor (CR3)

Beta Glucan Fragment

Captured Bacterium

Two More Immune-Supporting Ingredients

▪Zinc▪Phagocytosis▪Generation of oxidative burst

▪Vitamin C▪Protects cell membrane from oxidative burst

Wellmune Improves Mood State▪ S.M. Talbott and J.A. Talbott. Baker's Yeast Beta-Glucan

Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women J Am Coll Nutr. August 2012 vol 31 no. 4 pp 295-300.

▪ S.M. Talbott and J.A. Talbott. Effect of BETA 1, 3/1, 6 GLUCAN on upper respiratory tract infection symptoms and mood state in marathon athletes Journal of Sports Science and Medicine (2009) 8, pp 509-515.

▪ Placebo controlled studies showing decreased confusion, fatigue, tension, anger and increased vigor after stress.

nutraMetrix® Immune Benefits

▪Boosts the body’s natural immune response.▪Clinical trials show Wellmune® promotes a healthy immune system.

▪Promotes beneficial activity of macrophages.▪Promotes healthy energy levels and vitality.▪Improves mental clarity.