supplementary information - blood compatibility of mesoporous silica nanoparticles … · ·...
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Yildirim et. al. | Blood Compatibility of Mesoporous Silica Nanoparticles | http://bg.bilkent.edu.tr 1/8
Supplementary Information
Impact of mesoporous silica nanoparticle surface functionality on
hemolytic activity, thrombogenicity and non-specific protein
adsorption
Adem Yildirim ab, Erol Ozgur ab, Mehmet Bayindir abc∗
aUNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.
bInstitute of Materials Science and Nanotechnology, Bilkent University, 06800 Ankara, Turkey
cDepartment of Physics, Bilkent University, 06800 Ankara, Turkey
∗Corresponding author: E-mail: [email protected]
We have provided TEM images of A-MSN, M-MSN, Ph-MSN, T-MSN, R-MSN and PEG-MSN
(Fig. S1 and S2); Fluorescence spectrum of R-MSN (Fig. S3); FTIR spectra of all eight MSNs (Fig.
S4); TGA spectra of aminopropyl functionalized MSNs (Fig. S5); and Hemolysis results of HSA
coated MSNs (Fig. S6).
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
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Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
Yildirim et. al. | Blood Compatibility of Mesoporous Silica Nanoparticles | http://bg.bilkent.edu.tr 3/8
Fig. S1 TEM images of (a) A-MSN, (b) M-MSN, (c) Ph-MSN (d) T-MSN and (e) R-MSN. The
hightograms at right show the particle size distribution of particles. The histograms were generated
by measuring the diameter of 100 particles from the TEM images.
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
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Fig. S2 TEM image of PEG-MSN. Thin organic layer formed around the particles can be observed
from the TEM image.
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
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Fig. S3 Fluorescence spectrum of R-MSN. The bright fluorescence of Rhodamine B dye can be
clearly seen.
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
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Fig. S4 FT-IR absorption spectra of all MSNs. The C-H absorption peak around 3000 cm-1 is more
distinct for functionalized MSNs.
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
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Fig. S5 TGA spectra of aminopropyl modified MSNs. As the APTES/TEOS molar percentages
increased the weight loss also increased.
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013
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Fig. S6 Hemolysis results of HSA coated MSNs. With increasing HSA concentration reduced
hemolytic activity was observed.
Electronic Supplementary Material (ESI) for Journal of Materials Chemistry BThis journal is © The Royal Society of Chemistry 2013