Supplementary Figure 1. Methylation levels at individual CpGs in four loci: A (INS), B (SLC16A3), C (VAV1), D (ZNF512)) assayed on the Illumina Infinium array (“beta value”, on the X-axis) vs. the value obtained by bisulfite pyrosequencing (on the Y-axis). Although assay sensitivities vary at each CpG site (slopes greater or lesser than 1), methylation values for all four assays show significant correlations between assays. (cg# in graph heading after gene name is Illumina ID)

Supplementary Figure 2. Methylation levels at two CpGs that differ significantly between groups within the ZNF512 gene (A, P<0.05 at each CpG, see Table 2) the SLC16A3 gene (B, P < 1.8 X 10-6 for cg14417329; see Table 1).

AAAS CHI3L1 FLJ44674 KLK9 PEX10 SMPD3 ABCA3 CHRM1 FLJ44861 KMO PEX6 SNAPC5 ABCA5 CHRNA4 FLJ46230 KNG1 PFKP SNURF ABCC8 CHST3 FMNL1 KPNA1 PGBD4 SNX5 ABHD5 CHST6 FNDC6 KRT13 PGLYRP1 SOCS6 ACOT7 CKAP1 FOSL1 KRT24 PHB2 SOX18 ACSL3 CLEC4E FOXD2 KRT6E PHLDB3 SPATA18 ACSL6 CLIC3 FOXD4L1 KRTAP11-1 PIGO SPATA8 ACTR2 CLIPR-59 FOXI1 KRTAP15-1 PIK3R3 SPINT1 ACVR2A CLK2 FRK KRTHA2 PKD2 SPRR1B ACY3 CMTM5 FSD1NL KRTHB6 PKP1 SPRY4 ADAM21 CNIH2 FSHB LAMC1 PLCD1 SPSB1 ADAMTS9 CNKSR3 FSTL1 LAT1-3TM PLEC1 SSX2 ADSS CNTNAP4 FXYD4 LBR PLEKHA4 ST3GAL5 AHCYL1 COBRA1 G10 LCE1F PLEKHB1 STAC3 AHNAK COL13A1 GABRB1 LEF1 PLEKHK1 STIP1 AHR COMMD1 GABRR1 LGI4 PLOD1 STX18 ALDH4A1 COPA GALM LGR5 PNOC SULT1A1 ALG14 COX7A1 GALNACT-2 LGR8 POM121 SULT1C2 ALKBH COX8A GALNTL5 LIF POMT2 SUPT7L ALX4 CPA3 GALR1 LMAN2 POMZP3 SURF5 AMOTL2 CPA5 GAS2L2 LOC126248 POU3F3 SYNGR2 ANGPTL2 CPSF1 GATA4 LOC129530 PPA1 SYNJ2 ANXA7 CRELD1 GCKR LOC161247 PPBPL2 TADA3L APBA2 CRYGB GCSH LOC221091 PPM1B TAP2 APOC1 CTSZ GEFT LOC284912 PPP1R2 TBC1D16 ARHGEF19 CUEDC1 GENX-3414 LOC63928 PPP1R9A TBPL2 ARIH2 CWF19L1 GFI1 LOC90580 PPP3CC TCF19 ARL1 CXADR GGTLA1 LOC91689 PRDM10 TCF20 ARL2BP CYB5A GJA4 LOX PRDM2 TCF21 ARL6IP2 CYBASC3 GJB1 LRAT PRKCBP1 TCL1B ARPC3 CYP1A1 GK2 LRP6 PRKG1 TCN2 ASAH3 CYP20A1 GNAQ LRRC16 PRND TDGF1 ATF5 CYP2B6 GNAS LRRC4 PRPH TEX15 ATOH1 CYP4X1 GNL1 LY6D PRSS7 TFF3 ATP10A CYP8B1 GOLPH3 LY75 PSARL TGFBR1 ATP12A DAAM1 GOLPH4 LYZL4 PSIP1 THAP9 ATP1B3 DAD1 GPHA2 MAB21L2 PSMB3 TIA1 ATP5D DAZAP1 GPR107 MAD1L1 PSMB4 TIGD3 ATP5S DCAKD GPR132 MAN1A2 PSMB6 TIMM10 ATP6V1B2 DDX42 GPR15 MAP1A PSME1 TIMM44 ATP6V1D DDX49 GPR21 MAP1LC3A PTK6 TLE6

ATP9A DEXI GPR24 MAP2K5 PTPN6 TLX2 ATPBD4 DGCR8 GPR42 MAP3K7IP1 PTPRE TMC6 B3GNT1 DGKA GPX4 MAP6D1 PTPRO TMCC2 B3GTL DGKE GRIN2C MAPBPIP QTRT1 TMED7 BARHL1 DGKH GSG1 MAPK11 RAB14 TMEM20 BCAM DHDDS GSTP1 MARK2 RAB20 TMEM25 BCDIN3 DHFR GTF2B MAS1L RAB3GAP1 TMEM39B BCL2 DKFZp434B1231 GUCA1C MBNL1 RAI1 TMEM88 BIK DLG4 H3F3B MC1R RALGDS TMPRSS11F BLMH DLL3 HACE1 MCCC2 RAMP1 TNFRSF1A BMPR2 DMBT1 HDAC10 MCM6 RAPGEF1 TNNI1 BRD8 DMBX1 HDHD3 MDM4 RAPGEFL1 TNS4 BRI3 DMN HELLS ME2 RASL10B TP53BP1 BTBD11 DMRTC1 HERC1 MERTK RASL11A TPTE C10orf111 DOK5 HERC1 MEST RBM21 TRIAP1 C10orf42 DPM1 HERC5 MGC17839 RBM4 TRIB2 C11orf56 DPP4 HIST1H1D MGC26744 REEP2 TRIM42 C12orf11 DPYSL3 HIST1H4K MGC26885 RELB TRIM59 C12orf36 DUSP16 HIST2H2AA MGC26963 RFPL3 TROAP C12orf43 DUSP3 HIST3H3 MGC29891 RFX1 TRPM2 C14orf153 DUSP4 HK3 MGC7036 RGS14 TRPM5 C15orf20 E2F6 HLA-DMB MGC9712 RLN1 TRPM8 C15orf27 EBI3 HNF4G MKLN1 RLN2 TRSPAP1 C15orf39 EDG4 HNRPH3 MLCK RNF170 TRY1 C17orf71 EDN2 HNRPM MLR1 RNF182 TSPAN1 C1orf142 EEA1 HNRPU MON1A RNF36 TTC12 C1orf177 EGLN2 HOOK1 MPZL1 RNF40 TTC22 C1orf21 EIF2C1 HOXA7 MRGPRX1 RPL22 TTLL4 C1orf54 EIF3S9 HOXA9 MRPL11 RPL7 TTPA C1orf83 EIF4E HRIHFB2122 MRPL16 RPP14 TXNDC6 C20orf165 ELAVL4 HS747E2A MRPS26 RPRM TXNL6 C20orf67 ELOVL3 HSA9761 MRPS33 RPS15A UBA2 C20orf85 ELOVL6 HSF2BP MRPS5 RPS23 UBA52 C2orf17 ENTPD1 HSPA12B MSH3 RPS29 UBE3A C2orf33 EPHA5 HSPA1A MSH6 RPS3A UGT1A6 C3 EPHX2 HSPA5 MTERF RSN ULBP1 C3orf24 ERBB2 HSPA5BP1 MTERFD3 RTN4IP1 UNQ2541 C3orf58 ERGIC1 HSPB1 MTHFR RUFY3 UNQ9438 C5AR1 ERMAP HSPB2 MUC1 RUNX3 UPF3A C7orf23 ESPN HTATIP2 MXD1 RXRA USHBP1 C7orf25 ESR1 HYAL4 MYO1C S100A12 USP44 C9orf16 ET IFT81 NANP S100A13 UTS2D C9orf78 ETNK2 IGF1 NCBP1 S100P VAMP3 C9orf85 EVX1 IGF2 NCK1 SALL4 VASP CAD EXDL2 IGF2AS NDFIP1 SBP1 VCPIP1 CALM3 EZH2 IKBKB NDUFS2 SCARF1 VGLL2 CALML3 FAF1 IL17 NEIL1 SCO1 VHL

CALML5 FAM107A IL1F9 NF2 SCO2 VPS13A CAMK2D FAM109A IL28B NFATC2 SCT VPS45A CAPN12 FAM62C IL32 NFS1 SDHC VSNL1 CARHSP1 FBN3 IL9 NHP2L1 SEC11L1 WIRE CASC3 FBS1 ILF3 NINJ1 SEC23B WNT10B CASP8 FBXL8 ILK NIPSNAP3A SEC24D WNT6 CBLL1 FBXO17 INPP5D NME4 SECTM1 XCL2 CCDC13 FBXO21 IQGAP2 NOL1 SEPT5 XCR1 CCDC25 FBXO24 IRF5 NOL3 SEPT6 XLKD1 CCL14 FBXW12 ISG20L2 NOL6 SERPINA4 XPNPEP2 CCL20 FCER2 ISLR NPM2 SERPINA5 XRCC1 CCL7 FCGR1A ITGA10 NT5E SERPING1 XRN2 CCL8 FEM1B ITGA2 NTN4 SETD6 YWHAH CCND1 FER1L3 ITPR2 OAZ2 SFRP4 YY1AP1 CCND3 FIBP JAG2 OCIAD1 SFRS1 ZA20D3 CCT6A FKBP10 JARID1A OLFML1 SGCB ZBP1 CD276 FKHL18 JRK OR10J1 SGPP2 ZCCHC11 CD300E FKRP K-ALPHA-1 OR12D2 SH2D4B ZDHHC12 CD300LG FLJ11155 KARS OR12D3 SH3GL1 ZMPSTE24 CD302 FLJ12118 KATNB1 ORC2L SH3TC1 ZNF207 CD320 FLJ12571 KBTBD3 OTUB1 SHANK1 ZNF286 CD33 FLJ12700 KBTBD4 P2RX1 SKP2 ZNF295 CD47 FLJ20643 KCNA2 P2RX3 SLC10A2 ZNF335 CD8B1 FLJ21062 KCNJ14 P4HA3 SLC13A2 ZNF438 CDC42EP1 FLJ21125 KCNJ16 PADI4 SLC16A3 ZNF447 CDC91L1 FLJ22318 KCNJ4 PAK2 SLC17A4 ZNF502 CDH7 FLJ22555 KCNN4 PAK6 SLC22A18 ZNF511 CDKL1 FLJ23191 KCNQ1 PARP2 SLC25A18 ZNF512 CDKL3 FLJ23447 KCTD7 PAX6 SLC25A24 ZNF567 CDKN3 FLJ23514 KDELC1 PCBP4 SLC26A7 ZNF577 CDR2 FLJ23657 KIAA0182 PCDH7 SLC29A3 ZNF663 CENTB2 FLJ25006 KIAA0773 PCSK5 SLC35E4 ZNF677 CEP55 FLJ33814 KIAA0907 PDCD1 SLC37A1 ZNF77 CETP FLJ35725 KIAA1018 PDE3A SLC39A5 ZNFN1A2 CGI-38 FLJ37927 KIAA1913 PDIA3 SLC5A10 ZNFN1A3 CGI-69 FLJ39599 KIF13B PDIK1L SLN CHCHD2 FLJ39822 KIF1B PDPK1 SLURP1 CHFR FLJ43826 KLK13 PDZRN3 SMNDC1 Supplementary Table 1. Genes whose methylation differs between normal colon mucosa of cancer patients and controls at a false discovery rate of 0.05 (Benjamini-Hochberg, (31)).

Network Molecules in Network Network

Score # Focus Molecules

Top Function

1

Akt, AQP7, ATP9A, CDK9, Cg, CGB5, CGB8, CHFR, DLK1, ERK, ERK1/2, FSH, GATA2,

GNRH2, HIST2H4A, Histone h4, Hsp70, IL1B, INPP5D, KCNQ1, Lh, Mapk, MAPK15, MUC5B,

P38 MAPK, p85 (pik3r), PDPK1, PI3K, Pka, Pkc(s), PTPase, Ras,

RASSF5, RNA polymerase II, ZEB1

33 18 Cell Morphology,

Carbohydrate Metabolism,

Molecular Transport

2

ALAS1, Alp, Ap1, APOA1, C1QC, CCL8, CD55, DUSP5,

ELK4, GCNT1, GSTP1, IL1, IL12 (complex), IL12 (family),

Immunoglobulin, Interferon alpha, IRAK, IRF5, Jnk, LDL, MAPK10, NFAT (complex),

NFkB (complex), NGFR, NT5E, PDCD1, PDGF BB, Ras homolog, Rxr, S100A3,

SERPING1, Tgf beta, TNFRSF4, Trypsin, VAV1

33 18

Cellular Movement, Hematological System

Development and Function,

Immune Cell Trafficking

3

AHNAK, ALAS1, ANPEP, ARFGAP1, ARHGAP11A,

C12ORF24, CCNG2, COL13A1, CX3CR1, CYP2B1, DDX49,

DUSP5, EGF, FXYD7, G0S2, GAS1, Ggt, GGT5, GSTA5,

HGS, HNF4A, HSD17B1, IL2, JAG2, MEPCE, MLH1, PTPN22,

retinoic acid, SEMA3B, SERTAD3, SLCO1A2, USH1C, USHBP1, VitaminD3-VDR-RXR,

ZC3H11A

26 15

Lipid Metabolism, Small Molecule Biochemistry,

Cellular Growth and Proliferation

4

AHNAK, ALB, ALPL, ALPP, ASAH2, CCNG2, CCT6A, CD55,

CELF2, ceramide, D-sphingosine, EGFR, ESR1,

estrone sulfate, EXOC6, formaldehyde, GCN1L1, GSTA5,

HEXIM1, ICOSLG, KLF10, KRT16, LDB1, LTC4S, MCPT1, MYOF, NAAA, PKN1, SGSH, SLC16A3, SLCO1C1, STRN,

TCN2, TGFB1, TMEM55B

21 13

Cell Death, Lipid Metabolism,

Small Molecule Biochemistry

5

ACAD11, ACO2, ALDOA, AP1S1, ARHGEF6, ARHGEF7,

BRF1, CORO6, GP5, GP9, GP1BA, GP1BB, HFE,

HSP90AB1, HSPA1B, IL3, MIR181C (includes EG:406957),

NACA, PARVB, PHLDB2, Rab11, RAB11A, RAB11FIP2, RAB11FIP5, RPS3A, SEMA6B, SLC27A1, TFR2, TFRC, thyroid

hormone, TRIM21, TROVE2, TSSK6, YWHAG, YWHAZ

20 12

Cardiovascular System Development and

Function, Genetic Disorder,

Hematological Disease

6

2-deoxy-D-ribose, alanine, ALOXE3, APP, ATP1A2, beta-

estradiol, Ca2+, CASP8, D-xylose, DLG4, ENPEP, EPHA1,

FBXO6, GABRR2, GRB14, HABP2, HAS1, INS1, IPO4,

ISG20L2, ITLN1, KDELR1, L-aspartic acid, L-lysine,

Lipoxygenase, NDUFS2, NEK6, PKN1, RAD23A, RAMP1, ribose,

SQSTM1, SRC, SULT1C2, TAC3

19 12

Amino Acid Metabolism, Small Molecule Biochemistry,

Cancer

Supplementary Table 2. Top six IPA network summaries using 114 input genes whose methylation differs between normal colon mucosa of cancer patients and controls at P<1.8 X 10-6 (Bonferroni).

Network Molecules in Network Network Score

# Focus Molecules

Top Function

1

ALAS1, ATP9A, CD55, CEBPG, Cg, CGB5, CGB8, DLK1, DUSP5,

EFNA1, ELK4, EPHA1, ERK, FANCA, FSH, GNRH, GNRH2,

Growth hormone, HDL, Histone h4, IL1, IL1B, Immunoglobulin, INS, ITPR3, LDL, Lh, MCM5, MID1,

NFkB (complex), S100A3, S100A9, TNFRSF4, Vegf, ZEB1

43 22

Cellular Compromise,

Carbohydrate Metabolism, Small

Molecule Biochemistry

2

Akt, Alp, ALPP, Ap1, APOA1, AQP7, ARHGEF11, ASH1L, BRF1, C1QC, Caveolin, CDK9, ERK1/2,

FGF19 (includes EG:9965), GCNT1, HIST2H4A, Histone h3,

Interferon alpha, Jnk, Mapk, MAPK10, MAPK15, MUC5B, NFAT (complex), NGFR, P38 MAPK, p85

(pik3r), PI3K, PRAME (includes EG:23532), Ras, Ras homolog, RASSF5, RNA polymerase II,

VAV1, YWHAB

36 19

Carbohydrate

Metabolism, Molecular Transport, Small

Molecule Biochemistry

3

A1CF, ACSM3, ACTR5, AGA, ALB, AQP8, ARFGAP1, beta-estradiol,

C12ORF24, CELF2, CIDEC, EXOC6, FBXO6, FXYD7, GAS1, GCHFR, HNF4A, ITGB1, LIMS1,

LSR, LTC4S, MCPT1, MLH1, MYC, PROM1, RAB18, RBBP8, ROBO3, RYR3, SEMA3B, SGSH, SNRPN,

SPAG9, TGFB1, ZC3H11A

26 15

Connective Tissue Development and Function, Tissue

Morphology, Tissue Development

4

2-deoxy-D-ribose, alanine, ALOXE3, C11ORF82, C4BPA,

Ca2+, D-xylose, ENPEP, ESR1, estrone sulfate, GATA2, Gpcr,

GSK3B, hydrogen peroxide, IL13, INS1, ITLN1, KCNQ1, L-aspartic

acid, Lipoxygenase, NEK6, P2RY1, PARVB, Pka, PPP2R1B,

progesterone, RAB32, RAB11FIP5, ribose, SLC43A3, SLC5A2, SLCO1C1, SMPDL3A, TNF,

TRAM1

24 14

Cellular Assembly and Organization, Amino

Acid Metabolism, Molecular Transport

5

26s Proteasome, AP1S1, ASAH2, ATP1A3, ATXN1, ceramide,

CORO6, EGFR, FUT2, GABRR2, GIGYF2, GP9, GP1BB, HSPA1B,

IRF3, IRS4, KIAA1217, KSR1, MIR181C (includes EG:406957),

NAAA, PHLDB2, PSMC2, PSME2, RAD23A, RGS7, RICTOR, RIN1,

RNF41, SQSTM1, TBC1D5, TMEM55B, TRIM21, TSSK6, USP8,

YWHAZ

17 11

Genetic Disorder,

Hematological Disease, Lipid Metabolism

Supplementary Table 3.Top five IPA network summaries using 114 input genes whose methylation differs between normal colon mucosa of cancer patients and controls using false discovery rate of 0.05 (Benjamini-Hochberg,(31)).

TargetID SYMBOL Cancer AVG_Beta Cancer DiffScore Control AVG_Beta MAPINFO CPG_ISLAND_LOCATIONS

cg05279864 ABCB4 0.7947106 8.325549 0.7789699 86947255

cg04737046 ABCB4 0.8261084 -9.920546 0.8558276 86947306

cg18655915 ABCB4 0.7461269 9.908489 0.7261046 86947735

cg23058901 ALX4 0.5018783 4.90662 0.4858576 44281335 11:44281312-44281846

cg14753432 ALX4 0.4917212 -3.156633 0.5065503 44281409 11:44281312-44281846

cg15522957 ALX4 0.4173523 -6.796269 0.4514619 44281501 11:44281312-44281846

cg18546622 ALX4 0.2414988 -5.251261 0.2669592 44281605 11:44281312-44281846

cg00061629 ALX4 0.2580074 -3.054433 0.2788964 44281834 11:44281312-44281846

cg19358442 ALX4 0.1711905 3.909486 0.1532148 44282263 11:44282161-44283221

cg04549333 ALX4 0.09182489 1.734059 0.08680536 44282399 11:44282161-44283221

cg14144305 ALX4 0.1412091 -1.903209 0.1496726 44282536 11:44282161-44283221

cg11260848 ALX4 0.1617977 4.919742 0.1440194 44282836 11:44282161-44283221

cg07696033 ALX4 0.09650142 1.47134 0.09080752 44282986 11:44282161-44283221

cg25363445 ALX4 0.1219306 10.45251 0.1038854 44283092 11:44282161-44283221

cg00415164 ALX4 0.03873584 22.67469 0.02485198 44283674 11:44283505-44284554

cg08993172 ALX4 0.06578037 3.147872 0.06015378 44283843 11:44283505-44284554

cg04970352 ALX4 0.1373084 -6.397138 0.1583672 44283975 11:44283505-44284554

cg08914623 ALX4 0.05188698 10.39327 0.0387951 44284148 11:44283505-44284554

cg00418150 ALX4 0.4001562 14.06677 0.3661075 44284445 11:44283505-44284554

cg16977035 ALX4 0.4619918 17.27003 0.401544 44287050 11:44286979-44288424

cg11797994 ALX4 0.4159221 0.7242088 0.4115545 44287307 11:44286979-44288424

cg26365854 ALX4 0.06421678 -4.271511 0.07217824 44287479 11:44286979-44288424

cg15817236 ALX4 0.06492395 0.5359459 0.06193421 44287938 11:44286979-44288424

cg04988423 ALX4 0.06719135 1.39322 0.05824892 44288153 11:44286979-44288424

cg13807496 ALX4 0.1000681 -3.809303 0.1095901 44289116 11:44288779-44289748

cg27318318 ALX4 0.07539359 -1.189935 0.07974335 44289425 11:44288779-44289748

cg22269180 ATP10A 0.6768881 10.1329 0.6494347 23523118 15:23522920-23523591

cg12582965 ATP10A 0.9190308 1.704099 0.9151635 23523421 15:23522920-23523591

cg20119871 ATP10A 0.8514904 -8.144432 0.8633783 23523493 15:23522920-23523591

cg19930802 ATP10A 0.8671564 3.6164 0.8598385 23523567 15:23522920-23523591

cg23623692 ATP10A 0.7170666 12.51582 0.678086 23554557 15:23554004-23555229

cg14001035 ATP10A 0.7156124 1.841854 0.7044119 23577245 15:23577189-23577798

cg11015241 ATP10A 0.8851926 2.410804 0.877657 23577342 15:23577189-23577798

cg17260954 ATP10A 0.8481386 -1.856057 0.8580858 23577440 15:23577189-23577798

cg08831522 ATP10A 0.7691495 -0.7132397 0.774448 23577507 15:23577189-23577798

cg10734665 ATP10A 0.4658548 -3.604482 0.4953431 23658503 15:23658498-23660531

cg19326876 ATP10A 0.2615347 0.3927664 0.2542878 23658751 15:23658498-23660531

cg17793621 ATP10A 0.2217049 2.582045 0.1952498 23659177 15:23658498-23660531

cg15523238 ATP10A 0.1549248 0.1374129 0.1533068 23659889 15:23658498-23660531

cg22797991 ATP10A 0.08395101 0.3232561 0.08208697 23659894 15:23658498-23660531

cg08828036 ATP10A 0.755803 -24.0744 0.7934952 23660297 15:23658498-23660531

cg26062856 ATP10A 0.6919494 0.304485 0.6892806 23660518 15:23658498-23660531

cg11979382 BCDIN3 0.0544886 3.874565 0.07162636 99864955 7:99863663-99866414

cg17607973 BCDIN3 0.1756184 -31.77794 0.2620706 99865344 7:99863663-99866414

cg13369981 BCDIN3 0.04088774 1.164582 0.03846468 99865437 7:99863663-99866414

cg11719452 BCDIN3 0.06128948 5.754376 0.05390026 99865712 7:99863663-99866414

cg16049587 BCDIN3 0.0914904 6.77266 0.08066972 99865926 7:99863663-99866414

cg12584718 BCDIN3 0.2337449 -0.7428136 0.2387368 99866338 7:99863663-99866414

cg08223235 BCL2 0.8037033 0.2745102 0.8023242 59054814 18:59054789-59055400

cg12459502 BCL2 0.79283 -10.12791 0.8129059 59055217 18:59054789-59055400

cg25059899 BCL2 0.8660096 -12.24885 0.8803906 59055308 18:59054789-59055400

cg23756272 BCL2 0.7946193 -4.344353 0.8082169 59055398 18:59054789-59055400

cg21602520 BCL2 0.1313142 2.566531 0.1133332 59136360 18:59136000-59137100

cg17602451 BCL2 0.02427687 0.4588436 0.02368594 59136625 18:59136000-59137100

cg01803238 BCL2 0.0375752 1.790126 0.03454842 59137006 18:59136000-59137100

cg11330108 BCL2 0.05332635 -0.7168493 0.05499636 59137095 18:59136000-59137100

cg09752703 BCL2 0.041194 -2.106973 0.04586665 59137602 18:59137551-59139457

cg03813215 BCL2 0.05003007 4.256256 0.04783024 59137659 18:59137551-59139457

cg08554462 BCL2 0.1711605 -31.38017 0.287304 59137891 18:59137551-59139457

cg14455307 BCL2 0.03068344 7.012843 0.02468809 59138409 18:59137551-59139457

cg11255230 BCL2 0.03986005 3.824787 0.03340692 59138788 18:59137551-59139457

cg05927017 BCL2 0.0763488 8.933274 0.05429713 59139135 18:59137551-59139457

cg24408313 BCL2 0.3320334 13.68338 0.2616042 59139445 18:59137551-59139457

cg26453588 BIK 0.4770393 -15.12756 0.5417705 41835965 22:41835870-41837797

cg08954856 BIK 0.08460552 -24.41305 0.1209555 41836250 22:41835870-41837797

cg10432177 BIK 0.0419973 2.232579 0.03872849 41836535 22:41835870-41837797

cg25018755 BIK 0.04168412 18.08803 0.03536424 41836896 22:41835870-41837797

cg15820809 BIK 0.06231865 0.3418896 0.06158285 41837313 22:41835870-41837797

cg17179881 BIK 0.1009476 7.514534 0.09128942 41837609 22:41835870-41837797

cg17095753 BRAF 0.0127054 -2.930068 0.01405956 140270393 7:140270307-140271594

cg23066879 BRAF 0.0358928 -10.1468 0.04740484 140270526 7:140270307-140271594

cg11414046 BRAF 0.01538165 -1.676063 0.01655098 140270663 7:140270307-140271594

cg14094063 BRAF 0.008993597 10.58014 0.007300803 140270939 7:140270307-140271594

cg10141022 BRAF 0.04843616 1.157123 0.04652291 140271374 7:140270307-140271594

cg03148461 BRAF 0.05811731 1.263458 0.05578672 140271535 7:140270307-140271594

cg21043558 BRAF 0.309741 -7.268303 0.334796 140271834

cg18108237 BRAP 0.02167351 -1.952465 0.02330806 110608067 12:110607482-110609048

cg16312916 BRAP 0.01994618 -6.0844 0.02432116 110608347 12:110607482-110609048

cg19020694 C12orf24 0.02914963 -15.68119 0.04804797 109390438 12:109390152-109392093

cg24588599 C12orf24 0.03219279 -2.182174 0.03466355 109390700 12:109390152-109392093

cg17119688 C12orf24 0.04027346 -10.53055 0.04983882 109391110 12:109390152-109392093

cg06290168 C12orf24 0.2327567 -32.11103 0.3551883 109391393 12:109390152-109392093

cg09188980 CALCA 0.1536462 -11.40716 0.1812572 14949954 11:14949913-14950639

cg14348532 CALCA 0.1392047 -4.263476 0.1504034 14950138 11:14949913-14950639

cg06295856 CALCA 0.1280042 -2.10975 0.1373949 14950218 11:14949913-14950639

cg09068492 CALCA 0.1507411 -7.782136 0.1857171 14950234 11:14949913-14950639

cg22183706 CALCA 0.122405 -8.667234 0.1427607 14950394 11:14949913-14950639

cg01971122 CALCA 0.09810717 -9.790613 0.1186668 14950505 11:14949913-14950639

cg26833169 CALCA 0.1934226 4.789607 0.1722837 14950621 11:14949913-14950639

cg10467022 CALCA 0.1310624 0.2377843 0.1296893 14951559 11:14951538-14952683

cg25095814 CASP8 0.1065307 10.80781 0.06413984 201806261

cg05130485 CASP8 0.2334014 12.57821 0.1641526 201806502

cg26799474 CASP8 0.3541659 23.45637 0.2234261 201807196

cg22898761 CASP8 0.6564645 -0.1001813 0.6571537 201857221 2:201856922-201857713

cg23410113 CASP8 0.8505189 -0.01802487 0.8506145 201857328 2:201856922-201857713

cg26986815 CASP8 0.8234679 -0.1235039 0.8239323 201857614 2:201856922-201857713

cg00858899 CCND1 0.05884929 -3.240321 0.06696163 69164458 11:69164197-69168027

cg10539418 CCND1 0.03389557 1.520025 0.03253455 69164893 11:69164197-69168027

cg08170622 CCND1 0.04345426 -8.878087 0.05699763 69165058 11:69164197-69168027

cg05164185 CCND1 0.03265043 -3.406622 0.03647475 69165593 11:69164197-69168027

cg25060573 CCND1 0.02714928 -9.601268 0.03271232 69166302 11:69164197-69168027

cg05200606 CCND1 0.08043063 0.2373 0.07893874 69167000 11:69164197-69168027

cg09637363 CCND1 0.632287 -4.687859 0.652542 69167825 11:69164197-69168027

cg16794682 CCND1 0.7573057 0.1675432 0.7563131 69170132 11:69170075-69170635

cg06539449 CCND1 0.7491632 -11.71634 0.7812256 69170189 11:69170075-69170635

cg07339327 CCND1 0.8760138 -23.85792 0.9106348 69170290 11:69170075-69170635

cg13608094 CCND1 0.8582185 -18.50692 0.9060303 69170417 11:69170075-69170635

cg12266049 CCND1 0.899168 -15.27036 0.9259586 69170515 11:69170075-69170635

cg19047670 CCND1 0.7210294 -6.590185 0.7370451 69170632 11:69170075-69170635

cg04717045 CCND1 0.8347549 -2.559166 0.8433667 69177970 11:69177944-69178494

cg00953256 CCND1 0.6623112 -1.783886 0.6708784 69178056 11:69177944-69178494

cg02723533 CCND1 0.9651249 -10.0853 0.9715894 69178172 11:69177944-69178494

cg11802013 CCND1 0.7645978 -2.128467 0.773017 69178356 11:69177944-69178494

cg07426960 CCND1 0.3172534 5.891827 0.2874762 69178471 11:69177944-69178494

cg25425078 CCND2 0.0249234 0.6444689 0.02412425 4252038 12:4248289-4252642

cg13574590 CCND2 0.04737473 6.618573 0.04100414 4252402 12:4248289-4252642

cg00888007 CCND2 0.0160624 18.98258 0.01179538 4252445 12:4248289-4252642

cg14914982 CCND2 0.05522811 -6.311415 0.06346654 4253246 12:4252826-4255273

cg26989531 CCND2 0.182051 13.95552 0.1600357 4253378 12:4252826-4255273

cg02765328 CCND2 0.02799516 3.909566 0.02511643 4253542 12:4252826-4255273

cg17886028 CCND2 0.05477854 -0.4720908 0.05574876 4253768 12:4252826-4255273

cg16310717 CCND2 0.1010512 -1.171945 0.1041218 4253880 12:4252826-4255273

cg12382902 CCND2 0.02196117 -0.988088 0.02294798 4253960 12:4252826-4255273

cg16994506 CCND2 0.07390503 1.696764 0.06948023 4253985 12:4252826-4255273

cg08069899 CCND2 0.05638839 -8.92348 0.06910288 4254031 12:4252826-4255273

cg13801381 CCND2 0.0226147 4.27353 0.01795044 4254283 12:4252826-4255273

cg17580045 CCND2 0.07832947 4.012358 0.07066181 4255151 12:4252826-4255273

cg01880569 CDH13 0.4515709 -13.36748 0.5074933 81217829 16:81217810-81219323

cg08977371 CDH13 0.1307698 -18.95923 0.158016 81217991 16:81217810-81219323

cg08747377 CDH13 0.06512534 -9.719672 0.07822438 81218171 16:81217810-81219323

cg00806490 CDH13 0.2221291 -11.00767 0.2547925 81218374 16:81217810-81219323

cg13759328 CDH13 0.1219088 -13.23166 0.1529627 81219022 16:81217810-81219323

cg19369556 CDH13 0.09004257 -3.084928 0.09679299 81219226 16:81217810-81219323

cg16777782 CDH13 0.8662017 13.42305 0.8096015 81228834 16:81228442-81229032

cg19854301 CDH13 0.7797625 12.06639 0.7302938 81228951 16:81228442-81229032

cg02168291 CDH13 0.4887354 16.10515 0.396357 81229021 16:81228442-81229032

cg11653709 CDKN2A 0.2526572 -12.91957 0.2925692 21958146 9:21958106-21958899

cg12840719 CDKN2A 0.139385 -6.278927 0.1590844 21958233 9:21958106-21958899

cg09099744 CDKN2A 0.1289044 -5.302542 0.1533628 21958372 9:21958106-21958899

cg07752420 CDKN2A 0.2243212 -5.571905 0.2554846 21958681 9:21958106-21958899

cg10895543 CDKN2A 0.2309689 -15.05049 0.2818516 21958832 9:21958106-21958899

cg13479669 CDKN2A 0.0430117 4.012773 0.03838468 21984108 9:21983444-21986348

cg03079681 CDKN2A 0.04658134 1.067863 0.04491221 21984223 9:21983444-21986348

cg26673943 CDKN2A 0.04275136 1.856057 0.04031124 21984965 9:21983444-21986348

cg00718440 CDKN2A 0.07469666 -17.00836 0.1021092 21985312 9:21983444-21986348

cg17904068 CHFR 0.9385125 -0.2121574 0.9391719 131930874 12:131930864-131931625

cg21232015 CHFR 0.7901437 3.819761 0.7776605 131934294 12:131934293-131934917

cg02519218 CHFR 0.6493503 -4.160622 0.6813658 131934359 12:131934293-131934917

cg20066677 CHFR 0.8225822 -7.672662 0.8350698 131934493 12:131934293-131934917

cg24532476 CHFR 0.7818981 -28.97716 0.8196341 131934639 12:131934293-131934917

cg17524886 CHFR 0.9008152 -9.030734 0.9103396 131934782 12:131934293-131934917

cg22381955 CHFR 0.9359358 -5.016988 0.9434499 131940022 12:131939857-131940762

cg26609691 CHFR 0.9677133 2.818271 0.9658722 131940299 12:131939857-131940762

cg17522601 CHFR 0.9033912 -3.334798 0.9091503 131940460 12:131939857-131940762

cg06462703 CHFR 0.9458553 -1.627698 0.9473976 131940637 12:131939857-131940762

cg13270853 CHFR 0.9353054 -1.364267 0.9369911 131945722 12:131945626-131946355

cg21432513 CHFR 0.9120201 -2.399817 0.91738 131945843 12:131945626-131946355

cg17003970 CHFR 0.7769779 -0.4206365 0.7864637 131945934 12:131945626-131946355

cg17387870 CHFR 0.3641573 -4.367807 0.3932444 131973680 12:131973620-131975130

cg00338702 CHFR 0.1112928 -4.151295 0.1271696 131973767 12:131973620-131975130

cg19027571 CHFR 0.04658541 1.647113 0.04379791 131973958 12:131973620-131975130

cg23653008 CHFR 0.04383049 0.8008889 0.0425511 131974492 12:131973620-131975130

cg27040423 CHFR 0.04469093 -7.895908 0.0544307 131974535 12:131973620-131975130

cg04044684 CHFR 0.07576223 -3.128309 0.08690377 131974930 12:131973620-131975130

cg20535781 CHFR 0.3745802 -4.962068 0.3946813 131975086 12:131973620-131975130

cg23679724 CTSZ 0.3886261 22.12285 0.3164601 57014873

cg06385087 CTSZ 0.01692808 0.8986416 0.01644763 57015298 20:57015249-57016051

cg01663968 CTSZ 0.04776568 1.885394 0.04532563 57015401 20:57015249-57016051

cg16179125 CTSZ 0.04163798 -0.3277903 0.04313366 57015516 20:57015249-57016051

cg13021192 CTSZ 0.08441725 1.84306 0.07942504 57015608 20:57015249-57016051

cg23265096 CTSZ 0.2336571 18.61697 0.203429 57015989 20:57015249-57016051

cg01623438 CTSZ 0.5458078 7.223115 0.510724 57016289

cg08719486 DAPK1 0.3467739 3.874565 0.3743954 89301921 9:89301899-89304060

cg13814950 DAPK1 0.0439727 -13.68035 0.05593615 89302335 9:89301899-89304060

cg22571217 DAPK1 0.03198846 -8.233474 0.03713604 89302339 9:89301899-89304060

cg08797471 DAPK1 0.2279238 -14.44991 0.2917837 89302940 9:89301899-89304060

cg19734228 DAPK1 0.1107322 -6.683119 0.1411409 89303413 9:89301899-89304060

cg15746719 DAPK1 0.3172224 -0.2070684 0.3236275 89303633 9:89301899-89304060

cg24754277 DAPK1 0.4086823 1.627698 0.387915 89303976 9:89301899-89304060

cg17090012 DAPK1 0.8199356 -1.776555 0.8284078 89313366 9:89312885-89313476

cg03641225 DIRAS3 0.2934466 13.81117 0.2508265 68285127 1:68285082-68285689

cg24871743 DIRAS3 0.4766025 5.209252 0.4450074 68285238 1:68285082-68285689

cg22901840 DIRAS3 0.6023312 1.358429 0.5956542 68285365 1:68285082-68285689

cg13697378 DIRAS3 0.5940045 8.80138 0.5608966 68285433 1:68285082-68285689

cg09118625 DIRAS3 0.6090703 7.195054 0.5759502 68285559 1:68285082-68285689

cg21808053 DIRAS3 0.4625046 12.97924 0.4268909 68285651 1:68285082-68285689

cg02317907 DIRAS3 0.60999 2.864481 0.5891654 68288376 1:68288302-68289231

cg19114595 DIRAS3 0.6173007 11.48372 0.5897043 68288565 1:68288302-68289231

cg11465163 DIRAS3 0.4551934 0.07971526 0.4537065 68288681 1:68288302-68289231

cg22500004 DIRAS3 0.5049272 12.87012 0.4482327 68288860 1:68288302-68289231

cg05392265 DIRAS3 0.5050784 -0.1844985 0.5063547 68289041 1:68288302-68289231

cg06191076 DIRAS3 0.4460396 1.800713 0.4391143 68289051 1:68288302-68289231

cg16148270 DIRAS3 0.5539142 0.07626891 0.5530977 68289053 1:68288302-68289231

cg12986021 DIRAS3 0.3963303 1.088105 0.3892397 68289215 1:68288302-68289231

cg12041387 DLX5 0.1833879 0.7605221 0.1784051 96488107 7:96487969-96489640

cg00503840 DLX5 0.4188373 -2.16983 0.4380085 96488445 7:96487969-96489640

cg20080624 DLX5 0.262823 -3.464334 0.2830049 96489047 7:96487969-96489640

cg13462129 DLX5 0.321791 -11.07681 0.3878311 96489217 7:96487969-96489640

cg27016494 DLX5 0.2809775 -6.641689 0.3125941 96489522 7:96487969-96489640

cg18873386 DLX5 0.2981474 -8.291203 0.3285069 96489851 7:96489769-96490524

cg11500797 DLX5 0.3030684 -9.364966 0.3576712 96490059 7:96489769-96490524

cg02101486 DLX5 0.1430092 -3.300129 0.1588792 96490181 7:96489769-96490524

cg24115040 DLX5 0.1735771 -6.087785 0.2059688 96490311 7:96489769-96490524

cg08878323 DLX5 0.169118 -3.05267 0.1826274 96490400 7:96489769-96490524

cg06911084 DLX5 0.3990809 -12.47966 0.4699048 96490830 7:96490825-96492388

cg06537230 DLX5 0.3376973 -7.233095 0.3650187 96491119 7:96490825-96492388

cg16924616 DLX5 0.1681948 -0.4208833 0.1726021 96491553 7:96490825-96492388

cg09150117 DLX5 0.08723946 0.100164 0.08655466 96491803 7:96490825-96492388

cg13344740 DLX5 0.3023719 -8.214437 0.3417404 96492068 7:96490825-96492388

cg11997899 DLX5 0.2278529 0.5524329 0.222429 96492119 7:96490825-96492388

cg00096922 DLX5 0.04479342 -3.524342 0.0497624 96492121 7:96490825-96492388

cg01169726 DLX5 0.175353 -1.856057 0.1838953 96492361 7:96490825-96492388

cg18805835 DNAJC18 0.2026373 -1.856057 0.2462816 138802953 5:138802889-138803304

cg05284582 DNAJC18 0.02716618 -17.13731 0.03484436 138802960 5:138802889-138803304

cg10356060 DNAJC18 0.01797568 4.033911 0.01579993 138803005 5:138802889-138803304

cg25707005 DNAJC18 0.09109072 -1.241033 0.0961102 138803099 5:138802889-138803304

cg23261102 DNAJC18 0.03144526 -5.992639 0.035256 138803113 5:138802889-138803304

cg19238398 DNAJC18 0.09964704 6.918879 0.09240885 138803147 5:138802889-138803304

cg12120741 EDNRB 0.6064429 -13.87982 0.6450492 77390307 13:77390197-77391989

cg03086857 EDNRB 0.2449727 -7.744167 0.2879852 77390569 13:77390197-77391989

cg23316360 EDNRB 0.4162707 -3.629776 0.4577416 77390917 13:77390197-77391989

cg15836660 EDNRB 0.1767552 -6.957737 0.2101188 77391129 13:77390197-77391989

cg12847373 EDNRB 0.1696603 -3.776691 0.193517 77391350 13:77390197-77391989

cg24745738 EDNRB 0.2579795 -0.5988292 0.2654453 77391959 13:77390197-77391989

cg08983760 EDNRB 0.6215803 0.7132397 0.6182601 77447583

cg18003135 EDNRB 0.7564272 6.08323 0.7386364 77447658

cg09875273 ERBB2 0.05653786 -12.68575 0.08439993 35097513 17:35097487-35098143

cg24649641 ERBB2 0.03002485 -0.001761166 0.03002733 35097645 17:35097487-35098143

cg23906291 ERBB2 0.03176684 -1.313059 0.03460385 35097749 17:35097487-35098143

cg10394385 ERBB2 0.09315766 -1.973832 0.09669719 35097815 17:35097487-35098143

cg19752722 ERBB2 0.0421372 -14.09064 0.05717205 35098105 17:35097487-35098143

cg22778981 ERBB2 0.223404 -7.079636 0.2519894 35109659 17:35109518-35110599

cg26111030 ERBB2 0.1187904 -8.486648 0.1496289 35109904 17:35109518-35110599

cg11993754 ERBB2 0.2037151 -13.85054 0.2645655 35110039 17:35109518-35110599

cg16065186 ERBB2 0.1009806 -5.135937 0.1259304 35110189 17:35109518-35110599

cg27005179 ERBB2 0.02683716 -24.73272 0.04020664 35110312 17:35109518-35110599

cg13263114 ERBB2 0.06069637 -1.317583 0.06444559 35110596 17:35109518-35110599

cg14086033 FEN1 0.09745773 -9.535522 0.1320387 61316397 11:61316278-61317629

cg01447420 FEN1 0.06295907 -3.132342 0.07888222 61316499 11:61316278-61317629

cg02005336 FEN1 0.04400925 -6.232125 0.05474428 61316699 11:61316278-61317629

cg22704775 FEN1 0.03252294 -10.12791 0.04067546 61316702 11:61316278-61317629

cg15963971 FEN1 0.04174329 8.11217 0.03498347 61316764 11:61316278-61317629

cg18009798 FEN1 0.03439591 2.373937 0.03053814 61316796 11:61316278-61317629

cg11730100 FEN1 0.08757091 -1.973287 0.09501372 61316870 11:61316278-61317629

cg03114244 FEN1 0.0431945 0.06023232 0.04309724 61316931 11:61316278-61317629

cg12699371 GALR1 0.08500474 -21.86184 0.1117033 73090412 18:73090255-73093032

cg26721264 GALR1 0.09208877 -16.10515 0.1263201 73090715 18:73090255-73093032

cg15343119 GALR1 0.1164152 -5.999928 0.1314327 73090773 18:73090255-73093032

cg10486998 GALR1 0.1102853 -11.70039 0.1384752 73090775 18:73090255-73093032

cg04534765 GALR1 0.2141075 -7.914258 0.26383 73091357 18:73090255-73093032

cg00662556 GALR1 0.338207 -9.118587 0.3942352 73092352 18:73090255-73093032

cg05896682 GALR1 0.3000228 -5.973505 0.3359388 73093018 18:73090255-73093032

cg18123948 GATA4 0.1580323 -12.22544 0.1964602 11598190 8:11596976-11598339

cg10866709 GATA4 0.1103788 -0.06093525 0.1106224 11598770 8:11598711-11600557

cg14900471 GATA4 0.09302182 -1.536961 0.1042101 11599029 8:11598711-11600557

cg21073927 GATA4 0.1193607 0.1025991 0.1186309 11599564 8:11598711-11600557

cg00090147 GATA4 0.2353557 -1.193004 0.2471326 11599776 8:11598711-11600557

cg08369065 GATA4 0.2072269 -3.155116 0.2244613 11600092 8:11598711-11600557

cg14134005 GATA4 0.1543173 -13.30424 0.1868113 11600451 8:11598711-11600557

cg25216696 GATA4 0.3321296 -0.9022633 0.3446314 11602760 8:11602473-11604934

cg24646414 GATA4 0.4872308 -20.37847 0.5586636 11603134 8:11602473-11604934

cg09626984 GATA4 0.4133172 -0.3159822 0.4179785 11603505 8:11602473-11604934

cg11981599 GATA4 0.3050931 0.3286119 0.3005735 11603935 8:11602473-11604934

cg20279283 GATA4 0.4554525 -2.470598 0.4771865 11604272 8:11602473-11604934

cg01546563 GATA4 0.1990735 -5.371618 0.2331923 11604598 8:11602473-11604934

cg19172575 GATA4 0.4452453 -6.462417 0.4822702 11605130 8:11605055-11605961

cg13434842 GATA4 0.5274581 -11.89377 0.6018419 11605305 8:11605055-11605961

cg02990612 GATA4 0.4091361 -4.249825 0.432107 11605426 8:11605055-11605961

cg17795240 GATA4 0.2957744 3.874565 0.2810724 11605666 8:11605055-11605961

cg26020513 GATA4 0.6436324 -4.384214 0.6711695 11605765 8:11605055-11605961

cg25268451 GNAS 0.4689319 0.1418738 0.4683299 56847934 20:56847904-56850722

cg14597908 GNAS 0.4035619 -2.248855 0.4100419 56848355 20:56847904-56850722

cg05558390 GNAS 0.4098099 -0.7095082 0.4134556 56848772 20:56847904-56850722

cg24975842 GNAS 0.4917892 -2.694741 0.5064779 56849616 20:56847904-56850722

cg18619398 GNAS 0.5482014 18.41761 0.5102561 56849901 20:56847904-56850722

cg01355739 GNAS 0.6658058 2.687241 0.6548592 56850283 20:56847904-56850722

cg20582984 GNAS 0.6493212 2.594984 0.6388249 56850628 20:56847904-56850722

cg15160445 GNAS 0.4209225 0.8367004 0.4147313 56860144 20:56860042-56860698

cg04457481 GNAS 0.3805002 3.575062 0.3661876 56860230 20:56860042-56860698

cg03606258 GNAS 0.5617877 1.453872 0.5217429 56860330 20:56860042-56860698

cg06324048 GNAS 0.3566875 14.46474 0.3295821 56860498 20:56860042-56860698

cg16833551 GNAS 0.5656717 4.656679 0.5437476 56860632 20:56860042-56860698

cg01817393 GNAS 0.3316617 -1.947697 0.3477921 56861037 20:56860981-56861502

cg27661264 GNAS 0.2514952 3.074957 0.2362829 56861133 20:56860981-56861502

cg17414107 GNAS 0.4318366 4.024533 0.4034983 56861225 20:56860981-56861502

cg00943909 GNAS 0.4678641 1.486912 0.4553474 56861337 20:56860981-56861502

cg24346429 GNAS 0.4260506 1.732311 0.4142036 56861427 20:56860981-56861502

cg21988465 GNAS 0.6292554 1.100972 0.6233819 56862672 20:56862299-56864797

cg07284407 GNAS 0.5121365 7.316195 0.4945295 56863253 20:56862299-56864797

cg21625881 GNAS 0.6417968 6.935843 0.6299166 56863708 20:56862299-56864797

cg14203179 GNAS 0.5597156 6.770125 0.5443836 56864058 20:56862299-56864797

cg25283297 GNAS 0.6515046 1.013915 0.6481732 56864311 20:56862299-56864797

cg09437522 GNAS 0.2868627 22.51814 0.2510998 56864597 20:56862299-56864797

cg01565918 GNAS 0.8922703 -1.608827 0.8968292 56890887 20:56890432-56890958

cg10011623 GNAS 0.27742 4.859784 0.2612918 56896922 20:56896598-56901302

cg27027803 GNAS 0.6149766 14.98954 0.5872155 56898137 20:56896598-56901302

cg25983380 GNAS 0.3415668 10.59512 0.2939147 56898834 20:56896598-56901302

cg22885821 GNAS 0.02443627 0.7732077 0.02391072 56899316 20:56896598-56901302

cg09598225 GNAS 0.06273802 1.506446 0.06067934 56900234 20:56896598-56901302

cg06044900 GNAS 0.03300387 -0.2144531 0.03335988 56901206 20:56896598-56901302

cg10862848 GNMT 0.4343446 0.373724 0.4304325 43035964 6:43035706-43036927

cg27588902 GNMT 0.1679042 -3.045478 0.1815933 43036129 6:43035706-43036927

cg23696834 GNMT 0.05764757 -13.94023 0.07974468 43036323 6:43035706-43036927

cg24101359 GNMT 0.1125642 -11.25469 0.1570448 43036473 6:43035706-43036927

cg14338887 GNMT 0.146028 -11.34299 0.1964252 43036478 6:43035706-43036927

cg10056627 GNMT 0.1591762 -8.101001 0.1880229 43036751 6:43035706-43036927

cg24751129 GNMT 0.5350399 12.25143 0.4822977 43036898 6:43035706-43036927

cg18849169 GPX3 0.5390977 -0.6645358 0.5435097 150379974

cg21504918 GPX3 0.08505065 -9.977863 0.1008092 150380194 5:150380065-150380874

cg07699362 GPX3 0.04015952 -10.90965 0.05423807 150380332 5:150380065-150380874

cg21516478 GPX3 0.09670544 -11.47195 0.1160301 150380521 5:150380065-150380874

cg17820459 GPX3 0.07522234 -14.25636 0.09874792 150380724 5:150380065-150380874

cg03104936 GRB10 0.6595989 0.1994688 0.6572452 50816662 7:50816652-50818533

cg25915982 GRB10 0.6953153 -3.084038 0.7051848 50816909 7:50816652-50818533

cg09150232 GRB10 0.5164605 2.800776 0.5016338 50817133 7:50816652-50818533

cg08835688 GRB10 0.6841958 2.461767 0.671945 50817425 7:50816652-50818533

cg12903171 GRB10 0.4019395 7.918655 0.3744972 50818058 7:50816652-50818533

cg24183958 GRB10 0.04521842 -13.22802 0.05656487 50827667 7:50827590-50829211

cg06790324 GRB10 0.1266899 -10.37166 0.1681979 50828058 7:50827590-50829211

cg06386517 GRB10 0.06838278 -2.990351 0.08492717 50828360 7:50827590-50829211

cg24302095 GRB10 0.0775422 -9.463012 0.1043061 50828543 7:50827590-50829211

cg20651681 GRB10 0.109651 -10.1194 0.1412773 50828912 7:50827590-50829211

cg15774495 GRB10 0.0856114 -17.49216 0.1132175 50829043 7:50827590-50829211

cg26163537 GRB10 0.1108738 -4.759543 0.1260949 50829086 7:50827590-50829211

cg11492040 H19 0.3865159 5.501493 0.3574397 1973089 11:1973035-1973716

cg06197492 H19 0.4136588 4.890821 0.3688536 1973181 11:1973035-1973716

cg10602543 H19 0.6047327 6.919909 0.5884272 1973323 11:1973035-1973716

cg23977670 H19 0.7253964 2.669989 0.7146031 1973424 11:1973035-1973716

cg11716026 H19 0.7266099 -5.51088 0.7541968 1973513 11:1973035-1973716

cg22172494 H19 0.6132704 6.158434 0.5868247 1973938 11:1973888-1974871

cg26808784 H19 0.5646685 9.048039 0.5265526 1974059 11:1973888-1974871

cg25852472 H19 0.5591687 11.24725 0.5234896 1974240 11:1973888-1974871

cg15269875 H19 0.6842089 11.53599 0.6471072 1974594 11:1973888-1974871

cg21167159 H19 0.7460592 18.73538 0.7130681 1974730 11:1973888-1974871

cg13145013 H19 0.7632061 12.85904 0.7309526 1974781 11:1973888-1974871

cg15317267 H19 0.5993577 1.526196 0.5898018 1974823 11:1973888-1974871

cg04715462 H19 0.7060844 -0.5120198 0.708824 1974863 11:1973888-1974871

cg07342901 H19 0.6440155 16.33001 0.5918294 1975300

cg17769238 H19 0.5711992 6.131623 0.5571732 1976144 11:1976057-1976501

cg02657360 H19 0.4106438 2.922714 0.3954765 1977136 11:1976944-1977329

cg02807948 IGF2 0.4420179 -1.856057 0.4225002 2110567 11:2110452-2111041

cg22956483 IGF2 0.3197775 21.85417 0.2646901 2111008 11:2110452-2111041

cg02166532 IGF2 0.3401857 -4.207717 0.3646039 2116429 11:2115427-2119259

cg20339650 IGF2 0.1867733 -9.678257 0.222338 2117458 11:2115427-2119259

cg13756879 IGF2 0.07745229 -3.016651 0.08804459 2118049 11:2115427-2119259

cg13993218 INS 0.3902057 -1.856057 0.2938349 2138442

cg00613255 INS 0.653728 22.70133 0.5970681 2138952

cg25336198 INS 0.3430264 23.44693 0.2438743 2139194

cg03366382 INS 0.6338928 27.19989 0.5518875 2139220

cg19779211 KCNQ1 0.09738395 -8.060353 0.112542 2422067 11:2421914-2423515

cg17575811 KCNQ1 0.04952853 -5.468777 0.06067373 2422985 11:2421914-2423515

cg08303146 KCNQ1 0.01681121 -1.147954 0.01787213 2423231 11:2421914-2423515

cg05418487 KCNQ1 0.1184882 38.27305 0.07393849 2423465 11:2421914-2423515

cg12578166 KCNQ1 0.2607383 34.96205 0.1927378 2423485 11:2421914-2423515

cg01734338 KCNQ1 0.6704938 0.1668918 0.6678985 2447807 11:2447407-2447956

cg04719766 KCNQ1 0.8088776 0.1907672 0.8077828 2499156 11:2498865-2499473

cg17229197 KCNQ1 0.7252341 2.226974 0.7137203 2499264 11:2498865-2499473

cg12949760 KCNQ1 0.6625429 9.39432 0.6297802 2499438 11:2498865-2499473

cg06719391 KCNQ1 0.4074214 -25.86067 0.4960412 2510906 11:2510592-2511245

cg16465939 KCNQ1 0.4930715 -10.36193 0.5458372 2510986 11:2510592-2511245

cg27491887 KCNQ1 0.4473196 -3.103734 0.4597961 2511159 11:2510592-2511245

cg08007665 KCNQ1 0.7433662 15.16945 0.7092957 2550433 11:2550370-2550883

cg26750319 KCNQ1 0.9481725 4.365911 0.9330426 2550536 11:2550370-2550883

cg20751395 KCNQ1 0.8356963 -1.885394 0.8402978 2550729 11:2550370-2550883

cg27119222 KCNQ1 0.6270688 0.1465173 0.6250864 2676805 11:2676705-2678812

cg06233503 KCNQ1 0.2951868 -7.437272 0.3362015 2769250 11:2768881-2770074

cg19728223 KCNQ1 0.332181 -7.763673 0.3768793 2769697 11:2768881-2770074

cg17820828 KCNQ1 0.4521001 -15.68701 0.5207601 2769874 11:2768881-2770074

cg16778148 KCNQ1 0.8961921 3.816669 0.8904414 2774498 11:2774483-2775004

cg26879282 KCNQ1 0.9292187 1.490463 0.9269628 2774567 11:2774483-2775004

cg16609872 KCNQ1 0.3676957 0.2733424 0.3634371 2784940 11:2784925-2785484

cg19923326 KCNQ1 0.4793012 0.9341905 0.4729785 2785354 11:2784925-2785484

cg09226684 KLK10 0.2065453 -2.751312 0.221077 56211905 19:56211831-56213022

cg09254939 KLK10 0.08984087 -3.06999 0.1033535 56212071 19:56211831-56213022

cg11846956 KLK10 0.2090018 0.4864312 0.2027564 56212194 19:56211831-56213022

cg13343486 KLK10 0.08673412 -0.2567923 0.08878905 56212345 19:56211831-56213022

cg11459714 KLK10 0.1170442 -1.379833 0.1249555 56212470 19:56211831-56213022

cg08818784 KLK10 0.06781925 -10.72634 0.08987657 56214010 19:56213378-56214712

cg21869055 KLK10 0.05631379 -15.74881 0.08088146 56214266 19:56213378-56214712

cg24512400 KLK10 0.09657486 -7.424575 0.1195055 56214373 19:56213378-56214712

cg15910208 KLK10 0.05422913 -1.856057 0.06243732 56214400 19:56213378-56214712

cg11170179 KLK10 0.1173663 -11.86756 0.1370221 56214579 19:56213378-56214712

cg06130787 KLK10 0.09689732 12.86928 0.05771466 56215362

cg19356189 KLK10 0.1597708 0.5102361 0.1576625 56216502

cg06611310 LOC129285 0.05903468 -11.03726 0.08954807 48521035 2:48520890-48521959

cg14059729 LOC129285 0.02410471 0.05218904 0.02380843 48521158 2:48520890-48521959

cg04826422 LOC129285 0.04201719 -14.57411 0.06113188 48521329 2:48520890-48521959

cg24076392 LOC129285 0.04716709 -12.12016 0.06126519 48521378 2:48520890-48521959

cg14698961 LOC129285 0.02794987 2.168428 0.02509253 48521391 2:48520890-48521959

cg09262269 LOX 0.1414624 -4.952412 0.1633892 121440328 5:121440312-121442369

cg22836153 LOX 0.05613767 -26.01673 0.08885726 121440601 5:121440312-121442369

cg02548238 LOX 0.07284046 -16.62634 0.1000932 121440949 5:121440312-121442369

cg01824804 LOX 0.1224802 -12.54045 0.155412 121441377 5:121440312-121442369

cg01429321 LOX 0.07554558 -9.040059 0.09809875 121441696 5:121440312-121442369

cg06508445 LOX 0.037356 -12.66789 0.04922318 121441987 5:121440312-121442369

cg11960393 LOX 0.03981097 0.5557286 0.03875138 121442071 5:121440312-121442369

cg04014889 MAGEL2 0.5536484 13.55059 0.4871515 21441686

cg01678091 MAGEL2 0.566123 12.3862 0.5202596 21441779

cg02982734 MAGEL2 0.7029691 5.975411 0.6858433 21442141 15:21442139-21442830

cg21325760 MAGEL2 0.898735 12.43781 0.8866974 21442495 15:21442139-21442830

cg02490034 MEST 0.3819155 11.78454 0.3235283 129913072 7:129912883-129914215

cg09059945 MEST 0.1868947 10.15774 0.1422201 129913254 7:129912883-129914215

cg09872616 MEST 0.2353618 14.5148 0.1647917 129913418 7:129912883-129914215

cg08077673 MEST 0.246522 14.00065 0.1861085 129913604 7:129912883-129914215

cg01888566 MEST 0.3763162 22.40019 0.27966 129913749 7:129912883-129914215

cg15164103 MEST 0.2707638 16.71881 0.1973937 129914107 7:129912883-129914215

cg17347253 MEST 0.5666485 -8.54914 0.6069404 129917524 7:129917351-129920395

cg07427065 MEST 0.6677197 -11.6409 0.7013394 129917832 7:129917351-129920395

cg13917504 MEST 0.6864256 0.6992282 0.6824641 129918494 7:129917351-129920395

cg18183281 MEST 0.7404844 -15.15466 0.78083 129919741 7:129917351-129920395

cg02330106 MGMT 0.6352227 -0.1471361 0.6366533 131154830 10:131154808-131155770

cg25946389 MGMT 0.2539586 -1.298126 0.2644502 131155063 10:131154808-131155770

cg12434587 MGMT 0.05496353 6.906239 0.02691673 131155199 10:131154808-131155770

cg19706602 MGMT 0.1145361 4.693841 0.1020878 131155425 10:131154808-131155770

cg12981137 MGMT 0.04900177 6.858133 0.0225049 131155565 10:131154808-131155770

cg02941816 MGMT 0.04400226 -0.896797 0.04716618 131155686 10:131154808-131155770

cg26201213 MGMT 0.3320374 15.19254 0.2665076 131155786

cg24580056 MGMT 0.8876594 -2.692761 0.8918418 131211577 10:131211399-131211975

cg12040555 MGMT 0.8423564 7.292857 0.8151582 131211820 10:131211399-131211975

cg14129786 MGMT 0.5637907 10.18868 0.4917545 131211937 10:131211399-131211975

cg20537325 MGMT 0.8749297 -10.08367 0.884814 131238411 10:131238346-131238929

cg27056559 MGMT 0.8791823 -4.209541 0.8748076 131238474 10:131238346-131238929

cg07638938 MGMT 0.776444 1.407536 0.762523 131238589 10:131238346-131238929

cg10036895 MGMT 0.8673519 -0.6844286 0.8707122 131238654 10:131238346-131238929

cg04473030 MGMT 0.8122813 -1.498311 0.8184816 131244772 10:131244704-131245359

cg00904483 MGMT 0.9180498 1.174311 0.9141678 131244863 10:131244704-131245359

cg10333959 MGMT 0.8880424 -1.352166 0.8917856 131244930 10:131244704-131245359

cg02381948 MGMT 0.9019776 -2.85435 0.9103088 131245102 10:131244704-131245359

cg20778669 MGMT 0.8791593 -6.059679 0.8926685 131245207 10:131244704-131245359

cg07453748 MGMT 0.8511032 -2.368613 0.8559023 131245292 10:131244704-131245359

cg02803836 MGMT 0.8754629 3.900307 0.8667581 131302497 10:131302456-131302963

cg19680672 MGMT 0.7172532 2.590488 0.7048095 131302569 10:131302456-131302963

cg03271907 MGMT 0.865248 -6.643323 0.8861981 131302633 10:131302456-131302963

cg18488970 MGMT 0.6973196 -4.596208 0.7113985 131302691 10:131302456-131302963

cg17686260 MGMT 0.7781555 -3.141301 0.8153744 131302754 10:131302456-131302963

cg16698623 MGMT 0.7803681 3.827133 0.7619739 131302958 10:131302456-131302963

cg03956628 MLH1 0.3658638 -8.64784 0.4198118 37008604

cg24607398 MLH1 0.5108358 -6.170169 0.5533388 37008629

cg10990993 MLH1 0.5911115 -5.482474 0.6297339 37008636

cg18320188 MLH1 0.3711241 -10.71843 0.4304326 37008984 3:37008972-37010459

cg02279071 MLH1 0.05212159 -4.918977 0.06430607 37009158 3:37008972-37010459

cg13846866 MLH1 0.04190025 -1.608398 0.04561657 37010403 3:37008972-37010459

cg20588069 MSX1 0.2371585 -5.587461 0.2536274 4911340 4:4908144-4911629

cg15696627 MSX1 0.05287784 0.09166782 0.05258039 4912084 4:4912015-4913147

cg26615830 MSX1 0.03380269 -3.499404 0.04673098 4912231 4:4912015-4913147

cg15755084 MSX1 0.04641712 -4.993536 0.05812037 4912584 4:4912015-4913147

cg11930592 MSX1 0.02439559 -10.92519 0.03282823 4912721 4:4912015-4913147

cg06677140 MSX1 0.05223048 -14.32914 0.07098284 4912916 4:4912015-4913147

cg03717979 MSX1 0.03958588 -13.85026 0.04963138 4913085 4:4912015-4913147

cg03199651 MSX1 0.06193629 -2.16983 0.06485187 4913671 4:4913563-4914786

cg14167596 MSX1 0.05064503 -6.12432 0.06273638 4913811 4:4913563-4914786

cg20161179 MSX1 0.062638 0.0983808 0.06243904 4914183 4:4913563-4914786

cg22609784 MSX1 0.3184997 0.3672149 0.3154983 4914579 4:4913563-4914786

cg09573795 MSX1 0.5764696 -4.922587 0.6084058 4914775 4:4913563-4914786

cg27038439 MSX1 0.704097 0.2157815 0.7020119 4915221 4:4915141-4915899

cg24840099 MSX1 0.3013588 2.534266 0.282391 4915331 4:4915141-4915899

cg09748975 MSX1 0.5215916 0.4557239 0.5157959 4915433 4:4915141-4915899

cg03843978 MSX1 0.3332495 3.377253 0.3173392 4915526 4:4915141-4915899

cg20891301 MSX1 0.5726182 -0.05218904 0.5731004 4915612 4:4915141-4915899

cg01785568 MSX1 0.3335568 1.705167 0.3213145 4915734 4:4915141-4915899

cg12862537 NNAT 0.8694197 -7.641956 0.8873374 35582093 20:35581886-35583655

cg22298088 NNAT 0.8087829 -10.41077 0.8357503 35582274 20:35581886-35583655

cg22510412 NNAT 0.7747583 -4.618121 0.7887102 35582535 20:35581886-35583655

cg18433380 NNAT 0.7740071 -9.477193 0.809922 35582608 20:35581886-35583655

cg21588305 NNAT 0.8287398 0.1265058 0.8280044 35582869 20:35581886-35583655

cg23566503 NNAT 0.691579 -14.12705 0.7413852 35583164 20:35581886-35583655

cg10642330 NNAT 0.6898043 -2.638195 0.7078023 35583475 20:35581886-35583655

cg08409225 OBFC2B 0.2242752 -9.807948 0.2834434 54904004 12:54903894-54904729

cg14816013 OBFC2B 0.06290309 -0.7237655 0.06710105 54904421 12:54903894-54904729

cg17709466 OBFC2B 0.0374149 9.117425 0.03032633 54904451 12:54903894-54904729

cg25245322 OBFC2B 0.0511849 0.7958567 0.04677705 54904463 12:54903894-54904729

cg11722639 OBFC2B 0.02085874 -1.705167 0.02572559 54904466 12:54903894-54904729

cg22591065 OBFC2B 0.05918758 0.5069503 0.05817205 54904481 12:54903894-54904729

cg02153528 OBFC2B 0.09600896 12.93116 0.08278408 54904915

cg11219178 OSBPL5 0.4958932 15.1441 0.4465684 3077525 11:3077516-3078062

cg25852715 OSBPL5 0.881557 7.356018 0.8666723 3077600 11:3077516-3078062

cg12514506 OSBPL5 0.8060589 14.42308 0.7782053 3077862 11:3077516-3078062

cg07873128 OSBPL5 0.8826078 -6.680756 0.8912426 3077976 11:3077516-3078062

cg23617121 OSBPL5 0.9250138 -9.523673 0.9487051 3078036 11:3077516-3078062

cg12970008 OSBPL5 0.1162438 -6.847612 0.1491931 3142671 11:3142568-3143433

cg20345446 OSBPL5 0.1950659 -5.127762 0.2185113 3143380 11:3142568-3143433

cg06131936 OSBPL5 0.2138716 18.06292 0.1761411 3143847

cg07236943 PEG10 0.06627394 -1.901791 0.07186974 94122422 7:94122326-94124641

cg23096644 PEG10 0.05310271 -4.595692 0.05996772 94122570 7:94122326-94124641

cg25524350 PEG10 0.08456182 -1.588393 0.09047772 94122829 7:94122326-94124641

cg19107595 PEG10 0.5161454 -7.307412 0.5469717 94123578 7:94122326-94124641

cg08291000 PEG10 0.4698373 16.71841 0.4503951 94123896 7:94122326-94124641

cg16492735 PEG10 0.3555192 2.154004 0.3464609 94124144 7:94122326-94124641

cg06695761 PEG10 0.5988443 8.311698 0.5861152 94124462 7:94122326-94124641

cg21270593 PEG10 0.9713138 -1.060737 0.9724424 94131186 7:94131111-94132325

cg21405195 PEG10 0.7816349 0.7108325 0.77568 94131321 7:94131111-94132325

cg22647507 PEG10 0.8423571 1.088105 0.8390947 94131571 7:94131111-94132325

cg06943865 PEG10 0.8758764 2.090566 0.8729348 94131716 7:94131111-94132325

cg01488147 PEG10 0.8365874 -8.600226 0.8623753 94132016 7:94131111-94132325

cg19781251 PEG10 0.9511036 -1.024954 0.9521828 94132214 7:94131111-94132325

cg23517677 POLR2G 0.7179567 -8.921292 0.7369252 62284848

cg21850239 POLR2G 0.02506695 -12.11192 0.03674568 62285564 11:62285024-62286097

cg11372696 POLR2G 0.05490863 -14.97582 0.08398198 62285566 11:62285024-62286097

cg16467694 POLR2G 0.02900159 -7.295363 0.03529331 62285774 11:62285024-62286097

cg26125443 POLR2G 0.02781863 -3.964841 0.03036153 62285789 11:62285024-62286097

cg22176017 POLR2G 0.1591192 -9.236401 0.2127085 62286036 11:62285024-62286097

cg15544721 PPP1R9A 0.5754746 11.66004 0.5436049 94374627

cg11164400 PPP1R9A 0.2384094 24.96751 0.1926626 94374723 7:94374717-94375964

cg16872560 PPP1R9A 0.0513747 -6.052435 0.06095348 94374922 7:94374717-94375964

cg19221959 PPP1R9A 0.04447244 -0.1255925 0.04514455 94375283 7:94374717-94375964

cg04951204 PPP1R9A 0.05848491 -9.90797 0.0672498 94375520 7:94374717-94375964

cg15287183 PPP1R9A 0.1075156 12.59541 0.08705659 94375669 7:94374717-94375964

cg09643313 PPP1R9A 0.1299839 -15.28557 0.1564916 94375829 7:94374717-94375964

cg19921492 PSMB6 0.1737576 -27.87509 0.2387887 4646192 17:4645846-4646896

cg16882703 PSMB6 0.139295 3.524292 0.1277623 4646292 17:4645846-4646896

cg20693880 PSMB6 0.06924675 1.27338 0.06712905 4646436 17:4645846-4646896

cg21295602 PSMB6 0.1681405 -17.68636 0.2364478 4646593 17:4645846-4646896

cg17191186 PSMB6 0.1736809 -17.26702 0.2264201 4646595 17:4645846-4646896

cg24221059 PSMB6 0.08373649 -20.5216 0.1277271 4646690 17:4645846-4646896

cg19402885 PTPRO 0.1199903 -10.28013 0.1421159 15366503 12:15366460-15367398

cg27196745 PTPRO 0.1415608 -12.29757 0.1751649 15366586 12:15366460-15367398

cg06357925 PTPRO 0.07002436 -12.91871 0.09402325 15366598 12:15366460-15367398

cg10646402 PTPRO 0.07792714 -8.348509 0.1051138 15366757 12:15366460-15367398

cg09126273 PTPRO 0.1436807 -6.936513 0.1753699 15367034 12:15366460-15367398

cg09440289 PTPRO 0.1318061 -19.51271 0.1859473 15367257 12:15366460-15367398

cg09470640 PTPRO 0.04177966 -5.583705 0.04713121 15367295 12:15366460-15367398

cg24053587 PTPRO 0.05198617 -21.49744 0.07279138 15367352 12:15366460-15367398

cg11843304 PTPRO 0.7126013 10.04939 0.6764686 15392604 12:15392536-15393111

cg11970458 PYCARD 0.1812335 12.80323 0.1658068 31120982 16:31120978-31121976

cg15247144 PYCARD 0.02138917 3.381976 0.0197618 31121231 16:31120978-31121976

cg05361373 PYCARD 0.06164046 4.893564 0.05688949 31121384 16:31120978-31121976

cg09587549 PYCARD 0.05026925 2.623159 0.04741166 31121627 16:31120978-31121976

cg15468095 PYCARD 0.09229572 9.414217 0.07719404 31121902 16:31120978-31121976

cg12100791 PYCARD 0.2045346 11.61468 0.155687 31121918 16:31120978-31121976

cg18987220 RAB32 0.7954354 1.036671 0.790444 146905940 6:146905888-146907189

cg20098887 RAB32 0.04916618 -9.542958 0.06237502 146906213 6:146905888-146907189

cg14889768 RAB32 0.06057012 -5.487056 0.07326935 146906222 6:146905888-146907189

cg23833452 RAB32 0.1652187 -8.853184 0.2013244 146906445 6:146905888-146907189

cg22030890 RAB32 0.1200502 -19.64898 0.1648135 146906926 6:146905888-146907189

cg04113075 RAB32 0.07918686 -16.31063 0.09810918 146907180 6:146905888-146907189

cg13221796 RB1 0.4548865 7.578506 0.4113843 47774920

cg08383063 RB1 0.03922377 -18.06292 0.04609936 47775435 13:47775308-47776840

cg24937706 RB1 0.01903485 1.132866 0.01850202 47775720 13:47775308-47776840

cg10552385 RB1 0.01483796 -9.249012 0.01788571 47776038 13:47775308-47776840

cg17055959 RB1 0.08206554 -0.2539161 0.08275216 47776467 13:47775308-47776840

cg01738359 RB1 0.03562516 -1.998709 0.03716208 47776640 13:47775308-47776840

cg19447496 RB1 0.8630401 0.62516 0.8601547 47789073 13:47788780-47789303

cg19296958 RB1 0.8365403 -13.37943 0.8547717 47789271 13:47788780-47789303

cg27182551 RB1 0.8581828 -2.066365 0.8652716 47790552 13:47790461-47792049

cg19427472 RB1 0.8271791 1.064582 0.8230615 47790949 13:47790461-47792049

cg13431205 RB1 0.6042839 0.08853072 0.6030867 47791175 13:47790461-47792049

cg03085377 RB1 0.6397057 -0.5059402 0.6457908 47791377 13:47790461-47792049

cg18481241 RB1 0.6696957 0.2964031 0.6664907 47791728 13:47790461-47792049

cg16153267 RB1 0.4231716 2.171837 0.4057654 47791969 13:47790461-47792049

cg00059930 RB1 0.6654185 0.9230899 0.6589749 47792383 13:47792306-47793951

cg26119796 RB1 0.5013228 1.364267 0.4924508 47792596 13:47792306-47793951

cg19254235 RB1 0.4351113 0.5550214 0.4303916 47793174 13:47792306-47793951

cg07880715 RB1 0.6400457 5.094011 0.6182702 47793479 13:47792306-47793951

cg20333306 RB1 0.8727674 2.839613 0.8612418 47937679 13:47937627-47938195

cg25002911 RB1 0.6862627 5.054371 0.6733073 47937987 13:47937627-47938195

cg02655204 RB1 0.6427842 -1.388727 0.6472055 47938051 13:47937627-47938195

cg02723372 RUNX3 0.8466926 -0.4216549 0.8478425 25101169 1:25101076-25101799

cg25178645 RUNX3 0.9498812 2.101687 0.9473363 25101274 1:25101076-25101799

cg14645650 RUNX3 0.9610675 1.451228 0.9600694 25101388 1:25101076-25101799

cg27360282 RUNX3 0.9173175 1.893162 0.9142802 25101509 1:25101076-25101799

cg18231267 RUNX3 0.9175687 1.283536 0.9139315 25101686 1:25101076-25101799

cg04757093 RUNX3 0.6418152 0.02430931 0.6416528 25101779 1:25101076-25101799

cg18813928 RUNX3 0.9651601 0.2947172 0.964913 25107093 1:25106952-25107518

cg00572797 RUNX3 0.9701709 -13.43658 0.9769246 25107166 1:25106952-25107518

cg08705994 RUNX3 0.9717633 -0.465285 0.9723592 25107236 1:25106952-25107518

cg23919867 RUNX3 0.9482359 -16.61459 0.9541625 25107293 1:25106952-25107518

cg00117172 RUNX3 0.109853 -2.000989 0.1185284 25128425 1:25127692-25131906

cg06377278 RUNX3 0.02013369 9.079229 0.01329661 25128956 1:25127692-25131906

cg22737001 RUNX3 0.03314741 2.101687 0.03068603 25129616 1:25127692-25131906

cg24019564 RUNX3 0.1662249 4.777483 0.1497312 25130153 1:25127692-25131906

cg03171924 RUNX3 0.4041749 -0.1897939 0.4060774 25130919 1:25127692-25131906

cg14182690 RUNX3 0.6229296 16.76829 0.5556329 25163534 1:25163450-25163764

cg13461622 RUNX3 0.5313458 13.77491 0.472805 25163972

cg06037693 RUNX3 0.7754964 23.29203 0.7263832 25164659

cg16529592 RUNX3 0.6808113 18.28386 0.6216206 25164802

cg07580475 SEMA3B 0.829304 -0.9572784 0.8313073 50279053

cg14824983 SEMA3B 0.7318711 13.20039 0.7104522 50279428

cg02657721 SEMA3B 0.08612104 0.8567547 0.08430898 50280835

cg10546523 SEMA3B 0.0174885 5.705385 0.01504205 50285488 3:50285369-50286362

cg17289734 SEMA3B 0.04083691 3.651472 0.03800443 50285645 3:50285369-50286362

cg24816455 SEMA3B 0.1730039 32.37925 0.0880461 50285770 3:50285369-50286362

cg22037648 SEMA3B 0.06302627 5.703877 0.05330601 50286013 3:50285369-50286362

cg14911395 SEMA3B 0.5583405 3.100236 0.5446605 50286217 3:50285369-50286362

cg26918728 SEMA3B 0.7912737 1.844732 0.7853013 50286339 3:50285369-50286362

cg12069309 SEMA3B 0.3970248 3.851596 0.3803418 50287917 3:50287560-50290055

cg09811393 SEMA3B 0.6148198 2.055778 0.6073413 50288217 3:50287560-50290055

cg08097657 SEMA3B 0.7106603 0.008813297 0.7105806 50289000 3:50287560-50290055

cg24019851 SEMA3B 0.7437357 2.886737 0.7262858 50289295 3:50287560-50290055

cg13550608 SEMA3B 0.8268659 19.52519 0.7787655 50289658 3:50287560-50290055

cg20837735 SERPINB5 0.4373161 10.98374 0.3502243 59295157 18:59294878-59295284

cg08411049 SERPINB5 0.4560327 18.37351 0.3524345 59295230 18:59294878-59295284

cg15422147 SERPINB5 0.5088665 3.11072 0.4732257 59295319

cg00226904 SERPINB5 0.6103781 -13.09413 0.647363 59308045 18:59308015-59308744

cg07331725 SERPINB5 0.8983873 2.857696 0.8898014 59308458 18:59308015-59308744

cg06682185 SERPINB5 0.7558948 3.898886 0.7421009 59308595 18:59308015-59308744

cg23824713 SERPINB5 0.8515117 -4.26165 0.8649414 59308718 18:59308015-59308744

cg21019522 SLC22A18 0.4006299 4.883269 0.3765554 2877365

cg19906550 SLC22A18 0.5472594 7.148353 0.5154896 2877375

cg16873863 SLC22A18 0.5491723 14.07771 0.4895996 2877752

cg16035277 SLC22A18 0.1238904 0.8196738 0.1202706 2879840 11:2879777-2880396

cg24139421 SLC22A18 0.02155065 -1.63244 0.02270723 2880154 11:2879777-2880396

cg06211616 SLC22A18 0.06552842 -0.05233124 0.06589 2880235 11:2879777-2880396

cg24528523 SLC22A18 0.1264109 9.606133 0.1158253 2880384 11:2879777-2880396

cg22858288 SLC22A18 0.6971015 -13.95133 0.7647961 2886898 11:2886834-2887801

cg04726200 SLC22A18 0.7245358 -19.98104 0.7945421 2887061 11:2886834-2887801

cg19497444 SLC22A18 0.7257445 -20.96922 0.777444 2887370 11:2886834-2887801

cg03336167 SLC22A18 0.5863768 -7.932598 0.6353406 2887571 11:2886834-2887801

cg23698969 SLC22A18 0.9153563 -13.87029 0.9270231 2887741 11:2886834-2887801

cg19240938 SLC22A18 0.8259375 8.383995 0.8079563 2898612 11:2898556-2899108

cg18655584 SLC22A18 0.8374943 -1.801958 0.8426192 2898669 11:2898556-2899108

cg12510502 SLC22A18 0.9189282 2.595222 0.9156379 2898752 11:2898556-2899108

cg00891541 SMPD3 0.645928 -10.07848 0.7044073 67038988 16:67038237-67039167

cg10556064 SMPD3 0.673473 -11.2915 0.7258313 67038990 16:67038237-67039167

cg22116290 SMPD3 0.1266169 0.5955426 0.1246051 67039469 16:67039271-67040730

cg23758485 SMPD3 0.1031731 -0.1721624 0.1044039 67039703 16:67039271-67040730

cg15201635 SMPD3 0.02847578 1.780181 0.02623063 67040138 16:67039271-67040730

cg19297232 SMPD3 0.6593115 -9.986833 0.7156184 67040522 16:67039271-67040730

cg17217677 SMPD3 0.8210033 -20.84988 0.8700421 67040695 16:67039271-67040730

cg11265941 SNRPN 0.4085234 -10.45067 0.4564934 22619831

cg19803984 SNRPN 0.4104824 5.043903 0.3850105 22619883

cg16321029 SNRPN 0.4962004 0.6168911 0.4899484 22619943

cg26033681 SNRPN 0.3532792 8.870242 0.3277312 22620469

cg25978208 SNRPN 0.6776795 -12.52746 0.7200097 22644337 15:22644176-22644728

cg02171545 SNRPN 0.553151 -7.821018 0.6069257 22644459 15:22644176-22644728

cg02305723 SNRPN 0.6740383 -3.9745 0.7067515 22644549 15:22644176-22644728

cg22678136 SNRPN 0.6859684 -5.499322 0.7277339 22644614 15:22644176-22644728

cg27644292 SNRPN 0.5196915 -6.244223 0.5511175 22674380 15:22674353-22674888

cg25657700 SNRPN 0.7583314 -7.990469 0.804543 22674584 15:22674353-22674888

cg24993443 SNRPN 0.7073162 -9.830451 0.7635208 22674642 15:22674353-22674888

cg21870668 SNRPN 0.4825803 -12.08409 0.5479862 22674824 15:22674353-22674888

cg22555495 SNRPN 0.534941 32.02275 0.5013131 22752317 15:22751044-22752323

cg16896647 SYK 0.06257279 18.3699 0.05302448 92603597 9:92603527-92604494

cg07160163 SYK 0.02354484 1.813962 0.02207033 92603599 9:92603527-92604494

cg02608019 SYK 0.05126045 8.973645 0.04160124 92603849 9:92603527-92604494

cg14304761 SYK 0.02902638 2.93855 0.02715908 92603970 9:92603527-92604494

cg10025443 SYK 0.0474081 7.653354 0.04136189 92604160 9:92603527-92604494

cg05801648 SYK 0.08268102 6.427151 0.07063001 92604277 9:92603527-92604494

cg23447996 SYK 0.1655359 9.494159 0.1245765 92604424 9:92603527-92604494

cg13518327 THRB 0.0526404 -16.86109 0.06694555 24510778 3:24510366-24512597

cg09805010 THRB 0.04085612 -8.790144 0.06193452 24511081 3:24510366-24512597

cg15385623 THRB 0.1819412 -15.35575 0.213189 24511313 3:24510366-24512597

cg24120841 THRB 0.060263 1.088411 0.05646902 24511566 3:24510366-24512597

cg21303011 THRB 0.06514034 2.212386 0.05972939 24512181 3:24510366-24512597

cg08319404 THRB 0.2481442 18.3525 0.1899497 24512439 3:24510366-24512597

cg16175263 TNFRSF10C 0.241613 -5.231212 0.2781366 23016330 8:23016236-23017035

cg05636175 TNFRSF10C 0.2535 -5.50826 0.2872797 23016342 8:23016236-23017035

cg27090216 TNFRSF10C 0.09544238 -10.33291 0.136289 23016406 8:23016236-23017035

cg14015044 TNFRSF10C 0.2271208 -5.529696 0.2702091 23016564 8:23016236-23017035

cg01407244 TNFRSF10C 0.2802935 -15.96732 0.3482769 23016952 8:23016236-23017035

cg02938601 TNFRSF10C 0.3297466 -7.82942 0.3795021 23017033 8:23016236-23017035

cg02517489 UBE3A 0.03993725 -15.90456 0.04981317 23234168 15:23234149-23235624

cg12177023 UBE3A 0.0226088 -18.62781 0.0319272 23234344 15:23234149-23235624

cg18766912 UBE3A 0.1835779 -24.59473 0.262561 23235002 15:23234149-23235624

cg12572011 UBE3A 0.01782933 4.034422 0.01534152 23235178 15:23234149-23235624

cg23681243 UBE3A 0.02720464 -1.144241 0.02822144 23235181 15:23234149-23235624

cg00792740 UBE3A 0.04949333 4.392811 0.04607179 23235581 15:23234149-23235624

cg27458888 UBE3A 0.03179127 -13.44557 0.03862109 23235671

cg05881762 UBE3A 0.06742793 -1.856057 0.06447936 23235942

cg22782492 VHL 0.05144387 -20.65029 0.07756338 10159007 3:10157841-10160111

cg03509024 VHL 0.02118409 -1.935288 0.02260044 10159013 3:10157841-10160111

cg16869108 VHL 0.5403455 19.06173 0.4423263 10159319 3:10157841-10160111

cg20916523 VHL 0.6104484 11.48721 0.5369033 10159584 3:10157841-10160111

cg24092914 VHL 0.5694196 10.49015 0.5108352 10159877 3:10157841-10160111

cg25539131 VHL 0.804503 -1.411699 0.8118548 10164941 3:10164924-10165440

cg27226214 VHL 0.8485065 0.7721972 0.8446398 10165289 3:10164924-10165440

cg25094569 WT1 0.1032576 -9.454772 0.1267626 32405345 11:32404590-32406255

cg13301003 WT1 0.2927859 -4.438913 0.3145437 32405830 11:32404590-32406255

cg04096767 WT1 0.3248363 -3.607483 0.3471656 32406026 11:32404590-32406255

cg12006284 WT1 0.2388506 -3.167352 0.2574339 32406214 11:32404590-32406255

cg16501028 WT1 0.4251723 -12.17034 0.4629066 32406576 11:32406516-32407359

cg04456238 WT1 0.2641 -9.0166 0.3022313 32406680 11:32406516-32407359

cg05222924 WT1 0.2061416 -4.55524 0.2303703 32407062 11:32406516-32407359

cg06516124 WT1 0.1758697 -15.85391 0.2216488 32407167 11:32406516-32407359

cg25782229 WT1 0.2427191 -18.14186 0.2942587 32407268 11:32406516-32407359

cg12781568 WT1 0.4590691 -4.597452 0.4844931 32408614 11:32408563-32409903

cg01693350 WT1 0.538826 -5.529693 0.5734254 32408763 11:32408563-32409903

cg15446391 WT1 0.4100006 -2.540053 0.4256824 32408946 11:32408563-32409903

cg13641903 WT1 0.4951534 -2.035982 0.5084258 32409184 11:32408563-32409903

cg22533573 WT1 0.1424484 0.891549 0.1384202 32409347 11:32408563-32409903

cg16463460 WT1 0.3537653 -4.53387 0.372615 32411294 11:32411271-32413831

cg22511262 WT1 0.1406611 -5.721784 0.1582157 32411768 11:32411271-32413831

cg16092786 WT1 0.1788782 -8.61239 0.2113905 32412311 11:32411271-32413831

cg25563456 WT1 0.1039817 -3.123196 0.1173587 32412645 11:32411271-32413831

cg15107670 WT1 0.1805509 -5.082025 0.2115827 32413335 11:32411271-32413831

cg22975913 WT1 0.0616129 0.1768825 0.06103337 32414303 11:32414112-32415699

cg01464985 ZNF512 0.2913844 -9.790613 0.3431046 27659126 2:27659123-27659757

cg25926679 ZNF512 0.1614453 2.989261 0.1500871 27659266 2:27659123-27659757

cg06866862 ZNF512 0.2145937 -19.6797 0.3256389 27659268 2:27659123-27659757

cg18611281 ZNF512 0.2267666 -21.54993 0.2986217 27659348 2:27659123-27659757

Supplementary Table 4. All CpGs interrogated by the Infinium array in the 65 genes contained in Table 2. Average beta values are given for cancer (n=30) and control (n=18) samples. “Cancer DiffScore” is related to P-value by the relationship DiffScore = 10sgn(beta-valueCancer- beta-valueControl) log10p (see Illumina Users Guide). In this data set, DiffScores of >approximately 5.5 or <approximately -5.5 correspond to P<0.05. MAPINFO position and CpG Island locations are given in NCBI Build 36 coordinates. A number of examples of 3 or more contiguous CpGs within a candidate being methylated significantly differently and in the same direction have been shown in bold type.

cg15609321 ZNF512 0.1075432 -8.667234 0.1341157 27659397 2:27659123-27659757

cg19451391 ZNF512 0.1942108 -19.97966 0.266167 27659422 2:27659123-27659757

cg07975063 ZNF512 0.1590654 -13.36331 0.2073789 27659431 2:27659123-27659757

cg22584335 ZNF512 0.1193285 -15.28557 0.1744026 27659571 2:27659123-27659757

cg02247582 ZNF512 0.05212787 -4.976694 0.06202766 27659621 2:27659123-27659757

cg10665018 ZNF688 0.1333831 3.661656 0.1247832 30490382 16:30490076-30491410

cg00822607 ZNF688 0.06451955 -0.07312319 0.06468257 30490419 16:30490076-30491410

cg09938681 ZNF688 0.02559195 4.202303 0.02300454 30490422 16:30490076-30491410

cg01343729 ZNF688 0.06308278 11.85634 0.05253032 30490431 16:30490076-30491410

cg23660191 ZNF688 0.04596231 0.4151828 0.04514761 30490443 16:30490076-30491410

cg27586455 ZNF688 0.05031432 -8.684612 0.06109172 30490525 16:30490076-30491410

cg10526232 ZNF688 0.05706204 -0.006714005 0.05709262 30490543 16:30490076-30491410

cg03942436 ZNF688 0.03016876 -1.856057 0.02502859 30490549 16:30490076-30491410

cg11141013 ZNF688 0.03083019 -2.444824 0.03440259 30490557 16:30490076-30491410

cg25549413 ZNF688 0.3469852 -11.99954 0.4198009 30490971 16:30490076-30491410

cg03309050 ZNF688 0.0315961 -1.856057 0.04256084 30491237 16:30490076-30491410

cg17794261 ZNF688 0.02683482 -0.7329133 0.02748137 30491260 16:30490076-30491410