Substances Delivered ByIontophoresis As Reported In The Literature

©2009 Encore Medical, L.P., and Affiliates. 0409 114C

Substances Delivered By Iontophoresis As Reported In The Literature

Ion Polarity Solution Purpose / Condition ReferenceAcetic Acid - 2-5% acetic acid solution Calcium deposits, calcified tendonitis 27, 29, 37Atropine sulfate + 0.001-0.01% solution Hyperhidrosis 13Calcium + 2% calcium chloride solution Myopathy, myospasm, frozen joints 26Chloride - 2% sodium chloride solution Sclerolytic; scar tissue, adhesions,

keloids25, 45

Citrate - 2% potassium citrate solution Rheumatoid arthritis 7Copper + 2% copper sulfate solution Astringent; fungus infection 19,24Dexamethasone - 4mg/cc dexamethasone sodium

phosphateTendonitis, bursitis, arthritis, tenosynovitis

Peyronie’s Disease15, 20, 22

Gentamicin sulfate + 8mg/cc Ear chondritis 30Glycopyrronium bromide + 0.05% solution Hyperhidrosis 1, 35Hyaluronidase + “Wyadase” solution Absorption enhancement; edema,

scleroderma, lymphedema21, 36, 42

Idoxuridine - 0.1% solution Herpes simplex 9, 10, 12Iodine - “Iodex” ointment Sclerolytic, antimicrobial; fibrosis,

adhesions, scar tissue, trigger finger31, 46

Iron/titanium oxide + Skin pigmentation 2Lidocaine + 4% lidocaine with or without

epinephrineSkin anesthesia; trigeminal neuralgia 4, 40

Lithium + 2% lithium chloride solution Gouty arthritis 28Magnesium + 2% magnesium sulfate Muscle relaxant, vasodilator; myalgias,

neuritis, deltoid bursitis, low backspasm

47

Mecholyl (acetyl-beta-methylcholine chloride)

+ 0.25% solution Vasodilator, muscle relaxant; radiculitis,varicose ulcers, discogenic low backarthritis

21, 33

Meladinine - 1% solution of sodium salt Vitiligo 34Methyl prednisilone sodium

succinate- Aphthous stomatitis, post-herpetic

neuralgia11

Penicillin - Infected burn wounds 39, 43Pilocarpine + Sweat test (cystic fibrosis) 6, 14Poldine methyl sulfate - 0.05-0.5% solution Hyperhidrosis 18, 23Potassium iodide - 10% solution Scar tissue 38Salicylate - 2% sodium salicylate solution Analgesic, sclerolytic; plantar warts, scar

tissue, myalgias16

NaCl - 2-3% solution Scar tissueSilver + Chronic osteomyelitis 3, 41Vincristine

Vinblastine+ Vincristine: 0.01% solution in 9%

saline + 5% DMSOReduce congestion; post-herpetic

neuralgia trigeminal neuralgia8

Water + / - H+ / OH- Palmar, plantar, axillary hyperhidrosis 1, 17, 18,32, 44

Zinc + 20% zinc oxide (suspension) Antiseptic; ulcers, dermatitis, woundhealing

5

1. Abell, E. and K. Morgan, 1974. The treatment of idiopathic Hyperhidrosis by glycopyrronium bromide and tap water iontophoresis. Brit. J. Dermatol. 91:87-91.2. Batner, H. 1961. Cataphoresis in dermabrasion tattooing. Plast. Reconstr. Surg. 27:613-617.3. Becker, R. and J. Spadaro, 1978. Treatment of orthopaedic infections with electrically generated silver ions. J. Bone Joint. Surg. 60A:871-881.4. Bezzant, J., Stephen, R., Petelenz, T. and S. Jacobsen, 1988. Painless cauterization of spider veins with the use of iontophoretic local anesthesia. J. Amer. Acad. Dermatol.

19:869-875.5. Corwall. 1981. M. Zinc iontophoresis to treat ischemic skin ulcers. Phys. Ther. 61:359-360.6. Coury, A., Fogt, E., Norenerg, M. and D. Untereker, 1983. Development of a screening system for cystic fibrosis. Clin. Chem. 29:1593-1597.7. Coyer, A. 1954. Citrate iontophoresis in rheumatoid arthritis of the hands. Ann. Phys. Med. 2:16.8. Csillk, B., Knyihar-Csillik, E. and A. Szucs. 1982. Treatment of chronic pain syndromes with iontophoresis of vinca alkaloids to the skin of patients. Neurosci. Lett. 31:87-90.9. Gangarosa, L., et al. 1977 Iontophoretic assistance of 5-iodo-2-deoxyuridine penetration into neonatal mouse skin and effects on DNA synthesis. Proc. Soc. Exp. Biol. Med.

154:439-44310. Gangarosa, L., et al. 1979. Iontophoretic application of idoxuridine for recurrent herpes labialis: report of preliminary clinical findings. Methods Find. Exp. Clin. Pharmacol. 1:105-

109.11. Gangarosa, L., et al. 1982. Third International Congress On Modern Pain Control (Abstracts). p. 221.12. Gangarosa, L., et al. 1989. Iontophoretic treatment of herpetic whitlow. Arch. Phys. Med. Rehabil. 70:336-34013. Gibinski, K., Giec, L., Zmudzinski, J., et al. 1973. Transcutaneous inhibition of sweat gland function by atropine. J. App. Physio. 34:850-852.14. Gibson, L. and R. Cooke. 1959. A test for the concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis. Pediatrics. 23:545-549.15. Glass, J., Stephen, R. and S. Jacobsen. 1980. The quantity and distribution of radiolabeled dexamethasone delivered to tissues by iontophoresis. Int. J. Dermatol. 19:519-525.16. Gordon, N. and M. Weinstein. 1969. Sodium Salicylate iontophoresis in the treatment of plantar warts (a case report). Phys. Ther. 49:869-870.17. Grice, K. 1980. Hyperhidrosis and its treatment by iontophoresis. Physiother. 66:43-44.18. Grice, K. Sattar, H. and H. Baker. 1972. Treatment of idiopathic hyperhidrosis with iontophoresis of tap water and poldine methysulfate. Brit. J. Dermatol. 86:72-78.19. Haggard, H., Strauss, M. and I. Greenberg. 1939. Fungus infections of hand and feet treated by copper iontophoresis. J. Amer. Med. Assoc. 112:1229.20. Harris, P. 1982. Iontophoresis: clinical research in musculoskeletal inflammatory conditions. J. Orthopaed. Sports Phys. Ther. 4:109-112.21. Harris, R. 1967. Iontophoresis. In: Therapeutic electricity and ultraviolet radiation, S. Licht (ed). Waverly Press. Baltimore, MD. 156-178.22. Hasson, S., et al. 1988. Effect of iontophoretically delivered dexamethasone on muscle performance in a rheumatoid arthritic joint. Arthritis Care Res. 1:177-182.23. Hill, B. 1976. Poldine iontophoresis in the treatment of plantar and palmar Hyperhidrosis. Austral. J. Dermatol. 17:92-93.24. Jersild, O. and N. Piesner. 1940. Treatment of epidermophytia on the extremities with iontophoresis of copper. Acta Derm. Venereol. (Stockh). 21:268-279.25. Kahn, A. and J. Kahn. 1959. Iontophoresis. J. New York State Soc. Physiother. Annual Issue (June).26. Kahn, J. 1975. Calcium iontophoresis in suspected myopathy. Phys. Ther. 55:376-377.27. Kahn, J. 1977. Acetic acid iontophoresis for calcium deposits. Phys. Ther. 57:658-659.28. Kahn, J. 1982. A case report: Lithium iontophoresis for gouty arthritis. J. Orthopaed. Sports Phys. Ther. 4:113-114.29. Kahn, J. 1989. Suspected heel spur management: A case report. Orthopaed. Rev. 1:7.30. LaForest, N. and C. Cofrancesco. 1978. Antibiotic iontophoresis in the treatment of ear chondritis. Phys. Ther. 53:32-34.31. Langley, P. 1984. Iontophoresis to aid in releasing tendon adhesions: suggestions from the field. Phys. Ther. 64:1395.32. Levit, F. 1980. Treatment of hyperhidrosis by tap water iontophoresis. Cutis. 26:192-194.33. Macht, M. and M. Bader. 1948. Iontophoresis with acetyl-beta-methylcholine and blood flow through the hand at low environmental temperatures. J. Appl. Physiol. 1:205.34. Moawad. M. 1969. Treatment of vitiligo with 1% solution of the sodium salt of meladinine using the iontophoresis technique. Dermatol. Monatsschr. 155:388-394.35. Morgan, K. 1980. The technic of treating hyperhidrosis by iontophoresis. Physiother. 66:45.36. Popkin, R. 1951. The use of hyaluronidase by iontophoresis in the treatment of generalized scleroderma. J. Invest. Dermatol. 16:97-102.37. Psaki, C. and J. Carroll. 1955. Acetic acid ionization: a study to determine the absorptive effects upon calcified tendonitis of the shoulder. Phys. Ther. Rev. 35:84-87.38. Puttemans, F., et al. 1982. Iontophoresis: mechanism of action studied by potentiometry and x-ray fluorescence. Arch. Phys. Med. Rehabil. 63:176-180.39. Rapperport, A., et al. 1965. Iontophoresis: a method of antibiotic administration in the burn patient. Plast. Reconstruc. Surg. 36:547-552.40. Russo, J., Lipman A., Comstock, T., Page, B. and R. Stephen. 1980. Lidocaine anesthesia: comparison of iontophoresis, injection and swabbing. Amer. J. Hosp. Pharm. 37:843-

847.41. Satyanand, A., Saxena, A. and A. Agarwal. 1986. Silver iontophoresis in chronic osteomyelitis. J. Indian Med. Assoc. 84:134-136.42. Schwartz, H. 1955. Use of hyaluronidase by iontophoresis in treatment of lymphedema. Arch. Intern. Med. 95:662-668.43. Sela, M., Peled, I., Zagher, A. and S. Taicher. 1985. Maxillofacial prosthesis and iontophoresis in management of burned ears. J. Prosthet. Dent. 53:226-227.44. Shrivastava, S. and G. Singh.1977. Tap water iontophoresis for palmar hyperhidrosis. Brit. J. Dermatol. 96:189-195.45. Sloan, J. and K. Soltani. 1986. Iontophoresis in dermatology. J. Amer. Acad. Dermatol. 15:671-684.46. Tannenbaum, M. 1980. Iodine iontophoresis in reducing scar tissue. Phys. Ther. 60:792.47. Weinstein, M. and A. Gordon. 1958. The use of magnesium sulfate iontophoresis in the treatment of deltoid bursitis. Phys. Ther. Rev. 38:96-98.

IMPORTANT

Chattanooga, in accordance with its FDA cleared labeling and instructions, does NOT endorse or recommend the use of the Phoresor® System with any medications, chemicals orsubstances other than those described in current official Phoresor and/or Electrode Instruction Guides and labeling. Also, Chattanooga, doesNOT endorse or recommend modification oruse of the Phoresor System (including electrodes) in a manner other than specifically shown in current official Phoresor and/or Electrode Instruction Guides and labeling. The referencelist presented above is provided only as an informational service for those interested in performing independent work involving iontophoresis.

4717 Adams Road, P.O. Box 489Hixson, TN 37343 U.S.A.1-423-870-22811-800-592-7329 U.S.A.chattgroup.com

©2009 Encore Medical, L.P., and Affiliates. 0409 114C