subjectindex 1962...
TRANSCRIPT
ABS -AID
(1)86828682868286828682
rates 8682
868286828682
867386968671871586718672
86718715
869687158715
868586858685
(3)
87068706
87158715
86968696867286718715867186718671
8715869686968671
8715
8715
86718671
8671
86718715
869687158671
867386728673
bronchomotor responses
dichloroi soproterenol
8675
8675
8675
8699
8699
8675(10)
1962SUBJECT INDEX
3955-1
ABSORPTION
absorption kinetics
body fluid exposure
diffusion layer pH
dissociation constants
drug solubility
experimentally observed
implant surface area
physicochemical properties
serum solubility
subcutaneous pellet
implantation
theoretically calculated
rates
ACETAZOLAMIDE (2)
chlorphthalidolone comparison 8720
electrolyte excretion 8720
8720intact animals
ACETYLCHOLINE
aortic chains
atropine
8671brain betaine estersbrain choline esters
chronic denervation
cocaine modification
concentration effect
contraction response
dose effect
dose-response curves
8715
epinephrine pretreatment
ether narcosis
frog rectus preparation
intra-arterial injection
8672isolated rabbit aorta
methachol me
muscarinic action
nicotinic action
nictitating membrane
norepinephrine modification
norepinephrine pretreatment
pentobarbital narcosis
phase responses
phenoxybenzamine modi fication
postganglionic action
potentials
postganglionic responses
potentiating action
preganglionic nerve
stimulationrat brain extracts
reserpine pretreatment
serotonin pretreatment
spinal cats
sympathetic ganglia
8673TM-lO pretreatment
tone effectstttotal1t acetylcholine
8682 activity
vasoconstrictor activity
8682 vasodilator activity
ACETYLSTROPHANTHIDIN (4)
frequency-force relationship
isolated heart muscle
post-stimulation potentiation
ADRENAL GLANDS (5)epinephrine concentration 8706
morphine-tolerant animals 8706
nalorphine pretreatment 8706
nalorphine-induced withdrawal 8706norepinephrine concentration 8706
1 -phenyl -2-hydrazinopropane
(11B 516)rectal temperature
ADRENALECTOMY (6)2,2’-bipyridine hyperglycemia 8711
blocking effect 8711
fasted rats 8711
ADRENERGIC RECEPTOR MECHANISM(7)bronchiolar smooth muscle 8692
86928692
pulmonary vasomotor responses 8692
sympathomimet ic
bronchodilators 8692
ADRENOCORTICAL STEROIDS (8)
al dosterone
cardiotonic action
isolated heart muscle
ALCOHOL INTOXICATION,
EXPERIMENTAL (9)
albino mice
chioro form- induced
liver damage
ALDOSTERONE
cardiotonic action
direct myocardial effect 8675
AID-BAR VOL. 135
isolated heart muscle 8675 AORTA, ISOLATED (21)
pH values 8675 acetyicholine constrictor
Gamma-ANINOBUTYRIC ACID (11) effect 8715
brain content 8707 acetylcholine dilator effect 8715
morphine tolerant animals 8707 rabbit aortic chains 8715
nalorphine-induced abstinence 8707 ARTERIES, PULMONARY (22)
AMPHETAMINE (12) anesthetized dogs 8687
motor activity response 8669 bretylium pretreatment 8687
tetrahydrocannabinols 8669 cardiac response 8687
d-AMPHETAMINE (13) dichloroi soproterenol
aggregated animals 8698 pretreatment 8687
albino mice 8698 DMPP response 8687drug antagonists 8698 epinephrine pretreatment 8687
excitatory effects 8698 heart rate 8687
isolated animals 8698 heart-lung preparation 8687
lethal effects 8698 left ventricular force 8687
strain difference 8698 partial occlusion 8687
variable responses 8698 right ventricular pressure 8687
ANALGESICS (14) sympathetic cardiac reflexes 8687
cellular adaptation 8678 systemic blood pressure 8687
morphinized rats 8678 systemic flow 8687
narcotic agents 8678 ATROPINE (23)
ANESTHETICS, GENERAL (15) ACh responses 8672
brain esters 8696 blocking action 8714
ether narcosis 8696 DFP-induced discharge 8672
pentobarbital narcosis 8696 ganglionic stimulants 8714
“total” acetylcholine postganglionic potentials 8672
activity 8696 sympathetic ganglia 8672
ANTACIDS (16) AUTONOMIC GANGLIA (24)
polymyxin B-induced anesthetized cat 8714
gastric hemorrhage 8702 blocking agents 8714
protective activity 8702 DMPP stimulant action 8714
ANTICHOLINERGIC AGENTS (17)
polymyxin B-induced
gastric hemorrhage
protective activity
ANTIDIURESIS (18)
benzothiadiazines
diabetes insipidus
ANTIHISTAMINES (19)
polymyxin B-induced
gastric hemorrhage
protective effect
ANTIHYPERTENSIVE AGENTS (20)
experimental atheromatosis 8718
hypertensive rats 8718 BARBITAL (26)
hypocholesterolemic activity 8718 acute toxicity 8694
mecamylamine 8718 blood levels 8694
normotensive rats 8718 diffusion rate 8694
reserpine 8718 distribution volume 8694
5-NT stimulant action 8714
inferior mesenteric ganglion 8714
8702 AUTONOMIC NERVOUS SYSTEM (25)
8702 acetylcholine effect 8691
blood pressure 8691
8720 heart phosphorylase a
8720 activity 8691
isolated heart 8691
parasympathetic stimulation 8691
8702 sympathetic ganglionic
8702 stimulation 8691
SUBJECT � INDEX
5-2
8694
8694
8694
8694
8694
8694
BAR-BLO
(34)
(28)
8720
8720
8720
8720
8720
8720
8720
8720
8720
cyclopenthiazide
diabetes insipidus
dose-response curves
hydrochlorothiazide
trichlormethiazide
BENZOYL-l-ARGININE ETHYL ESTER
(BABE) (29)
heparinized plasma hydrolysis 8701
human subjects 8701
(30)
(31)
( 32)
8711
86748674867486748674.86748674
8674
8703870187038701870187018703
867786868713
86868668
86898677871886778674
86898697
86978676
87138674866886868697
8716
8674
86698669
8718
8718
866886768674
8664
8664
8664
8714
8714
86678667
8665
8665
(33)
1962SUBJECT INDEX
5-3
environmental temperature
male rats
mortality rate
oil-water distribution
plasma protein binding
rectal temperature
BARBITURATES
albino rats
brain 5-NT content
BENZOTHIADIAZINES
action duration
antidiuretic potency
benzydroflumethiazi de
chlorothiazide
oxalated plasma hydrolysis
serum hydrolysis
BENZYLHYDRAZINE
MAO inhibitor activity
NQS effect
preincubation period
BENZYLOXYGRANINE
blocking action
ganglionic stimulants
BIOASSAY
brain 5-NT content
CNS depressants
heart
indoleacetic acid formation
monoamine oxidase activity
in vitro
sympathetic ganglia
tissue homogenates
tryptamine conversion
venus mercenaria heart
2 , 2 ‘ -BIPYRIDINE
blood glucose responses
chelating agent
dose-response relationships
fasted rats
fed rats
hyperglycemic activity
time-response relationships
toxicity
BLADDER
atropine
carbachol
contraction response
hexamethonium
(27) intravesical pressure
8667 pelvic nerve preparation
8667 tetraethylammonium
tremorine effect
BLOOD ‘ (35)
anesthetized rabbits
arginine esterase activity
CSF-blood transport
esterolytic activity
heparin effect
human subjects
lipid-insoluble substances
BLOOD PRESSURE (36)
acetylcholine
acetylcholine response
anesthetized cats
anesthetized chickens
8701 anesthetized dogs
8701 8676 8689 8697 8716
anesthetized rabbits
anesthetized rats
antihypertensive agents
atropine
atropine effect
8676
basilar artery ligation
carotid body chemoreceptors
carotid sinus baroreceptorscarotid sinus denervation
C6-C1-4 tissue concentration
C-O pressor reflex
C-O pressor response
8665 compound 48/80
8665 cyclopropane effects
8665 cyclopropane responses
8665 depressor activity
8667 dichloroisoproterenol
pretreatment
8711 epinephrine pressor response
8711 8677
8711 experimental atheromatosis
8711 experimental hypertension
8711 guanethidine effect
8711 hexamethonium blockade
8711 hexamethonium effect
VOL. 135
866987138686868986898677
8689
8704870586968678
8678
8704
869686678700
8693
8704
8705866686968705
8713870587058667
86668700870087008706
866886868676
87168676868986768686871886898669868686748686
86688674
( 38)
(39)
870686668696870686668704
86668706
8704
8696
8704
SUBJECT INDEX
S-4
BLO-BRA
hexamethonium pretreatment
hexamethonium-C 14
histamine response
hydroquinone responses
intracarotid injection
intravenous injections
intravertebral injection
isoproterenol depressor
response
lobeline
male rats
midbrain section
nicotine
nicotine-like actions
norepinephrine pressor
response
8677norepinephrine response
parabromdylamine effect
phenoxybenzamine pretreatment
8677pressor effects
pressor responses
resorcinol responses
ret ama
serotonin response
serum cholesterol levels
spinal cord transection
spinal section
tissue histamine depletion
tremorine
tryptamine response
tyramine response
vagotomy
8676vagus nerve stimulation
BLOOD SUGAR (37)
2,2’-bipyridine hyperglycemia 8711
fasted rats 8711
BODY TEMPERATUREmorphine-tolerant dogs
nalorphine administration
BRAIN
albino mice
albino rats
gamma-aminobutyric acid
content
amygdala
anesthetized cats
anesthetized dogs
area postrema
ataxia
behavioral effects
betaine ester concentration
cellular adaptation
cerebral cortical slices
8700chloral hydrate concentration
choline ester concentration
8669 CNS depressants
8677 cross-cellular adaptation
8718 H3-DCI localization
8669 depression stages
8677 electrical activity
8676 epinephrine uptake
ether narcosis
8669 evoked seizure activity
hexamethonium-C 14
concentrat ion
hippocampus
gamma-hydroxybutyrate5-hydroxytryptamine content
8707intercolumnar tubercle
KC1-stimulated slicesmeperidine
methadone
morphine tolerant animals
8707morphinized rats 8678
8700
nalorphine reversal 8678
nalorphine-induced abstinence 8706
8707norepinephrine concentration 8706
oxygen consumption 8700
8674 pentobarbital narcosis 8696
pharmacological responses 8713
1 -phenyl -2-hydrazinopropane
(JB-5l6)pineal body
8706 rat brain extracts
8706 rectal temperature
reserpine effect
8704 righting reflex
8667 special areas
species differences
8707 tissue homogenates
8705 “total” acetylcholine
8666 activity
8693 trichloroethanol
8666 concentration
BRE -CEN
8683
8683
8683
8683
8683
8683
8683
8697
86978697
8697
869786978697
87068716
870687178716
8717870887178717
87088706
8708
8690
8690
871787168717
8708
8678
870087008700870086788700870086788700
871187058667866786678666
866787058667
8685
86858685
8685
8716
8691
869187168691
8691
8691
8689
8689
8689
8697
8697
8697
869786978697
8697
(46)
1962SUBJECT INDEX
5-5
BRETYLIUN TOSYLATE (40)
action mechanism 8687
DMPP responses 8687
heart-lung preparation 8687
pulmonary arterial occlusion 8687
BROM-LYSERGIC ACID DIETHYLAMIDEblocking action (41) 8714
ganglionic stimulants 8714
BUTYNAMINE (42)
butynamine-Cl4 administration
N-demethylation � vitro
des-N-methyl butynamine
formation
enzyme activity
human subjects
metabolism in vivo
radioactive metabolites
CARBONIC ANHYDRASE INHIBITION
brain 5-HT content (43) 8667
methazolamide 8667
CARDIOACTIVE GLYCOSIDES (44)
concentration effect
frequency-force relationship
positive inotropic effect
post-stimulation potentiation
CARDIOVASCULAR SYSTEM (45)anesthetized dogs
autonomic nervous system
blood pressure
cyclopropane responses
heart contractile force
heart phosphorylase a
activity
isolated heart
resorcinol isomers
spinal cord action site
sympathetic stimulation
CAROTID BODY
anesthetized dogs
chemoreceptor sensitivity
cyclopropane inhalation
CAROTID SINUS (47)
acute hemorrhage
anesthetized dogs
arterial blood pressure
baroreceptor sensitivity
constant pressure distensions 8697
cyclopropane. inhalation 8697
electrocardiogram 8697
intraluminal pressure
nerve action potentials
peak frequency discharge
pressure-frequency discharge
curves
pulsatile stimulation
receptor pressure threshold
vagosympathetic nerve block
CATECHOLAMINES (48)adrenal gland content
anesthesia levels
brain content
chronotropic effects
cyclopropane inhalation
endogenous release
heart content
heart’ muscle
inotropic effects
intestine content
morphine tolerance
morphine-tolerant animals
nictitating membrane content
norepinephrine sensitization
N-oxide analogs
plasma concentration
pyridine derivatives
spleen content
CELLS, CEREBRAL CORTEX (49)
cerebral cortical slices
8700
cross-cellular adaptation
KC1-stimulated slices
meperidine
methadone
morphine adaptation
morphinized rats
nalorphine effect
nalorphine reversing effect
oxygen consumption
CENTRAL NERVOUS SYSTEM (50)adrenal medullary hormones
albino mice
albino rats
analgesics
anesthetics
anesthetized cats
anticonvul sant s
behavioral studies
bioassay
2 , 2 ‘ -bipyridine-induced
hyperglycemia 8711
blood-brain barrier
brain
brain 5-HT levels
carbonic anhydrase inhibitors
VOL. 135
chioro form-ethanol
pretreatment
hepatotoxic susceptibility
liver content
liver damage
liver lipids
�-CHLOROMERCURIBENZOATE
acid-base balance
chlorothiazide activity
electrolyte excretion
inhibitor activity
meralluride comparison
mercurial diuresis
renal blood flow
renal hemodynamic changes
renal perfusion pressure
pentobarbital sleeping time
reflex activity
reflexes
reserpine pretreatment
sedatives
spontaneous motor activity
saline diuresis
urine flow
water excretion
2-CHLOROMERCURIPNENYLinhibitor activity
mercurial diuresis
CHLOROTHIAZIDE
antidiuretic effect
diabetes insipidus
probenecid influence
CHLORPHENIRAMINE
polymyxin B-induced
8703 gastric hemorrhage
8703 protective effect
8703 C}LLORPHTHALIDOLONE
8703 action duration
8703 antidiuretic potency
8703 diabetes insipidus
8703 electrolyte excretion
8703 CHLORPROMAZINE
polymyxin B-induced
CSF-blood transport
intracisternal injection
intraventricular injection
lipid-insoluble substances
radioactivity measurements
( 52)
( 53)
( 58)
( 59)
(60)
(61)
(62)
8711 gastric hemorrhage
8711 protective effect
8711 CHOLESTEROL
antihypertensive agents
8704
8667
8704
8704
8704
trichloroethanol comparison 8704
CHLOROFORM (54)
acute ethanol intoxication
chloroform pretreatment
hypertensive rats
serum levels
CHOLINESTERASES
bovine erythrocytes
intestinal mucosa
8699 neostigmine comparison 8674
8699 tremorine inhibitor activity 8674
CEN-CHOSUBJECT INDEX
S -6
catatonia
catecholamine content
cerebellum
depressant drugs
depressant effects
EEG
epinephrine infusion
epinephrine uptake
guanethidine inhibitor
8666
8666
8667
8667
8669
8666
86668667
8705
8705
8666
8666
effect 8668
8705
8705
8667
8666
8667
8705
8705
8669
86668667
8705
8669
8666
8668
hexobarbital sleeping time
gamma-hydroxybutyrate
hypnotics
hypothalamus
MAO inhibitors
tetrahydrocannabinol s
tissue concentration
vasomotor activity
CEREBROSPINAL FLUID
anesthetized rabbits
C14-labeled saccharides
urinary excretion
CHELATING AGENTS
2 , 2 ‘ -bipyridine
fasted rats
hyperglycemic response
CHLORAL HYDRATE
albino mice
brain 5-HT content
brain tissue concentration
hypnotic activity
metabolism
( 51)
atherogenic diet
fec#{225}l excretion
86998699
8699
8699
8699
(�-CMB)
(55)8680
8680
8681
8680
8681
8680
8681
8681
868186808681
8681
SULFONATE(56)8680
8680( 57)
8720
8720
8720
8702
8702
8720
8720
8720
8720
87028702
8718
87188718
87188718
8674
8674
(64)
8685
8685
post-stimulation potentiation 8685
rate-dependent mechanism 8685
CORONARY BLOOD FLOW (65)
isolated perfused rat heart 8677
posterior pituitary hormone 8677
COTININE (66)
chloroform- soluble
87208720
872087208720
8714
8714
8702
8702
8692
8692
(72)
(73)
( 74)
(67)
(68)
(69)
8683
8683
8683
86728672
86698669
86878714
8687
(79)
1962SUBJECT INDEX
COC-DIN
5-7
COCAINEacetylcholine response
blocking action
contraction response
ganglion stimulants
intravenous administration
nictitating membrane
reserpine pretreatment
CONTRACTION , HEARTisolated heart muscle
ouabain effect
metabolite s
human subject
metabol sm
oral administration
urinary excretion
CYCLOPROPANEaction mechanism
anesthesia levels
anesthetized dogs
8716
carotid body chemoreceptors
carotid sinus baroreceptors
circulatory responses
corneal reflex
lid reflex
sympathoadrenal responses
CYPROHEPTADINE
polymyxin B-induced
gastric hemorrhage
protective effect
N-DEMETHYLATIONbutynamine
rat liver microsomes
substrate concentration
DEXTRAN
CSF-blood transport
nephrectomized animals
DIABETES INS IPIDUS,
EXPERIMENTALac e tazol ami de
antidiuretic effect
(63) benzothiadiazines
8671 hydrochlorothiazide
8714 hypothalamic electrolytic
8671 lesions
8714 male rats8671 water intake
8671 DIBENZYLINE
8671 blocking action
ganglionic stimulants
polymyxin B-induced
gastric hemorrhage
protective effect
DICHLOROISOPROTERENOL
reversing action
sympathomimetic
bronchodi lators
� -DICHLOROISOPROTERENOLalbino mice 8693
8709 anesthetized dogs 8693
8709 lipoid solubility 8693
8709 metabolism 8693
8709 physiological disposition 8693
8709 plasma concentration 8693
tissue binding 8693
8697 tissue distribution 8693
8716 DIGITALIS GLYCOSIDES (75)
8697 frequency-force relationship 8685
isolated heart muscle 8685
8697 post-stimulation potentiation 8685
8697 DIHYDROERGOTAMINE (76)
8716 adrenergic blockade 8711
8716 2 , 2’ -bipyridine hyperglycemia 8711
8716 fasted rats 8711
8716 DIISOPROPYL FLUOROPHOSPHATE (77)
acetylcholine effect 8672
ganglionic blocking agents 8672
8702 intra-arterial injections 8672
8702 postganglionic action
potentials 8672
postganglionic discharge 8672
repetitive preganglionic
S timulat ion
sympathetic ganglia
DIMETHYL-HEPTYL-PYRAN (DMHP) (78)
(70) chemical structure
8703 pharmacological effects
8703 1 , l-DIMETHYL-4-PHENYL-PIPERAZINIUN (DMPP)
(71) action site
8720 anesthetized cat
8720 atropine pretreatment
neutral compounds
organic weak acids
organic weak bases
physicochemical properties
DIM-ENZ
biphasic response
bretylium pretreatment
ganglionic blocking agents
ganglionic stimulation
8714
heart rate
heart-lung preparation
inferior mesenteric ganglion
left ventricular force.
right ventricular pressure
systemic blood flow
systemic blood pressure
DIPHENYLHYDANTQIN (80)brain 5-NT content
1 ,4-DIPYRROLIDINO-2-BUTYNE
(TRE1&�RINE) (81)action sites
autonomic effects
DIURESIS, MERCURIAL (82)ammonium chloride
pretreatment
anesthetized dogs
chloride excretion
chlormerodrin response
�-chl oromercuriphenyl
sulfonate
�-CMB inhibitor activity
dibenaminedimercaprol reversal
dose-response relationship
glomerular filtration
mercaptomerin response
mersalyl response
nondiuretic mercurial effects
oxophenar sine
SY-28urine flow
DIURESIS, WATER (83)
human subjects
8667
ELECTROCARDIOGRAManesthesia levels
867.4 anesthetized rats
8674 cyclopropane inhalation
posterior pituitary
ELECTROENCEPHALOGRAM
arousal response
ascending reticular system
cortical areas
evoked seizures
ganima-hydroxybutyrate
spindling
thalamo-cortical recruitment
ELECTROLYTES (88)
acetazolamide
chlorphthal idolone
hydrochlorothiazide
urinary excretion
ENZYMES (89)albino mice
autonomic nervous system
8677
lobeline inhibitor activity 8677
urine volume 8677
DIURETICS , MERCURIAL (84)
electrolyte excretion
blood arginine esterase
activity
butynamine N-demethylation
chl oroforni- induced
heart phosphorylase a
activity
heparin effect
human subjects
isolated heart
liver fluke homogenates
liver succinic dehydrogenase
SUBJECT INDEX
activity
perfused kidney
water excretion
DRUGS, ADMINISTRATIONabsorption rate
barbiturates
cholesterol
codeine
medrol
(85)
8687
86878714
8687
8687
86878714
86878687
86878687
8680868086808680
86808680
86808680868086808680
86808680
868086808680
86818681
8681
868286828682868286S2
morphine
subcutaneous pellet
implantation
sulfonamides
tetracycline
theobromin#{235}
theophylline
tolbutamide
urea
liver damage
demethylase activity
ethanol pretreatment
glycolytic systems
VOL. 135
(86)
86828682868286828682
8682
868286828682868286828682
871686778716
hormone 8677
(87)8705870587058705870587058705
8720872087208720
86998691
87018683
869986838&99
8679
86918701870186918679
8699
(90)
ENZ-GAN
8665 “total” acetylcholine
8679 activity 8696
8683 ETHER, DIETHYL (95)
8665 brain 5-NT content 8667
8679 inhalation anesthesia 8667
8665 ETHYL MERCURY CHLORIDE (96)
mercurial diuresis 8680
8670 nondiur#{233}tic mercurial 8680
86 70 N-ETHYL-NORTROPINE -BENZHYDRYL-
8670 ETHER (97)
8670 antiarrhythmia action 8684
isolated cat heart 8684
8715 isolated heart muscle 8684
pentylenetetrazol 8684
(91)
8692
8692
8670
8670
8715
8670
8692
8702
8702
8692
8670
8692
(98)
(99)
(92) 8714
8666
866&
8666
benzyloxygramine
brom-lysergic acid
diethylamide
8666
8666
8666
8666
8679
8679
8679
8672
86738714
8673
8714
8714
86738714
8672
8714
86738714
86738672
8673
87138714
8714
8672
8714
8714
8713
8672
8699
8699
8699
(93)
(94)
1962
SUBJECT INDEX
5-9
MAO activity
phosphofructokinase activity
rat liver microsomes
sensitivity assay
serotonin effect
tissue homogenates
EPHEDRINE
action mechanism
inhibitor activity
isolated rabbit ileum
reserpine pretreatment
EPINEPHRINE
acetylcholine response
bronchomotor responses
DCI pretreatment
dose-response curves
inhibitor activity
isolated aorta
isolated rabbit ileum
perfusion pressure
polymyxin B-induced
gastric hemorrhage
protective effect
pulmonary arterial pressure
reserpine pretreatment
ventilation overflow
H3-EPINEPHRINE
blood-brain barrier
CNS uptake
intravenous infusion
isolated brain tissue
labeled amine incubation
in vitro
pituitary slices
reserpine pretreatment
tissue slices
ETHANOL
acute intoxication
albino mice
blood content
chloroform-induced
liver damage
hepatotoxic susceptibility
liver content
liver lipids
oral administration
physiological response
ETHERanesthetized rats
brain esters
FASCIOLA HEPATICA
glycolysi sliver fluke homogenates
serotonin effect
GANGLIONIC BLOCKING AGENTS
acetylcholine responses
gamma-aminobutyric acid
anesthetized cat
atropine
8666 cell group responses
cocaine
DFP-induced postganglionic
discharge
dibenzyline
differential blockade
DMPP-induced stimulation
epinephrine
ganglionic transmission
hexame t honi um
8714
8699 hexamethonium-Cl4
8699 5-HT-induced stimulation
8699 inferior mesenteric ganglion
8699 intra-arterial injections
8699 lysergic acid diethylamide
8699 morphine
pharmacological activity
8696 postganglionic action
8696 potentials
VOL. 135
(105)
(100)
8672
8672
8672
86738673
8713
8673
8673
8714
8714
8673
8687
8687
8714
8714
8673
8673
8673
di gitoxin
N,N-dimethylformamide muscle
extracts
drug effects
epinephrine
epinephrine /norepinephrine
ratio
(102)
morphine-induced convulsions
8712
8689
8717
8665
8689
8712
8717
8708
8717
8689
8712
8712
8712
8712
8708
8717
8717
8689
86658712
8708
8708
87128712
8689
8712
87178717
8712
8712
8717
8712
8689
8717
8689
8665
8712
8684
8684
8684
8684
8684
86688668
8668
8668
8688
8688
8668
8668
8688
8688
8668
8688
8688
8668
8668
(106)
SUBJECT INDEX
S -10
GAN-HEA
preganglionic nerve
stimulation
presynaptic nerve terminals
sympathetic ganglia
8673
synaptic depressants
tetraethylammonium
tissue distribution
.�- tubocurarine
GANGLIONIC STIMULANTSacetyicholine effect
anesthetized cat
blocking agents
cell group responses
DNPP activity
8714
heart - lung preparation
5-hydroxytryptamine activity
inferior mesenteric ganglion
nicotine
sympathetic ganglia
tetramethylammonium
GASTRIC HEMORRHAGE
gastric ulcer formationhemostasi s
mortality
polymyxin B induced
protective agents
GLYCOLYSISliver fluke homogenates
serotonin-treated flukes
GUANETHIDINE
anesthetized dogs
blood pressure
blood-brain barrier
bradycardia
cardiac norepinephrine
content
cardioaccelerator effect
central administration
central inhibition
heart rate
intact rat heart
intravenous admini stration
isolated mammalian heart
reserpine comparison
vasodepressor effect
vasomotor activity
HARMALINE
brain 5-HT content
HEART“aging” effect
anesthetized intact dogs
atropine pretreatment
bioassay
blood pressure
cardiac glycosides
cardiac output
catecholamine content
8717
competence index
contractile force
8712
heart-lung preparation
inotropic effects
(101) intravertebral injection
8702 MAO activity8702 methacholine
8702
8702
8702
morphine-tolerant animals
nerve stimulation
nucleic acid fragments
8679 open-chest dogs
8679 8712
(103) ouabain
N-oxide analogs
pentobarbital failure
perfusion experiments
potassium
pyridine derivatives
rate effect
8717
resorcinol responses
right atrial pressure
spinal cord transection
tissue homogenates
veratri dine
HEART ARRHYTHMIA
A-V block
parasympathetic blockade
pentylenetetrazol
premature ventricular
(104) contractions
8667 sinus bradycardia
(107)
(108)
86848684
8684
8717
8717
8717
8717
8717
87178717
8717
8717
8717
8717
8691
8691
86918675
8688
8691
8691
8691
8684
8691
8675
8688
8675
8675
8684
8691
8691
8688
8684
8688
8688
8688
8674
8684
8691
8688
8691
86748688
86888688
8691
86 75.
1962
SUBJECT INDEX
S-ll
sinus tachycardiaventricular fibrillation
ventricular tachycardia
HEART AURICLES
atropine pretreatment
chronotropic effects
DCI pretreatment
epinephrine
inotropic effects
isolated cat auricles
nicotine pretreatment
N-oxide analogs
pyridine derivatives
reserpine pretreatment
SKF-6890A pretreatment
HEART, ISOLATED
acetylcholine
acute hemorrhage
adrenalectomyaldosterone
arterial pressure
atropine
autonomic nervous system
bretyl ium
cardiac arrhythmias
carotid blood pressure
cat hearts
competence tests
contraction amplitude
coronary flow
coronary perfusion
dichloroi soproterenol
DMPP
dose-response curves
N-ethyl -nortropine-
benzhydryl -ether
guanethi dine
heart rate
8691
heart-lung preparation
inotropic effects
isolated cat heart
isometric systolic tension
left atrial pressure
McNeil -A-343
negative chronotropic effect
norepinephrine
norepinephrine content
norepinephrine response
open-chest rat preparation
pentobarbital-induced failure
HEA-HEA
pentylenetetrazol effect 8684
perfused rabbit heart 8676
perfused rat heart 8677
phosphorylase a activity 8691
physostigmine 8691
posterior pituitary hormone 8677
pulmonary arterial pressure 8688
rabbit heart 8674
reserpine pretreatment 8688
retama 8676
right atrial pressure 8688
S-A pacemaker sensitivity 8688
systemic output 8688
tremorine 8674
vagal stimulation 8691
veratramine 8688
work capacity 8688
HEART MUSCLE, ISOLATED (109)
aldosterone 8675
cardiac arrhythmias 8684
cardioactive glycosides 8685
cat atrium 8685
cat papillary muscles 8675
8684
contraction amplitude 8684
contraction force 8675
dose-response curves 8684
electrograms 8684
frequency-force relationship 8685
guinea-pig ventricle 8685
heart rate 8684
inotropic effects 8675
isolated cat auricles 8684
isolated cat heart 8684
myograms 8684
ouabain 8675
parasympathetic blocking
agents 8684
pentylenetetrazol 8684
pH values 8675
post-stimulation potentiation 8685
rabbit atrium 8685
rabbit ventricle 8685
SC-8lO9 8675
tetrahydrocortisol 8675
Tyrode-solution incubation 8685
ventricular threshold 8684
HEART RATE (110)
atropine effect 8674
bradycardia 8674
C6-C14 tissue concentration 8713
8716
8688
8688
8674
8713
8688
8688
8688
8716
8674
8674
8674
VOL. 135
8669
8705
8669
8669
8686
8686
8686
8702
8686
8686
8702
8686
8686
8686
8702
8686
8702
(116)
(117)(112)
(113)
8 701
8 701
8672
8714
(118)
8686
8720
8720
8720
8720probenecid influence
8672 Gamma-HYDROXYBUTYRATE, SODIUM
albino mice (119)8705
behavioral studies 8705
8713 blood pressure 8705
8713 CNS depressant 8705
8713 EEG 8705
8713 heart rate 8705
8713 lethal toxicity 8705
8713 pentobarbital comparison 8705
8713 5-HYDROXYTRYPTAMINE (120)
871387138713
87138713
87138713
86678714
86678667
866786678714
8714
SUBJECT INDEX
S-12
HEA-HYD
cyclopropane effects
dose-response curves
guanethidine
hexamethonium effect
hexamethonium-C 14
isolated dog heart
norepinephrine response
reserpine
tachycardia
tetraethylanznonium
tremorine
vagus nerve stimulation
8713
HEMOSTASISalbino rats
polymyxin B-induced
gastric hemorrhage
HEPARIN
blood arginine esterase
activity
human subjects
}LEXAMETHONIUN
ACh responses
blocking action
DFP-induced postgangl ionic
discharge
differential ganglionic
blockade
ganglionic stimulants
preganglionic nerve
stimulation
8673sympathetic ganglia
8673HEXANETHONIUM-N-METHYL-C]-4 (114)
anesthetized cats
autoradiograms
blood pressure
distribution volume
ganglion blockade
ganglion concentrations
intravenous administration
nephrec tomy
nictitating membrane
pharmacological activity
plasma concentration
pupillary light response
renal clearance
tissue distribution
tissue/plasma ratios
urinary excretion
HEXOBARBITAL HYPNOSIS (115)
DMHP effect
gamma-hydroxybutyrate
MOP effect
sleeping time
8705
HISTAMINEanesthetized chickens
bioas says
compound 48/80 injection
hemorrhagic lesions
histamine injection
oxytocin injection
(111) rat stomach
8702 serotonin injection
tryptamine injection
8702 urinary excretion
HISTAMINE LIBERATIONalbino rats
anesthetized chickens
gastric ulcer formation
polymyxin B-induced
gastric hemorrhage 8702
serotonin- induced
vasodepression 8686
8672 tryptamine-induced
vasodepres sion
8673 HYDROCHLOROTHIAZIDE8714 acetazolamide combination
antidiuretic effect
8672 diabetes insipidus
8713 albIno rats
8713 anesthetized cat
bioassay
brain content
8707CNS depressants
fluorimetric assay
ganglionic blocking agents
ganglionic receptors
ganglionic stimulant action 8714
inferior mesenteric ganglion 8714
8711
8711
8711
8711
( 1 25)
(126)
(127)
( 1 28)
87118711
8711
8718
8718
8718
8718
8718
8718
8718
(129)
HYD-ISO
8669
8669
8676
8670867686768670
8670
8676
86708676
8708
8708
87038703870387038703
8719
87198719
8719
8719
8719
866486648664
866486648664866486648664
86648664
8692
869286708670869286928670
(130)
8704
8704
8704
8704
8704
8704
8675
8717
8717
8717
8717
8675
8675
8717
8675
8717
8675
(132)
(133)
1962SUBJECT INDEX
5-13
intraperitoneal
administration 8667
morphine tolerant animals 8707
nalorphine-induced abstinence 8707
HYPERGLYCEMIA (121)
adrenalectomy
adrenergic blockade
2 , 2 ‘ -bipyridine induced
blood glucose
dihydroergotamine
pretreatment
edathamil calcium disodium
pretreatment
fasted rats
ferrous iron pretreatment
pentobarbital -morphine
pretreatment
spinal transection
zinc pretreatment
HYPERTENSION, EXPERIMENTAL (122)atherogenic diet
body weight
male rats
mecamylamine effect
reserpine effect
serum cholesterol level
systolic pressure
HYPNOTICS (123)action duration
albino mice
chloral hydrate
depression stages
intraperitoneal injection
intravenous injection
neurological state
trichloroethanol
INOTROPISM (124)
aldosterone
cat papillary muscle
catecholamine release
heart-lung preparation
isolated cat auricles
isolated heart muscle
ouabain
N-oxide analogs
pH values
pyridine derivatives
SC-8l09
INTESTINAL MOTILITY
cat small intestine
tetrahydrocannabinol s
INTESTINE, ISOLATEDatropine effect
dose-response curves
motility
muscle strips
rabbit ileum strips
reserpine pretreatment
retama
sympathomimetic amines
8711 tone changes
INTESTINE, SMALL
8711 catecholamine content
8711 morphine-tolerant animals
8711 INULIN-H3
anesthetized rabbits
CSF-blood transport
intracisternal injection
intraventricular injection
urinary excretion
IODOACETATEcontraction rate
prolonged stimulation
ryanodine pretreatment
skeletal muscle relaxation
stimulation frequency
twitch contraction height
IPRONIAZID
8704 MAO inhibitor activity
8704 NQS effect
preincubation period
ISOCARBOXAZID (131)
alkylhydrazid analdgs
BZH formation
concentration effect
MAO inhibitor activity
NQS influence
preincubation period
ISOPROPYLHYDRAZINE
MAO inhibitor activity
preincubation period
ISOPROTERENOL
bronchomotor responses
DCI pretreatmentinhibitor activity
isolated rabbit ileum
perfusion pressure
pulmonary arterial pressure
reserpine pretreatment
ISO-MER
ventilation overflow
KIDNEY (134)
creatinine clearance
electrolyte excretion
meral luride
mercurial diuretics
nondiuretic mercurials
perfusion pressure
renal blood flow
urine flow
water excretion
LIPID-SOLUBILITY (135)
anesthetized rabbits
CSF-blood transport
lipid-insoluble substances
LIVER DAMAGE (136)
acute ethanol intoxication
albino mice
chloroform induced
function tests
histopathologic examination 8699
LIVER FLUKE (137)
adenosine-3 ‘ , 5 ‘ -phosphate
formation
VOL. 135
8692 LYSERGIC ACID DIETHYLAMIDE (140)
blocking action 8714
ganglionic stimulants 8714
8681
8681 MANNITOL (141)
8681 CSF-blood transport 8703
8681 intrav#{233}ntricular injection 8703
8681 urinary excretion 8703
8681 MECAMYLAMINE (142)8681 ACh responses 8672
8681 DFP-induced postganglionic
8681 discharge 8672
experimental atheromatosis 8718
hypertensive rats 8718
8703 hypocholesterolemic effect 8718
8703 hypotensive activity 8718
8703 normotensive rats 8718
oral administration 8718
8699 postganglionic action
8699 potentials 8672
8699 sympathetic ganglia 8672
8699 MEPERIDINE (143)
brain 5-HT content 8667
cerebral cortical slices 8700
cross-cellular adaptation 8700
8679 morphinized rats 8700
8679 MEPROBAMATE TOLERANCE (144)
8679 development mechanism 8695
8679 male albino rats 8695
8679 MEPROBAMATE-C14 (145)
8679 blood levels 8695
8679 brain levels 8695
8679 daily administration 8695
8679 excretion rate 8695
8679 fat levels 8695
8679 fecal excretion 8695
8679 intraperitoneal injection 8695
8679 male albino rats 8695
8679 meprobamate-pretreated
animals 8695
8699 metabolic inactivation 8695
8699 muscle levels 8695
8699 nontolerant animals 8695
8699 tolerance development 8695
urinary excretion 8695
8699 urinary metabolite excretion 8695
whole body activity 8695
8677 MERCURIAL COMPOUNDS (146)
8677 renal circulation 8681
8677 renal perfusion pressure 8681
aerobic glycolysis
anaerobic glycolysis
enzyme activity
fasciola hepatica
glucose utilization
glycolytic enzyme systems
hexosephosphate concentration
homogenate preparations
intact parasites
lactic acid production
phosphofructokinase activity
serotonin effect
substrate effect
LIVER FUNCTION (138)
albino mice
BSP retention
chloroform pretreatment
ethanol pretreatment
succinic dehydrogenase
activity in vitro
LOBELINE (139)anesthetized rats
antidiuretic activity
vasopressin release
SUBJECT INDEX
S-l4
urinary sodium concentration 8681
urine flow 8681
8681
(147)
(155)
86818680
8680
8681
8681
MER-MOR
______ 8665
8664
8664
8664
8664
heart 8665
iproniazid inhibition 8664
ISH inhibition 8664
isocarboxazid inhibition 8664
rat liver mitochondria 8664
sympathetic ganglia 8665
tissue homogenates 8665
MONOAMINE OXIDASE INHIBITORS
brain 5-HT content (156)8667
8706
8667
(149)
8704
8704
8693
8709
8709
8693 morphine-tolerant animals
morphine-tolerant rats
non-hydrazine derivatives
NQS effect8693
8704
8709
8709
8693
8664
8664
8708
8706
8664
8664
8706
rat liver mitochondria 8664
tissue catecholamines 8708
MORPHINE (157)
adrenal catecholamine content 8706
8709
8693
8704
8693
8698
8698
8698
8698
(152)
(153)
(154)
8667
8714
8706
8707
8706
8667
8708
8678
8678
8706
8700
8700
8706
8706
8714
8667 chronic administration
8667 8707 8708
cross-cellular adaptation
8680 depression adapted rats
8680 excitatory abstinence
8669 experimental animals
8669 ganglionic stimulants
1962
SUBJECT INDEX
S -15
vasoconstrictor activity
MERCURIALS , NONDIURETIC
electrolyte excretion
inhibitor activity
mercurial diuresis
perfused kidney
water excretion
IIERSALYL (148)
#{163}-CMBreversal 8680diuretic response 8680
mercuric chloride: glutathione 8680
8680methyl mercury chloride
METABOLISM, DRUGalbino mice
chloral hydrate
conjugate formation
cotinine
desmethylcotinine excretion
ll� -dichloroi soproterenol
3 ,4-dichloromandelic acid
format ion
enzymatic reduction
human subjects
hydroxycotinine
oxidative deamination
gamma-(3-pyridyl) -beta-N-oxo-
methylbutyramide
tissue distribution
trichloroethanol formation
urinary metabolites
8709
METAGLYCODOL (150)amphetamine mortality
antagonist activity
hexobarbital sleeping time
mouse strains
METHADONE (151)
cerebral cortical slices 8700
cross-cellular adaptation 8700
morphinized rats
METHAZOLAMIDEbrain 5-HT content
carbonic acid inhibitor
METHYL MERCURIC CHLORIDEmercurial diuresis
nondiuretic . mercurial
METHYL-OCTYL-PYRAN (MOP)
chemical structure
pharmacological effects
MONOAMINE OXIDASE
activity assay in vitro
aerobic preincubation
anaerobic preincubation
BAR-induced inhibition
�-dimethylaminobenzyl
hydrazine inhibition
brain norepinephrine content
harmal me
hydrazine derivatives
i socarboxazid
1 -phenyl -2-hydrazinopropane
(JB 516)
8708
albino rats
8678
blocking action
body temperaturebrain gamma-aminobutyric acid
brain catecholamine content
brain 5-HT content
8707
cardiac catecholamines
cellular adaptation
8700 cerebral cortical slices
8700
syndrome
MOR-NAL
8708
8708
8700
8700
8708
8706
8678
8707
8706
8706
8707
8708
87088706
VOL. 135
8692
8692
8686
8686
8686
8692
8686
8686
8686
8715
8671
8671
8698
8698
8698
8698
8698
8698
8698
8698
8698
8698
8698
8715
8692
8692
8692
8686
8686
8692
8692
8692
8686
8686
8685
8685
8685
(159)
8719
8719
8719
8719
8719
8719
8719
8719
8719
8719
8719
87198719
8678
8678
8700
8700
8678
8678
8700
86788700
8678
SUBJECT INDEX
5-16
intestine catecholamines
JB-5l6 effect
meperi dine
methadone
morphine-induced convulsions
nalorphine effect
8708
nalorphine reversal
nalorphine-induced abstinence
pentobarbital anesthesia
sedation
single doses
8708
splenic catecholamines
tissue norepinephrine
tolerance effects
8707 8708
withdrawal response
MOUSE STRAINS (158)
aggregated animals
amphetamine mortality
anticonvulsant effects
drug antagonists
drug susceptibility
hexobarbital sleeping time
isolated animals
mixed strains
mortality determinations
strain difference
variable responses
MUSCLE, SKELETAL
acid-extract analysis
ATP levels
contraction rate
creatine phosphate levels
frog sartorius
L-alpha-GP levels
IAA rigor
iodoacetate effect
prolonged stimulation
relaxation mechanism
relaxation rate
ryanodine effect
ryanodine rigor
ryanodine-IAA effect
stimulation frequency
twitch contraction height
MUSCLE, SMOOTH (160)acetylcholine response
8715
atropine pretreatment
bronchioles
bronchomotor responses
chicken urine-samples
compound 48/80 treated
chickens
contraction response
dichloroi soproterenol
guinea-pig ileum
histamine treated chickens
intestinal strips
isolated rabbit aorta
“muscarinic” receptors
nictitating membrane
8690
norepinephrine content 8690
pressor substance
pretreatment
8678 pulmonary vasomotor responses
alpha-receptors
beta-receptors
serotonin desensitization
serotonin treated chickens
sympathetic nerve stimulation
sympathomimetic
bronchodilators
tolazoline pretreatment
tripelennamine blocking
action
tryptamine treated chickens
MYOCARDIAL CONTRACTILITY (161)intact rabbit heart
8719 isolated heart muscle
8719 ouabain effect
8719 pentobarbital-induced
depression 8685
post-stimulation potentiation 8685
rate-dependent mechanism 8685
NALORPHINE (162)antagonist :agonist ratio
cerebral cortical cells
cerebral cortical slices
cross-cellular adaptation
KC1-stimulated cortical
slices
morphine adaptation
morphinized rats
nalorphine-morphine
8671 combination
narcotics
8692 reversing action
NAP -OXY
(167)
8664 binding sitesbronchomotor responses
DCI pretreatment
dose-response curves
8678 8671
8678 inhibitor activity
isolated aorta
isolated rabbit ileum
membrane catecholamine
(165)
8700
8678
8700
8678
8677
8677
8677
8690
8713
8690
(168)
(169)
8671
8715
86908692
8692
8670
8670
8715
8670
8690
8671
8690
8671
8690
8670
8712
8712
8712
8712
8712
8712
8712
8712
8712
8712
8685
8675
8675
8675
8685
8685
8685
8678
8678
8700
8678
8700
8700
8678
8671
8690
8713
86718671
8690
8671
8690
8690
OUABAIN
frequency-force relationship
inotropic action
isolated heart muscle
8685
8671 pH values
post-stimulation potentiation
“therapeutic” effect
8713 “toxic” effect
8671 OXYGEN CONSUMPTION (170)
albino rats
8671 cerebral cortical slices
8674 8700
cross-cellular adaptation
8671 KC1-stimulatory response
8669 meperidine
8674 methadone
8669 morphine-induced cellular
8674 adaptation
1962SUBJECT INDEX
S -17
1 , 2-NAPHTHOQUINONE-4-SULFONATE
SODIUM (NQS) (163)
BZH-induced MAO inhibition
in vitro
isocarboxazid-induced MAO
inhibition in vitro 8664
NARCOTICS (164)
cellular adaptation
cerebral cortical slices
8700
cross-cellular adaptation
in vitro
morphine tolerance
morphinized rats
nalorphine reversal
NICOTINE
anesthetized rats
antidiuretic potency
vasopressin release
NICTITATING MEMBRANE (166)
acetylcholine action 8671
anesthetized cats 8690
8713
catecholamine content
C6-Cl4 ganglion concentration
contractile responses
8713
dose-response curves
epinephrine sensitivity
hexamethonium-C 14
“muscarinic” receptorsnorepinephrine
norepinephrine sensitivity
phenoxybenzamine modification
postganglionic denervation
preganglionic denervation
preganglionic nerve
stimulation
8674
preganglionic sympathetic
stimulation
reserpine pretreatment
8690spinal cats
superior cervical ganglion
superior cervical
gangl ionectomy
sympathetic nerve stimulation
TEA pretreatment
tetrahydrocannabinol s
tremorine effect
tyramine
NOREPINEPHRINE
acetylcholine response
content
nictitating membrane
nictitating membrane
sensitivity
phenoxybenzamine modification
removal mechanism
reserpine pretreatment
NUCLEIC ACID FRAGMENTS
adenines
cardiac nerve stimulation
cytidines
drug effects
heart muscle extracts
hypoxanthine
inosines
open-chest dogs
uridines
xanthine
morphinized rats 8700 subcutaneous temperature 8694nalorphine reversal 8678 “total” acetylcholine
activity 8696PAPILLARY MUSCLES (171) PENTOBARBITAL HYPNOSIS (175)
aldosterone 8675 albino mice 8699
antiarrhythmia agents 8684 chloroform pretreatment 8699
DCI pretreatment 8717 ethanol pretreatment 8699
epinephrine 8717 sleeping time 8699
inotropic effects 8675 PENTYLENETETRAZOL (176)
8717 cardiac arrhythmias 8684ouabain 8675 cardiac tissue 8684
N-oxide analogs 8717 concentration effect 8684
pentylenetetrazol 8684 convulsant threshold 8698
pyridine derivatives 8717 mouse susceptibility 8698
reserpine pretreatment 8717 parasympathetic blocking
SC-8109 8675 agents 8684
SKF-689OA pretreatment 8717 phenobarbital antagonism 8698PARASYMPATHETIC BLOCKING AGENTS strain difference 8698
N-ethyl-nortropine- (172) PHENOBARBITAL (177)benzhydryl-ether 8684 amphetamine mortality 8698
pentylenetetrazol-induced antagonist activity 8698
arrhythmias 8684 mouse strains 8698PARASYMPATHETIC NERVOUS SYSTEM, PHENOLSULFONPHTHALEIN (178)
GANGLION (173) CSF disappearance rate 8703blocking Effect 8713 intracisternal injection 8703
hexamethonium-Cl4 intraventricular injection 8703
concentration 8713 plasma levels 8703
tremorine inhibitor activity 8674 transport process 8703tremorine stimulant activity 8674 urinary excretion 8703
PENTOBARBITAL (174) PIPERACETAZINE (179)
acute toxicity 8694 amphetamine mortality 8698
anesthetized rats 8696 antagonist activity 8698
blood levels 8694 lethal effect 8698
brain concentration 8694 mouse susceptibility 8698
brain esters 8696 strain difference 8698
brain 5-HT content 8667 PLASMA (180)
brain-blood concentration catecholamine concentration 8716ratio
diffusion rate
8694
8694
cyclopropane inhalation
H3-DCI concentration
8716
8693
distribution volume 8694 disappearance rates 8693
environmental temperature 8694 8713
gamma-hydroxybutyrate 8705 epinephrine concentration 8716
liver concentration 8694 fluorescence development 8710
liver-blood concentration fluorimetric determination 8710
ratio 8694 hexamethonium-C14
male rats 8694 concentration 8713
mortality rate 8694 human subjects 8710
oil-water distribution 8694 oral spironolactone
plasma protein binding 8694 administration 8710
rectal temperature 8694 spironolactone metabolite
sleeping time 8705 levels 8710
OXY-PLA
SUBJECT INDEX
VOL. 135
5-18
(185)
(186)
(187)
1962
SUBJECT INDEX
S -19
sulfuric acid-f luorogen
tissue/plasma ratios
POLYNYXIN B (181)
albino rats
drug antagonism
gastric hemorrhage production
gastric ulcer formation
histamine liberation
intraperitoneal injection
pylorus-ligated rats
subcutaneous injection
time-response curves
POSTERIOR PITUITARY HORMONE
(VASOPRESSIN) (182)
coronary blood flow
coronary vasoconstriction
ECG
isolated heart
lobeline-induced release
nicotine-induced release
PROCAINE (183)
ACh responses 8672
cervical sympathetic ganglion 8672
DFP-induced postganglionic
discharge 8672
postganglionic action
potentials 8672
PUPIL (184)
carbachol pretreatment
hexamethonium pretreatment
phenoxybenzamine pretreatment
tremorine-induced mydriasis
PYRIDINES
atropine pretreatment
cardiac effectscatecholamine release
dose-response curves
methyl derivatives
nicotine pretreatment
N-oxide analogs
PYRILAMINE
polymyxin B-induced
gastric hemorrhage
protective effect
REFLEXES
flexion reflex
knee jerk
linguomandibular reflex
tetrahydrocannabinol s
PLA-RET
8710 RESERPINE (188)
8713 blood-brain barrier 8666
epinephrine uptake 8666
8702 experimental atheromatosis 8718
8702 guanethidine comparison 8688
8702 hypertensive rats 8718
8702 hypocholesterolemic effect 8718
8702 hypotensive activity 8718
8702 inhibitor activity 8666
8702 isolated mammalian heart 8688
8702 isolated rabbit ileum 8670
8702 normotensive rats 8718
oral administration 8718
organ sensitivity 8670
8677 pretreatment effect 8670
8677 special CNS areas 8666
8677 sympathomimetic amines 8670
8677 RESORCINOL ISOMERS (189)
8677 arterial pressure responses 8689
8677 cardiac contraction force 8689
cardiovascular system 8689
open-chest dogs 8689
spinal cord action site 8689
sympathetic stimulatory
effect 8689
RESPIRATION (190)
anesthetized cats 8669
carotid sinus denervation 8676
8674 hexamethonium blockade 8676
8674 rate changes 8669
8674 respiratory paralysis 8669
8674 retama stimulatory action 8676
tetrahydrocannabinols 8669
8717 RETAMA (191)
8717 adrenalectomy 8676
8717 adrenergic blocking agents 8676
8717 anesthetized dogs 8676
8717 atropine pretreatment 8676
8717 B-TM-lO pretreatment 8676
8717 cardiovascular actions 8676
carotid sinus denervation 8676
hexamethonium blockade 8676
8702 hexamethonium pretreatment 8676
8702 isolated intestine 8676isolated uterus 8676
peripheral actions 8676
phenoxybenzamine pretreatment 8676
8669 respiration 8676
8669 smooth muscle 8676
8669 sympathectomy 8676
8669 vagotomy 8676
(193)
RYA-SYM
RYANODINE
alpha-glycerokinaseL-alpha-GP dehydrogenase
iodoacetate effect
skeletal msucle relaxation
SACCHARIDES 14
anesthetized rabbits
CSF disappearance rates
intracisternal injection
intravenous injection
intraventricular injection
plasma levels
urinary excretion
SALIVARY SECRETION (194)
atropine blockade
chorda tympani section
hexamethonium
submaxillary gland
tetraethylammonium blockade
tremorine-induced salivation
SEROTONIN (195)acetylcholine response
anesthetized chickens
aortic chains
dose-response curves
glycolytic enzyme activity
histamine depleted animals
histamine release
pressor response
intact parasites
liver fluke homogenates
vasodepressor response
SPINAL CORD (196)action site
acute transection
resorcinol isomers
sympathetic circulatory
stimulation
SPIRONOLACTONE (ALDACTONE) (197)
de-thioacetylated derivative
(SC -9376)fluorimetric determination
human subjects
oral administration
plasma metabolite levels
plasma sulfuric acid-
fluorogen
SC-9376 structural
relationship
SUBJECT INDEX
S -20
VOL. 135
(192) SPLEEN (198)
8719 catecholamine content 8708
8719 morphine-tolerant animals 8708
8719 STOMACH (199)
8719 albino rats 8702
atropine 8702
gastric secretion 8702
hemorrhagic lesions 8702
8703 histamine 8702
8703 histamine content 8702
8703 polymyxin B 8702
8703 pylorus-ligated rats 8702
8703 serotonin content 8702
8703 STRYCHNINE (200)
8703 lethal effects 8698
mephenesin antagonism 8698
8674 meprobamate antagonism 8698
8674 mouse susceptibility 8698
8674 strain difference 8698
8674 SUCROSE (201)
8674 CSF-blood transport 8703
8674 intraventricular injection 8703
urinary excretion 8703
8715 SULFONAMIDES (202)
8686 antidiuretic activity 8720
8715 diabetes insipidus 8720
8715 metabolic responses 8720
8679 saliuretic compounds 8720
8686 structure action relationship 8720
8686 urinary electrolyte excretion 8720
8686 urine volume 8720
8679 water intake 8720
8679 SYMPATHETIC NERVOUS SYSTEM (203)8686 brain norepinephrine function 8706
bronchomotor response 8692
8689 cardiovascular reflexes 8668
8689 cardiovascular stimulation 8689
8689 central administration 8668
DCI pretreatment 8692
8689 guanethidine effect 8668
intravenous administration 8668
morphine-tolerant animals 8706
8710 resorcinol isomers 8689
8710 spinal cord action site 8689
8710 splanchnic nerve activity 8668
8710 thoracic postganglionic
8710 stimulation 8692
SYMPATHETIC NERVOUS SYSTEM,8710 GANGLION (204)
acetylcholine effect 8672
8710 anesthetized cats 8672
8673
DCI reversing action 8692atropine effect 8672 pulmonary arterial injection 8692
bioassay 8665 sympathetic nerve stimulation 8692
blocking effect 8713 ventilation overflow 8692
cell group responses 8673
chronic denervation 8672 TEMPERATURE, ENVIRONMENTAL (208)
DFP effect 8673 barbital distribution 8694DFP-induced postganglionic barbital toxicity 8694
discharge 8672 male rats 8694differential blockade 8673 pentobarbital distribution 8694epinephrine content 8690 pentobarbital toxicity 8694
external carotid nerve 8673 TEMPERATURE, RECTAL (209)
functional heterogeneity 8673 barbital distribution 8694
ganglionic blocking agents 8672 barbital toxicity 86948673 male rats 8694
ganglionic stimulants 8673
hexamethonium-C14pentobarbital distribution
pentobarbital toxicity
8694
8694
concentration 8713 TETRAETHYLAMMONIUN (210)
intra-arterial injections 8672 ACh responses 8672
8673 chronic denervation 8672MAO activity 8665 DFP-induced postganglionic
norepinephrine content 8690 discharge 8672
postganglionic action differential ganglionic
potentials 8673 blockade 8673
preganglionic nerve dose effect 8673
stimulation 8672 postganglionic action
8673 potentials 8673
preganglionic section 8690 preganglionic nerve
procaine effect 8672 stimulation 8672
reserpine pretreatment 8690 repetitive preganglionic
retama stimulatory effect 8676 stimulation 8673
superior cervical ganglion 8672 sympathetic ganglia 8672
8673 8690 8673
through fibers 8673 TETRAHYDROCANNABINOLS (211)
thyroid nerve 8673 action site 8669
d-tubocurarine effect 8672 amphetamine-induced activity 8669
SYMPATHETICO-ADRENAL SYSTEM(205) anesthetized cats 8669
anesthetized dogs 8716 atropine pretreatment 8669
cyclopropane responses 8716 blood pressure 8669
nictitating membrane 8716 carotid sinus denervation 8669
pupil diameter 8716 decerebrate cats 8669
SYMPATHOMIMETIC AMINES (206) dibenamine pretreatment 8669
dose-response curves 8670 intestinal motility 8669
inhibitor activity 8670 nictitating membrane 8669
isolated rabbit ileum 8670 pharmacological effects 8669
organ sensitivity 8670 piperoxan pretreatment 8669
reserpine pretreatment 8670
SYMPATHOMIMETIC BRONCHODILATORS
reflexes
respiration
8669
8669
anesthetized dogs (207)8692 spinal section 8669
arterial perfusion pressure 8692 toxicity 8669
bronchomotor responses 8692 vagotomy 8669
1962
SUBJECT INDEX
SYM-TET
S -21
histamine release
8674 pressor response
8674 vasodepressor response
d-TUBOCURARINE
8686
8686
8686
(217)
8672
8672
8672
8672
8672
(218)
8670dose-response curves 8671
inhibitor activity 8670
isolated rabbit ileum 8670
8672 nictitating membrane 8671
phenoxybenzamine modification 8671
8672 reserpine pretreatment 8670
8672
8674 (219)
8674 8676
8674 8676
86748674
8674 (220)
8674 8715
isolated aorta 8715
8674 VASODEPRESSION (221)
8674 anesthetized chickens 8686
histamine mediated mechanism 8686
8704 serotonin response 8686
8704 tryptamine response 8686
8704 VASODILATORS (222)
8704 acetylcholine activity 8715
8704 isolated aorta 8715
VASOMOTOR SYSTEM (223)
8686 central inhibition 8668
8686 guanethidine effect 8668
( 214)
(215)
TRA-VAS
SUBJECT INDEX
VOL. 135
S -22
TRANSMISSION, GANGLIONIC (212)
anesthetized cats
DMPP response
inferior mesenteric ganglion 8674
postganglionic discharge 8674
superior cervical ganglion 8674
tremorine 8674
TRANSMISSION , SYMPATHETIC
GANGLIONIC (213)
acetylcholine effect 8672
DFP-induced postganglionic
discharge 8672
ganglionic blocking agents 8672
intra-arterial injections 8672
postganglionic action
potentials
preganglionic nerve
stimulation
presynaptic terminals
TREMORINE
action sites
anesthetized dogs
autonomic effects
biphasic effect
cardiovascular system
cholinesterase inhibition
hypothermic response
peripheral ganglionic
activity
urinary bladder
TRICHLOROETHANOL
albino mice
brain tissue concentration
chloral hydrate comparison
chloral hydrate metabolite
hypnotic activity
TRYPTANINE (216)
anesthetized chickens
histamine depleted animals
acetyicholine responses
DFP-induced postganglionic
di scharge
intra-arterial injection
preganglionic stimulation
sympathetic ganglia
TYRANINE
action mechanism
UTERUS
isolated guinea-pig uterus
re t ama
VASOCONSTRICTORS
acetylcholine activity
8719
8677
8688
86678696
8687
8687
8682
8714
8667
8667
8709
8669
8703
8702
8686
Paasonen N K
Page I H
Penna M
Phillips B N
Plaa C L
Price H L
8716
Prockop L D
Robb J S
Rossi C V
Schanker L S
Schmidt J L
8707 Schneider J A
8668 Schoepke H G
8711 Schwartz M A
8698 Seraydarian M W
8690 Setnikar I
8706 Shanfeld J
Shideman F E
8688 Sjoerdsma A
8699 Smith C N
Smith T H F
8690
8704
8684
8720
8669
8716
8705
8676 8668
8713
8704
87098683
8679
8687
8693
8706
8678
86758694
8720866686718685
86818672
86868689
8698872086978666
Vargas R
Volle R L
8673
Walaszek E J
Walton R P
Weaver L C
Welsh M
Widdicombe J
Wilson C W M
1962
AUTHOR INDEX
VOL. 135
Nelson E 8682 Yim G K W 8695
Abbott B C
Allmark M G
Alper M H
Anderson E G
Ara R
Aramendia P
Aviado D M
8692
Ballard B E
Bindler E
Bonnycastle D D
Bonnycastle N F
Bowman E R
Boyd E S
Brodie B B
Brodie D A
Bunag R D
Cafruny E J
Castro de la Mata
8687 8692
Cervoni P
Cooper J R
Covino B G
Crawford J D
Dagirmanjian R
Deutsch S
Drakontides A B
Dunn M J
Easton N R
Farah A E
8685Fleming W W
Floch M H
Friedman A H
Frost L
Funderburk W H
Furchgott R F
Gantt C L
Gatgounis J
Gillen W
Gochman N
Grewal R S
Groisser V W
Gyermek L
Haugaard N
Hess M E
Hilton J C
Hosein E A
Jelliffe R W
Jenden D J
Kaji H K
Kaneko Y
Kenny A D
Kerley T L
Kirpekar S N
8681 Klingman C I
R 8707 8708
Krayer 0
Kutob S D
Levine R J
Linde H W
Lovenberg W
Lu F C
McCubbin J W
Mclsaac R J
8683 Mackay F J
McKennis H JrMcMahon R E
8680 Mansour T E
Martinez
8670 L de Letona J
8701 Mayer S E
8674 Maynert E W
8720 8707 8708
8705 Miller T B
8690 Miya T S
Noreno 0 M
Morey E R
8710 Murray A W
8689
8684
87108677
8701
8714
8691
8691
8676
8696
8715
8719
8665
8716
8665
8677
8680
8695
8702
8711
8666
Takemori A E
8700
Tanz R D
Temelcou 0
Terry N L
Titus E
Trendelenburg U
Tuttle R S
8688
8668
8692
8695
8699
8697
8703
8712
8718
8703
8670
8705
8717
8664
8719
8694
8691
8717
86658674
8718
1962 NOTICE VOL. 135
to Subscribers and Readers
Because of the comprehensive nature of the Journal index, the following
explanatory comment, with special reference to subject analysis, seems
appropriate at this time.
Subject Content: This is available to the reader by simple, coordinate
search of the Subject Index. Coincident display of pertinent headings and
subheadings, arranged alphabetically, assures the searcher that significant
information will not be missed. The information thus acquired may be divided
into three categories:
First: The Number of Articles Cited on Each Subject.
Rapid survey of the entry numbers listed opposite the subheadings will
indicate the scope and variety of topic coverage. The subheadings describe
the subject content in unit terms, with separate access for each idea.
For the convenience of direct page reference, AUXILIARY INDEX-PART I
presents a table of Index to Pages.
Second: The Number of Subjects Covered in Each Article.
The Subject Index admits topic headings according to the relative impor-
tance of competing information within each article By the liberal use of
these selected headings, numbered serially in parenthesis, a convenient sys-
tem of complete cross-reference is provided for the reader.
For the purpose of cross-reference, AUXILIARY INDEX-PART II is recommended.
It presents a table of index to Subject Headings, in which the heading
numbers appear below the appropriate underscored entry numbers. The corres-
ponding headings may be quickly located by reference to the parenthetic
heading numbers in the subject index.
Third: The Associations of Ideas Related to the Subject of Search.
Ready comparison of ideas described under one heading with those listedunder the alternative headings will often lead to a fund of relevant facts.
In this manner, tracing ideas through the total system should open the way
to useful material that is beyond the limits of restricted fields of inquiry.
MARCH
Auxiliary Index-Part I
Index to Pages
VOLUME 135, 1962
JANUARY FEBRUARYEntry � Entry
8664 1 8684 136
8665 7 8685 142
8666 11 8686 1518667 17 8687 156
8668 21 8688 164
8669 25 8689 174
8670 34 8690 180
8671 39 8691 191
8672 45 8692 197
8673 54 8693 204
8674 62 8694 213
8675 71 8695 223
8676 79 8696 230
8677 84 8697 233
8678 89 8698 240
8679 94 8699 245
8680 102 8700 252
8681 112 8701 256
8682 120 8702 259
8683 128
Entry
8703
8704
8705
8706
8707
8708
8709
8710
8711
8712
8713
8714
8715
8716
8717
8718
8719
8720
266
271
275
285
296
300
306
312
317323335344
349
354
358
367374
382
Al -1
1962 Auxiliary Index-Part II VOL. 135
Index to Subject Headings
8664 8669 8673 8678 8685 8691 8698 8703 8709 8715
30 36 204 39 4 89 177 51 66 21
130 50 210 49 44 108 179 70 149 91
131 78 157 64 200 128 160
132 115 8674 162 75 8692 135 8710 167
155 125 34 164 109 7 8699 141 180 195
156 154 36 170 161 73 9 178 197 220
163 166 62 169 91 54 193 222
187 81 8679 133 89 201 8711
� 190 108 89 � 160 93 6 8716
32 211 110 98 36 167 136 8704 33 36
89 166 102 116 203 138 39 37 45
105 � 173 137 117 207 175 53 50 48
155 90 184 195 160 123 52 67
204 91 194 195 � � 149 76 86
126 212 8680 216 39 39’ 215 121 110
� 133 214 55 221 74 49 180
39 167 56 149 143 8705 8712 205
50 188 � 82 � 180 151 39 105
92 206 8 96 22 157 50 168 8717
188 218 10 147 40 8694 162 87 48
108 148 79 26 164 115 8713 105
� � 109 153 100 174 170 119 36 10727 3 124 208 174 39 124
32 63 169 8681 8688 209 8701 99 171
39 160 171 55 103 29 8706 110 185
43 166 84 108 8695 35 5 114 �2J�50 167 � 134 110 144 89 38 166 20
53 218 36 146 188 145 112 39 173 36
80 108 147 48 180 61
95 8672 126 8689 8696 8702 156 204 122
104 3 190 � 36 3 16 157 142
120 23 191 1 45 15 17 203 8714 188
143 77 204 85 105 39 19 23
152 99 219 189 94 58 8707 24 8719
156 113 8683 196 174 60 11 31 129
157 142 8677 42 203 68 39 41 159
174 183 36 69 8697 72 120 63 192
204 65 89 8690 36 91 157 72 8720
� 210 83 48 46 101 79 2
36 213 86 8684 160 47 111 99 18
50 217 108 97 166 67 116 8708 100 28
103 139 106 167 117 48 113 57
203 �21 165 108 204 8698 181 105 120 59
223 3 182 109 13 186 127 140 71
99 171 �2i 150 199 156 157 88
8669 100 8678 172 25 158 8703 157 8715 118
12 113 14 176 45 176 35 198 3 202
AI-2
NOTICE
to Subscribers and Readers
Attention is directed to the current method (ACC) of using entry numbers
opposite the unit terms and names comprising the Subject and Author sections
of the Journal Index. These entry numbers coincide with the appropriate ac-
cession numbers listed serially at the left of the titles in the Register of
Articles. Their purpose is to condense and unify the three parts of the in-
dex, and to expedite its use.
For a brief guide to the use of the current index please consult pages
AI-l, and AI-2. Objectives and method are discussed under Notice to Readers
and Subscribers.
For direct page reference, an Index to Pages by entry numbers is tabulated
on page AI-l.
For cross-reference of subject matter, an index to Subject Headings by
entry numbers is presented on page AI-2.
The possibility has been considered that additional copies of the index,
bound separately, might be of value to libraries and to other subscribers
and readers for use in reference work. Such a separate distribution would
be justified only if the sale of a significant number of copies could be
assured. It is suggested that anyone interested in such separate indexes
write a letter to the Publisher who can then determine the feasibility of
separate distribution.
AI-3