DEPAR TMENT OF PHYSIOLOGY

Annual ReportJuly 1, 1967 - June 30, 1968

ACADEMIC STAFFE. B. Brown, Jr., Ph. D., Professor and Chairrr~anAlan M. Thompson, Ph. D., Professor and Acting ChairmanDonald Johnson, Ph. D., Associate ProfessorG. N. Loofbourrow, Ph. D., Associate ProfessorL. F. Sullivan, Ph. D., Associate ProfessorAlan Goodridge, Ph. D. , Assistant ProfessorKenneth L. Goetz, Ph. D., Assistant ProfessorJames Rhodes, M. D., Assistant ProfessorJohn W. Trank, Ph. D., Assistant ProfessorA. Stark Wolkoff, M. D., Assistant Professor

POSTDOCTORAL FELLOWS

Paul Hensleigh, M. D. , supported by Ob-Gyn Training GrantNorberto Gonzalez, M. D., National Research Council Fellow, Argentina,

and CV Research Training Grant Fellow, 10-1-65 to 9-30-67.James Scherbenske, Ph. D., Public Health Service Postdoctoral Fellow,

9-1-67 to 8-31-68. (1 FZ AM-34, 671-01)Dr. Takuma Hojo, M. D. 9-1-65 to 8-8-67, returned to Tokyo Medical

College, Dept. of Surgery, Tokyo, Japan.Dr. Arlo Hermreck, M. D. Postdoctoral Research Fellow, PHS July 1, 1967

to June 30, 1968. (1 FZ-HE-36, 073-01)Dr. Larry Welling (Captain), Left 5/ZZ/68 - 169th Brigade, U. S. Army,

Denver, Colorado.

GRADUATE STUDENTS

Larry Welling, M. D.Paul Hensleigh, M. D.Conrad JohansonBarbara McDougalMartin KramenDennis WaringGary BondSam Steele has M. A. + M. D.

Degree sought

Ph.DPh. D.Ph.D.Ph. D.Ph. D.Ph. D.Ph. D.Ph. D.

PRELIMINAR Y EXAMWritten Cral

April 1968 May 3, ~968

May 1968 May 1968March 1968 March 1968March 1968 March 1968

May 1968 May 1968May 1968 May 1968Left for military serviceon 6/6/68.

Working on thesisCleve HowardEdward MartinFrank Scamman

Carol HendleyGary SlickArlo Hermreck,

Kyra Riegle

M.D.

M.A.Ph. D.Ph. D.Ph.D.M.A.Ph. D.Ph. D.

working on thesis

On Lawrence Campus this yr.

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KA W VALLEY HEAR T STUDENTSDoloresOlsen

Mike Briggs

(The Science Talent Search Program,summer 1967)

W1EDICAL STUDENTSPhil RhodesRaedene Sc hmidt

Stephen AshRobt. BoydThomas OglevyJohn GoheenMax StearnsSam Steele

- Summer Research Fellows

TEACHING

The integrated CQUrse in 11Basic Human Biology" for nurses was not taughtthis summer. The Physiology Course for Medical Students was againscheduled during the winter and spring quarters, with the last two weeksof the year devoted to the combined course in Endocrinology.

Graduate courses taught during the past year were:#322 - Dr. Loofbourrow - Physiology of the Nervous System. Fa111967.#310 - Dr. Thompson - Transport and Permeability -Winter 1967.#315 - Dr. Sullivan - Renal Electrolyte Excretion - Spring 1968.

Graduate Seminars #351 offered during the year were:Fall: Regulation of Metabolic Pa.thways - Dr. Alan GoodridgeWinter: None

Spring: None

VISITORS AND OUTSIDE SPEAKERS:

Oct. 31, 1967 Francisco drande, M. D., Professor of Physiology,Univ. of Minnesota, spoke on "Fat Mobilizing effect ofglucagon in birds. II

Nov. 13, 1967 Robt. Hazelwood, Ph. D. of Dept. of Biology, Univ. of Houston,was guest lecturer for the departments of Biochemistry andPhysiology. His talk was on the "Problems in AvianCarbohydrate Metabolism. "

Dec. 19. 1967 Merrill Tarr, Ph. D., Postdoctoral Fellow, Dept. of Physiology.Duke Univ. was a visitor in our department. He presentedthe seminar to our group and his topic was "Voltage-clampstudies on Cardiac Muscle. "

Feb. 14, 1968

April, 1968

May 3, 1968

May 6, 1968

May 20, 1968

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Dr. Richard Malvin, Renal Functions in Marine Animals.

Dr. Robert B. Sanders, Assistant Professor, Departmentof Comparative Biochemistry and Physiology, Universityof Kansas, Lawrence, Kansas, talked on "Action ofEpinephrine and Insulin on Amino Acid Transport. "

Dr. D. M. Aviado visited the medical center and gave ashort talk to members of the Pharmacology and Physiology

jdepartments.

Dr. .Rudolf C1arenburg, Associate Professor, Departmentof Physiological Sciences, Kansas State University,Manhattan, Kansas. "Removal of an Atherogenic Factor fromthe Human Diet. "

Arthur J. Vander, M. D., Assoc. Prof., Dept. of Physiology,Univ. of Michigan, Ann Arbor, Michigan. "Control ofRenin Release. "

REVIEW OF THE YEAR:

The Chairman of the Department of Physiology, Dr. E. B. Brown, Jr. wason sabbatical from August on of this academic year and was working at OxfordUniversity with Drs. Dan Cunningham and Charles Michel. He was greatlymissed and the arduousness of his job is now fully appreciated by the ActingChairman, Dr. Alan Thompson. However, the programs of the departmentcontinued actively and aggressively in his absence. The department is fortunateto have obtained a new full time Assistant Professor, Dr. Merrill Tarr,

starting May 1, 1968. Dr. Tarr received very thorough training for his Ph. D.at Western Reserve University, completed his degree in the spring of 1967,and spent the summer and the past academic year as an NIH PostdoctoralFellow with Dr. John Moore at Duke University. Dr. Tarr has already obtaineda research grant from the Kansas Heart Association and is waiting to hearfrom a larger grant application to the Public Health Service. He alreadyhas several significant publications on muscle electrophysiology, specificallyh~art and smooth muscle. INe believe that he will make a very valuablemember of the department and will have a particularly important place in thecardiovascular group at this institution, since there has long been a needfelt for an ,electrophysio10gist. Dr. Alan Goodridge has been a highly valued

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member of the department for almost two years and we regret that he hasdecided to leave as of July 1, 1968, to accept a position with the Banting andBest Department of Medical Research at the University of Toronto. TheToronto department is made up entirely of people interested in metabolism,which was an extremely attractive point to Dr. Goodridge.

Teaching of the Medical Physiology course this year was similar to that lastyear, with a readjustment of lecture assignments to cover the material inrespiration and acid-base balance usually covered by Dr. Brown. Largeamounts of time were invested by staff members this year in the meetingsof the various committees concerned with the over-all revision of the medical

school curriculum. In addition to meetings with individuals from otherdepartments, this department has had several extensive internal discus sionsof the problems involving curriculum revision. The concensus hasbeen thatthe basic first-year course in physiology could probably be two-thirds or les sof the present cour se in length, that the laboratories could be substantiallycut down in time, and that the time released in this way would be used betterin further contacts with third and fourth-year students.

With respect to the discussion in last year's progress report concerning theproblems imposed by the present space available for teaching, additionalexperience during the past academic year has accentuated some of theseproblems. It appears that of the four laboratories now available for studentteaching jointly by the Physiology and Pharmacology Departments, one ispoor for teaching purposes and another is almost impossible because ofproblems in space, physical arrangement of the room, and ventilation. Inaddition, problems in obtaining rooms for conferences and examinations, as wellas informal unplanned discussion of experiments, have become more acuteduring the past year.

Our graduate program in the past year took a real step forward with sixPh. D. candidates completing their two-day written and their oral preliminaryexamlnations succes sfully.

Employee Recognition Awards were made May 23, 1968. In our Departmentfour members were recognized, with five year awards to Dr. E. B. Brown, Jr.,Dr. Alan Thompson, and Constance Leonard. Dr. G. N. Loofbourrow wasgiven the 15 year award.

AMA-AAMC Accreditation Visit by the Liaison Committee was made to our. Department in January.

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ACTIVITIES OF STAFF:

Dr. E. B. Brown, Jr., Professor and Chairman

Was elected to a three-year term as Secretary-Treasurer of the newlyorganized Association of Chairmen of Departments of Physiology (ACDP)at the fall meeting of the American Physiological Society, 1967.

Dr. Brown is on sabbatical leave working in the physiology laboratoriesat Oxford University, England, with Drs. Cunningham, Lloyd and Michel.from September 1967 through August 1968.

He attended the Council meeting of the ACDP on April 15 in Atlantic City,New Jersey.

Participated in the program of the Anesthesiology Department at KUMCin April 1968.

Dr. Alan M. Thompson, Professor and Acting Chairman

Beginning September 1, 1967, through August 31, 1968, was Acting Chairmanof the Physiology Department in the absence of Dr. E. B. Brown, Jr., whois on sabbatical leave.

Attended APS Meetings in Washington. D. C., August 23, 1967. At thesame meetings Dr. Thompson was elected interim Secretary-Treasurerof the newly formed As sodation of Chairmen of Departments of Physiology.Dr. Brown was elected to the three-year position, with Dr. Thompsonvolunteering to assume the duties of this office for the first year. Heorganized and attended meetings of the Association in August and April,as well as an Executive Council meeting in December.

Attended the Biological Interfaces meeting of the N. Y. Academy of Sciencesin New York City and consulted in laboratories in Philadelphia and Chicago-December 1967.

Gave four lectures on transport at California College of Medicine in LosAngeles - February 1968.

Gave a paper at Spring meetings of F ASEB in Atlantic City April 15-20, 1968.

Gave two lectures to Inhalation Therapy Postgraduate Course May 20, 1968

Graduate student recruitment trip to Pittsburg, Kansas, and Springfield,Missouri, November 1967.

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Attended Lake of the Ozarks Core and Track COffiffiittee Meeting Dec. 1,1967, and in the spring of 1968.

Taught Graduate Course #310 on Transport and Perrr.eability, Winterquarter, 1967.

Supervised Lester Wade and Conrad Johanson - Graduate students.

Dr. Kenneth L. Goetz, Assistant Profes sor

Attended Heart Meetings in San Francisco, October 1967.

Decerr.ber 1, 1967, attended Core and Track COffiffiittee Meeting at Lake ofthe Ozarks Osage Beach. Attended curricu1uffi committee, Lake of theOzarks, May nand 12, 1968.

Supervised research and theses for Cleve Howard and Gary Slick,graduate students who will get their M. S. degrees this fall.

Supervised work of Arlo Herffireck, M. D., Postdoctoral Fellow inPhysiology.

Recruitment trip for Graduate School candidates - Jan. 11, 1968 to WilliaffiJewel and Warrensburg State Teachers College.

Talked to Caduceus Society of Emporia State on March 20, 1968, Effiporia, Ks.

Presented a talk at postgraduate sYffiposiuffi on Inhalation Therapy,Battenfeld Auditoriuffi, May 1968.

Presented three cardiovascular physiology courses (Jan., Apr., June) to

postgraduate nurses as part of Regional Medical Prograffi for trainingcoronary intensive care nur se s.

Talked to pediatric cardiologists June 7, 1968.

Talked to Sant and Water Club of KUMC May 15, 1968.

Talked to Kaw Valley Scholars, June 30, 1968.

Acted as consultant to Midwest Research Institute.

Hosted Site Visit of Drs. Davis, Haffiilton and Peiss in connection with

application for three y~:r NIH grant on July 19, 1967.

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Dr. Alan G. Goodridge

Decerr..ber 4-5, 1967 - Recruitrr..ent trip to interest prospective studentsfrorr.. area colleges in our graduate school prograrr.. here at KUMC. -went to Sterling, Kansas.

August 26-Sept. 1, 1967, attended meeting of the American Institute ofBiological Sciences at College Station, Texas, and presented paper on"Effects of insulin and glucagon on metabolism of chick adipose tissuein vitro. II

Taught seminar course #351 in Fall of 1967 to Physiology Departrr..entGraduate Students.

Dr. Donald C. Johnson

Attended Meetings of Arr..erican Association of Anatomy, New Orleans-April 1968.

Attended Federation Meetings in Chicago 1967.

Participated in joint prograrr.. in Reproductive Physiology with variousdepartrr..ents at Kansas State University and Lawrence Carr..pus. Hadtwo meetings this year - Lawrence and Manhattan.

Lectured at University of Missouri's Veterinary School in March 1968.

Dr. G. N. Loofbourrow

Writing Textbook on Neurophysiology.

Is a member of Life Sciences and Pharrr..acy Area Corr..mittee of theGraduate School.

Merr..ber of Children's Rehabilitation Unit Advisory Council

Directs work of a Summer student frorr.. McAllister College, supported

by Kaw Valley Heart Association

Librarian for our department and continues to review rr..anuscripts forDr. E. Gellhorn, Professor Err..eritus of Neurophysiology, Universityof Minnesota.

8

Dr. James B. Rhodes

Has joint appointment. He is Assistant Professor. Departmentof Medicine and Departrrent of Physiology

American Gastroenterology Association meeting in Philadelphiain May, 1968.

Attended FASEB meetings in Atlantic City in April, 1968.

Attended Midwest Gut Club meeting in February, 1968.

Gave lectures to Kansas Circuit Course in Gastroenterology. Attendingstaff at St. Luke's Hospital, House Staff at St. Luke's Hospital, Post-graduate lecture in Gastroenterology at Menorah Medical Center. infall 1967.

Participated in elective courses. Throughout the year the GI Sectionhas an elective course in correlated Gastroenterology which is presentedevery Saturday morning for one hour.

Consultant in Gastroenterology at the K. C. Veterans AdministrationHospital.

Dr. Lawrence P. Sullivan

Attended the Nephrology meetings in Los Angeles in Cctober 1967.

F ASEB meetings in April 1968.

Member of KUMC Res. Corr..m., Computer Corr..rr..ittee, CurriculumCorr..mittee and Renal Dialysis Committee.

Dr. Sullivan is in the 3rd year of his Career Development Award,July 1, 1967.

Principal advisor to Dr. J. Scherbenske. PHS Postdoctoral Fellow.

Taught Graduate Course on Renal Electrolyte Excretion in Spring 1968.

Gave lectures on diuretics in the Pharmacology Course for Medicalstudents.

9

Dr. Merrill Tarr

Dr. Tarr began his appointment in our department on 5-1-68 asAssistant Professor of Physiology. Dr. Tarr received his B. A. inChemistry and Physiology in 1962 from University of Kansas atLawrence. He obtained the Ph. D. in Physiology in 1967 from WesternReserve University, Cleveland, Ohio. Dr. Tarr comes to us fromDuke University at Durham, North Carolina, where he was a PHS Post-doctoral Fellow.

Dr. Tarr will teach in the Medical Physiology course which all

graduate students take and will eventually teach and graduate course

in Electrophysiology, and he will serve as advisor for some of thegraduate students.

Dr. Tarr's field of interest in Electrophysiology of cardiac muscles;

electrophysiology of smooth muscle; permeability of cardiac membrane.

Dr. John W. Trank

October 3, 1967 - Lectured to Cardiovascular group in our library.

October 31 and November 2, 1967 - Lecture and demonstration fornurses.

Recruitment trip to area colleges and Universities in Wichita, Winfieldand North Newton, Dec. 11 and 12, 1967, for the purpose of interestingstudents in our graduate school program here at KUMC.

February 12 and 13, 1968, Attended meeting in Houston, Texas, betweenNational Institute of Child Health and Development and Nassau

Technology Utilization Per sonnel. Dr. Trank was a repr esentativeof KUMC in this endeavor - - Nas sau Bay Hotel.

I

f

I

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Dr. A. Stark Wolkoff

Presented toAffierican College of Obstetrics and Gynecology May 4-9,1968:

Breakfast conference on "The Fetal Environffient. "

Lectureship at Washington Univ. Medical School at Mt. Sinai,"Fetal Environffient'J and 11Newer Aspects in Rh Diseases. "

Attended "Curriculuffi Conferencell at Lake of Ozarks for COffiprehensiveCare at Univ. of Kansas Med. Center.

Attended Affi. Assn. of Gynecological Professors ffieeting inNew Orleans, March 4-5, 1968.

Delegate to the National C.onference of the Society of the Sigma Xi,zheld at Wentworth-by-the-Sea in New Haffipshire, September 24-27, 1967.

President of the University of Kansas Medical Center Sigffia Xi Club.

Scheduled four hourly lectures for Sigma Xi Club at University ofKansas Medical Center.

Chairffian of the Standards COffimittee.

Chairffian of the Utilization Review COffimittee.

Meffiber of the Comprehensive Ccire Corr~mittee.

11RESEARCH

Research grants which were active during the year were the following:

Intracellular corr.pensatory changes in response to chronic respiratoryacidosis and alkalosis. Air Force Contract #AF 41(609)-3005, USAFSchool of Aerospace Medicine, Brooks Air Force Base, Texas. PrincipalInvestigator: E. B. Brown, Jr. Jan 1, 1967 to Dec. 31, 1967. $17,068.Extended to Dec. 31, 1968 without additional funds.

Factors controlling renal excretion of arr.rr.oniurr., hydrogen and potassiurr..National Science Foundation. #GB-43l4. Frincipaiinvestigator: L. P. Sullivan.Feb. 1, 1967 to IViay 31, 1968. $54,600. Extended without additional funds.

Career Developrr.ent Award #5-K3-GM; 11, 898-03.transport. Dr. Brown in behalf of Dr. Sullivan.

Renal tubular potassiurr.

Diuretic agents and ion transport in the toad bladder. lROl AM 10227,USPHS. Principal Investigator: L. P. Sullivan, Jan. 1, 1968 to Dec. 31, 1968.$13, 949.

Right atrial pressure and heart rate. USPHS #1 ROl HE-08803. PrincipalInvestigator: K. L. Goetz. June 1, 1967 to Dec. 31, 1967 without additionalfunds. $13, 300.

Kansas Heart Association: Coronary blood flow as related to right heartpressure. Principal Investigator: K. L. Goetz. July 1, 1967 to June 31,1968.$4, 300. 00.

A study of Atrial Receptors. USPHS #1 ROI HE 11560-01. Principal Invest.K. L. Goetz. This is a three year grant, frorr. 5/1/68 to 4/30/71, with thefir st year total of $18, 660.

Institutional Grant. Decerr.ber 1, 1967 to April 30, 1968. $2, 800.

PHS Training Grant. Frograrr. Director: E. B. Brown, Jr.July 1, 1967 to June 30, 1968. $37, 864.

#5 - TlGM1137 -04.

Kansas Heart Association Grant #66R1603.Dr. J. W. Trank.

July 1, 1967 to June 30, 1968.

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American Cancer Society #P-426. Hormonal and nutritionalregulation of

lipogenesis during development and growth. $37, 380 from Dec. 1, 1966 to

Nov. 30, 1968. Dr. A. G. Goodridge.

Regulation of lipogenesis during development. 1 ROI AM 11123-01. Principal

Investigator:A. G. Goodridge. $1,700. Jan. 1. 1968 to Dec. 31, 1968.Supplement $10, 000 for purchase of scintillation counter.

Eli Lilly Research Fund, $4,.000 - Dr. A. G. Goodridge.

Nonelectrolytetransportalterationin perfused brain. USPHS NB 07059-01.PrincipalInvestigator:Dr. A. M. Thompson. Jan. 1, 1967 to I:.ec. 31, 1968.$26,585. Jan. 1, 1966 to Dec. 31. 1967, $21, 250.

Dr. Thompson is one of the Co -Investigators on USPHS #NB- HE 06907 - 02.June 1, 1967 to August 31, 1968. $60,000. Interdepartmental project grant.Prognosis and theory in cerebrovascular disease.

PopulationCouncil Inc. - Jan. 1, 1967 to Dec. 31. 1967. $10, 000.Neurohormone-Hypophyseal Gonadotropin and SteroidInteractions.Dr. D. C. Johnson. .

American Cancer Society- Jan. 1. 1967-Dec. 31. 1967 - $10,500Jan.!, 1968:Dec. 31. 1968 - $ 9.900

Role ofGonadotropins in Exper. yvarian Tumorigenesis. Dr. DonaldC. Johnson.

NationalScience Foundation - June 1. 1966-July 1, 1968 - $19.150GB-5213. Developmentof Male and Female HypophysealGonadotropinPatterns. Dr. Donald C. Johnson.

National Institutesof Health - RO I-HD03097 - 01. Follicle StimulatingHormone Control in the Male. March 1, 1968 - Feb. 28, 1969-$15,352.,Dr. Donald C. Johnson.

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13PUBLICA TICNS:

Brown, E. B., Jr., VI[.G. Kim, and F. A. Moorehead. Intracellular pHduring metabolic acidosis of intracellular and extracellular origin.Proc. Soc. Exp. Biol. and Med. 126:595, 1967.

Kim, W. G. and E. B. Brown, Jr. Potassium Transfer with constant

extracellular pH. J. Lab. and Clin. Med. 71(4):678-685, 1968.

Gonzalez, N. C., Takuma Hojo, and E. B. Brown, Jr. Myocardial PotassiumUptake with constant arterial potassium concentration. JAP 24(4):498-502,1968.

Martin, Edward D., Franklin L. Scamman, Benjamin A. Attebery, andE. B. Brown, Jr. Time-related adjustments in acid-base status of extra-cellular and intracellular fluid in chronic respiratory acidosis. USAFSchool of Aerospace Medicine, Aerospace Medical Division (AFSC) BrooksAF Base, Texas SAM-TR-67-116, Dec. 1967.

Goodridge, A. G. (1968) Metabolism of Glucose-U-14C in vitro in adiposetis sue from embryonic and growing chicks. Am. J. Physiol. 2 14: 897 -901.

Goodridge, A. G. (1968) Lipolysis in vitro in adipose tissue from embryonicand growing chicks. Am. J. Physiol. 214:901-907.

Goodridge, A. G. and E. G. Ball, Lipogenesis in the pigeon: In vivo studie s.Am. J. Physio!. 213:245-249, 1967.

Goodridge, A. G. and E. G. Ball. The effect of prolactin on lipogenesis inthe pigeon: In vitro studies. Biochemistry 6:2335-2343.

Goodridge, A. G. (1965) Conversion of [U_14C] Glucose into Carbon Dioxide,glycogen, cholesterol and fatty acids in liver slices from embryonic andgrowing chicks. Biochem. J. (in press).

Goodridge, A. G. (1968) Citrate-Cleavage enzyme, I Malic' enzyme and

certain dehydrogenases in embryonic and growing chicks. Biochem. J.

(in press).

Goodridge, A. G. (1968). The effect of starvation and Starvation followed."

by feeding on enzyme activity and the metabolism of [U _l4C] glucose inliver from growing chicks. Biochem. J. (in press).

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Goetz, K. L. and F. Hanis. A convenient skin button connector for

withdrawal of blood samples. J. Appl. Physiol. 22 (6):1l65-1166,1967.

Johnson, D. C. 1967 - Gonadotropin patterns in male and female rats:Plasma LH and FSH at various ages evaluated by the method of parabiosis.Acta Endocrinologica. 56:165-176, 1967.

Stockton, K. and D. C. Johnson, 1968. FSH in the pituitary of castrateand cryptorchid parabiotic male rats. J. Reproduction and Fertility 15:373.

Boyd, R. and D. C. Johnson, 1968 (in press) Gonadotropin patterns in maleand female rats: Inhibition of LH release by testosterone propionate inanimals gonadectomized at puberty. Acta Endocrinologic.

Greenwald, G. S. and D. C. Johnson, 1968 (in press) Gonadotropic requirementsfor maintenance of pregnancy in the hypophysectomized rat. Endocrinology.

Loofbourrow, G. N. Neuromuscular Integration. Chapter, Science andMedicine of Exercise and Sports, Warren N. Johnson Ed. Harper and Bros. ,New York, (in press).

Cady, A. B., J. B. Rhodes, A. Littman and R. K. Crane. Significance oflactase Deficit in Ulcerative Colitis. J. Lab. Clin. Med. 70:279-286,1967.

Rhodes, J. B., A. E. Eicholz and R. K. Crane. Studies on the organizationof the brush border in intestinal epithelial cells. IV. Amino Peptidaseactivities in microvillus membranes of manster intestinal brush border s.

Biochim. Biophys. Acta. 135, 959. 1967.

Rhodes, J. B. Peptidases of the small intestine. Am. Physiol. Soc.Handbook of Physiology, Section on the Alimentary Tract. In press.

Scherbenske, M. J. and L. P. Sullivan. A study of the relationship betweenNa and K Transport in isolated toad bladders. Fed. Proc. 27:747.1968.

Pendleton. Robt. G.. Lawrence P. Sullivan, Jerald M. Tucker and RobertE. Stevenson III. The effect of a benzothiadiazide on the isolated toad

bladder. Accepted for publication. J. Pharm. Exper. Thera. 1968.

Pendleton, Robert G., Lawrence P. Sullivan and Jerald M. Tucker. Theeffect of Chloromerodrin on the isolated toad bladder. Accepted for publi-cation. J. Pharm. Exper. Therapeutics 1968.

15

Tarr, M. and N. Sperelakis. Decreased intercellular resistance duringspontaneous depolarization in ffiyocardiuffi.Affi.J. Physiol.212: 1503 -15H, 1967.

Trank, J., R. Fetter, and R. M. Lauer. A spray-on electrode for

recording the electrocardiogram during exercise. J. Appl. Physiol.24(2):267 -268, 1968.

Thompson, A. M., R. C. Robertson, and T. A. Bauer. A rat head-perfusion

technique developed for the study of brain uptake of ffiaterials. J. Appl.

Physio!. 24(3): 407 -411, 1968.

Wolkoff, A. S., Steele, S.M., and Jackson, G. B. SOffieAspects of BloodLactate levels in the ffiother and fetus. To be published.

Bawden, J. W. and Wolkoff, A. S. Fetal Blood ca1ciuffi responses to ffiaternal

calciuffi infusion in sheep. Affi. J. Ob-Gyn, 99:55-60, Sept. 1, 1967.