r

therapy

STREPTOKINASE IN THROMBOEMBOliC CONDIT~ONS

Where pulmonary embolectomy may not be readily undertaken the use of streptokinase is effective and safe therapy in a

variety of thromboembolic conditions. Streptokinase, in a fixed regimen of 1 ,7SO,OOOIU over 12 hours and 30 minutes,

was given to 50 patients. In 12 with massive pulmonary embolus, 7 recovered completely after a single infusion, and 3

recovered after a second infusion. Two of the patients died due to failures of management rather than to complications

of the streptokinase therapy. Venous patency was restored in 21 of 32 patients with iliofemoral venous occlusion. A

single case of vena caval occlusion failed to respond to streptokinase. Hypersensitivity occurred in 1-patient and bleeding

in 4, requiring discontinuation of the infusion. In the 5 patients who had a repeated infusion within a few days of the

first, no serious problems occurred.

Colin, J.F. et al.: East African Medical Journal 52: 495 (Sept. 1975)

INPHARMA 10th January, 1976 p8