st-elevation myocard infarc
TRANSCRIPT
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ST-ELEVATION MYOCARDIAL INFARCTION
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Infark miokard akut adalah nekrosis miokard yang disebabkan oleh tidak adekuatnya pasokan darah akibat sumbatan akut arteri koroner.
IMA dengen elevasi segmen ST merupakan bagian dari spektrum Sindroma koroner akut.
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Major Risk Factors (Exclusive of LDL Cholesterol) That Modify LDL Goals Cigarette smoking Hypertension (BP 140/90 mmHg or on
antihypertensive medication) Low HDL cholesterol (<40 mg/dL)† Family history of premature CHD
CHD in male first degree relative <55 years CHD in female first degree relative <65
years Age (men 45 years; women 55 years)
† HDL cholesterol 60 mg/dL counts as a “negative” risk factor; its presence removes one risk factor from the total count.
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Life-Habit Risk Factors
Obesity (BMI 30) Physical inactivity Atherogenic diet
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Emerging Risk Factors
Lipoprotein (a) Homocysteine Prothrombotic factors Proinflammatory factors Impaired fasting glucose Subclinical atherosclerosis
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FoamFoamCellsCells
FattyFattyStreakStreak
IntermediateIntermediateLesionLesion AtheromaAtheroma
FibrousFibrousPlaquePlaque
ComplicatedComplicatedLesion/RuptureLesion/Rupture
Endothelial dysfunction
Smooth muscleand collagen
From first decadeFrom first decade From third decadeFrom third decade From fourth decadeFrom fourth decade
Growth mainly by lipid accumulationThrombosis,haematoma
Adapted from Stary HC et al. Circulation 1995;92:1355-1374.
Atherosclerosis Timeline
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Dislipidemia ----- Atherosclerosis ----- CVD A Progressive Disease
CRP=C-reactive protein; LDL-C=low-density lipoprotein cholesterol.
Libby P. Circulation. 2001;104:365-372; Ross R. N Engl J Med. 1999;340:115-126.
Monocyte LDL-C
Adhesion molecule
Macrophage
Foam cell
OxidizedLDL-C
Plaque rupture
Smooth muscle cells
CRP
Plaque instabilityand thrombusOxidationInflammationEndothelial
dysfunction
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Atherothrombosis: Thrombus Superimposed on Atherosclerotic Plaque
Adapted from Falk E, et al. Circulation. 1995;92:657-671.
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Myocardial Hypoxia
↓ ATP
Impaired Na+, K+ - ATPase ↑ Anaerobic metabolism
↑ Extracellular K+ ↑ Intracellular Na+ ↑ Intracellular Ca++
Altered membrane potential
Arrhytmias
Intracellular edema
↑ Intracellular H+
Chromatin clumpingProtein denaturation
CELL DEATH
↓ ATP↑ Proteases↑ Lipases
Adapted from Naik H, Sabatine MS, Lilly LS, 2007. Acute Coronary Syndrome. In: Lilly LS, ed. Pathophysiology of Heart Disease 4th Edition. USA: Lippincott Williams & Wilkins; 168-196
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Pathology & ECG
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Diagnosis of Acute MI STEMI / NSTEMI
At least 2 of the following
Ischemic symptoms
Diagnostic ECG changes
Serum cardiac marker elevations Time is muscle
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Pemeriksaan Penunjang
1. EKG2. Enzim jantung
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ECG assessment
ST Elevation or new LBBBST Elevation or new LBBBSTEMISTEMI
Non-specific ECGNon-specific ECGUnstable AnginaUnstable Angina
ST Depression or dynamicST Depression or dynamicT wave inversionsT wave inversions
NSTEMINSTEMI
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Diagnosis Banding
1. perikarditis akut2. Emboli paru3. Diseksi aorta akut4. Kostokondritis5. Gangguan gastrointestinal
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Acute Management
Initial evaluation & stabilization
Efficient risk stratification
Focused cardiac care
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Chest pain suggestive of ischemia
12 lead ECG Obtain initial
cardiac enzymes electrolytes, cbc
lipids, bun/cr, glucose, coags
CXR
Immediate assessment within 10 Minutes
Establish Establish diagnosisdiagnosis
Read ECGRead ECG Identify Identify
complicationcomplicationss
Assess for Assess for reperfusionreperfusion
Initial labsInitial labsand testsand tests
Emergent Emergent carecare
History & History & PhysicalPhysical
IV accessIV access Cardiac Cardiac
monitoringmonitoring OxygenOxygen AspirinAspirin NitratesNitrates
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Focused History Aid in diagnosis
and rule out other causes
Palliative/Provocative factors
Quality of discomfort Radiation Symptoms
associated with discomfort
Cardiac risk factors Past medical history
-especially cardiac
Reperfusion questions
Timing of presentation
ECG c/w STEMI Contraindication
to fibrinolysis Degree of STEMI
risk
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Terapi
Aspirin 150-300 mg Clopidogrel 300 mg Oksigen 2-4 L Nitrat sublingual Morfin 2-5 mg intravena Penilaian dan stabilisasi hemodinamik Monitoring EKG Nilai kemunkinan reperfusi (fibrinolitik
atau PCI Primer)
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Komplikasi
Aritmia Syok kardiogenik Edema paru akut Perikarditis
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Prognosis
Killip TIMI Risk
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DATA PRIBADI
Nama pasien : Tn. N. Pasaribu Umur : 49 Tahun Jenis kelamin : Laki-Laki Pekerjaan : Wiraswata Alamat : Desa Simorangkir Agama : Kristen Tanggal Masuk : 15 April 2011 Berat badan : 95 kg ; Tinggi badan :
176 cm
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ANAMNESA KeluhanUtama : Nyeri dada Anamnese :
hal ini dialami pasien sejak 2 hari sebelum masuk rumah sakit. Nyeri seperti terbakar di dada kiri dan menjalar ke rahang bawah. Awalnya nyeri dirasakan setelah pasien berkebun. Nyeri tersebut tidak berkurang dengan beristirahat. Keringat dingin tidak dijumpai. Pasien mengeluh mual selama serangan, mual (-). Setelah 4 jam os merasakan nyeri yang terus-menerus, os berobat ke praktek dokter umum di Tarutung, dan os dinyatakan menderita sakit jantung. Os diberikan ISDN oleh dokter di Tarutung tersebut dan kemudian os dirujuk ke RS di Medan. Nyeri dirasakan sedikit berkurang setelah diberi ISDN. Kemudian os berobat ke praktek dr. P. ManikSp.JP(K) dan oleh dokter tersebut os dirujuk ke RS HAM. Saat tiba di UGD RS HAM, pasien masih mengeluhkan nyeri di dada kirinya. Riwayat sesak nafas, jantung berdebar, kaki bengkak, pingsan, dan batuk tidak ditemui.
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Riwayat merokok dijumpai sejak kira-kira 25 tahun lalu, setengah bungkus per hari. Os sudah 8 tahun terakhir berhenti merokok. Konsumsi alkohol dan tuak dijumpai. Os menderita sakit asam urat selama 5 tahun ini
Faktor resiko PJK : laki-laki, obesitas, ex-smoker, DM (-), hipertensi (-), riwayat PJK dalam keluarga (-)
Riwayat Penyakit Terdahulu : asam urat Riwayat Pemakaian Obat : Tidak jelas
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PEMERIKSAAN FISIK
KeadaanUmum : lemahStatus present : CMTD : 100/60 mmHgHR : 85 x/iRR : 24x/i
Temp : 36,5ºC
Anemia (-)
Sianosis(-)
Ikterus(-)
Dyspnoe(-)
Edema(-)
Ortopnoe(-)
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Kepala: mata :konjungtivapalpebra inferior pucat (-/-), sclera ikterik (-/-), RC (+/+) pupil isokor ka=ki
Leher : JVP R+2 cmH2O Thorax :
Inspeksi : Simetrisfusiformis Palpasi: SF ka = ki, kesannormal Perkusi : sonordikedualapanganparu Auskultasi : vesikuler
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Jantung: Batas atas :ICS III sinistraBatas kanan:Linea sternalisdextra ICS VBatas kiri :1cm medial LMCS ICS V
S1 (N), S2 (N), S3 (-), S4 (-) Regulitas: reguler Murmur - Punctum maximum : -Radiasi: -
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Paru: SP : vesikulerST :Rongkibasah(-)
wheezing (-)
Abdomen: Palpasi: soepel H/L/R : tidakterabapembesaran Asites: (-)
Ekstremitas : Superior : sianosis (-), clubbing finger (-) Inferior : oedemapretibial (-), pulsasiarteri
(+/+), akralhangat
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Interpretasi EKGEKG TARUTUNG
SR, QRS rate 79x, QRS axis : normo axis, P wave (+) normal, PR interval 0.16”, QRS duration 0,08, ST elevasi : III, AVF; Q path. : - , T inverted -, LVH -, RVH -, VES –
Kesan : SR + STEMI inferior
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INTERPRETASI EKGEKG RS HAM (CVCU)
SR, QRS rate 64x, QRS axis : normo axis, P wave (+) normal, PR interval 0.16”, QRS duration 0,08, ST elevasi : III, AVF; Q path. : III, AVF T inverted II, III, AVF; LVH -, RVH -
Kesan : SR + STEMI inferior
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INTERPRETASI FOTO THORAX
CTR: 50%, Segemen Aorta danpulmonal : Normal, , PinggangJantung : (-), Apex downward, Kongesti (+), Infiltrat (-).
KESAN : normal
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HASIL LABORATORIUM
DarahLengkap : Hb : 17 g %
Eritrosit : 5, 92 x 106/mm3
Leukosit : 14,4 x 103/mm3
Hematokrit : 52,9 % Trombosit : 223 x 103/mm3
AGDA : pH : 7,425 pCO2 : 32,1 mmHg pO2 : 108,9 mmHg HCO3 : 21,3 mmol/L Total CO2 : 21,5 mmol/L BE : -2,6 mmol/L SaO2 : 98,2%
FaalHati SGOT : 130 U/L SGPT : 46 U/L
Troponin– T : 1,8
CK-NAC :805
CK-MB :77
Glukosadarahsewaktu : 142 mg/dL
Ginjal Ureum : 36 mg/dL Kreatinin : 0,72 mg/dL
Elektrolitserum Natrium (Na) : 127
mEq/L Kalium (K) : 4,8 mEq/L Klorida (Cl) : 111 mEq/L
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DIAGNOSADiagnosis kerja:
STEMI inferior onset 2 harikillip I TIMI risk 2/14
Fungsional : KILLIP I Anatomi: Right Coronary Artery Etiologi:arterosklerosis
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PENGOBATAN Bedrestsemifowler O2 2-4 L/I Inj.enoxaparin0,6 cc/12
jam (5 hari) Clopidogrel 4x75mg,
selanjutnya 1x 75 mg Aspilet2x80mg,
selanjutya 1x 80 mg ISDN 3x5mg Simvastatin 1x40mg Captopril3x6,25mg Morfin 2,5 mg IV
RENCANA PEMERIKSAAN SELANJUTNYA
Lipid profile Angiografikoroner
PROGNOSIS
Vitam : dubia ad bonam
Functionam : dubia ad bonam
Sanactionam: dubia ad bonam
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FOLLOW UP EKG 13 April 2011 (RS TARUTUNG)
SR, QRS rate 79x, QRS axis : normo axis, P wave (+) normal, PR interval 0.16”, QRS duration 0,08, ST elevasi : III, AVF; Q path. : - , T inverted -, LVH -, RVH -, VES –
Kesan: SR + STEMI inferior 15 April 2011 (IGD RS HAM, Pukul 18.11)
SR, QRS rate 69x, QRS axis : normo axis, P wave (+) normal, PR interval 0.16”, QRS duration 0,08, ST elevasi : III, AVF; Q path. : III, AVF , T inverted II, III, AVF ;LVH -, RVH -, VES –
Kesan: SR + STEMI inferior 15 April 2011 (CVCU, Pukul 19.00)
SR, QRS rate 64x, QRS axis : normo axis, P wave (+) normal, PR interval 0.16”, QRS duration 0,08, ST elevasi : III, AVF; Q path. : III, AVF T inverted II, III, AVF; LVH -, RVH -,VES-
Kesan: SR + STEMI inferior
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16 April 2011 (Ruangan, Pukul 05.15)SR, QRS rate 63x, QRS axis : normo axis, P wave (+) normal, PR interval 0.16”, QRS duration 0,08, ST elevasi : III, AVF; Q path. : III, AVF; T inverted II, III, AVF; LVH -, RVH -,VES-
Kesan : SR + STEMI inferior 18 April 2011 (Ruangan, Pukul 07.00)
SR, QRS rate 73x, QRS axis : normo axis, P wave (+) normal, PR interval 0.2”, QRS duration 0,08, ST elevasi : (-); Q path. : III , T inverted II, III, AVF; LVH -, RVH -, VES –
Kesan : SR + STEMI inferior
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TERIMA KASIH