(souvenir) chascon 2020 · 2020. 12. 19. · chascon 2020 1 (souvenir) chascon 2020 “science and...

CHASCON 2020

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(Souvenir)

CHASCON 2020 “Science and Technology Innovations”

USHERING IN THE ERA OF MAKE IN INDIA

14th CHANDIGARH SCIENCE CONGRESS (ONLINE MODE)

17-19 DECEMBER, 2020

ORGANISED BY

PANJAB UNIVERSITY, CHANDIGARH

In Association with

CHANDIGARH REGION INNOVATION AND KNOWLEDGE CLUSTER

(CRIKC)

chascon.puchd.ac.in [email protected]

mailto:[email protected]

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TEAM CHASCON WELCOMES

YOU TO E-SOUVENIR OF

CHASCON-2020

Patron:

Prof. Raj Kumar

Vice Chancellor

Panjab University, Chandigarh

Website: chascon.puchd.ac.in

Email: [email protected]

Coordinator

Prof. Desh Deepak Singh

Professor, Department of

Biotechnology

Panjab University

Sector-25, Chandigarh-160014


Co-Coordinator

Prof. Sandeep Sahijpal,

Professor, Department of

Physics, Panjab University

Sector-14, Chandigarh-160014


mailto:[email protected]:[email protected]

CONTENTS

TITLE PAGE NUMBER

About CHASCON 4

About Panjab university 4

About CRIKC 5

Organizing committee 6

Team Chascon 2020 7

Messages 8

Speakers (Abstract of Talks) 17

Scientific Sessions

38

o Pharmaceutical Sciences 44

o Physical Sciences 72

o Mathematical Sciences 105

o Engineering and Management Sciences 123

o Life Sciences 141

o Earth and Environmental Sciences 170

o Basic Medical Sciences and Dental Sciences 196

o Chemical Sciences 238

Sessions: Panel Discussion 262

Acknowledgements 263

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ABOUT CHASCON 2020

Panjab University, Chandigarh in association with Chandigarh Region Innovation and Knowledge

Cluster (CRIKC) is organizing Chandigarh Science Congress (CHASCON-2020)- ONLINE MODE

from December 17th to 19th 2020 on the theme “Science and Technology Innovations: Ushering in

the era of Make in India” realizing that science and technology are the key elements in the

economic growth of Modern India.

Panjab University along with the CRIKC institutions has been organizing CHASCON every year

since 2007. The Congress has come a long way and continues to encourage the young and

innovative minds by providing them with a suitable platform for interaction with researchers,

academicians and industry leaders from all over the country. Several eminent scientists and experts

from various fields are expected participate and deliberate on the theme. The technical sessions will

comprise of plenary lectures, oral and poster presentations.

The 14th Chandigarh Science Congress would be an event to rejoice science and technology and

would showcase for what is being done and can be done in Chandigarh region to define the future

India.

ABOUT PANJAB UNIVERSITY

Panjab University (PU), established in 1882 at Lahore (Now in Pakistan) was shifted to

independent India in 1947. It is one of the four universities established in India before partition by

the then Federal Government. In 1956, PU shifted to Chandigarh and in 1966, after re-organization

of Punjab and was made as an Inter State Body Corporate under the Act of Parliament. PU is

imparting education to over 2.5 lakh students through its 78 teaching and research departments

located on the twin campus at Chandigarh and through 195 affiliated/constituent colleges spread

over Punjab and Chandigarh besides 4 Regional centers at Mukatsar, Ludhiana, Hoshiarpur and

Kauni.

PU has a long tradition of pursuing excellence in teaching and research in Science & Technology,

humanities, social sciences, performing arts and sports. By virtue of its history, experience,

achievements, and philosophy, PU has a national character and it enjoys an international stature

drawing both the faculty and students from all over the country and different parts of the globe. PU

faculty includes some of the most distinguished scientists and academicians. Over the years, the

reputation of the PU has grown to emerge as an institution at the pinnacle in innovative teaching,

research and community outreach. Its alumni include two former Prime Ministers and several past

and present cabinet ministers of the country, two Noble Laureates, a large number of Fellows of

various Academies, both in Science and Social Science, Theatre Artists, Actors. There is hardly any

sphere where the university has not made its mark. The university is ranked amongst the top

Universities in India and Internationally by various agencies/bodies.

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ABOUT CHANDIGARH REGION INNOVATION AND KNOWLEDGE

CLUSTER (CRICK)

Initiated by PU, the institutions in Chandigarh region called for the creation of Knowledge Cluster

in 2012, named as Chandigarh Region Innovation and Knowledge Cluster (crikc.puchd.ac.in) with

a view to expand technological innovations by close collaboration of academia and the private and

government sectors using accumulated knowledge. The ecosystem is expected to expand its

technological innovations in Chandigarh region on a global level. At present CRIKC has thirty

institutions from the region that are collaborating in various areas of National and Global priority.

The Govt. of India has recently recognized CRIKC model and is planning to create similar

knowledge

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ORGANIZING COMMITTEE

Chief Patron

▪ Prof. Raj Kumar

Vice Chancellor, Panjab University, Chandigarh

Advisory Committee

▪ Professor R K Singla, Dean University Instructions, Panjab

University (PU)

▪ Professor VR Sinha, Dean Research, PU

▪ Professor Prince Sharma, Dean Faculty of Science, PU

Organizing committee

▪ Professor Bhupinder Singh Bhoop, UIPS, PU

▪ Professor SK Tomar, Mathematics Department, PU

▪ Professor Rajat Sandhir, Biochemistry Department, PU

▪ Professor Archana Bhatnagar, Biochemistry Department, PU

▪ Dr. Ganga Ram Chaudhary, Chemistry Department, PU

▪ Professor Daizy Batish, Botany Department, PU

▪ Dr. Rohit Sharma, Microbial Biotechnology, PU

▪ Professor Desh Deepak Singh, Biotechnology Department, PU (Coordinator)

▪ Professor Sandeep Sahijpal, Physics Department, (Co-coordinator)

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Team CHASCON 2020

COMMITTEES NAMES

STUDENT

COORDINATOR

Manmehar Kaur

REGISTRATION COMMITTEE

1.

2.

3.

4.

5.

6.

Divyanshu Bansal

Maitri

Riya Sharma

Vasudha Sharma

Drishti Moudgil

Harshita

SOUVENIR

1.

2.

3.

4.

5.

6.

Riya Rani

Janvi

Pallavi

Eshita Jain

Harshita

Gurleen Kaur

CERTIFICATE COMMITTEE

1.

2.

3.

4.

5.

6.

7.

Pulkit Sharma

Magnolia

Akanksha Nayyar

Varinda

Prabhnoor

Gautam Pandey

Brinder

ORATION COORDINATORS

1.

2.

3.

4.

5.

6.

7.

8.

Lovepreet Singh

Manmeher Kaur

Pooja Aggarwal

Mahima Arora

Harshita

Amandeep Singh

Nimisha Raina

Richika Arora

SESSION COORDINATORS

1.

2.

3.

4.

5.

6.

7.

Gurleen Kaur (Basic Medical Science and Dental Science)

Nimisha Raina (Life Sciences)

Maitri (Pharmaceutical Sciences and Earth and Environment

Sciences)

Pooja Aggarwal (Chemical Sciences)

Aman Murari (Physical Sciences)

Akanksha Nayyar (Mathematical Sciences)

Hrishika Raj (Engineering and Management Sciences)

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MESSAGES

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MESSAGE

Dear Colleagues

It is with great pleasure that I greet you on behalf of the Chandigarh Science Congress on

December 17-19, 2020 at Panjab University, Chandigarh in collaboration with Chandigarh Region

Innovation and Knowledge cluster (CRIKC). This year we came up with the theme: ““Science and

Technology Innovations: Ushering in the era of Make in India”.

Following its tradition, this year the congress again offers a wide range of highly interactive

sessions on the role of start-ups and New Education Policy (NEP) in creating environment for

innovations and further to discuss the related issues. This congress is a wonderful opportunity to not

only educate students and young researchers but also deepen understanding of changing ideas and

innovative methods of problem solving. We also expect to provide technical demonstrations, and

numerous opportunities for informal networking.

I am convinced that this is an excellent event for professionals that will allow you to learn many

new things as well as share your experience. See you at Chandigarh Science Congress!!!

Professor Ravinder Kumar Singla

Prof. Ravinder Kumar Singla

Dean University Instructions


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MESSAGE

It is a matter of immense pleasure and pride that Panjab University (PU) in association with

Chandigarh Region Innovation and Knowledge Cluster (CRIKC) is hosting the Fourteenth

Chandigarh Science Congress from December 17-19, 2020 through online mode on the topic:

“Science and Technology Innovations: Ushering in the era of Make in India”. Several eminent scientists and experts from various fields will participate and deliberate on the

theme. Such Conferences provides jovial environment for the academicians and research scholars to

present their work and exchange their views and ideas with the fellow researchers. I am sure that

this conference will also ignite the young minds for innovation and motivate them to work towards

making country self sufficient and self reliant.

I take this opportunity to congrats the organizing team of CHASCON and CRIKC institutions for

making this Fourteenth Chandigarh Science Congress possible, despite this unprecedented situation

due to COVID-19.

I extend my best wishes for the success of the conference.

Professor V R Sinha

Professor V R Sinha

Dean Research

Panjab University

https://en.wikipedia.org/wiki/Panjab_Universityhttps://creativecommons.org/licenses/by-sa/3.0/

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MESSAGE

CHASCON (Chandigarh Science Congress) unequivocally has become the face of Panjab

University’s scientific academia. Since its inception, CHASCON has grown from strength to

strength and has blossomed from regional to national to international event hosting academic

luminaries from across the globe. CHASCON-2020, an three days event from Dec.17-19, has been

aptly titled in line with the Honorable Prime Minister’s wishes to make India an “Atamnirbhar”

country through science and technology innovations and is believed to encompass academic

sessions for all walks of science, including “Start-Up and Entrepreneurs” and “COVID-19

Vaccines” and “New Education Policy”. This year’s CHASCON is being organized online, one of

the positive fallouts of Covid-19 pandemic, and is being endeavored as a “NO PENNY SPENT”

event.

I wish CHASCON-2020 a great success.

Prof. Prince Sharma

Prof. Prince Sharma Dean Faculty of Science Panjab University

https://en.wikipedia.org/wiki/Panjab_Universityhttps://creativecommons.org/licenses/by-sa/3.0/

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Prof. S.K. Mehta

Coordinator, CRIKC

Professor, Chemistry

Department, Panjab University

MESSAGE

On behalf of Chandigarh Region Innovation and Knowledge Cluster (CRIKC), It gives us immense

pleasure to extend our warm greetings to you all for hosting the 14th Chandigarh Science Congress

(CHASCON-2020) being held at Panjab University during 17-19th December, 2020. Ever since its

inception in 2013, CRIKC has been closely associated in taking the CHASCON agenda forward. It

needs to be mentioned that CHASCON aims and objectives are very much in sync with the CRIKC

objectives. Briefly the essential motto of CRICK is to foster and sustain close academic alliances

between institutions of higher education and research in the Chandigarh region, to facilitate

innovation and knowledge creation. Broadly speaking this is also the underlying objective of

holding CHASCON by Panjab University every year since 2007.

We are happy to note that CHASCON is an important event to promote the exchange of

knowledge, innovations and experiences for future developments of technologies in industrial

applications that address societal needs. The intensive deliberations during CHASCON would be

quite helpful in providing the researchers with the concepts and methods to plan, conduct, and

organize research activities. This will also an opportunity for young researchers to interact with the

renowned experts on a one to one basis, to clarify their doubts and questions leading to a healthy

interactive sessions. It also provides a very good opportunity to large number of researchers to

showcase their research activities, besides promoting interactions amongst the scholars from

different institutions of the region.

The 14th Chandigarh Science Congress entitled,’ Science and Technology Innovations:

Ushering in the era of Make in India’ is very much in accordance with our national priorities.

We are sure that the congress would bring large number of researchers from CRIKC

institutions on a common platform to take innovations in science and technology for the

benefit of our country. On the occasion, we would like to extend our best wishes to the organizers

as well as all the participants of CHASCON for grand success of the event.

Prof. S.K. Mehta and Prof. M.M. Gupta

Coordinators, CRIKC

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SPEAKERS

(ABSTRACT OF TALKS)

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Indian Planetary Missions

Abstract

The planetary exploration program in India started with the Chandrayaan-1 orbiter mission to the

Moon in 2008. This was followed by a mission to Mars, the Mars Orbiter Mission (MOM),

launched in November 2013 and arrival on Mars in September 2014. The second India mission to

Moon is the ongoing Chandrayaan-2 mission. India also has a planned mission to study Sun from

the L1 vantage-point called the Aditya-L1, as well as future planetary missions. This talk will

briefly discuss the Indian planetary missions, related challenges, and highlight the science derived

from them.

Dr. Anil Bhardwaj

FNA, FASc, FNASc

J. C. Bose National Fellow

Director, Physical Research

Laboratory, Ahmedabad


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Professor Amulya K Panda a leading expert in field of vaccine development in the country will talk

on challenges in vaccine development and way forward.

Professor Amulya K Panda

Director, National Institute of

Immunology, New Delhi


Challenges in Development of Vaccines


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ADVANCES IN CHEMICALTECHNOLOGY and CHEMICAL

ENGINEERING

Abstract

Chemical Industry is highly science based and has always been evolving. Catalytic Transformations

have brought out dramatic changes, starting with the synthesis of ammonia and have fetched many

Nobel Prizes. Some examples are ethylene to ethylene oxide, propylene to propylene oxide with

hydrogen peroxide, n-butane to maleic-anhydride, cat-cracking, platforming, etc. More recent

examples are metathesis, asymmetric synthesis, etc. Separation Technology has witnessed major

advances with the advent of Pressure Swing Adsorption, Chiral Engineering, Membrane

separations, including nano-filtration, Reactive Distillation/Extraction, Divided Wall Columns, etc.

Bio-transformations will make a major impact, particularly through Directed Evolution, and a

reference can be made for many intermediates for APIs and even vanillin, substitute for sandal

wood oil, etc. New Technologies will emerge to exploit renewable raw materials, including lignin

and renewable energy, etc. The future of the essential Chemical Industry is very bright and

celebrates science behind these ventures

Professor MM Sharma, FRS

Emeritus Professor of Eminence

Institute of Chemical Technology,

Mumbai


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Impact of Carbohydrate Science in Innovation Niches

Abstract

The important chemical, biological and materials properties inherent in carbohydrates provide

immense wealth to value additions arising from these naturally-occurring biomolecules. Many

frozen technological advancements of carbohydrates rely on their structural properties and energy

storage capacities, glaring examples of which are the cellulose fibres and food starches,

respectively. Atomic view of these chemical entities will also reveal their fine constitutions and

these fine constitutions are rich source to unravel multitude of biological roles that sugars are

involved with in the maintenance and sustenance of life. Innovation niches are thus clear

possibilities arising from varied roles and properties of carbohydrates. Innovation niches pertaining

to healthcare, energy production and evolution of new materials are abound when utilizing

carbohydrates in general. Water-resistant cellulosic fibre and a paper resulting from thereof,

vaccine development and drug repositioning are some of the illustrative innovation niches. Many

innovative niches are in offing at scientific and technological frontiers. The lecture will endeavour

into bringing out some of the innovative niches arising from the science of carbohydrates.

Professor N. Jayaraman

Department of Organic Chemistry

Indian Institute of Science,

Bangalore 560 012


[email protected]

mailto:[email protected]:[email protected]

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Immunogen design for a COVID-19 vaccine

Abstract

An affordable, efficacious vaccine against SARS-CoV-2, the causative agent of the ongoing

COVID-19 pandemic is essential to curb infections and minimize disease spread. Neutralizing

antibodies that prevent viral entry into host cells are currently the clearest correlate of protection

and are largely directed against the Receptor Binding Domain of the viral Spike protein. Most

current vaccines in clinical testing require low temperature storage, a major impediment to

widespread deployment. We describe a highly expressed, thermotolerant Receptor Binding Protein

derivative that induces titers of neutralizing antibodies well above those required for protection in

animal challenge studies, and higher than several vaccine candidates currently in clinical trials.

Such a subunit vaccine formulation holds great potential to combat COVID-19.

Professor Raghavan Varadarajan,

Molecular Biophysics Unit

Indian Institute of Science Bangalore



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Sustainability and Drug Discovery and Development: Bridging the Gap

Abstract

Chemistry holds the centre stage of the drug discovery and development program.1 It is inherently

implied that the development of modern chemistry needs to be well integrated to the various facets

of drug discovery and development. In the context of modern development of chemistry addressing

sustainability is the key indicator leading to the cultural change under the slogan of green

chemistry. To keep pace with the modern developments in chemicals research and cope up with the

necessity of sustainable development2it is pertinent to continue to enrich medicinal chemists’

synthetic tool box.3The inadequate implementation of the modern developments of synthetic

methodologies in practicing medicinal chemistry4has been of concern and much talked about topic

due to its otherwise negative impact on new drug discovery narrowing down the chemical space

and hencelimitingthe IP (Intellectual Property) space as well. These indicate the necessity to bridge

the gap of modern chemistry development and the practices in new drug discovery for sustainable

medicinal chemistry research.5Towards this endeavour the present would showcase a few case

studies of sustainable approaches integrating the recent development of synthetic methodologies6 to

generate7and optimize8new therapeutic leads as well as new processes9of therapeutic agents.

References: 1. M. MacCoss, T. A. Baillie, Science, 2004, 303, 1810.

2. P. Tundo, P. Anastas, D. S. Black, J. Breen, T. Collins, S. Memoli, J. Miyamoto, M. Polyakoff, W.

Tumas, Pure Appl. Chem. 2000, 72, 1207.

3. S. D. Roughley, A. M. Jordan, J. Med. Chem. 2011, 54, 3451.

4. D. G. Brown, J. Boström, J. Med. Chem. 2016, 59, 4443.

5. M. C. Bryan, B. Dillon, L. G. Hamann, G. J. Hughes, M. E. Kopach,E. A. Peterson, M.Pourashraf, I.

Raheem, P. Richardson, D. Richter, H. F. Sneddon, J. Med. Chem. 2013, 56, 6007.

6. S. V. Chankeshwara, A. K. Chakraborti, Org. Lett. 2006, 8, 3259. G. L. Khatik, R. Kumar, A. K.

Chakraborti, Org. Lett. 2006, 8, 2433.A. K. Chakraborti, S. Rudrawar, K. B. Jadhav, G. Kaur, S. V.

Professor Asit K. Chakraborti

Department of Chemistry,

S. S. Bhatnagar Block, Main Campus,

Indian Institute of Technology-Ropar,

Rupnagar, Punjab 140001, India

Email: [email protected],


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Chankeshwara, Green Chem. 2007, 9, 1335. N. Parikh, D. Kumar, S. Raha Roy, A. K. Chakraborti,

Chem. Commun. 2011, 47, 1797.

7. K. Seth, S. K. Garg, R. Kumar, P. Purohit, V. S. Meena, R. Goyal, U. C. Banerjee, A. K.

Chakraborti,ACS Med. Chem. Lett. 2014, 5, 512.P. Shah, T. M. Dhameliya, R. Bansal, M. Nautiyal, D.

N. Kommi, P. S. Jadhavar, J. Padma Sridevi, P. Yogeeswari, D. Sriram, A. K. Chakraborti, Med. Chem.

Commun. 2014, 5, 1489.S. Pancholia, T. M. Dhameliya, P. Shah, P. S. Jadhavar, J. Padma Sridevi, P.

Yogeshwari, D. Sriram, A. K. Chakraborti, Eur. J. Med. Chem. 2016, 116, 187. T. M. Dhameliya, R.

Tiwari, A. Banerjee, S. Pancholia, D. Sriram, D. Panda, A. K. Chakraborti, Eur. J. Med. Chem. 2018,

155, 364.

8. K. Seth, P. Purohit, A. K. Chakraborti, Org. Lett.2014, 16, 2334; P. Purohit, K. Seth, A. Kumar, A. K.

Chakraborti, ACS Catal. 2017, 5, 2452.B. V. Pipaliya, A. K. Chakraborti, J. Org. Chem.2017, 82, 3767.

9. D. N. Kommi, D. Kumar, K. Seth, A. K. Chakraborti, Org. Lett.2013, 15, 1158. D. N. Kommi, D.

Kumar, A. K. Chakraborti, Green Chem. 2013, 15, 767.K. Seth, S. Raha Roy, B. V. Pipaliya, A. K.

Chakraborti, Chem. Commun. 2013, 49, 5886

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NMR approach to investigate glycan structure and function

Yoshiki Yamaguchi

Yoshiki Yamaguchi, Ph.D.

Laboratory of Pharmaceutical Physical Chemistry

Tohoku Medical and Pharmaceutical University

Address: 4-4-1 Komatsushima, Aoba-ku, Sendai,

Miyagi 981-8558, Japan


Abstract

Glycans are highly diverse and the structural complexity has a great potential to work as signalling

molecule or functional modulator in biomolecular network system. To figure out the functional role

of each glycan, we believe structural glycobiology approach will play a significant role. Especially,

solution NMR spectroscopy is the only method to provide structure and dynamics of biomolecules

in solution at atomic level. We have developed an NMR method to analyse the structure and

dynamics of immunoglobulin G as a model glycoprotein (1) and the study is now expanded to

analyse glycan-lectin interaction (2) and glycolipid (3). I will present some of our activities working

on glycan structure and function by solution NMR.

(References)

1. Kato K, Yamaguchi Y, Arata Y. Stable-isotope-assisted NMR approaches to glycoproteins using

immunoglobulin G as a model system. Prog. NMR Spect. 56, 346-59 (2010)

2. Nagae M, Yamaguchi Y. Sugar recognition and protein-protein interaction of mammalian lectins

conferring diverse functions. Curr. Opin. Struct. Biol. 34, 108-15 (2015)

3. Kanie and Yamaguchi et al. Structural analysis of a novel lipooligosaccharide (LOS) from

Rhodobacterazotoformans. Carbohydr. Res. 473, 104-114 (2019)


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Opportunities in Nanotechnology

Abstract

Since the invention of the semiconductor transistor in 1947, the phenomenal progress in electronics

systems is enabled by the transistor scaling in the micro to nano regime coupled with very large

scale to giga scale integration, driven by storage and compute applications. It is contemplated that

nanotechnology and heterogeneous integration must drive the Moore's law in future. In addition,

with the advancement in Nanotechnology, the stage is now set for future Nanosystems to be

equipped with massive sensory functions, specifically with biological and chemical sensors, going

beyond conventional compute and storage paradigm. I will also present two case studies from our

research:

(i) Biosensor systems for point of care diagnostics: the story of managing the sensing of multiple

analytes in blood and urine with an eventual goal to realize "Lab on Palm"

(ii) Gas sensor systems for environmental monitoring, breath analysis and hazardous gas leakage

detection, with an eventual goal to realize the "Electronic Nose"

With this backdrop, I will end my talk with some thoughts on future challenges in achieving highly

complex Nano enabled Systems.

Professor Navakanta Bhat

Centre for Nano Science and

Engineering (CeNSE), Indian

Institute of science Bangalore


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Ups and Downs in the Himalaya - using the ancient sedimentary record to

constrain Himalayan uplift and erosion

Abstract

The present-day bedrock geology of the Himalaya reflects the sum of its geological history of rock

formation and erosion, but an historical view of the evolution of the Himalaya requires us to infer

the previous history of rocks once deposited in the Himalaya but since eroded. This is challenging,

but is best addressed by looking at intervals of geological time that are widely represented both

across the orogen and laterally within it. The Neoproterozoic and Cambrian offers one such

interval, and is also represented in the Indian foreland basin and in outcrop on the cartoon itself.

This talk will present current understanding of the record of the northern India margin during that

interval and then consider when these rocks were uplifted and eroded, and how that might have

impacted global geochemical signatures many millions of years after these deposits themselves

formed.

Nigel Hughes

Dept. of Earth and Planetary Sciences

University of California, USA


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Structural biology of coronaviruses

Abstract

The first report on a novel virus infecting the upper respiratory track and causing common cold like

symptoms in humans appeared in 1965. Two years later, electron micrographs of the virus revealed

that the virus particles resembled distorted spheroids of 70-80 nm diameter. It was named

coronavirus based on the appearance of the spike proteins protruding from the virus particles. The

protein capsid of coronaviruses is constructed from four proteins, the spike protein, the envelop

protein, the membrane protein and the nucleic acid associated protein. The capsids are also

surrounded by a bilayer lipid membrane. The size of coronavirus is large compared to common

human viruses such as polio virus, the particles of which possess icosahedral symmetry and have

diameters of ~ 30 nm. Infection by a novel strain of coronavirus was recognized in 2003 in the

Guangdong province of China which caused severe infection of the human respiratory track. The

virus strain was named Severe Acute Respiratory Syndrome coronavirus (SARS-coronavirus). This

initiated intense work towards determining the three-dimensional structures of coronavirus genome

encoded proteins. Another strain of corona virus was found to cause widespread infection in Saudi

Arabia (Middle Eastern Respiratory Syndrome MERS-coronavirus) and many other Arabian

countries. The 2019 pandemic of SARS coronavirus, Covid-19, is unprecedented in its impact. This

has resulted in an unbelievable volume of research on coronavirus encoded proteins in a short span

of time. The work on the structural biology of coronaviruses will be briefly discussed in this

presentation.

M.R.N. Murthy; [email protected]; [email protected]

Professor MRN Murthy

Distinguished Professor and

Astra Zeneca Chair,

Institute of Bioinformatics

and Applied Biotechnology

Biotech Park, Electronic

City Phase I,

Bengaluru 560100,


mailto:[email protected]:[email protected]:[email protected]

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Clinical management of COVID and the way forward for innovation

Abstract

Covid pandemic struck the mankind as a bolt from blue. There was no preparedness in terms of

infrastructure, manpower, materials and human readiness to tackle this deadly disease. There were

not SOPs in the literature. The treatment and prevention guidelines changed almost on daily basis.

There was lot of panic amongst public as well as the health care workers.

As the first case of Covid positive with mild symptoms arrived in our hospital on 18th March, the

patient was treated in a private room. The SOPs were prepared by making a COVID care group so

that the patient is treated optimally as well as the disease is not spread to the relatives of the patients

as well as health care workers.

The protocols included round the clock monitoring of the patient in an isolation room, symptomatic

medicinal care, provision of proper diet, proper disposal of biomedical waste (BMW), sanitations of

the area at frequent intervals, provision of proper patient protective equipment (PPE) to health care

workers, education of the health care workers regularly, liaising with the administration regarding

reporting of the cases, contact tracing and quarantine of the family. The other tasks included setting

up and sprucing up the isolated ICU, starting of the testing lab, setting up of special operation

theatres, optimal management of air circulation/ air conditioning, running of the screening OPD,

restricting the entry points of the hospital so that patients with covid like symptoms can be traced,

Prof Ravi Gupta MS, FRCS, FACS, FAMS

(Medical Supdt);

Jyoti Kathwal PhD (Principal College of

Nursing),

Sonali Shamdasani DNB (Deputy Medical

Supdt)

Department of Hospital Administration,

GMCH Chandigarh



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procurement of PPEs, sanitizers, drugs etc, provision of diet and refreshments to the HCWs

working tirelessly.

Due to curfew/ lockdown many health care workers were not able to commute from their homes to

hospital. So, provision of transport with special curfew passes as well as provision of in-house

accommodation for HCWs by converting one private room wing of the hospital into temporary

accommodation area was done. Also, three floors of one hospital block were ear marked for covid

patients to avoid mixing of COVID-19 and non-COVID-19 patients.

Every day the meeting of COVID-19 care group was held from 10 am to 12 noon to review the

SOPs on the basis of experience of team members as well as on the basis of ever-changing

guidelines from the literature and the government.

In addition to the COVID-19 care, the routine emergency care was also provided to emergency

patients who could be potential source of spread of virus. Hence all precautions of Covid

prevention were incorporated into the routine non covid care of patients as well. As the number of

cases increased and more sick patients started coming in, a special 100 bedded covid hospital (for

critically ill patients) was established in south campus sector 48 where in the provision of ICU beds

and oxygen was made in a record time due to the active efforts of all team members of the hospital

as well as the engineering department.

With further increase in the spike of the disease, another 155 beds were created in GMCH for

critically ill patients (total 255 including south campus). During all this time, there was a great

whole hearted support from Chandigarh Administration as well as Government of India for

providing all kinds of logistic, material and financial support like provision of 55 ventilators, PPE

kits etc. The situation of covid care of the tricity was monitored on daily basis by Chandigarh

Administration through video conferencing.

Till now, in GMCH we tested a total number of RTPCR 21885, out of which 3481 were positive

and --- total number of RAT 8488 and 537 positives.

Total patients screened in screening OPD were 11690.

Total number of admissions in GMCH main campus were 3969, out of which 1892 were positive.

No. of COVID positive patients admitted in GMCH South Campus were 330, in Sood Dharmshala

(CCC) were 1650 and in Dhanwantry Hospital were 820.

CHASCON 2020

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Production of various microbial metabolites and use of enzymes and whole

cells for the process development

Production of various microbial metabolites and use of enzymes and whole cells

for the process development Uttam Chand Banerjee

Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education &

Research

Sector – 67, SAS Nagar – 160062, Punjab, India.

The fermentative product, rifamycin B is biologically inactive and needs

chemical/biochemical transformation. One of the soil isolates, Curvularia lunata, was found

to have rifamycin oxidase activity. The growth and production of enzyme was fully

optimized in shake flask as well as in Fermenter with the determination of various kinetic

parameters of biotransformation. We had optimized the growth and streptokinase production

by Streptococcus equisimilis in 150 L bioreactor having 100 L working volume in controlled

pH and temperature. A highly activity phytase has been isolated, bioprocess was optimized

and technology was transferred to industry. One of the soil isolates, Pseudomonas putida

was found to produce ADI with higher specific activity. Process parameters were completely

optimized for the growth and production of ADI by P. putida. The cell disruption processes

by various methods were optimized and ultimately ADI was purified. Growth and production

of mycophenolic acid by Penicillium brevicompactum, growth and production of Shikimic

acid by Bacillus megaterium, Tachrolimus by Pseudomonas sp. and interferon beta by

Professor UC Banerjee

Professor & Head,

Pharmaceutical Technology

In-charge Biotechnology, NIPER,

SAS Nagar



CHASCON 2020

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recombinant E. coli were optimized in 10 L laboratory scale reactor. It is known that

chirality plays an important role in the efficacy of many drugs and agrochemicals. Among

different enzymes used for biocatalytic reactions, lipases, nitrilase, nitrile hydratase, epoxide

hydrolase and oxidoreductases have found to have tremendous applications. Pseudomonas

aeruginosa lipase mediated kinetic resolution of (RS)-1-chloro-3-(3,4-difluoro phenoxy)-2-

propanol to enantiomerically pure (S)-alcohol for the synthesis of a drug, lubeluzole was

achieved in our laboratory. Nitrilases from Alcaligens faecalis was used for the

biotransformation of racemic mandelonitrile. Further the A. faecalis nitrilase has been cloned

into a vector pJOE2775 and transformed into E. coli JM109 cells. Nitrilases produced in the

recombinant E. coli JM109 has been purified and formed into cross-linked enzyme

aggregates (CLEAs). Enantiopure α-hydroxy acids especially (R)-(-)-mandelic acid is a key

intermediate for the synthesis of several pharmaceuticals. A number of carbonyl reductase

producing microorganisms were isolated and screened from the soil using acclimatization

technique. The (S)-selective microorganisms were tried for the bioreduction of complex

heteroaryl ketone. Candida viswanathii MTCC 5158 has been found to be capable of

carrying out enantioselective reduction of a number of prochiral aryl ketones like

acetophenone, acetonaphthone, acetyl pyridine, acetyl thiophene and N, N-dimethyl-3-keto-

3- (2-thienyl)-1-propanamine (DKTP). Among all the strains, Metschnikowia koreensis

(MTCC 5520), Candida viswanathii MTCC 5158, Geotrichum candidum, Candida

parapsilopsis, and Candida melibiosa were selected on the basis of their ability to carry out

the (S)-selective reduction of ketones.

CHASCON 2020

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Engineering Nanoelectronic Devices beyond the speed of conventional

Rectifiers

Abstract

Most efforts on graphene electronic devices have been made on graphene transistors. This is a very

challenging task and often requires generating a suitable bandgap in order to achieve a reasonable

on/off ratio while preserving the carrier mobility. In contrast to transistors, the functionality of

some types of diodes does not necessarily require a large bandgap. In particular, a nano-rectifier

known as the ballistic rectifier can greatly benefit from the extremely long carrier mean-free-path in

graphene while being not sensitive to the size of bandgap. Ballistic rectifier structures can be

fabricated by creating an asymmetric cross-junction in a single-layer graphene. A high mobility of

graphene ensures a mean-free-path well beyond that required for the device to operate in the

ballistic regime. This enables a very high intrinsic responsivity at room temperature. Taking

advantage of the four terminal device architecture in which the output channels are orthogonal to

the input channels, it is shown that the device noise is hardly influenced by the input and is mainly

limited by thermal noise, and this enables an exceptional noise-equivalent power in the order of

pW/Hz1/2 . High-frequency characterization and imaging experiments at hundreds of GHz have

also been carried out.

References

1. A. K. Singh, G. Auton, E. Hill, A. Song, Graphene based ballistic rectifiers, Carbon 84, 124,

2015.

2. G. Auton, J. Zhang, R. Kumar, H. Wang, X. Zhang, E. Hill and A. Song, Nature

Communications, 7, 11670, 2016

3. A. Garg, N. Jain, S. Kumar, S. R. Kasjoo, and A. K. Singh, Nanoscale Advances, 1(10), 4119,

2019.

4. A. K. Singh, S. R. Kasjoo, and A. M. Song, IEEE Trans. Nanotechnol., 13(3),527, 2014. 5. A.

Garg, N. Jain, and A. K. Singh, J. Comput. Electron., 17 (2), 562, 201

Dr. Arun Kumar Singh Dept. of

Electronics and Communication

Engineering, Punjab

Engineering College (Deemed to

be University, Chandigarh

(India)



CHASCON 2020

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Glycoimmunology: sugars on the fuss for improved

immunotherapies?

Abstract

The more we understand the immune responses, the more we ally it to specific glycan alterations,

and this has motivated the development of targeted immunotherapies. Our group has been

particularly interested in understanding how glycans expressed at the cell surface can interfere with

immunity. One of our interests has been the sialylated antigens, as sialyl Tn (STn) and sialyl Lewis

X. These are aberrantly expressed in several cancers and associated with aggressiveness and

immune tolerance. We developed novel antibodies which show high specificity against STn and its

derivatives, reacting with higher intensity to cancer tissue but not healthy tissues. These antibodies

are currently being explored for diagnostic purposes and have potential therapeutic applications.

Recently, it was found that SARS-CoV-2 infections also lead to aberrant expression of sialylated

glycans. These findings open an opportunity for re-purposing anti-tumour associated glycan based

therapies to fight viral infections.

In another perspective, we have inquiry patients/families with congenital disorder of glycosylation

for alteration in their immune responses. Our recent findings suggest that relevant immune

disfunction exist and relate to the disease aggressiveness.

In this talk, I will present an overview of the current ongoing project and latest results.

Paula Videira

Glycoimmunology Group @

UCIBIO

Departamento Ciências da Vida

Faculdade de Ciências e Tecnologia

Universidade Nova de Lisboa

2829-516 Caparica, Portugal


http://sites.fct.unl.pt/glycoimmunology/homemailto:[email protected]

CHASCON 2020

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Impact of Laser assistance on the accuracy of micro holes generated on

carbon reinforced composite using electrochemical discharge machining

Abstract

Electrochemical discharge machining (ECDM) is a prominent hybrid process for machining of

difficult to cut materials. In recent years, various research investigations have been attempted to

enhance the process capability of ECDM using further hybridization with ultrasonic, magnetic,

rotary assistance etc. In present work, an attempt has been made to enhance the process capability

of ECDM process by LASER assistance. The proposed technique explore the effect of LASER

assisted electrochemical discharge machining (LA-ECDM) on output quality characteristics such as

overcut and taper of hole. The purpose of low power LASER is assist the machining process by

localized heating of electrolyte. A comparative study has been performed between LA-ECDM and

ECDM process. Carbon fiber reinforced polymer composite was machined with four input process

parameters as tool diameter, tool travel rate, tool rotation and duty cycle. The investigation reveals

that overcut and taper of hole decreases approximately by 10–12 % with assistance of LASER. The

micro-hole machined by LA-ECDM exhibits superior machining quality in terms of circularity of

hole, dimensional accuracy and surface damages. SEM micrographs shows uniform distribution of

carbon fibers all along the machined surface. This improvement is attributed to formation of stable

and thinner gas film during machining. The behaviour of gas film and spark phenomenon during

ECDM and LA-ECDM has been investigated using high shutter speed camera.

Dr. Sarabjit Singh

Department of Mechanical

Engineering, Panjab Engineering

College, Chandigarh


CHASCON 2020

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Translation of Knowledge into Innovation

Abstract

Innovation is the main driver of modern economy. India ranks 48 in world ranking of global

innovation index. India is third amongst low middle-income group and is preceded by Vietnam (42)

and Ukraine (45). There is disparity in our ranking in Knowledge and creative output. India ranks

very high in terms of quality of scientific publications (21st globally) and the quality of its

universities (22nd) but ranks low in creative output (64). In creative output Vietnam is ranked at 38

and Ukraine at 44. From this it is obvious that having knowledge alone is not adequate. As a nation

we need to gear up in better translation of knowledge to innovation (Creative output). To translate

knowledge into innovation, there is a need for creative thinking and hard work. The process of

translating knowledge to innovation is not always successful. The failure rate is very high in

pharmaceutical innovation. In a talk fundamental of translating knowledge in to Innovation

successfully will be discussed. The journey of translating knowledge in to Innovative products will

be illustrated by three success stories in which author were involved:

1) K-M media for whole eye ball preservation: This allows preservation of whole eyeball using simple techniques and product. This was based on simple observation made by a

technician which led to knowledge creation and ultimately Innovation

2) Risorine for tuberculosis: This is based on a well-documented Ayurveda principal of enhancement of efficacy by TRIKTU. Further research using modern methods led to

piperine as a world’s first bio enhancer which when added to Rifampicin led to decreased

amount of rifampicin with improved safety profile and sustained bioavailability of

Rifampicin.

3) Sepsivac for gram negative sepsis and COVID-19 (Treatment and Prophylaxis): Sepsivac is an immunomodulator of Indian origin. Simple observation during its clinical development

led to exploration of its unique properties leading to its approval as an adjunct to gram

negative sepsis to reduce mortality. Looking at similarities between gram negative sepsis

and COVID-19 , it is being repurposed for COVID-19. Data suggest, Sepsivac is able to

a) provide prophylaxis against COVID-19 b) improve outcome in critically ill patients with covid-19. c) Modulated Platforms for Drug Delivery

Dr. Bakulesh Khamar

Executive Director,

Cadila Pharma, Ahmedabad


CHASCON 2020

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Modulated Platforms for Drug Delivery

Professor VR Sinha

Professor, UIPS, PU

Dean Research, Panjab University

Abstract

The delivery of drugs is a crucial factor in formulation development for the affective therapy. Most

of the formulations are for the immediate release of the drug. These formulations achieve quick

onset of action leading to rapid increase in the blood drug levels but having short duration of action.

This necessitates the multiple administrations to the drug resulting poor compliance in case of

chronic therapy. To overcome these limitations sustained release formulations were developed.

These systems provided multiple benefits viz. lower frequency of drug administration, extended

duration of action, lower side effects, improved patient convenience and compliance. First sustained

release formulation came in the market in year 1952. Further research was focused not only to

achieve extended release but also to control the release rate of the drug from the formulations.

Further targeting and site-specific delivery of the drug can reduce both the drug dose as well as

associated side effects. The modified release systems is utilized for delivery of drugs through

transdermal, buccal/sublingual, oral, parenteral, implantation, ocular, nasal pulmonary,

rectal/vaginal routes. Each route has its own advantages and limitations necessitating specific

design appropriate for delivery of the drug through the intended route of administration. Several

novel delivery systems which are in the market have been developed using several innovative

design, concept and modulation techniques for drug release. These modulated systems can

maximize therapeutic benefits.

CHASCON 2020

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SCIENTIFIC SESSIONS

CHASCON 2020

39

S.

No.

Section Departments/Centres/Institutes Section coordinator

1 Basic Medical

Sciences and Dental

sciences

o Biochemistry o Biophysics o Biotechnology o Microbiology o Microbial Biotechnology o Dental Science (HSJIDS) o Stem Cell & Tissue

Engineering

o Human Genome o Systems Biology &

Bioinformatics

o Nuclear Medicine o Public Health

• Professor Jagat Bhushan (Dental Science)

• Professor AS Naura (Biochemistry)

• Professor Gurparkash Singh Chahal (Dental Science)

2 Life Sciences o Botany o Zoology o Anthropology o Forensic Science

• Professor DaizyBatish (Botany)

• Professor Harpreet Kaur (Zoology)

3 Pharmaceutical

Sciences

o UIPS • Professor Alka Bali

• Dr. Neelima Dhingra 4 Chemical Sciences o Chemistry • Professor Gurjaspreet Singh

• Professor Rohit Kumar Sharma

(Chemistry)

5 Physical Sciences o Physics o Nanoscience &

Nanotechnology

o Medical Physics

• ProfessorVipin Bhatnagar

• Dr. Lokesh Kumar (Physics)

6 Mathematic sciences o Mathematics o Statistics o Computer Sciences

• Professor Dinesh Khurana (Mathematics)

7 Engineering and

Management Sciences

o Engineering & Technology (UIET)

o Chemical Engineering and Technology (UICET)

o Sophisticated Analytical Instrumentation Facility

o University Institute of Applied Management Sciences

o University Business School o University Institute of Hotel &

Tourism Management

o Fashion Technology and Vocational Development

• Professor Savita Gupta

• Dr. Madhu Khatri (UIET)

• Professor Sanjeev Sharma (UIAMS)

8 Earth and

Environmental

Sciences

o Geology o Geography o Environmental Sciences

• Professor Rajeev Patnaik (Geology)

CHASCON 2020

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Program for CHASCON-2020 (ONLINE MODE)

Day Program Title of Talk Time

17th December,

2020

(Thursday)

Inaugural function Prof. DD Singh,

Prof. Prince Sharma,

Prof. RK Singla, DUI, PU

Prof. Raj Kumar, Vice

Chancellor, PU

Chief Guest Lecture Prof.

Anil Bhardwaj, Director,

Physical Research Lab.

Ahmedabad

Program introduction

Lecture

Indian Planetary

missions

10-11.00 AM

Lecture

Prof. Amulya K Panda (Director, NII, New Delhi)

Challenges in

Development of

Vaccines'

11.00-11.45AM

Session

(Pandemics Covid-19)

Prof. MRN Murthy (Astra Zeneca Chair, IBAB,

Bangalore)

Prof. R Vardarajan (Molecular Biophysics Unit,

IISc, Bangalore)

Lunch

Prof. Ravi Gupta (Medical Superintendent,

Govt Medical College &

Hospital -32, Chandigarh)

Dr. Paula Videira Glycoimmunology Group @

UCIBIO, Departamento

Ciências da Vida, Faculdade

de Ciências e Tecnologia,

Universidade Nova de

Structural biology of

corona viruses

Immunogen design for

COVID vaccine

Clinical management of

COVID and the way

forward for innovation

Glycoimmunology:

sugars on the fuss for

improved

immunotherapies?

11.45-12.15PM

12.15-1.00PM

1.00-1.15 PM

1.15-2.00PM

2.00-2.45 PM

http://sites.fct.unl.pt/glycoimmunology/home

CHASCON 2020

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Lisboa, 2829-516

Caparica, Portugal

Session (Chemistry

and drug discovery)

Prof. Yoshiki

Yamaguchi (Tohoku Medical and

Pharmaceutical University,

Japan)

Prof. AK Chakraborti (Department of Chemistry,

Indian Institute of

Technology-Ropar)

Prof. N Jayaraman

(Organic Chemistry,

IISc, Bangalore

NMR approach to

investigate glycan

structure and function

Sustainability and Drug

Discovery and

Development: Bridging

the Gap

Impact of Carbohydrate

Science in Innovation

Niches)

2.45-3.30PM

3.30-4.15PM

4.15-5.00PM

Lecture

Professor M. M.

Sharma, (Emeritus Professor of

Eminence

Institute of Chemical

Technology, Mumbai)

Advances in Chemical

Technology and

Chemical Enginnering

5.00PM-5.45PM

Panel Discussion

Start ups (Coordinator

Dr. Rohit Sharma,

Panjab University,

Chandigarh)

Panel members: Dr.Rohit Sharma, Project Leader,

BioNEST, Panjab University,

Chandigarh

Dr.Ashutosh Pastor, Manager

Incubation, FITT, IIT, New

Delhi

Dr. Malay Dixit, CEO, Piscium

Health Sciences,Pvt.

Ltd.,Mumbai.

Dr.Anasuya Roy, Founder

CEO,Nanosafe Solutions Pvt.

Ltd., New Delhi

Ms. Pragati Aggarwal, i-TTO,FITT,

IIT, New Delhi

5.45 PM-6.45PM

CHASCON 2020

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Lecture

Prof. Nigel Hughes

(Dept. of Earth and

Planetary Sciences

University of California

Riverside)

Ups and Downs in the

Himalaya - using the

ancient sedimentary

record to constrain

Himalayan uplift and

erosion"

6.45 PM-7.30 PM

18th December,

2020 (Friday)

Scientific section

activities

E-posters, oral

presentations of selected

abstracts, subject specific

lectures

Full day activity

19th December,

2020(Saturday)

Session (Engineering

and Nano Science)

Prof. Navakant Bhatt (Centre for NanoScience and

Engineering (CeNSE), IISc,

Bangalore)

Prof. UC Banerjee (Department of

Pharmaceutical Technology,

NIPER, SAS Nagar, Panjab)

Dr. Arun Singh

(Deptt of Electroincs

and Instrumentation,

Panjab Engineering

College, Chandigarh)

Dr. Sarabjit Singh

(Department of

Mechanical

Engineering, Panjab

Engineering College,

Chandigarh)

Prof. VR Sinha

(Dean Research, Panjab

University)

Prof. SK Mehta, Prof.

MM Gupta, Panjab

Opportunities in

Nanotechnology

Production of various

microbial metabolites

and use of enzymes and

whole cells for the

process development

Engineering Nano

electronic devices beyond

the speed of conventional

rectifiers

Impact of Laser

assistance on the

accuracy of micro holes

generated on carbon

reinforced composite

using electrochemical

discharge machining

Modulated Platforms for

Drug Delivery

10.00AM-10.45AM

10.45-11.30AM

11.30AM-12.00PM

12.00 PM-12.30PM

12.30-1.00PM

1.00-1.30 PM

CHASCON 2020

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University, Chandigarh CRIKC activities

Lunch 1.30-2.00PM

Panel Discussion

NEP2020;Gearing

Science education for

Self Reliant India

(Coordinator Prof.

Latika Sharma, Panjab

University, Chandigarh)

Panelists:

Prof. Sarit Das Director

IIT Ropar

Prof. Ashok Srivastav

Dean/ Advisor SVSU

Prof. Vanana Patravale

ICT Mumbai

Prof. Prakash Babu

University Of Hyderabad

2.00PM-3.00PM

Valedictory function

Prof. VR Sinha, Dean

Research, Panjab

University

Dr. Bakulesh Khamar,

Executive Director,

Cadila Pharma,

Ahmedbad

Compilation of

proceedings

Overview

Translation of

Knowledge in to

Innovation

3.00-3.15 PM

3.15-4.00 PM

4.00-5.30PM

CHASCON 2020

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Pharmaceutical sciences

section

•University Institute of Pharmaceutical

Sciences

COORDINATORS:

Prof Alka Bali

Dr Neelima Dhingra

CHASCON 2020

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CHASCON 2020

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CHASCON 2020

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REGISTRANTS

Sr. No.

Name Affiliation

1. Harinder Kaur UIPS

2. Monica UIPS

3. Sruthi Laakshmi m SRM college of pharmacy, SRM institute of science and technology

4. SubhajitMandal SRM college of pharmacy, SRM institute of science and technology

5. Khushboo University Institute of Pharmaceutical Sciences, Panjab University

6. Dr. Poonam Arora chitkara college of pharmacy

7. Vivek p Chavda L. M college of pharmacy

8. Shamandeep Kaur National Institute of Pharmaceutical Education and Research, Mohali

9. Alisha Sachdeva UIPS, panjab university, Chandigarh

10. Abhay Uiet, Panjab University

11. Arpan Sharma Uiet, Panjab University

12. Laxmi Gharti UIPS, PU-CHd

13. Neelima Dhingra UIPS, PU-Chd

14. Dr Ashok KumarYadav University Institute of Pharmaceutical Sciences, Panjab University

15. Dr Sangeeta PilkhwalSah UIPS, PU-CHd

16. AmitaSarwal UIPS, Panjab University

17. Gurpreet Singh UIPS, Panjab University

18. VanditaKakkar UIPS, Panjab University

19. Parina Kumari University Institute of Pharmaceutical Sciences, Panjab University

CHASCON 2020

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ABSTRACT PARTICIPATION

Sr. No.

Name Institute Title

1. Sakshi UIPS Personalized Medicine: the new era

2. MansiPrashar UIPS Preparation and Characterization of

Norfloxacin Cocrystal

3. Harnoor Kaur UIPS 17a-aza-D-Homosteroids as 5alpha reductase inhibitors: synthesis and

characterization

4. Alka Kumari UIPS MAO inhibitors in contemporary treatment

of depression: current and future perspectives

5. Teenu UIPS QbD-enabled development of SLNs for Co-

delivery of sorafenib and crysin for improved biopharmaceutical performance

6. Nikhil Gupta LPU Jalandhar/Sunpharma Formation of sustained release mups

tablets of S (-) metoprolol succinate using wurster process

7. Preeti Shivalik college of pharmacy, Ropar

Nanoparticle drug delivery

8. B. Sivakumar UIPS Insilco docking studies of phytochemicals from adhatoda species against covid-19

target proteins

9. Ayush Jain Dr. H.S.J.I.D.S, Sec25, P.U,

Chandigarh Towards Building Indian Pharmaceutical

Empire

10. Shalini k Department of

pharmaceutical chemistry, SRM college of pharmacy

Antioxidant activity of Novel Polyherbal formulation for the Management of

Polycystic Ovarian Disease

11. Parul Sood

Department of Pharmaceutical Sciences

and Drug Research, Punjabi University, Patiala

Acute oral toxicity study of methanol extract of Morus alba L. (Moraceae) fruit

12. Mohit Kumar

Department of pharmaceutical sciences

and technology, MRSPTU, Bathinda

Transdermal patch formulation with combination of herbal and synthetic

compound for treatment of type-2 DM

CHASCON 2020

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13. Kalyani Kumari PGGCG- Sec-11 Chandigarh Effect of Oxytocin on the health of cattle.

14. Sheetal



Quality by design-based formulation of simvastatin loaded hydrogel sheet for

wound healing

15. ChakshuWalia DoPST, MRSPTU, Bathinda Bilayered nail lacquer of Itraconazole for

treatment of onchomycosis

16. DeekshaKumari DoPST, MRSPTU, Bathinda The Effect OfFABA Bean And Mung Bean

Starch On Tablet Properties: A Comparative Study Against Corn Starch

17. Sanjay Kant Dept of pharmaceutical

sciences technology, MRSPTU, Bathinda

Simultaneous estimation of Glipizide and ethanolic extract of MomordicaCharantia

with the help of simple HPLC method

18. Vinod Kumar Jaiswal

University Institute of Pharmaceutical Sciences,


Characterization of stress degradation products of azelastine hydrochloride by

employing LC-MS technique

19. Ranjot Kaur



Nebulized Surface-Active Lipid Particles of Ceftazidime Embedded into Microdroplets

for Site-Specific Delivery to Lungs

20. Pooja Singh UIPS, PU-Chd Development of validated stability

indicating methods (HPLC) of Ibrutinib

21. RipandeepKaur



Development, characterization and in vivo evaluation of choline analogue-based drug

delivery system of antimalarial drug

22. Deep Shikha Sharma Lovely Professional

University, Phagwara

Formulation of 5-Flurouracil loaded nanostructured lipid carriers for the management of diabetes retnopat

23. AkshitaJindal UIPS, Panjab University

Cocrystal of an antiulcer agent famotidine: a step towards modulation and

optimization of its biopharmaceutical properties

24. Prachi UIPS, Panjab University Cocrystal of mesalamine for enhancement

of its biopharmaceutical properties, utilizing supramolecular chemistry approach

CHASCON 2020

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E-POSTER PARTICIPATION

25. KabyaPratap royal UIAMS Panjab University Traditional plants and their

phytoconstituents for prevents and disease management; Influenza and COVID19.

26. Dr. Harpreet Kaur UIPS, Panjab University

Improving The Physicochemical &Biopharmaceutical Parameters Of 5-Flurouracil Using Crystal Engineering

Approach

27. Abhishek

SinghRathor UIPS, Panjab University

Designing, Preparation And Evaluation Of Cocrystals Of "Imatinib"

28. Manju University Institute

OfPharmaceutical Sciences, Panjab University

Diacerein: A Boon For Critically Ill Covid-19 Treatment Therapy

Sr.No. Name Affiliation Title

1. Radhika Yadav UIPS Injecting innovation into Indian pharma

2. Sangeeta Sharma UIPS TLRF agonist as an effective influenza vaccine

adjuvant

3. Priya Badyal UIPS The Dangers of Self Medication

4. Sumant Saini UIPS

QbD-Steered Development and validation of an RP-HPLC Method for Quantification of

Ferulic Acid: Rational application of Chemometric tools

5. PratishthaLambodra UIPS INDIA: the world's innovative pharmacy

6. Pooja Sharma DPSDR, Panjabi university,

Patiala Plants And Plant Metabolites Possessing

Anticancer Activity

7. Aanchal Devi UIPS National innovation and startups

8. Nisha Raina UIPS Role of HER in healthcare

9. Garima Khanna UIPS A Gene Bases Crispr/Cas9 Innovative Delivery

Approach For Cancer And Immunotherapy

10. Sanjeevni Dhamija UIPS A Gene Bases Crispr/Cas9 Innovative Delivery

Approach For Cancer And Immunotherapy

CHASCON 2020

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11. Rupam Sharma Shivalik college of pharmacy, Ropar

Science And Technology Innovations: Ushering In The Era Of Make In India &

Science And Tech In COVID-19

12. Mei nee chiu UIPS A gene-based CRISPR/Cas9 Innovative

Delivery Approach for Cancer and Immunotherapy

13. Somi Priya University Institute of

Pharmaceutical Sciences, Panjab University

Characterisation of Stress Degradation Products of Ibrutinib by Hyphenated Mass

Spectroscopic Techniques

14. Jastarn Toor UIPS, Panjab University,

Chandigarh

Current scenario of pharmaceutical nanotechnology products: challenges and

opportunities

15. Kapil Sharma

UIPS, Panjab University, Chandigarh


opportunities

16. Lalit Saraswat



opportunities

17. SinaTajeri



opportunities

18. Ishita Atwal UIPS, Panjab University Ayushkwath for enhancing immunity against

COVID-19

19. Kalyani Kumari PGGCG- Sec-11 Chandigarh Effect of Oxytocin on the health of cattle.

20. Shivani



Simvastatin loaded foam based topical formulation for effective wound healing

21. Vinod Kumar Jaiswal UIPS, PU-Chd Characterization of stress degradation

products of azelastine hydrochloride by employing LC-MS technique

22. Pooja Singh UIPS, PU-Chd Development of validated stability indicating

methods (HPLC) of Ibrutinib

23. KabyaPratap royal UIAMS Panjab University Traditional plants and their

phytoconstituents for prevents and disease management; Influenza and COVID19.

CHASCON 2020

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24. Khushboo Pathania UIPS, PU-Chd Lignin nanoparticles - A novel tool for drug

delivery

25. Lakshita Dogra University Institute of

Pharmaceutical Sciences, Panjab University

Analytical Quality-by-Design enabled HPLC method development and validation of

Voriconazole

26. Akanksha Sharma



Nanostructured Lipidic Carriers (NLCs) with Enhanced and Extended Dissolution Profiles:

Exploring Drug Release Kinetics using Mathematical Modeling

27. RozyKumari University Institute of

Pharmaceutical Sciences

Development and Validation of Analytical Method for Simultaneous Quantification of Artemether and Lumefantrine Using HPTLC

Method

28. Pallvitempta UIPS, PU-CHd Curcumin nano formulation for cancer

therapy: recent advancement

CHASCON 2020

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Personalised medicine: the new era of treatment Sakshi

UIPS, Panjab University

[email protected]

With this abstract I will give an overview of personalized medicine and why it’s so imperative and how we

can pave our way towards it.

What’s personalized medicine?

Personalized medicine is the tailoring of medical treatment to the individual characteristics of each patient

(1). Producing the medicine uniquely made for unique you. It is a multi-faceted approach to patient care that

not only improves our ability to diagnose and treat disease but offers the potential to detect disease at an

earlier stage when it is easier to treat effectively (1).

Why do we need personalized medicine?

The drugs we give our chemical molecules which interact with receptors and enzymes to cause their action.

These receptors and enzyme are made up of protein, which in turn are produced from RNA molecules which

are produced from DNA. So the precursor of everything is DNA and this biomolecule expresses itself

differently in everyone. We have genes which are translated differently to produce a protein which makes us

all unique phenotypically and genetically. This is the variability observed at a molecular level, the level

where drugs work. This is the reason we observe so poor response rates of drugs treating Alzheimer (30%),

diabetes (57%), migraine (50%), and oncology (25%) (4). Investment and development in making new drugs

are burgeoning, billion dollars are spent in producing new drugs, and still, we are getting low efficacy rates.

From the pool of information, we need to extract the precise one. Here is when personalized medicine comes

to rescue. Equipped with more precise tools, physicians can select a therapy or treatment protocol based on a

patient’s molecular profile that may not only minimize harmful side effects and ensure a more successful

outcome but can also help contain costs compared with a “trial-and-error “approach to disease treatment. (1)

Because the study we do while producing the drug is population-based, and we are targeting on an individual

level. From the genetic information of the patient, we can predict the best drug for them. So with the

example of diabetes, breast cancer and cardiovascular diseases, I will explain how personalized medicine

revolutionized the diagnosis and treatment (3). The best-known example is the CYP 450 enzyme and its

application to Coumadin/warfarin therapy. The correct personalized dosing of warfarin could prevent 17,000

strokes in the United States and avoid 43,000 emergency room visits. The Mayo Clinic and Medco2 tested

this prediction in 3,600 patients and found hospitalizations were reduced by 30 %.( 4).

How personalized medicine work?

Personalized medicine work at six strata:

“Risk Assessment: In which we study the genome of the individual. With Genetic testing and family history,

we can evaluate the risk for the disease.

Prevention: Behavior/Lifestyle/ Treatment intervention to prevent disease

Detection: Early detection of disease at the molecular level. With the advancement in technology, we can

detect diseases at a molecular level.

Diagnosis: Accurate disease diagnosis enabling individualized treatment strategy

Treatment: Improved outcomes through targeted treatments and reduced side effects

Management: Active monitoring of treatment response and disease progression” (1)

For the diseases having genetic variability and behavioral influence, we need personalized medicine more

than ever. Using electronic records and with biostatics, we can organize and analyze data eas

References:

1.http://www.personalizedmedicinecoalition.org/Userfiles/PMC

Corporate/file/pmc_age_of_pmc_factsheet.pdf

2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957753/


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3. Case studies in personalized medicines: Coursera

4.https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(01)01986-

4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471491401019864%3

Fshowall%3Dtrue

Preparation and characterization of norfloxacin cocrystals

Mansi Prashar1, Vikas2, Renu Chadha1 and Neelima Dhingra1*

1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India

Keywords: Norfloxacin- nicotinamide (NF- NIC); norfloxacin- cinnamic acid (NF- CN); intrinsic

dissolution; solubility.

ABSTRACT:

The pharmaceutical industries are observing a developing crisis in the procedure of drug development due to

the failure of some successful drug candidates exhibiting poor aqueous solubility. The solid phase

modification (i.e. formation of cocrystals) improves the physicochemical properties of active pharmaceutical

ingredients (APIs) such as bioavailability, solubility, intrinsic dissolution, melting point, stability.

Cocrystals are crystalline structure composed of at least two components (one is API and other is coformer),

where the components may be atoms, molecules or ionic compounds generally in a stoichiometric ratio

which are neither solvates nor simple salts. The components interact via non-covalent interaction such as

hydrogen bonding, van der Waals interaction. Norfloxacin is a broadspectrum antibiotic belonging to the

second generation of the fluoroquinolone’s. It has low permeability and belongs to the class IV of the

biopharmaceutics classification system, BCS because of its poor solubility. Present works report the

preparation and structural characterization of its two cocrystals norfloxacin– nicotinamide and norfloxacin–

cinnamic acid.

*Corresponding author:

Dr. Neelima Dhingra Assistant Professor

University Institute of Pharmaceutical Sciences Panjab

University,

Chandigarh-160014, India Phone number:

9876573312 Email:

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17a-Aza-D-Homo Steroids as 5α- Reductase Inhibitors: Synthesis and Characterization

Harnoor Kaur1, Priyanka Rana2, Neelima Dhingra1* 1University Institute of Pharmaceutical Sciences, Panjab University, Chandigar

Keywords: Benign Prostatic Hyperplasia; 5α- Reductase inhibitors; 17a-Aza-D-Homo Steroids.

Abstract:Benign Prostatic Hyperplasia (BPH) is one of the common and intricate oncologic problem associated with lower urinary tract symptoms (LUTS). It is an age‐related problem with a prevalence of

approximately 10% for men in their thirties, 20% for men in their forties, 50–60% for men in their sixties,

and a staggering 80–90% for men 70 years and above. Advancement in this field of research leads to

formation of the less invasive techniques and therapeutic treatment to provide relief from the LUTS. 5α-

Reductase is the key enzyme responsible for dihydrotestosterone (DHT) biosynthesis and has been

considered as an important target for designing inhibitors as potent therapeutic agents. Present work is

focused on the synthesis and characterization of 17a-Aza-D-Homo Steroid Esters, using various analytical

techniques such as Thin layer chromatography (TLC), Infra-red spectroscopy (IR), Proton nuclear magnetic

resonance spectroscopy (HNMR).

*Corresponding author:

Dr. Neelima Dhingra

Assistant Professor

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh

Tel:+919876573312

E-mail: [email protected]

MAO Inhibitors in Contemporary Treatment of Depression: Current and Future

Perspectives

Alka Kumari1, Neelima Dhingra1*

1University Institute of Pharmaceutical Sciences, Panjab University Chandigarh

Keywords: Depression, MAO inhibitors, current and future perspectives.

ABSTRACT:

Depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity

pessimism, anhedonia, sadness and adversely affect the person’s life. It is a common and recurrent disorder

accounting for significant morbidity and mortality worldwide. According to WHO, the total number of

people living with depression in the world is 322 million. Globally 11.3% of adults,8.7% of women and

5.3% of men have depression. It has been observed that COVID-19 lockdown and pandemic has increased

the depression symptoms by three times.Most of the antidepressants currently available act by enhancing the

activity of monoamine neurotransmitters, either by reuptake inhibition, enzyme inhibition or activity at pre-

about:blankmailto:[email protected]

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or postsynaptic receptors. Monoamine oxidases (MAOs) are involved in the oxidative deamination of

different amines and neurotransmitters. This pointed them as potential targets for several disorders and along

the last 70 years a wide variety of MAO inhibitors have been developed as successful drugs for the treatment

of complex diseases, being the first drugs approved for depression in the late 1950s. MAOIs can be a

powerful therapeutic intervention for patients with depression, panic disorder, who have failed first-line

treatments.

*For Correspondence

Dr. Neelima D Passi

Assistant Professor

University Institute of Pharmaceutical Sciences

Department of Pharmaceutical Chemistry

Panjab University

Chandigarh- 160014

Tel: +91-9876573312

E.mail: [email protected]

Formulation of sustained release mups tablets of s (-) metoprolol succinate

using wurster process

G. Nikhil1, G. Aman3, M. Paramjot1, G. Vikram2, W. Sheetu1

Department of Pharmaceutical Science,

Lovely Professional University, Phagwara Jalandhar, Punjab, India

1. Department of Pharmaceutical Science, Lovely Professional University Jalandhar, India

2. Associate Director, Emcure R&D, Bhosari, Pune, India

3. School of Pharmaceutical Sciences, Rajiv Gandhi ProdyogikiVishwavidhyalaya, Bhopal, India

ABSTRACT

The idea behind this research work was to develop pellets of S (-) Metoprolol succinate using platform

technology to get sustained drug release through the oral route. Wurster process was used to develop

sustained release MUPS tablets of MS by using few cushioning agents and different polymers such as


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Ethylcellulose (5cps and 10 cps), Eudragit, Methocel K100, and MethocelK4M to investigate the effect of

polymer coating on drug release pattern. Obtained tablets characterized by flow property, Assay,

Dissolution, SEM imaging, friability, etc. Prepared tablets were characterized by different methods and

found bulk density and tapped density of blend was 0.83±0.03g/ml and 0.90±0.02g/ml, surface morphology

was carried out by SEM analysis and drug encapsulation efficiency was 99.46 % also drug dissolution was

95.77% in up to 20 hrs. It was found that using a fixed combination of Methocel K4M and Methocel K100

will be a good option to get the desired sustained release pattern. MCC PH 102 is used for the sustained

release coating. This type of approach will be a better option to formulate a controlled delivery system for

highly soluble drugs (class-1 drugs).

Keywords: Wurster Process, Metoprolol Succinate, Oral controlled delivery, Pellets, MUPS table

Nanoparticle drug delievery system in oncology

Preeti

Shivalik college of pharmacy, Ropar

House no: 77/G Nangal Town Ship, Distt. Ropar

Cancer is the life threatening disease. Acc to NCI mortality rate in worldwide is 9.5 million. The main

demerit of anticancer drug is that they can occur apoptosis in cancerous cell as well as host cell.

Nanotechnology is smart approach which is target specific because of Folate receptor and

Asialoglycoprotein are able to make them directly bind by cancerous cell. In 2005 FDA approved a drug

ABRAXANE which is solvent free Albumin bound Paclitaxel used for Metastasis breast cancer. Major

Advantages of nanotechnology is that it must improved Therapeutic Index and increase the bioavailability by

increasing solubility due to increase surface area. They must Active targeted into cells without triggering P

Glycoprotein pump. PGA-Taxol, HPMA-DOX (For lung cancer) are the example of Polymeric nanoparticle

in the anticancer drug delivery. The SHELTH technique is the part of nanotechnology in which nanoparticles

are prevented from attacking by Immune system in EPR effect by covering them with PEG. Chemo-Gd-

Neutron capture therapy is the new discovery for breast cancer treatment and for gastric carcinoma or

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ovarian cancer treatment Cisplatin is encapsulated with ICG (Indo cyanine green).Various nanocatalyst such

as ZnO, CuFe2O4, Fe2O3 are used in synthesis of Anticancer drugs. Overall our study revealed that

Nanotechnology has the greatest scope in the research of oncology.

In silico docking studies of phytochemicals from adhatoda species against covid-

19 target proteins

B. Siva kumar and K. Ilango

Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and

Technology, Kattankulathur – 603203, Chengalpattu (Dt), Tamil Nadu, India. CORRESPONDING

AUTHOR email id: [email protected]

Abstract

A novel coronavirus (COVID-19) was identified as one of the severe acute respiratory syndrome coronavirus

(SARS CoV-2) and emerged as a pandemic disease in 2020.

The World Health Organization [WHO] has declared the current outbreak of a global public health crisis.

There is no drug or no suitablevaccines available against viral proteins till today. Hence, there is an urgent

need to develop inhibitor against the viral proteins for the coronavirus is a promising idea to develop

structure-based drugs from phytochemicals. Here, the novel drug was identified and well studied against the

viral receptors by using the molecular docking technique. Phytocompounds from Adhatoda like

Vascinolone, Vasicol, Adhatodine were selected for the present study. The analysis of drug-likeness is

predicted through these 5 parameters namely Lipinski rule, Ghose, Egan, Vebers&Muegge rules. As

molecular docking is routinely used for understanding drug-receptor interaction, the above-plant derived

compounds were subjected to molecular docking studies. Highest binding affinity ranging from -4.34 to -

8.02KJ/mol were obtained with 5R80, 5R81, 5R83, 6LU7, 6XA4, 7AD1 viral protein targets. Our study

reveals that Vasicinolone, Vasicol, Ahatodine could act as a promising molecule of choice to treat COVID

19.

KEYWORDS: SARS–Cov-2; COVID-19; vasicinolone, vasicol, adhatodine, coronavirus


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Antioxidant activity of Novel Polyherbal formulation for the

Management of Polycystic Ovarian Disease

Shalini K*1, Ilango K2

Department of Pharmacognosy*1, Department of Pharmaceutical Chemistry2,

SRM College of Pharmacy, SRM Institute of Science and Technology,

Kattankulathur-603 203, Chengalpattu (Dist), Tamilnadu, India.

Corresponding author mail id: [email protected]

Abstract

Polycystic ovarian syndrome (PCOS) is a multifactorial endocrine disorder predominantly affecting

between 5% - 10% of reproductive – aged women. PCOS women commonly have classical clinical

features of oligo- or anovulation, obesity, and hyperandrogenism. Moreover, PCOS can occur with

hyperinsulinemia, gluose intolerance, hperlipidemia, type 2 diabetes mellitus, hypertension, coronary

atherosclerosis, and endometrial cancer. Antioxidants are a class of molecules that can reduce the destructive

effects of free radicals. They are of two types: either enzymatic like superoxide dismutase, catalase,

glutathione peroxidase (GPx), and glutathione redutase (GR), or non-enzymatic such as glutathione (GSH),

ɑ-tocopherol (vitamin E), ascorbate (vitamin C), and ß-carotene. These antioxidants have been reported to

have an important role in the female reproductive system and in the pathogenesis of female infertility.

Oxidative stress has been associated with PCOS. Studies have suggested that oxidative stress seems to be

involved in PCOS by causing altered steroidogenesis in the ovaries, which subsequently contributes to

increasing androgen levels, distributing follicular development, and infertility. Moreover, factors such as

obesity, insulin resistance, and cardiovascular risks have shown to be linked to oxidative stress in PCOS

women. The study was designed as in vitro antioxidant potential of polyherbal formulation.

Polyherbal formulation was prepared using hydroalcoholic extract powder of the selected plants viz.

Asparagus racemosus, Caesalpiniabonducella, Saracaasoka, and Symplococusracemosus. Polyherbal

formulation were tested for scavenging activity against DPPH radical, total reducing power assay, and

hydrogen peroxide scavenging activity even when compared to ascorbic acid. The results showed that the

combination extract has best antioxidant effect at a dose of 200µg/ml when it was compared with ascorbic

acid as the reference standard.

Key words: Steroidogenesis, ɑ-tocopherol, Infertility, Oxidative stress.


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Acute oral toxicity study of methanol extract ofmorusalbal. (moraceae) fruit

Parul Sood1*, Pankaj Bhatia1, Karishma1, Diksha1, Richa Shri1

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala,

(147002), Punjab, India

*Corresponding Author: ParulSood, Department of Pharmaceutical Sciences and Drug Research, Punjabi

University, Patiala (147002), Punjab, India. Email id: [email protected]; 7018429747, 8427187366

ABSTRACT

Introduction: Different parts ofMorusalbaL. (Moraceae) are valued in traditional systems of medicine. The

fru

(souvenir) chascon 2020 · 2020. 12. 19. · chascon 2020 1 (souvenir) chascon 2020 “science and...

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