sodium bicarbonate revisited

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Post on 05-Jul-2015



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by the renowned pediatrician, Dr Satish Deopujari, National Chairperson (Ex) Intensive Care Chapter I A P Founder Chairman..... National conference on pediatric critical care Professor of pediatrics ( Hon ) JNMC:Wardha Nagpur : INDIA


  • 1. SodiumBicarbonateRevisited Sodium Bicarbonate Revisited

2. Acidosis is thought to have adverse physiological effects and generally is associated with increased mortality. Consequently, therapy to correct acidosis, usually with sodium bicarbonate is been widely used. In recent years, however, this approach is changing. Disease process Add acid Loose alkali acidosisImpaired acid excretion More than 100 years of Soda Bi Carbonate 3. Adverse Effects Of Acidosis . Depressed myocardial contractility Decreased catecholamine efficacy Arrhythmias Pulmonary vasoconstriction Glycolytic enzyme phosphofructokinase is pH dependent resulting in the impaired utilization of glucose Below 7.o 4. Sodium Bicarbonate Hypertonicity and hyperosmolality Hypercapnia and intracellular acidosis Ionized hypocalcaemia Decreased oxygen delivery Hypokalemia Increased organic acid production Rebound alkalosis Decreased VF threshold , arrhythmias Repeated doses : transient hypotension Intracellular acidosis / CSF acidosis Catecholamine inactivation Precipitation ( cal. carbonate ) Local infiltration necrosis 5. Hypertonicity and hyperosmolality 7.5 % sodium bicarbonate Sodium 0.9 mEq / ml Osmolality : 1700 mOsm /lit. Normal serum osmolality is around 290 1700 / 6 = 284 , thats why ideal dilution of S.B. should be 6 times and with 5 % dextrose 6. NaHCO3 Na + HCO3 H HCO3 H2O + CO2 Intracellular acidosis 7. 60 mmHg 90 % 7.4 7.8 7.0 Impaired tissue oxygenation with correction of acidemia . Hb. Sat.% RT. LT. 8. Oxygendelivery 24 to 48 hrs Low 2-3 DPG levels Secondary to reduced glycolysis Direct effect of pH on hemoglobin reducing affinity of oxygen acute acidemia facilitates oxygen delivery, whereas more chronic acidemia hampers oxygen delivery. Correcting acute acidemia could be more dangerous 9. Sodium Bicarbonate Hypertonicity and hyperosmolality Hypercapnia and intracellular acidosis Ionized hypocalcaemia Decreased oxygen delivery Hypokalemia Rebound alkalosis Decreased VF threshold , arrhythmias Increased lactate production Repeated doses : transient hypotension Intracellular acidosis / CSF acidosis Catecholamine inactivation Precipitation ( cal carbonate ) Local infiltration necrosis 10. Case 1 8 months old child with diarrhea and LRI is in shock His ABG is pH 7.01 Pco2 36 HCO3 5.5 ACIDOSIS LOW BICARB BUT CO2 IS HIGH ? WOULD BICARB BE INDICATED ? NO 11. Case 2. Preterm weighing 1.8 kg was on oral feeds and developed Diarrhea , junior resident noted that the baby was moderately Dehydrated and had respiratory rate of 58 / min. Bolus of normal saline was given followed by a dose of bicarb , thinking that the baby may be acidotic. After about 4 hours baby had seizures . Sugar normal and so was calcium , seizure were controlled but recurred Again . Though the serum calcium was normal These were hypocalcaemic seizures . Ionic calcium low 12. CASE 3. DKA WITH RT LOWER LOBE CONSOLIDATION AND HYPOXIA Ph 7.016 CO2 6 BICARB 6 PO2 58 Severe metabolic acidosis with mild hypoxia Sugar 689 , ketones ++++ , COMA Received bicarb with other standard protocol for DKAsugar 326 mg % Ph 7.36 CO2 34 BICARB 18 PO2 63 ABG LOOKS BETTER , MILD HYPOTENSION , ON SUPPORT SUGAR IS OK Patient deteriorates soon for no obvious reason , his sugar is OK , ABG = Acidosis Anion gap still wide , ketones not very high Ph 7.16 CO2 14 BICARB 9 PO2 57 8 HOURS AFTER LACTIC ACIDOSIS 13. Rapid correction of acidosis shifts curve to left..tissue hypoxia Mild hypotension Diabetics have low 2.3. DPG Soda bicarb. promotes lactic acidosis In severe DKA, bicarb therapy is not supported by the literature. In fact, at least 2 human studies have shown possible deleterious effects of bicarbonate administration even in patients with serum pH less than 7.0 . Thus the administration of sodium bicarbonate to patients with diabetic ketoacidosis cannot be recommended at any pH ( class 1 ) 14. Giving bicarbonate to a patient with a true bicarbonate deficit is not controversial Controversy arises when the decrease in bicarbonate concentration is the result of its conversion to another base which, given time, can be converted back to bicarbonate 15. What are the deleterious effects of acidemia ? Is acidemia severe enough to warrant therapy ? How much bicarbonate ? what are deleterious effects of Bicarbonates ? In considering acute bicarbonate replacement four questions should be thought of 16. SEVERE METABOLIC ACIDOSIS WITH ADEQUATE VENTILATORY SUPPORT HYPERKALEMIA HYPERMAGNESEMIA TRICYCLIC ANTI DEPRESSANT POISONING SODIUM CHANNEL BLOCKER POISONING Indications as per A.H.A. Sodium bicarbonate is further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturate-protein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of hemoglobin and its breakdown products. 17. How do I give soda bicarb Indication : if pH is less than 7.15 in DKA ( less than 7.1 and not improving ) HCO3 required = half of BW ( 15 HCO3 ) Dilute 4 to 6 times give over 2 hours Diluent : water for injection/5%dextrose Ensure adequate ventilation 18. carbicarb, an equimolar mixture of sodium bicarbonate and sodium carbonate. Carbonate preferentially combines with hydrogen ions resulting in production of bicarbonate rather than CO2. Carbonate can also combine with carbonic acid, a reaction which also produces bicarbonate. Thus the acidosis is titrated without the production of CO2 or the lowering of intracellular pH. ALTERNATIVE 19. Post resuscitation ..role of Soda Bicarbonate ? I dont have ABG facility and the patient is in shock Should I give Soda Bicarbonate Child with diarrhea and shock I would like to add S.B.. to normal saline bolus , comment If the child admitted with me has received large dose of S.B. what should I monitor ? How do I dilute S.B., Rate of infusion Role of S.B. in wide anion gap acidosis Intratracheal administration for treatment of metabolic A Can S.B. be used for treatment of hyponatremia ? ( equivalent to 6 % saline,7.5 % contains 0.9 mEq./ml) FAQ,S . 20. OVERDOSAGE: Should alkalosis result, the bicarbonate should be stopped and the patient managed according to the degree of alkalosis NORMAL SALINE may be given, potassium chloride is indicated if there is hypokalemia. Severe alkalosis may be accompanied by hyperirritability or tetany and these symptoms may be controlled by calcium gluconate. 21. THANKS


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