slides last updated: october 2013. there are two main types of lung cancer 1 1.howlader n, noone am,...
TRANSCRIPT
Slides last updated: October 2013
There are two main types of lung cancer1
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the
SEER web site, April 2013, accessed on 15/09/2013.
NSCLC (85.3% of lung cancer)
Lung Cancer (100%)
Other NSCLC(20.2% of lung cancer)
Large cell carcinoma(2.6% of lung cancer)
Squamous cell carcinoma(21.4% of lung cancer)
Adenocarcinoma(40.1% of lung cancer)
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER
web site, April 2013, accessed on 15/09/2013.
NSCLC can be further divided into different sub-types1
NSCLC: Adenocarcinoma
Adenocarcinoma
Adenocarcinoma lesions are usually peripherally located2
Most frequent in women and non-smokers2
Some patients have EGFR/ErbB1 mutations; these patients require a specific diagnosis and treatment approach3
40.1%1
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER
web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004. 3. Vijayalakshmi R, et al. Indian J Surg Oncol 2011;2:178‒188.
NSCLC: Squamous cell carcinoma
Squamous Cell Carcinoma2
Squamous Cell Carcinoma lesions are generally centrally located, near bronchi
Tends to spread locally
Closely correlated with smoking
21.4%1
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol
Haematol. February 2004.
NSCLC: Large cell carcinoma
Large Cell Carcinoma
Comprised of undifferentiated cells 2
Lesions are usually peripherally located but can occur anywhere 2
High tendency to metastasize 2
2.6%1
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol
Haematol. February 2004.
NSCLC: Other
Other, including Not Otherwise Specified (NOS) or Unknown
A classification of NOS or unknown is usually due to ineffective sampling and examination2
This classification is expected to decline in use due to more accurate biopsies and advances in immunohistochemistry and biomarker testing2
20.2%1
1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted
to the SEER web site, April 2013, accessed on 15/09/2013. 2. Righi L, Graziano P, Fornari A, et al. Cancer 2011;117:3416‒3423.