skin pathology, case 3
DESCRIPTION
Skin Pathology, Case 3. 40 year-old female with no significant past medical history presents with a 1 cm pigmented lesion on the back. The borders are irregular and the color is variegated. Describe the skin lesion. The "ABCDs" are helpful in the diagnosis of melanoma. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/1.jpg)
Skin Pathology, Case 3
• 40 year-old female with no significant past medical history presents with a 1 cm pigmented lesion on the back. The borders are irregular and the color is variegated.
![Page 2: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/2.jpg)
Describe the skin lesion
![Page 3: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/3.jpg)
The "ABCDs" are helpful in the diagnosis of melanoma. A: asymmetry- one side or half does not look like the other B: border irregularity C: color-black, or much darker than patient's other molesD: diameter > 6 millimeters
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Close up
Describe the skin lesion
![Page 5: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/5.jpg)
Close up
This melanoma is darker than any of the other pigmented lesions present.On close-up the lesion is seen to have an irregular border and also has uneven coloration with some darker areas.
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Describe the skin lesion
![Page 7: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/7.jpg)
This darkly pimented lesion was suspected of being a melanoma.It is shown undergoing excisional biopsy. When feasible, the entire lesion should be removed and submitted for histopathological diagnosis. This melanoma had a thickness of 0.6 mm. The patient was later treated with a wide local excision.
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Describe the skin lesion
![Page 9: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/9.jpg)
The lesion (melanoma) is asymmetrical, has an irregular border, very dark and irregular color, and was much larger than 6 mm in diameter.
![Page 10: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/10.jpg)
Describe the skin lesion
![Page 11: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/11.jpg)
Nodular melanoma. This lesion demonstrates all of the ABCDs.
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Epidermis with focal ulceration
Nests of malignant melanocytes within dermis
![Page 14: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/14.jpg)
Describe the high power findings
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Describe the high power findings
Clusters of malignant melanoma cells (in dermis)
Pigmented melanoma cells
![Page 16: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/16.jpg)
![Page 17: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/17.jpg)
Irregular nests of malignant melanoma cells within epidermis
Nodular aggregates of melanoma cells in dermis
![Page 18: Skin Pathology, Case 3](https://reader030.vdocuments.mx/reader030/viewer/2022032709/5681314d550346895d97ca07/html5/thumbnails/18.jpg)
Irregular nests of malignantmelanocytes in epidermis