skin cancer crash course - mghcme
TRANSCRIPT
Skin Cancer Crash Course:
Recognition and Management of Nonmelanoma Skin Cancer
Victor Neel, MD, PhDDirector, Dermatologic Surgery, MGH
Disclosures
Neither I nor my spouse/partner has a relevant financial relationship with a commercial interest
to disclose.
sebaceous carcinoma
sebaceous adenoma
sebaceoma
Microcystic adnexal ca
Mucinous eccrine carcinoma
Eccrine spriradenoma
Cylindroma
Poroma
Porocarcinoma
Nodular hidradenoma
Syringoma
Chondroid syringoma
Digital papillary adenocarcinoma
Extramammarary Paget’s
Basal cell carcinoma
Trichoepithelioma
Pilar sheath acanthoma
Tricholemmoma
Trichofolliculoma
Pilomatricoma
Trichoblastoma
Fibrofolliculoma
Desmoplastic trichoepithelioma
Pyogenic granuloma glomus tumor
Kaposi’s sarcoma Angiosacoma
Epitheliod hemangioendothelioma Masson tumor
Targetoid hemosiderotic hemangioma Angiokeratoma
Glomangioma AV hemangioma
Lipoma
angiolipoma
Spindle cell lipoma
liposarcoma
pleomorphic lipoma
Neurofibroma
Neurothekeoma
Schwannoma
Palisaded encapsulated neuroma
Merkel cell carcinoma
Atypical fibroxanthoma
Malignant fibrous histiocytoma
actinic keratosissquamous cell carcinomakeratoacanthomaseborrheic keratosis porokeratosis
sebaceous
eccrine
Blood Vesselsneural
fibroblastsfollicular
fat
epithelial
smooth muscle
Leiomyoma
Leiomyosarcoma
angioleiomyoma
immune cell
Lymphoma
Mast cell disease
histiocytosis
metastatic
Goals of This Talk
• Discuss the most common NMSC tumors you will see and possibly diagnose & treat
• Convince you to consider performing skin biopsies in your practice
Primary Care & Dermatology
• Too many patients, too many tumors
• Delayed diagnosis, delayed treatment
• Many skin cancers can be diagnosed and treated in primary care setting
• PCPs must definitively diagnosis and have treatment algorithms in place
US Skin Cancer Incidence
• >5 million new cases of NMSC each year
• BCC about 80%, SCC about 20%
• About 15,000 deaths per year from SCC, more than twice as many than melanoma
Causes of Nonmelanoma Skin Cancer
• Chronic UV exposure –> genetic mutations
• Immunosuppression– Organ transplant patients and CLL patients– 80% of transplant patients develop skin cancers– 200-fold increased risk of SCC
• Human papillomavirus - HPV 6,16 (vaccine may affect)
• Inherited diseases - XP, BCNS, albinism
Basal Cell CarcinomaStats
• most common cancer in humans
• 3 million new cases a year, increasing 5% per year
• 1/3 of all Caucasians will develop at leastone lesion
• billions of healthcare $$ spent
Basal Cell CarcinomaBiology
• very indolent growth – perhaps decades until clinically apparent
• rarely metastatic (<0.01%) but very lethal –usually in neglected or multiply-recurrent tumors – locally destructive (cosmetically devastating)
• >75% most sporadic tumors have defects in Sonic hedgehog signaling pathway (oral drug, vismodegib, topicals in develpoment)
Which Is BCC?
Basal Cell Carcinoma
• Subtypes– Nodulo-ulcerative (most common)
– Morpheaform (sclerosing, infiltrative)
– Micronodular
– Metatypical (basosquamous)
– Superficial (“multicentric”)
Basal Cell Carcinoma
• Subtypes
– Nodulo-ulcerative (most common)
Basal Cell Carcinoma
• Pigmented BCC • Can mimic MM
Basal Cell Carcinoma
• Subtypes– Morpheaform BCC
– Can look like scar
Basal Cell Carcinoma
• Subtypes
– Superficial “multicentric”
– Can be misdiagnosed as psoriasis, tinea or eczema
– Most common type on trunk and extremities
BCC or Tinea?
BCCTinea
itchy & scalyoften multiple
antifungals
crusts/bleedsusually singlesun-exposed
BCCs?
Basal Cell Carcinoma
• Course
– Slow, progressive growth
– Bleeding, ulceration, superinfection
– Enlarges over months to years
– Is capable of extensive tissue destruction (invading
into muscle, cartilage, and bone)
Suspected lesion Differential
diagnosis
?biopsy
?refer
Treatment
options
Actinic keratosis SK, wart, porokeratosis,
trichilemmoma
NO
NO
5-FU, imiquimod,
cryotherapy, PDT-ALA
Squamous cell
carcinoma, in situ
AK, discoid lupus, tinea
psoriasis, SK
YES
YES
5-FU, imiquimod, PDT-ALA,
cryotherapy, curettage
surgery
Squamous cell
carcinoma, invasive
SK, AK, BCC, pyoderma
gangrenosum
YES
YES
surgery, Mohs surgery,
radiation (rarely)
BCC, superficial
(body)
tinea, SCC in situ, discoid lupus,
porokeratosis, SCC in situ
?
?
5-FU, imiquimod,
cryotherapy, curettage,
surgery
BCC, nodular
(body)
nevus (melanocytic), molluscum YES
YES
cryo, curettage, surgery
BCC, infiltrative or
recurrent (body)
scar YES
YES
BCC, any type
(head & neck)
nevus, rosacea, angiofibroma,
syringoma, sebaceous
hyperplasia, tinea, discoid lupus,
SCC, trichoepithelioma,
telangiectasia, scar
YES
YES
Mohs surgery
Squamous Cell Carcinoma
• Second most common skin cancer in the general population
• Most common skin cancer in transplant recipients
• Appears on sun-exposed skin
• Red, scaly, firm, may ulcerate
• 1-15% metastasize (lip & ear)
Squamous Cell Carcinoma
• Arises primarily on sun-damaged skin– Precursor is actinic keratosis (AK) on sun-exposed sites
– 90% of AKs spontaneously resolve
• May occur anywhere on skin• Face
• Lips (usually lower)
• Ears
• Dorsal hands
• Chest
Diffuse AKs? 5-FU!!
Two Weeks of Topical 5-FU
Squamous Cell Carcinoma
• Metastasis more likely in:
– Recurrent tumors
– Those with diameter > 2 cm
– Those with depth > 6 mm
– Mucosal sites, periauricular skin (lip & ear)
– SCC arising from chronic wounds (Marjolin’s ulcer)
– Perineural invasion of larger nerve fibers
– Immunocompromised patients
Squamous Cell Carcinoma
• Subtypes– Keratoacanthoma
• Rapid initial growth
• May be painful (unlike most NMSCs)
• Exophytic nodule with central keratin-filled crater
• Remains stable for a few months
• May spontaneously resolve – new research!!
• Dermpath reports as well-differentiated SCC
Time to get the derm surgeonon the phone
Squamous Cell Carcinoma
• Subtypes
– Bowen’s Disease• Squamous cell carcinoma in situ
• Thin, erythematous, scaling plaques
• Can progress into, and/or coincide with invasive SCC
• Can be misdiagnosed as psoriasis, tinea, eczema or BCC
• Squamous cell carcinoma
• Basal cell carcinoma
• Melanoma
100-fold increase
10-fold increase
3.4-fold increase
Incidence Ratios of Skin Cancer in Transplant Recipients
Mortality from Metastatic Skin Cancerin Transplant Patients
Country Organ Cancer type
Mortality Rate
Australia
New Zealand
Kidney SCC 5% of all patients with SCC
Australia Heart All 27% total deaths occurring after the 4th yr post transplant
USA All SCC 3 yr cause specific survival 54%, n = 71
USA All Melanoma 30% (compared to 15% in general population)
A Lethal Tumor in a Transplant Patient
Please have your transplantpatients see a dermatologist for baseline evaluation
Surgical Emergencies in Dermatology
• SCC in immunosuppressed population
– Iatrogenic (organ transplant, anti-inflammatory states)
– CLL or other leukemias/marrow failures
AML – 80% blast, 0%PMNs
Suspected lesion Differential
diagnosis
?biopsy
?refer
Treatment
options
Actinic keratosis SK, wart, porokeratosis,
trichilemmoma
NO
NO
5-FU, imiquimod,
cryotherapy, PDT-ALA
Squamous cell
carcinoma, in situ
AK, discoid lupus, tinea
psoriasis, SK
YES
YES
5-FU, imiquimod, PDT-
ALA, cryotherapy,
curettage
surgery
Squamous cell
carcinoma, invasive
SK, AK, BCC, pyoderma
gangrenosum
YES
YES
surgery, Mohs surgery,
radiation (rarely)
BCC, superficial
(body)
tinea, SCC in situ, discoid lupus,
porokeratosis,
?
?
5-FU, cryotherapy.
curettage, surgery
BCC, nodular
(body)
nevus (melanocytic),
molluscum
YES
YES
cryo, curettage, surgery
BCC, infiltrative or
recurrent (body)
scar YES
YES
BCC, any type
(head & neck)
nevus, rosacea, angiofibroma,
syringoma, sebaceous
hyperplasia, tinea, discoid
lupus, SCC, trichoepithelioma,
telangiectasia, scar
YES
YES
Mohs surgery
Less Common Tumors
DFSP
Dermatofibroma
Extramammary Paget’s
Extramammary Paget’s
A Challenge to Primary Care:
DO YOUR OWN BIOPSIES!
Primary Care & DermatologyDelay in Diagnosis & Treatment
• Community dermatology shortage: 2-6 months
• Community surgical dermatology shortage (Mohs surgery): 1-3 months
Typical delay from Primary care to definitive treatment: 3-9 months!!!
Do a “real” skin exam
Document lesions and take a pre-biopsy photo & measurement
Do not be afraid to biopsy early – low-risk of complications
If the biopsy is inadequate or doesn’t fit the clinical picture, re-biopsy!
Essentials for Serious PCPs
• Don’t worry if your biopsies come back with benign diagnoses – steep learning curve
• If you treat a lesion, see the patient back to confirm improvement. If not improving biopsy or refer, DON’T KEEP TREATING!!
Essentials for Serious PCPs
This Is Not an Actinic Keratosis!
sterile #15 bladeclean gauze & Q-tips3cc lido/epibottle Drysol in roomvaseline & plaster
obtain signed consent
In-Office BiopsyCost: $1.50
Time: 5-10 minutes. CLEAN not STERILE prep
Reimbursement: $60-100 (CPT 11102)
Biopsy Video
Please refer biopsy-proven skin cancersto dermatologic surgery, not plastics
Nicotinamide for Prevention
• Nicotinamide (vitamin B3) 500mg BID
• ~25% reduction of SCC/BCC in high risk skin cancer patients at 1 yr
• low side effect profile
• (NOT NIACIN)
The dermatologist will see you!