single cell multi omics analysis on basic science...next generation • • transcriptomics...

Next Generation Sequencing Congress

Day 1 Steam 1:

Part 1: NGS And Future Directions

• Delivering Genomic-based Precision based Medicine

• Multi Omics Data Integration and Whole Genome

Sequencing Data Analysis

Part 2: Long Read Sequencing For Human Genomes And

De Novo Studies

Technological updates

• Identification of structural variants and improvements

in the characterisation of genetic variation

• Implications on biological mapping

• De novo cluster of long reads by gene from

transcriptomics

• Library Prep for Haplotype Phasing and De Novo

Sequencing

Other applications – whole length transcript and direct RNA

sequencing and alternative splicing

Day 2 Steam 1:

Part 1: Delivering Genomic Based Medicine

Accuracy, cost and coverage of short and long read

sequencing

• Pharmacogenomics and Genomic Based Medicine

• Clinical Cytogenetics: The Need For Nucleotide Resolution

Part 2: Short and Long Read Sequencing in the Clinic

• Applications in the Clinic Applications of Short and Long

Read Sequencing in Oncology, Immuno- oncology,

Cardiology and metabolic Diseases

• Precision Surveillance Of Multidrug-Resistant

Organisms And Infection Control Practice

Single Cell Analysis Congress

Day 1 Stream 2: Spatial Omics

Spatial Transcriptomics , Genomics and Spatial Profiling

• Integrating single-cell RNA-Seq with spatial transcriptomics

• Spatial cell atlases using in situ sequencing

• Barcoded solid-phase RNA capture for Spatial

Transcriptomics profiling

• Single-molecule RNA FISH method

• Digital Spatial Profiling- combining RNA sequencing and

protein profiling

Other Technologies

Imaging technology for detection and addressing challenges of

human samples versus mouse based samples

Day 1 Stream 3:

Part 1- Single Cell ‘Omics Analysis: Current And Emerging

Tools

Single cell multi - omics analysis

• Omics Analysis On Basic Science

• Genomics

• Transcriptomics

• Proteomics

• Epigenomics

Part 2: Single Cell in Clinical Use – Applications &

Diagnostic Development

Single Cell Therapeutic applications:

• neurology and immuno-oncology

• Single cell diagnostic development and clinical

applications

• Studies of Single Cell in Clinical Use - oncology,

• Emerging and Novel Tools: Microfludics, nanotechnology

and Imaging technologies

Single Cell Analysis Congress

Day 2 Stream 1: Single-Cell Analysis In Drug Discovery and

Development

Case studies: Oncology, Immunotherapy, Neurodegenerative,

Autoimmune and Rare diseases using multi-omics approaches

Pharma and academic focus –

• Single cell in discovery and development for target

validation

• Single Cell Analysis in T Cell and Antibody development

• Spatially resolved omics in drug discovery and validation

Day 2 Stream 2: Single Cell Analysis: Overcoming

Challenges

Challenge 1: Sample preparation, Cell Isolation and

Purification for single cell analysis

High Throughput Protein to Protein Interaction and Single Cell

Genomics

Challenge 2: bioinformatics:

• Statistical analysis of single cell data

• Cluster statistical methods for single cell analysis

• Dealing with multiomics data coming from single cell

analysis

Day One Interactive Workshop:

Discussion workshop: Accuracy, cost and coverage of short

and long read sequencing

Day Two Interactive Workshop:

Spatial Transcriptomics

Ideal for those who work in Single Cell Sample Preparation

and Bioinformatics

If you’re on Twitter, make sure to follow us

@NGSUSCongress and join the Congress conversation

on #NGSUS20

For more information please contact [email protected]

Confirmed Speakers 2020

Bruce Aronow

Cincinnati Children's

Hospital Medical Center

Brian Dougherty

Astra Zeneca

Franziska Michor

Dana-Farber Cancer

Institute

Chia-Lin Wei

The Jackson Laboratory

Bogdan Budnik

Harvard University

Esperanza Anguiano

BMS

Computational Biology

Molecular Biology

Molecular Diagnostics

Bioinformatics

Clinical Diagnostics Development

Long Read

Short Read

Single Cell Genomics

Single Cell Biology

Biochemistry

Single Cell Transcriptomics

Single Cell Proteomics

Drug Discovery

Translational Biomarkers

Diagnostics

NGS Platforms

Genome Sequencing

NGS Bioinformatics

Data Integration

Sample Preparation

Diagnostics Development

Single Cell RNA/DNA Sequencing

Microfluidic Solutions

Molecular Profiling

Protein Profiing

Single Cell Transcriptomics

Single Cell Proteomics

Meet Senior Decision Makers

350 delegates from leading research & academic institutions, clinical

research institutions as well as major pharmaceutical and biotech companies

will attend the event. Delegate job functions include:

Discover New Solutions

Formal and informal meeting opportunities offer delegates the chance to discuss

key solutions with leading service providers. Services to be discussed include:

Benefits to Attending

Hear from and meet with the key innovators in next generation sequencing, and single cell analysis. 2020 speakers include: Senior Director, Alnylam

Pharmaceuticals; Director, University of Illinois; Director, Massachusetts General Hospital

✓ Discuss the future of NGS and long lead sequencing, and benefit from critical discussions and thought-provoking presentations on Long read

sequencing For Human Genomes And De Novo Studies, Data analysis in denovo assembly and structural variants, Bioinformatics and mapping tools

✓ Deliver Genomic Based Medicine- Applications of long and short read sequencing in the Clinic

✓ Multi-Omic Single Cell Analysis - discuss and debate the critical challenges and opportunities in Genomic, Transcriptomics and Proteomics

✓ Benefit from updates and highlights in Spatial Transcriptomics, Genomics and Digital Spatial Profiling as well as implications on sample and data analysis.

✓ Discover the latest advancements in single cell analysis in drug discovery and development. The comprehensive agenda covers important areas such

as key therapeutic applications in oncology, neurology and immuno-oncology, and the latest diagnostics development

✓ Overcoming Challenges in library preparation, bioinformatics and multi-omic data integration

✓ Unparalleled networking opportunities. The two-day congress offers unrivalled networking opportunities, creating an interactive platform for high-level

scientific and business discussions. Participate in formal or informal discussions during our networking breaks and pre-organised 1-2-1 meetings

mailto:[email protected]


Confirmed and Reserved Speakers Include:

2020 Next Generation Sequencing USA Congress

• Cynthia Morton, Director of Cytogenetics, Harvard University

• Jane Wilkinson, Senior Director, Broad Genomics Alliance Management, Broad Institute at Harvard & Massachusetts Institute of Technology

• Chia-Lin Wei, Director of Genome Technology, The Jackson Laboratory

• Hank Wang, Professor of Clinical Pathology & Director of Microbiology, Virology & Molecular Diagnostics Laboratories, Westchester Medical Center

& New York Medical College

• Suzanne Leal, Sergievsky Family Professor of Neurological Sciences, Director - Center for Statistical Genetic - Columbia University

• Isidore Rigoutsos, Richard W. Hevner Professor of Computational Medicine, Director - Professor - Dept. of Pathology, Anatomy & Cell Biology,

Thomas Jefferson University

• Stuart A. Scott, Associate Professor, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, ,Division Head,

Pharmacogenomics, Director, Cytogenetics and Cytogenomics

• James Willey, Professor of Medicine and Pathology, George Isaac Chair for Cancer Research, University of Toledo

• Michael Heller, Professor, University of California, San Diego

• Rong Mao, Professor of Pathology, University of Utah School of Medicine, Medical Director, Molecular Genetics and Genomics, ARUP Laboratories

• Liudmila Sergeevna Mainzer, Technical Program Manager, Genomics, National Center for Supercomputing Applications, Research Assistant

Professor, Institute of Genomic Biology, University of Illinois

• Zhaohui Steve Qin, Associate Professor, Department of Biostatistics, Emory University

• Kiran Garimella, Senior Computational Scientist, Broad Institute

• Fritz Sedlazeck, Assistant Professor, Human Genome Sequencing Center, Baylor College of Medicine

• Cecilia CS Yeung, Assistant Professor - University of Washington, Dept. of Pathology, Medical Director - Molecular Oncology Laboratory, Fred

Hutchinson Cancer Research Center


https://www.jefferson.edu/university/jmc/departments/pathology.html

https://www.jefferson.edu/index.html


Confirmed and Reserved Speakers Include: 2020 Single Cell Analysis Congress

• Brian Dougherty, Executive Director of Translational Medicine, AstraZeneca Oncology R&D

• Bin Li, Director, Computational Biology, Takeda

• Esperanza Anguiano, Associate Director, Clinical Genetics and Genomics, Translational Medicine, Bristol-Myers Squibb Company

• Jin Jen, Director, Sequencing Research, Celgene

• Shanrong Zhao, Director, Pfizer

• WADE DAVIS, Director Computational Genomics, Genomics Research Center (GRC), AbbVie

• Qu Zhang. Senior Scientist, MedImmune

• Kalpit Shah, Former Senior Research Investigator, Bristol-Myers Squibb

• Dann Huh, Senior Scientist, Biogen

• Giovanni Tonon, Director, Center for Translational Genomics and Bioinformatics, Head, Functional Genomics of Cancer Unit, Division of Experimental Oncology, San

Raffaele Scientific Institute

• Gregory Timp, Professor, Notre Dame University

• Suraj P. Bhat, Professor, Vision Molecular Biology Laboratory, Stein Eye Institute, University of California

• Charles Wang, Director, Center for Genomics, Professor, Department of Basic Sciences, Loma Linda University School Of Medicine

• Bruce Aronow, Co-Director, Cincinnati Children's Hospital Medical Center

• Bogdan Budnik, Director of Proteomics, Harvard University

• Rob Mitra, Alvin Goldfarb Distinguished Professor of Computational Biology, Professor of Genetics, MGI

• Vladimir Kiselev, Informatics Team Leader, Wellcome Trust Sanger Institute

• Franziska Michor, Professor of Computational Biology, Department of Data Sciences, Dana-Farber Cancer Institute

• David H. Perlman, Principal Scientist, Proteomics and Target Discovery Lead, Merck Research Labs Cambridge Exploratory Sciences Center

• Xiaowei Zhuang, Howard Hughes Medical Institute Investigator, David B. Arnold Jr. Professor of Science, Professor of Chemistry and Chemical Biology, Professor of

Physics, Harvard University

• Michael Kharas, Lab Head, Kharas Lab, Memorial Sloan Kettering Cancer Center

• Aubrey Thompson, Professor of Cancer Biology, Mayo Clinic, US

• Lihua Julie Zhu, Professor and Head of Bioinformatics Core, University of Massachusetts

• May Dongmei Wang, Professor, Director of Biomedical Big Data Initiative, Georgia Institute of Technology and Emory University

• Yu-Hwa Lo, Professor, Electrical and Computer Engineering, National Nanotechnology Coordinated Infrastructure (NNCI)

• Nikolai Slavov, Professor, Northeastern University

• Joel Voldman, Professor of Electrical Engineering, Associate Head, Electrical Engineering and Computer Science, MIT

• Xianjun Dong, Director of Computational Neuroscience, Brigham and Women's Hospital

• Joshua Campbell, Co-Director of the Single Cell Sequencing Core and Assistant Professor, Boston University

• Guo-Cheng Yuan, Associate Professor, Dana-Farber Cancer Institute

• Abbas Rizvi, Associate Research Scientist, Maniatis Lab, Columbia’s Zuckerman Institute

• Sara Rouhanifard, Assistant Professor, Northeastern University

• Malte Kühnemund, CEO, CARTANA

• Mark Borodovsky, Director, Center for Bioinformatics & Computational Genomics, Georgia Tech and Emory University


http://www.ece.ucsd.edu/


2019 Next Generation Sequencing and Clinical Diagnostics & Single Cell Analysis Sponsors Included:

Bronze Sponsors:

Network And Programme Sponsors:



6th Annual Next Generation Sequencing & Single Cell Analysis USA Congress

Day One – 7 April 2020

07.30 – 08.20 Registration

08.20 – 08.25 Oxford Global’s Welcome Address

08.25 – 08.30 Chairperson’s Opening Address

6th Annual Next Generation Congress 6th Annual Single Cell Analysis Congress

08.30 – 09.00 Stream Keynote Address:

Genome Sequencing Data Analysis

CONFIRMED: Suzanne Leal, Sergievsky Family Professor

of Neurological Sciences, Director - Center for Statistical

Genetic - Columbia University

Stream Keynote Address:

A Multi-Center Cross-platform Benchmarking Study on scRNA-seq

• A multi-center cross-platform scRNA-seq study showing a large variation and batch effect existed across scRNA-seq

platforms/technologies and centers

• Batch correction is the critical in scRNA-seq study across different batch of experiments and the nature of biological

samples dictate the selection of best batch correction methods

• A large cross-platform/center scRNA-seq reference data consisting both mixed and non-mixed cells from two distinct

cell lines were generated for future benchmarking evaluation of new single-cell technologies and bioinformatics

algorithms

CONFIRMED: Charles Wang, Director, Center for Genomics, Professor, Department of Basic Sciences, Loma Linda

University School Of Medicine

6th Annual Next Generation Congress 6th Annual Single Cell Analysis Congress

Day 1 Steam 1

Part 1: Multi Omics Data Integration and Whole Genome

Sequencing Data Analysis

Day 1 Stream 2: Spatial Omics Day 1 Stream 3

Part 1: Single Cell Proteomics and Epigenomics

09.00 – 09.30 Stream Keynote Address:

Multi Omic Data Integration

RESERVED: Isidore Rigoutsos, Richard W. Hevner

Professor of Computational Medicine, Director

- Professor - Dept. of Pathology, Anatomy & Cell Biology,

Thomas Jefferson University

Stream Keynote Address:

A Multimodal Strategy for a Single Cell Atlas of the

Human Spinal Cord

RESERVED: Abbas Rizvi, Associate Research Scientist,

Maniatis lab, Columbia’s Zuckerman Institute

Stream Keynote Address: Single Cell Proteomics

CONFIRMED: Bogdan Budnik, Director of Proteomics,

Harvard University

09.30 – 10.00 Solution Provider Presentation

For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation


[email protected]



[email protected]

10.00 – 11.20 Morning Coffee & Refreshments, Poster Presentation Sessions, One to One Meetings x3


https://www.jefferson.edu/university/jmc/departments/pathology.html

https://www.jefferson.edu/index.html






Day One – 7 April 2020

11.20 – 11.50 Whole Genome Sequencing Data Analysis

CONFIRMED: Jane Wilkinson, Senior Director, Broad

Genomics Alliance Management, Broad Institute at

Harvard & Massachusetts Institute of Technology

Biotagging of Specific Cell Populations in Zebrafish

Reveals Gene Regulatory Logic Encoded in the Nuclear

Transcriptome

CONFIRMED: Scott E. Fraser, Provost Professor of

Biology and Bioengineering, Elizabeth Garrett

Professor of Convergent Biosciences, Director of

Science Initiatives, University of Southern California,

Translational Imaging Center

Single Cell Proteomics by Mass Spectrometry

CONFIRMED: Nikolai Slavov, Assistant Professor,

Northeastern University

11.50-12.20 The Performance Optimization for Next Generation

Sequencing Analysis In Clinical Environment

CONFIRMED: Liudmila Sergeevna Mainzer, Technical

Program Manager, Genomics, National Center for

Supercomputing Applications, Research Assistant

Professor, Institute of Genomic Biology, University of

Illinois

Barcoded Solid-Phase RNA Capture For Spatial

Transcriptomics Profiling

CONFIRMED: Esperanza Anguiano, Associate Director,

Clinical Genetics and Genomics, Translational

Medicine, Bristol-Myers Squibb Company

Single Cell ‘Omics Case Studies And Therapeutic

Applications: Epigenomics

CONFIRMED: Giovanni Tonon, Director, Center for

Translational Genomics and Bioinformatics, Head,

Functional Genomics of Cancer Unit, Division of

Experimental Oncology, San Raffaele Scientific Institute

12.20 – 12.50



[email protected]



[email protected]

12.50 – 13.50 Lunch, Poster Presentation Sessions

PART 2: Future Directions In Long Read Sequencing For

Human Genomes And De Novo Studies

FEATURED STREAM: Spatial Transcriptomics

Part 2: Single Cell in Clinical Use – Applications &

Diagnostic Development

13.50 – 14.20 Long Read Sequencing - Technological Updates

Identification Of Structural Variants And Improvements

In The Characterisation Of Genetic Variation

CONFIRMED: Chia-Lin Wei, Director of Genome

Technology, The Jackson Laboratory

Single-Cell Transcriptome Imaging And Cell Atlas Of

Complex Tissues

CONFIRMED: Xiaowei Zhuang, Howard Hughes Medical

Institute Investigator, David B. Arnold Jr. Professor of

Science, Professor of Chemistry and Chemical Biology,

Professor of Physics, Harvard University

Hidden Heterogeneity And Circadian-Controlled Cell Fate

Inferred From Single Cell Lineages

CONFIRMED: Franziska Michor, Professor of

Computational Biology, Department of Data Sciences,

Dana-Farber Cancer Institute





14.20 – 14.50 Investigating Fusion Genes and Breakpoints in

Cancer Genome

CONFIRMED: Cecilia CS Yeung, Assistant Professor -

University of Washington, Dept. of Pathology, Medical

Director - Molecular Oncology Laboratory, Fred

Hutchinson Cancer Research Center

Spatial Analysis of Single Fiber Cells of the Developing

Ocular Lens Reveals Regulated Heterogeneity of Gene

Expression

CONFIRMED: Suraj P. Bhat, Professor, Vision Molecular

Biology Laboratory, Stein Eye Institute, University of

California

Reproducible Data Analysis Pipeline for Clinical

Translation

CONFIRMED: May Dongmei Wang, Professor, Director of

Biomedical Big Data Initiative, Georgia Institute of

Technology and Emory University

14.50 – 15.20



[email protected]



[email protected]



[email protected]

15.20 – 16.20 Afternoon refreshments, Poster Presentation Sessions, One to One Meetings x2

16.20 – 16.50 Bioinformatics And Mapping Tools

CONFIRMED: Zhaohui Steve Qin, Associate Professor,

Department of Biostatistics, Emory University

Spatial Transcriptomics Analysis Pipeline

CONFIRMED: Guo-Cheng Yuan, Associate Professor, of

Computational Biology and Bioinformatics, Dana-

Farber Cancer Institute

Translation To Diagnostic And Therapeutic

Applications

CONFIRMED: Brian Dougherty, Executive Director of

Translational Medicine, AstraZeneca Oncology R&D

16.50 – 17.20 Cloud-Native Methods For Long Read SV Discovery In

Human Genomes

CONFIRMED: Kiran Garimella, Senior Computational

Scientist, Broad Institute

Tool Development to Enable Spatial Transcriptomics

Research

CONFIRMED: Yu-Hwa Lo, William SC Chang

Professor, Electrical and Computer Engineering, UCSD

Method for Dynamically Detecting Secretions from

Single Cells Using a Nanopore

CONFIRMED: Gregory Timp, Professor, Notre Dame

University

17.20 – 17.50 Whole Genome Sequencing in Cohort for

Cardiovascular Patients - Data Analysis Case Study

Using Nanopore Sequencing

CONFIRMED: Fritz Sedlazeck, Assistant Professor,

Human Genome Sequencing Center, Baylor College of

Medicine

ClampFISH And 3D Single-Cell Protein Atlas

CONFIRMED: Sara Rouhanifard, Assistant Professor,

Northeastern University

RNA Regulators Of Self-Renewal In Both Normal And

Leukemic Hematopoiesis

CONFIRMED: Michael Kharas, Lab Head, Kharas Lab,

Memorial Sloan Kettering Cancer Center

17.50 – 18.20 Developing Benchmarks for Challenging Variants With

Long Reads

RESERVED: Chi-Ming Li , Principal Scientist – Genome

Analysis Unit, Center of Excellence for NGS and Single

Cell Genomic Analysis

Spatial Cell Atlases with Next Generation In Situ

Sequencing • The “next generation in situ sequencing” (NGISS) has an

increased sensitivity and signal/noise and works on a larger

range of target RNA and sample types

• NGISS generates spatial cell atlases in high throughput and is

applicable on a range of tissue samples

• Spatial cell type maps on human brain tissue samples

CONFIRMED: Malte Kühnemund, CEO, CARTANA

Case Study: Pioneering Single Cell Technologies To

Advance Brain Repair

CONFIRMED: Ana Martin-Villalba, Professor, German

Cancer Research Centre

19.00 End of Day One & Networking Drinks


https://www.researchgate.net/publication/326472715_Spatial_Analysis_of_Single_Fiber_Cells_of_the_Developing_Ocular_Lens_Reveals_Regulated_Heterogeneity_of_Gene_Expression








Day Two – 8 April 2020

Next Generation Sequencing Single Cell Analysis

08.00 – 09.30 INTERACTIVE WORKSHOP: Accuracy, Cost And Coverage Of Short And Long Read

Sequencing

• Applications for long and short read

• Integration of short and long read technologies

• Comparison of Accuracy, Cost And Coverage Of Short And Long Read Sequencing

CONFIRMED:

Moderator: Stuart A. Scott, Associate Professor, Department of Genetics and

Genomic Sciences, Icahn School of Medicine at Mount Sinai, ,Division Head,

Pharmacogenomics, Director, Cytogenetics and Cytogenomics

Panellists:

Cynthia Morton, Director of Cytogenetics, Harvard University

James Willey, Professor of Medicine and Pathology, George Isaac Chair for Cancer

Research, University of Toledo

INTERACTIVE WORKSHOP: Spatial Transcriptomics

Spatial Transcriptomics allows the sequencing of the complete transcriptomes

from barcoded regions of intact tissue. The technology has the potential to

answer a wide range of biological questions concerning cellular function, but

analysis of the data presents a number of challenges which are not met by

existing analysis tools. The workshop aims to cover topics ranging from the

challenges of using Spatial Transcriptomics tools and technology in sample

preparation, data analysis and visualization. It also includes Mining the

transcriptome using spatial transcriptomics.

Day 2 Stream 1

PART 1: Long Read Sequencing and Short Read

Sequencing for Implementation of Genomic Medicine

Day 2 Stream 1: Single-Cell Analysis In Drug

Discovery and Development

Day 2 Stream 2: Single Cell Analysis: Overcoming

Challenges

09.30 – 10.00 Delivering Genomic-based Precision based Medicine

CONFIRMED: Stuart A. Scott, Associate Professor,

Department of Genetics and Genomic Sciences, Icahn

School of Medicine at Mount Sinai, Division Head,

Pharmacogenomics, Director, Cytogenetics and

Cytogenomics

Case Studies: Oncology, Immunotherapy,

Neurodegenerative, Autoimmune And Rare

Diseases Using Multi-Omics Approaches

CONFIRMED: Bin Li, Director, Computational

Biology, Takeda

Microfluidic Tools For Monitoring The Immune System

CONFIRMED: Joel Voldman, Professor of Electrical

Engineering, Associate Head, Electrical Engineering and

Computer Science, MIT

10.00 – 11.00 Morning Coffee & Refreshments, Poster Presentation Sessions, One to One Meetings x2


Presentations on Long Read Platforms & Data Analysis


[email protected]



[email protected]



[email protected]






6th Annual Next Generation Sequencing & Single Cell Analysis USA Congress Day Two – 8 April 2020


Genome Visualization and Analysis


[email protected]



[email protected]



[email protected]

12.00 – 12.30 A Time To Sequence In Clinical Cytogenetics: The Need

For Nucleotide Resolution

CONFIRMED: Cynthia Morton, Director of Cytogenetics,

Harvard University

Case Study: Single-Nuclei RNAseq In Human Brain

Neurons

CONFIRMED: Xianjun Dong, Director of

Computational Neuroscience, Brigham and

Women's Hospital

Biological Network Analyses Of Single Cell Data To Learn

About Intercellular Regulatory Biology Of Tissues And

Diseases

CONFIRMED: Bruce Aronow, Professor, UC Department of

Pediatrics, Cincinnati Children's Hospital Medical Center

12.30 – 13.30 Lunch, Poster Presentation Sessions

13.30 – 14.00

NGS and Delivering Genomic Based Medicine (TBA)

CONFIRMED: James Willey, Professor of Medicine and

Pathology, George Isaac Chair for Cancer Research,

University of Toledo

Single Cell RNAseq In Drug Development

CONFIRMED: Jin Jen, Director, Sequencing Research,

Celgene

Panel Discussion – Choosing Among Alternative Single

Cell Protocols And Technologies

• 10x, CellSeq, NucSeq, ATAC-Seq, and Spatial Seq

Technologies

• Platform Options and Inter-technology comparisons

• Sampling approaches and the effects of

development, aging, disease on sample integrity

• Validation methodologies at the level of gene, cell,

tissue

• Disease profiling versus normal tissues

• How do alternative technologies provide distinct

biological insights into cell lineages, tissues,

diseases

Moderator: Bruce Aronow, Professor, UC Department of

Pediatrics, Cincinnati Children's Hospital Medical Center

CONFIRMED:

• Charles Wang, Director, Center for Genomics,

Professor, Department of Basic Sciences, Loma Linda

University School Of Medicine

• WADE DAVIS, Director Computational Genomics,

Genomics Research Center (GRC), Abbvie






6th Annual Next Generation Sequencing and Clinical Diagnostics & Single Cell Analysis Congress


Part 2: Short and Long Read Sequencing – Applications in

the Clinic

Single-Cell Analysis In Drug Discovery and

Development

Single Cell Analysis: Emerging Trends and Technologies in

Single Cell Analysis

14.00 – 14.30 Sudden Cardiac Death Prevention With Molecular

Diagnosis

CONFIRMED: Rong Mao, Professor of Pathology,

University of Utah School of Medicine, Medical Director,

Molecular Genetics and Genomics, ARUP Laboratories

To Investigate The Transition And Diversity Spectrum

Of Innate Lymphoid Cells In Human Mucosal Tissues

By scRNA-seq

• Introduction to innate lymphoid cells (ILCs) and

its sub-classes

• RNA velocity to predict the future state of

individual cells

Transition among different ILC subsets by

CONFIRMED: Shanrong Zhao, Director, Computational

Biology and Bioinformatics, Pfizer Inc.

Gene Regulation (TBC)

CONFIRMED: Vladimir Kiselev, Informatics Team Leader,

Wellcome Trust Sanger Institute

14.30 – 15.00 Nature of Cell Free DNA in Cancer Patient Blood Samples

We have been investigating the nature of cell free (cf) DNA in

cancer patient blood samples. In particular looking for the

presence of mutations in the higher molecular weight cf-DNA

that is often found in cancer patient blood samples. Using a

new electrokinetic device (ACE chip, Biological Dynamics, San

Diego, CA) now allows sample to answer Multi-Omic analysis

of exosome and extracellular vesicle (EV) biomarkers as well

as cell free (cf) DNA and RNA from the “same” 20-50 µL blood,

plasma or serum sample.

CONFIRMED: Michael Heller, Professor, University of

California, San Diego, Distinguished Scientist - Knight

Cancer Institute at Oregon Health & Science University

(OHSU), Center for Cancer Early Detection and Research

Single Cell CRISPR + Single Cell RNAseq in Drug

Discovery = A Powerful Combination

• Challenges in CRISPR Pooled Screening

• Application of combination single cell CRISPR + Single

Cell RNAeq

• Examples of questions that can be addressed with

this approach

CONFIRMED: WADE DAVIS, Director Computational

Genomics, Genomics Research Center (GRC), AbbVie

Using Single Nucleotide Variations of Single-Cell RNA-Seq

to Identify Subpopulation and Genotype-phenotype Links

RESERVED: Lana Garmire, Director of Bioinformatics Core

and Associate Professor, University of Michigan

15.00 – 15.30 Afternoon Refreshments, Poster Presentation Sessions

15.30 – 16.00 NGS For Precision Surveillance Of Multidrug-Resistant

Organisms And Infection Control Practice

CONFIRMED: Hank Wang, Professor of Clinical Pathology

& Director of Microbiology, Virology & Molecular

Diagnostics Laboratories, Westchester Medical Center &

New York Medical College

Single Cell In Discovery For Immuno-oncology

CONFIRMED: Qu Zhang. Senior Scientist, MedImmune

Overcoming Bioinformatics Challenges

CONFIRMED: Rob Mitra, Alvin Goldfarb Distinguished

Professor of Computational Biology, Professor of

Genetics, MGI



6th Annual Next Generation Sequencing and Clinical Diagnostics & Single Cell Analysis Congress


Part 2: Short and Long Read Sequencing – Applications

in the Clinic

Single-Cell Analysis In Drug Discovery and

Development

Single Cell Analysis: Emerging Trends and Technologies in

Single Cell Analysis

16.00 – 16.30 Molecular Diagnostics Development

RESERVED: Andrea Ferreira-Gonzalez, Chair of the

Molecular Diagnostics Division and Director of the

Molecular Diagnostics Laboratory, VCU Health

Single Cell Proteomics and Drug Discovery

CONFIRMED: David H. Perlman, Principal Scientist,

Proteomics and Target Discovery Lead, Merck

Research Labs Cambridge Exploratory Sciences Center

Develop Machine Learning Algorithms For Computational

Analysis Of Biological Sequences: DNA, RNA And Proteins.

Our Primary Focus Is On Prediction Of Protein-Coding

Genes And Regulatory Sites In Genomic DNA

CONFIRMED: Mark Borodovsky, Director, Center for

Bioinformatics & Computational Genomics, Georgia Tech

and Emory University

16.30 – 17.00 Applications in the Clinic Applications of Long Read

Sequencing in Oncology and Immuno- oncology

Exploring Tumor Microenvironment & Disease

Modeling Using Single Cell RNASeq

CONFIRMED: Kalpit Shah, Former Senior Research

Investigator, Bristol-Myers Squibb

Overcoming Bioinformatics Challenges

CONFIRMED: Lihua Julie Zhu, Professor and Head of

Bioinformatics Core, University of Massachusetts

17.00 - 17.30 Illuminating Bacterial Epigenomes to Characterize

Pathogens and Microbiome

Single-Nucleus RNA-Seq Study On Human Spinal

Cords From ALS Patients (And Control) For Target

Discovery

CONFIRMED: Dann Huh, Senior Scientist, Biogen

Dealing With Multi- omics Data Coming From Single Cell

Analysis

CONFIRMED: Joshua Campbell, Co-Director of the Single

Cell Sequencing Core and Assistant Professor, Boston

University

17.30 End Of Conference


single cell multi omics analysis on basic science...next generation • • transcriptomics...

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