silk and silicon based bio-integrated electronics - slides

Dissolvable films of silk fibroin for

ultrathin conformal bio-integrated

electronics

Dawn John Mullassery

Electrical and Computer EngineeringUniversity of British Columbia

1

The Paper

John A Rogers 2

Overview

bull Motivation and Background

bull The technology

bull Future

3

httpwwwsingularitysymposiumcommoores-lawhtml

MOORErsquos LAW

ldquoThe observation made in 1965 by Gordon Moore co-founderof Intel that the number of transistors per square inch onintegrated circuits had doubled every year since theintegrated circuit was invented Moore predicted that thistrend would continue for the foreseeable futurerdquo

- Webopedia

4

Bio-Integration

6th International Conference on Intelligent and Advanced Systems 2016 (ICIAS2016) ieeemyorg httpwwwcomputerhopecomjargoneedsachtm 5

Bio-Integration

6

Existing Technology ndash Utah

httpwwwsciutahedu~gkabstractsbisti03 Acute human brain responses to intracortical microelectrode arrays challenges and future prospects - Eduardo etal doi 103389fneng201400024

7

Electro - Corticography

Recording Human Electrocorticographic (ECoG) Signals for Neuroscientific Research and Real-time Functional Cortical MappingN Jeremy Hill etal doi 1037913993 8

Two main areas

bull Bio-integrated or Biocompatible electronics

bull Transient electronics or Bioresorbableelectronics

9

Bio-Integrated Electronics

bull Epidermal Electronics

bull Non ndash uniform surfaces inside the body

10

Bio-Integrated Electronics - Brain

11


12

httprogersmatseillinoisedumultimediaphp

13

Bio-Integrated Electronics - Cardiac

Electrophysiology

A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etalFlexible foldable actively multiplexed high-density electrode array for mapping brain activity in vivo Jonathan Viventi etal

14


Electrophysiology

A Conformal Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology Jonathan Viventi etal 15


16

Bio-Integrated Electronics -

Spatiotemporal cardiac measurements

3D multifunctional integumentary membranes for spatiotemporal cardiac measurements and stimulation across the entire epicardium Lizhi Xu etal

ECG sensor Si strain gauge μ-ILED pH sensor Temperature sensor

17

Bio-Integrated Electronics - Advantages

bull High resolution results

bull Less complicated process

bull Similar process can be used for epidermal electronics

bull Non ndash invasive method

18

Transient Electronics

Electronic systems that dissolve resorb or otherwise physically disappear at programmed rates or specific triggered times

A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE 19

Thin Silicon Membranes Dissolve


Water Soluble Silicon

Silicon for Transient Electronics

bull Silicon Thickness - 35 nm

bull Dissolution Time ndash 10 days

bull Water ndash 04 ml

Silicon for Regular Electronics

bull Silicon Thickness -700 microm

bull Dissolution Time ndash600 to 1000 years

bull Water - 8 L


Silk membranes dissolve

22

Transient Electronic Device




A Physically Transient Form of Silicon Electronics etal 2012 VOL 337 SCIENCE

26

Why a novel approach

bull Biomedical Purposes

bull Environmental Sensors

bull Consumer Electronics

27

Biomedical Application ndash Transient Electronics


28

Biomedical Application ndash Surgical Site

Infections


Edible and Good

Magnesium ~ 100 mg vs ~ 300 mg

Silicon ~ 2 microg vs ~ 10 mg

30

Biomedical Applications

bull Drug Delivery

bull Electronic Aspirin

31

Environmental sensors amp e- waste

32


33

Next Few Years amp Future

bull Human body

bull Non ndash biomedical applications

bull Further R amp D required

34

Why will this be a classic paper

bull New approach to existing techniques of biomedical methods

bull Any form of biological surface ndash with minimal invasion

bull Not limited to biomedical

35

36

The Paper

John A Rogers 2

Overview


bull The technology

bull Future

3


MOORErsquos LAW


- Webopedia

4

Bio-Integration


Bio-Integration

6



7



Two main areas



9




10


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12


13


Electrophysiology


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Electrophysiology



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bull Water - 8 L



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28


Infections


Edible and Good



30


bull Drug Delivery


31


32


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bull Human body



34





35

36

Overview


bull The technology

bull Future

3


MOORErsquos LAW


- Webopedia

4

Bio-Integration


Bio-Integration

6



7



Two main areas



9




10


11


12


13


Electrophysiology


14


Electrophysiology



16





17






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bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


MOORErsquos LAW


- Webopedia

4

Bio-Integration


Bio-Integration

6



7



Two main areas



9




10


11


12


13


Electrophysiology


14


Electrophysiology



16





17






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bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36

Bio-Integration


Bio-Integration

6



7



Two main areas



9




10


11


12


13


Electrophysiology


14


Electrophysiology



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17






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bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36

Bio-Integration

6



7



Two main areas



9




10


11


12


13


Electrophysiology


14


Electrophysiology



16





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36



7



Two main areas



9




10


11


12


13


Electrophysiology


14


Electrophysiology



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17






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bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36



Two main areas



9




10


11


12


13


Electrophysiology


14


Electrophysiology



16





17






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bull Water - 8 L



22






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27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36




10


11


12


13


Electrophysiology


14


Electrophysiology



16





17






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bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


11


12


13


Electrophysiology


14


Electrophysiology



16





17






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bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


12


13


Electrophysiology


14


Electrophysiology



16





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


13


Electrophysiology


14


Electrophysiology



16





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


Electrophysiology


14


Electrophysiology



16





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


Electrophysiology



16





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


16





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36





17






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36






18














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36














bull Water - 8 L



22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


22






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36






26





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36





27



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36



28


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


Infections


Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36

Edible and Good



30


bull Drug Delivery


31


32


33


bull Human body



34





35

36


bull Drug Delivery


31


32


33


bull Human body



34





35

36


32


33


bull Human body



34





35

36


33


bull Human body



34





35

36


bull Human body



34





35

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