silence therapeutics unaudited preliminary results 2011
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Silence Therapeutics Unaudited Preliminary Results 2011 - March 2012.Featuring 2011 Highlights, an overview of Silence's performance and products, and an analysis of the commercial landscape of the field of RNAi.TRANSCRIPT
Unaudited Preliminary Results 2011
21 March 2012
New Team members with Proven Track Record of building value For shareholders
– Anthony Sedgwick, Ph.D., Chief Executive Officer ( Biotech Entrepreneur Novacta, Daniolabs, Cambridge Biotechnology, Roche)
– George Büchner, Ph.D., Head of Business development
(Novacta, Haptogen, Pharma Ventures)
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2011 Highlights
– Positive interim data presented at ASCO – Data showed excellent safety and indications of potential efficacy
– Leadership position validated by three new partnerships
– Top 10 pharma company, InteRNA Technologies and miRNA Therapeutics – Further deal signed with miRagen Inc in January 2012
– Positive clinical results from partners
– Quark and Pfizer positive Phase II results in diabetic macular oedema – Organisation streamlined
– Californian facility was closed, Board membership reduced
– Enhanced commercial focus – New business development team recruited
– Intellectual property strengthened
– PKN3 patent issued in Japan, Zamore re-issued in US, Tuschl I clarified (Europe) – Fundraising of £5.51m (net of expenses) in May 2011
– To fund development of pipeline and investment in RNAi technology platform
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2011 Post year-end Highlights
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– Dr Tony Sedgwick was promoted to Chief Executive Officer
– Deal announced with miRagen Therapeutics for the delivery of microRNAs using the DBTC liver delivery systems
– Silence's second deal on DBTC and third for microRNAs
– Creation of a Scientific Advisory Board – Two Key Opinion Leaders in the area of liver disease –announced today
RNAi – James Watsons vision 2012
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An Overview of Silence Therapeutics
• European Biotechnology Company
• Listed on LSE (AIM) with operations centralised in Berlin
• Cutting Edge technology- RNAi (Ribose Nucleic acid Interference)
• Experienced New Management Tony Sedgwick CEO –Geo Buchner Business
Several value drivers:
• External Milestones and Royalties (Quark)
• Internal Phase I First in Class Cancer Therapy (To be completed mid-2012)
• Low cost preclinical Pipeline
• Strong IP (e.g. AtuRNAi, Licenses to Fire & Mello and Zamore Patents)
• One of only 2 companies with prosecuted patents in area
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What is RNAi
Transformative technology
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RNAi can “Silence” Undruggable problem genes
Stabilised AtuRNAi Naked can target All
Genes
Targets that can be blocked by small
molecule drugs or antibodies
22,000 genes
Human Genome At the origin of numerous
diseases The RNAi technology
can target ALL OF THEM
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Two value drivers: External and Internal
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Potential External revenue streams
Novartis
$3-11 million
Pfizer
$4 million
Pfizer/Quark
$85 million
Novartis/Quark
$71-77 million
2012 2014 Remaining milestones
Total milestone potential: approx $170 million
PLUS further potential milestone payments from the AstraZeneca collaborations
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siRNA technology trigger
Commercial landscape: Delivering the great promise of RNAi
Development of successful delivery
solutions
Delivery challenges Identified
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And Internal value drivers…
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Silences AtuRNAi plus Disease “bespoke” delivery system makes a drug
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Atu027: New Cancer treatment in Phase I
• Atu027 ‘silences’ the production of PKN3 a Key regulator of blood and lymph vessel formation
• Inhibition of PKN3 leads to: • reduced oxygen supply to
tumour
• reduced tumour growth/metastases
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Atu027 is RNAi against PKN3 plus Atuplex
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Atu027: successfully progressed to a phase I
Investment
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Atu027 is safe in man and could be a new medicine for treating difficult cancers
• Atu027 Phase I interim data demonstrates safety (ASCO 2011)
• 10 out of 27 patients showed stable disease after treatment period
• Atu027 very well tolerated - effective dose exceeded
• Phase I results expected to report in mid-2012
• Biomarker data currently under evaluation
• Looking for Co development partner
• Validates AtuPLEX™ delivery technology
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AtuRNAi plus DACC system makes a drug for treating lung Cancer and life threatening lung disease
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Silence´s DACC delivery system: targets siRNAs to the lungs
• Address lung-specific diseases e.g. acute lunG injury/ARDS/Cancer by delivering siRNA primarily to the lungs
• Single dose sufficient to inhibit target gene
• Expression in the lungs for up to a month
• Atu111 in preclinical
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AtuRNAi plus DBTC system makes a drug for treating liver Cancer and life threatening liver disease
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Silence´s DBTC: targets siRNAs to the liver
• Address liver-specific diseases e.g. HCC, ischemia reperfusion injury
• Single dose inhibits gene
expression in the liver for up to 1 week
• Well tolerated (up to 8.3 mg/kg) • Preclinical studies ongoing
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Silence’s Revenue Stream
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Two value drivers: External and Internal
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Silence Power………………….
• New Management with proven track record
• Cutting Edge technology
• First in Class RNAi new cancer therapy
• One of only two companies with Prosecuted patents in area
• Lean organisation
• Pipeline of drugs and deals
• Undervalued
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Results for 2011
GBP ‘000s 2011 unaudited
2010 audited
Revenue
R&D spend
Admin costs
Restructuring costs
Operating loss
Other income/(expense)
Loss after tax
694 2,366
(137)
Net cash 3,688 3,567
(8,795)
(8,658)
-
(5,203)
(5,821) (3,361)
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(5,737)
(5,786)
(472)
(2,647)
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Newsflow 2012
Update on AstraZeneca collaboration
Sign delivery collaboration with miRagen
Start of Phase IIb trial of PF’-655 in DME (Quark/Pfizer)
Sign further collaboration agreements
Completion of enrolment in Atu027 trial
Start of Phase II trial of QPI-1002 in AKI (Quark/Novartis)
Publication of white paper on delivery technologies
Completion of Atu027 phase I trial
Completion of phase II trial of QPI-1002 delayed graft function
Start of phase Ib/II trial of Atu027
Further patent issuances
January 2012
January 2012
1Q 2012
1H 2012
1H 2012
1H 2012
1H 2012
Mid 2012
2H 2012
2H 2012
2H 2012
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Disclaimer
The statements made in this presentation may contain certain forward-looking comments. Actual
events or results may differ from the Company’s expectations. In addition to the matters described in
the presentation, future actions by the European Agency for Evaluation of Medicinal Products, the U.S. Food and Drug Administration or equivalent
regulatory authorities in other countries and results of pending or future clinical trials, as well as other
risk factors outlined from time to time in the Company’s regulatory filings, may affect actual
results achieved by the Company. The Alternative Investment Market (AIM) has not reviewed and does
not accept responsibility for the adequacy or accuracy of this presentation.
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Key peers
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