The BIOMEDICAL ENGINEERING Series Series Editor Michael R. Neuman

An Introduction to Biomaterials

Edited by Scott A. Guelcher

Jeffrey 0. Hollinger

L,tiP) Taylor &. Francis ^ ^ J Taylor & Francis Group

ßoca Raton London New York

A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa pic.

Contents

1. Introduction 1 Scott A. Guelcher and Jeffrey O. Hollinger

2. Fundamental Biological Requirements of a Biomaterial 3 James M. Anderson

3. Cell-Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations 15 Gregory M. Harbers and David W. Grainger

4. Protein Adsorption at the Biomaterial/Tissue Interface 47 Philip LeDuc and Yadong Wang

5. In Vitro Testing of Biomaterials 63 Shelley R. Winn, John Mitchell, and Hasan Uludag

6. Considerations for the In Vivo Testing of Biomaterials 81 Jeffrey O. Hollinger and Mark Citron

7. Fibrin and Its Applications 105 Bill Tazvil

8. Proteins and Amino Acid-Derived Polymers 121 Joshua C. Haarer and Kay C. Dee

9. The Poly(a-Esters) 139 Dennis D. Jamiolkowski and Edward J. Dormier

10. Polyurethanes 161 Scott A. Guelcher

11. Polymers Derived from L-Tyrosine 185 Joachim Kohn and Jaap Schut

12. Poly(Propylene Fumarate) 205 Xinfeng Shi and Antonios G. Mikos

13. Hyaluronan as a Biomaterial 219 John H. Brekke and Kipling Thacker

14. Chitosan 249 Frank Rauh and Michael Dornish

15. Alginate 261 Michael Dornish and Frank Rauh

16. Polyphosphazenes 273 Lakshmi S. Nair, Yusuf M. Khan, and Cato T. Laurencin

17. Metallic Biomaterials 291 Henry R. Piehler

18. Ceramic Biomaterials 311 Prashant N. Kumta

19. Biomaterials for Drug and Gene Delivery 341 Yihua Loo and Kam W. Leong

20. Orthopedic Prostheses and Joint Implants 369 Shanfeng Wang, Lichun Lu, Bradford L. Currier, and Michael J. Yaszemski

21. Dental Implants 395 Bruce A. Doli, Ash Kukreja, Ali Seyedain, and Thomas W. Braun

22. Tissue Engineering of Bone 417 Sanjeev Kakar and Thomas A. Einhorn

23. Tissue Engineering — Nervous System 441 Lizzie Y. Santiago and Kacey G. Marra

24. Cardiovascular Tissue Engineering 461 Priya Ramaswami and William R. Wagner

25. Tissue Engineering — Skin 485 Jonathan Mansbridge

26. Tissue Engineering of Ligaments 499 Gregory H. Altman and Rebecca L. Horan

27. Tissue Engineering of Articular Cartilage 525 James W. Larson III and Constance R. Chu

Index 539