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Best methods. Best results.

Science of SynthesisWorkbench Editions

New topic:

Biocatalysis in

Organic Synthesis

Science of Synthesis Workbench Editions

C-1 Building Blocks in Organic Synthesis reviews a wide variety of reactions by which one carbon atom is added to an organic molecule, forming a C-C bond. In spite of the numerous classic reactions of this kind, there has been enormous progress in recent years, especially for those reactions involving catalytic methods. Introduction of substituted methyl groups is a major challenge and only very recently the first catalysts have been discovered that enable the introduction of fluoromethyl groups in aromatics.

C-1 Building Blocks in Organic Synthesis

• Authoritative overview of a dynamic field, written by 54 experts

• Quality contributions providing the most reliable methodologies

• Including typical and general experimental procedures

C-1 Building Blocks in Organic Synthesis 1:Additions to Alkenes, Alkynes and Carbonyl Compounds

C-1 Building Blocks in Organic Synthesis 2:Alkenations, Cross Couplings, Insertions, Substitutions, and Halomethylations

Volume Editor:Piet W. N. M. van Leeuwen Institute of Chemical Research of Catalonia, Tarragona, Spain

The two volumes Science of Synthesis: Multicomponent Reactions critically review the state of the art of domino, sequential, and consecutive multicomponent reactions. They serve as the basis for practical application to reach the goals of diversity-oriented synthesis, reaction design, and novel synthetic concepts. As is typical for the Science of Synthesis series, the reference work on multicomponent reactions presents the best synthetic methods as judged by experts in the field and includes typical and general experimental procedures.

Multicomponent Reactions

• Comprehensive coverage of a field which is of great interest to the synthetic organic chemist

• Compiled by 63 leading chemists in the multicomponent reactions field

• Presentation of the best methodologies available today

Multicomponent Reactions 1: Reactions Involving a Carbonyl Compound as Electrophilic Component

Multicomponent Reactions 2: Reactions Involving an α,β-Unsaturated Carbonyl Compound as Electrophilic Component

Volume Editor:Thomas J. J. Müller Heinrich-Heine-University Düsseldorf, Germany

The content of these Workbench Editions is also part of a subscription to the hardcover edition and the license for the structure-searchable electronic version of Science of Synthesis, both available for institutional subscribers.

Tables of contents and sample pages of the Workbench Editions are available at www.thieme-chemistry.com

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Science of Synthesis Workbench Editions

Shū Kobayashi: “While most organic reactions have been carried out in organic solvents for a long time, negative aspects of organic solvents have come to the fore recently; many organic solvents are volatile, flammable, sometimes explosive, and have a damaging effect on human health or on the environment. Water is obviously the first choice of alternative solvent; water is clean, non-toxic, inexpensive, and the most environmentally benign. Water is really beautiful in nature, and indeed she chose water as a ‘solvent’. Many elegant in vitro reactions are carried out in water in our bodies, mainly catalyzed by enzymes. Why should mankind not choose to use water in synthesis?”

Water in Organic Synthesis is essential for the organic chemist in helping gain a thorough appreciation of the latest and most reliable available methods for using water in organic synthesis. It illustrates how water can often be a viable and green solvent in the laboratory and provides a detailed introduction to the subject: background information, evaluated methods, practical applications, industrial applications, special techniques, and an overview of the latest trends. The reference work also helps in inspiring chemists worldwide to find new approaches and techniques for the application of water in organic synthesis.

Water in Organic Synthesis

• Comprehensive overview of a rapidly progressing field, compiled by 47 experts

• Critical review of aqueous reactions, covering almost all types of organic reactions

• Including special techniques with water and industrial applications

• Emphasis on environmental aspects

Water in Organic SynthesisVolume Editor:Shū KobayashiUniversity of Tokyo, Japan

Metal-catalyzed cross-coupling reactions for the generation of both carbon-heteroatom and carbon-carbon bonds are of central importance in modern chemistry. In 2010 the Nobel Prize for Chemistry was awarded to chemists working in the field. These volumes are designed to provide a compilation of ‘best practices’ i. e. protocols that are most advanced and reliable, with a particular emphasis on the breadth of scope. Cross Coupling and Heck-Type Reactions is a practical guide to the most efficient, reliable, and useful metal-catalyzed cross-coupling reactions available.

Cross Coupling and Heck-Type Reactions

• 96 experts provide a critical review of the state of the art in this field

• Including the best methods currently available for the formation of new carbon-heteroatom and carbon-carbon bonds using metal-catalyzed cross-coupling reactions

• Highlighted with representative experimental procedures

Cross Coupling and Heck-Type Reactions 3:Metal-Catalyzed Heck-Type Reactions and C—C Cross Coupling via C—H Activation

Volume Editor:Mats LarhedUniversity of Uppsala, Sweden

Cross Coupling and Heck-Type Reactions 2:Carbon-Heteroatom Cross Coupling and C—C Cross Coupling of Acidic C—H Nucleophiles

Volume Editor:John P. WolfeUniversity of Michigan, USA

Cross Coupling and Heck-Type Reactions 1:C—C Cross Coupling Using Organometallic Partners

Volume Editor:Gary A. MolanderUniversity of Pennsylvania, USA

Victor Snieckus, Queen‘s University, Kingston, Canada: “At the risk of blasphemy, the Science of Synthesis compendia represent the King James Version of the Bible or, to paraphrase for our science, the most influential version of the most influential book in the practice of chemical synthesis, in what is now its most influential language.”

Adriaan J. Minnaard, University of Groningen: “Stereoselective Synthesis focuses on topics that have seen considerable progress and are most relevant for synthesis. As a hallmark of the Science of Synthesis series, it provides in addition selected general experimental procedures. Stereoselective Synthesis is a milestone, reflecting the progress in the field, a pleasure to read or just browse.”

In Stereoselective Synthesis expert authors present the best and most reliable methods currently available for the preparation of nonracemic compounds. These methods may be stoichiometric or catalytic, and the latter may include metal, organic, or enzyme catalysis. The three volumes of Stereoselective Synthesis provide an invaluable resource to the practicing synthetic organic chemist.

Stereoselective Synthesis

• The best and most reliable methods for the preparation of nonracemic compounds

• With typical experimental procedures for broad utility and application

• Compiled by over 120 expert authors

Stereoselective Synthesis 3: Stereoselective Pericyclic Reactions, Cross Coupling, C―H and C―X Activation

Volume Editor:P. Andrew EvansQueen‘s University, Canada

Stereoselective Synthesis 2: Stereoselective Reactions of Carbonyl and Imino Groups

Volume Editor:Gary A. MolanderUniversity of Pennsylvania, USA

Stereoselective Synthesis 1: Stereoselective Reactions of Carbon―Carbon Double Bonds

Volume Editor:Johannes G. de Vries DSM Pharmaceutical Products, Netherlands

Ben List: “I am proud to have helped co-editing the Science of Synthesis two volume set on Asymmetric Organocatalysis, which has been written by the top leaders in the field. In my biased opinion, this product is the ultimate and comprehensive reference work on the ever growing area it covers. Its organization is highly logical and, following the great tradition of the Science of Synthesis books, typical experimental procedures are provided as an additional attractive and useful feature.”

Asymmetric Organocatalysis is the first reference work giving an overview of this dynamic, young field that is rapidly gaining significance for economical and environmentally friendly organic synthesis. It comprehensively covers all the catalysts and reactions within the four distinct activation modes: Brønsted base catalysis, Brønsted acid catalysis, Lewis base catalysis and Lewis acid catalysis. Typical or general experimental procedures as well as mechanistic, technical and theoretical aspects are included, allowing the reader to clearly see how simple, clean and efficient this chemistry is.

Asymmetric Organocatalysis

• Authoritative, broad overview of the field compiled by 74 experts

• Critical presentation of the best organocatalytic and related methodologies available today for practical asymmetric synthesis

• Provides alternative, greener syntheses with simple and easily used catalysts helping avoid the use of expensive and/or toxic metals

Asymmetric Organocatalysis 1: Lewis Base and Acid Catalysts

Volume Editor:Benjamin ListMax-Planck-Institut für KohlenforschungMülheim a. d. Ruhr, Germany

Asymmetric Organocatalysis 2: Brønsted Base and Acid Catalysts, and Additional Topics

Volume Editor:Keiji MaruokaKyoto University, Japan

Science of Synthesis provides a critical review of synthetic methodology developed to-date in the fields of organic and organometallic chemistry. The unique series includes:

• Selection of molecular transformations by world-renowned experts with elaboration on scope and limitations

• Full-text descriptions of synthetic methods with practical experimental procedures immediately applicable in the lab

The Science of Synthesis Reference Library is part of the compre-hensive Science of Synthesis series and provides an authoritative coverage of topical areas. The Editor of each individual volume is a leader in the field and each volume is designed modularly, presenting a self-consistent overview of a specific topic. The authors make a critical selection of the most significant work reported in a given area.

Benefits for chemists

• What is the background and context to the field of research I am interested in?

• Which synthetic methodology is the most reliable?

• Which experimental procedures could I use?

• Which experts work in this field and what is their opinion?

Essential for the synthetic organic chemist

“Science of Synthesis is an indispensable tome of chemical information organized in an intuitive and logical way. It contains information on nearly every aspect of chemical reactivity and, for me, is the “go-to” resource for rapidly learning about a new area. I use it regularly in preparation for classes and for consulting visits – it simply gives me the information I need far more easily than any search engine is capable of – and very often contains references and insight that cannot be found anywhere else.”

Prof. Phil S. Baran The Scripps Research Institute,

La Jolla, CA, USA

“Today’s scientific community must struggle to find ways to effectively distill massive floods of information into real knowledge. Science of Synthesis does this superbly well with carefully selected content on synthetic organic chemistry that has been written and edited by leading authorities from around the world. Science of Synthesis is a must-have for all universities and research institutions involved in material synthesis.”

Prof. Ryoji Noyori RIKEN, Japan

Best methods. Best results.

This three-volume set Biocatalysis in Organic Synthesis comprises a broad contemporary overview on the state of the art in enzymatic methods for asymmetric synthesis and is particularly useful for academics and industrial researchers working in organicsynthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community.

• Broad contemporary overview on the state of the art in enzymatic methods

• Presentation of methods suitable for academics and industrial researchers working in the field of organic synthesis

• Including experimental procedures

Biocatalysis in Organic Synthesis Synthesis 1–3

Biocatalysis in Organic Synthesis

Volume Editor:Kurt FaberUniversity Graz, Austria

Volume Editor:Wolf-Dieter FessnerUniversity Darmstadt, Germany

Volume Editor:Nicholas TurnerUniversity Manchester, United Kingdom

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C-1 Building Blocks in Organic Synthesisvan Leeuwen 2014 • 1168 pp. • softcover • 2 Vol. ISBN 978-3-13-176511-6

C-1 Building Blocks in Organic Synthesis 1: Additions to Alkenes, Alkynes and Carbonyl Compounds2014 • 610 pp. • softcoverISBN 978-3-13-170771-0

C-1 Building Blocks in Organic Synthesis 2:Alkenations, Cross Couplings, Insertions,Substitutions, and Halomethylations2014 • 558 pp. • softcoverISBN 978-3-13-175131-7

Multicomponent ReactionsMüller2014 • 1278 pp. • softcover • 2 Vol.ISBN 978-3-13-176561-1

Multicomponent Reactions 1: Reactions Involving a Carbonyl Compound as Electrophilic Component2014 • 652 pp. • softcoverISBN 978-3-13-172861-6

Multicomponent Reactions 2: ReactionsInvolving an α,β-Unsaturated CarbonylCompound as Electrophilic Component2014 • 626 pp. • softcoverISBN 978-3-13-172851-7

Cross Coupling and Heck-Type ReactionsMolander / Wolfe / Larhed2013 • 2640 pp. • softcover • 3 Vol. ISBN 978-3-13-173411-2

Cross Coupling and Heck-Type Reactions 1: C—C Cross Coupling Using Organometallic PartnersMolander2013 • 1006 pp. • softcover ISBN 978-3-13-172871-5

Cross Coupling and Heck-Type Reactions 2: Carbon-Heteroatom Cross Coupling and C—C Cross Coupling of Acidic C—H NucleophilesWolfe2013 • 742 pp. • softcover ISBN 978-3-13-172881-4

Cross Coupling and Heck-Type Reactions 3: Metal-Catalyzed Heck-Type Reactions and C—C Cross Coupling via C—H ActivationLarhed2013 • 892 pp. • softcover ISBN 978-3-13-172891-3

Asymmetric OrganocatalysisList / Maruoka2012 • 1928 pp. • softcover • 2 Vol. ISBN 978-3-13-170591-4

Asymmetric Organocatalysis 1: Lewis Base and Acid CatalystsList2012 • 954 pp. • softcover ISBN 978-3-13-169361-7

Asymmetric Organocatalysis 2: Brønsted Base and Acid Catalysts, and Additional TopicsMaruoka2012 • 974 pp. • softcover ISBN 978-3-13-169371-6

Stereoselective SynthesisDe Vries / Molander / Evans2011 • 3165 pp. • softcover • 3 Vol. ISBN 978-3-13-166421-1

Stereoselective Synthesis 1: Stereoselective Reactions of Carbon―Carbon Double BondsDe Vries2011 • 1034 pp. • softcover ISBN 978-3-13-165161-7

Stereoselective Synthesis 2: Stereoselective Reactions of Carbonyl and Imino GroupsMolander2011 • 1016 pp. • softcover ISBN 978-3-13-165171-6

Stereoselective Synthesis 3: Stereoselective Pericyclic Reactions, Cross Coupling, C―H and C―X ActivationEvans2011 • 1118 pp. • softcover ISBN 978-3-13-165181-5

Water in Organic SynthesisKobayashi2012 • 960 pp. • softcover ISBN 978-3-13-169351-8

Biocatalysis in Organic SynthesisFaber/Fessner/Turner2014 • 1976 pp. • softcover • 3 Vol.ISBN 978-3-13-202871-5

Biocatalysis in Organic Synthesis 12014 • 648 pp. • softcoverISBN 978-3-13-174141-7

Biocatalysis in Organic Synthesis 22014 • 652 pp. • softcoverISBN 978-3-13-174171-4

Biocatalysis in Organic Synthesis 32014 • 676 pp. • softcoverISBN 978-3-13-174671-9

Volume pricesSingle volume EAAA € 259.99 | Am US $ 298.992-volume set EAAA € 449 | Am US $ 5493-volume set EAAA € 649 | Am US $ 899

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