scheme of teaching, examination & syllabus · trying to strive for academic excellence and...

M.Tech.: Nano-Technology (2016 - 18)

Scheme of Teaching, Examination &

Syllabus

Department of Mechanical Engineering

The National Institute of Engineering, Mysuru

M.Tech – Nano-Technology

Department of Mechanical Engineering, NIE, Mysuru Page 1

PREFACE

Dear Students,

Since it started in the year 1946, NIE is promoting excellence in education through highly

qualified faculty members and modern infrastructure. The Board of Directors believes in

continuous improvement in delivery of technical education. Thanks to Karnataka

government that designed and developed a seamless admission process through CET and

PGCET, many highly meritorious students are joining NIE, which has become a brand name

among hundreds of colleges in the country. Infact, NIE is one of the top ten preferred

colleges where all the seats got filled-up in the first round of 2016 BE admissions.

NIE has been granted permanent affiliation by VTU to all its courses. The concerted efforts

of stake holders at NIE have made it get autonomous status, prestigious TEQIP-I & II. We

are in the process of getting renewal of accreditation from National Board of Accreditation,

New Delhi.

Today NIE has of 7 UG, 13 PG and 5 Post-graduate Diploma programmes and 13 Centres of

Excellence with overall student strength of over 3500. NIE's journey to excellence, with the

main objective of continuous improvements of administrative and academic competence, is

envisioned through three major pillars: intellectual infrastructure, Programmes/services

offerings and institution building.

Our curriculum is designed to develop problem-solving skill in students and build good

academic knowledge. I am sure students who have joined NIE are poised for a better

technical education and experience.

Dr. G.L. Shekar Sept 2016

Principal



Dear Students,

It gives me great pleasure to welcome you to The National Institute of Engineering (NIE)

where academics and activities never cease as students are groomed in the fields of

engineering and technology. Our dedicated team of highly talented Faculty are always

trying to strive for academic excellence and overall personality development. The major

emphasis of imparting training at NIE is to encourage enquiry and innovation among our

students and lay the strong foundation for a future where they are able to face global

challenges in a rapidly-changing scenario. Here at NIE, we try to mould our students with

strength of character, self-confidence, technical competence & leadership in management so

as to transform them into insightful and honourable citizens of this great country.

NIE is making sincere efforts in meeting the global standards through new formats of

National Board of Accreditation, New Delhi and timely World Bank-MHRD initiative

TEQIP (Technical Education Quality Improvement Program). Efforts are being made to

design the curriculum based on Bloom’s Taxonomy framework, to meet the challenges of

the current technical education.

In case of any need, you are also welcome to seek the help of the Student Welfare Officer or

me. I sincerely hope that your academic pursuit in NIE will be fruitful and enjoyable in

every aspect and the experiences you gain here and the moments you spend here will be

cherished by you. Wishing you the very best.

Dr.G.S.Suresh Sept 2016

Dean (Academic Affair)



NATIONAL INSTITUTE OF ENGINEERING

VISION

NIE will be a globally acknowledged institution providing value based technological &

educational services through best-in-class people and infrastructure.

DEPARTMENT OF MECHANICAL ENGINEERING

VISION

Moulding students of Mechanical Engineering with clear concepts and practical knowledge by

imparting value based education for overall development as competent engineers.

MISSION

The Mechanical Engineering Department is committed to:

� Provide a strong foundation in mechanical engineering to make our engineers globally

competitive.

� Inculcate creativity and passion to develop innovative solutions to engineering problems.

� Creating centre’s of Excellence to provide faculty and students with opportunities to

strengthen their training research and leadership skills.

� Build relationships with globally acknowledged academic institutions and Industries in

India & abroad to enhance our teaching and research proficiency.



PROGRAMME EDUCATIONAL OBJECTIVES

� Graduates will have successful careers as engineers in the multidisciplinary field of

Nanotechnology

� Graduates will be able to pursue advanced studies and involve in a process of lifelong

learning.

� Graduates will address societal problems professionally, ethically with due attention to

environmental issues.

PROGRAMME SPECIFIC OUTCOMES

� Applying the knowledge of nanotechnology to solve multi-disciplinary problem

� Develop solutions for industry through the use of novel materials and process

� Analysing and solving problem in nanotechnology by hand on application of knowledge

and skills

GRADUATE ATTRIBUTES

� Engineering Knowledge

� Problem Analysis

� Design/Development of Solutions

� Conduct Investigations of complex problems

� Modern tools usage

� Engineer and Society

� Environment and Sustainability

� Ethics

� Individual & Team work

� Communication

� Project management & Finance

� Lifelong learning



PROGRAMME OUTCOMES

At the completion of two year post-graduate program, the students of Nano Technology are

expected to acquire the abilities to:

1. Apply knowledge and skills to solve complex technical problems which calls for insight

into the latest technologies and best engineering practices

2. Exhibit critical thinking and articulate effectively with clarity and able to demonstrate

good oral and written communication skills

3. Study research needs and trends and carry out literature review, research design, analyses

and interpretations in order to draw meaningful conclusions

4. Provide solutions to varied engineering problems by interpretation of data using modern

computational tools.

5. Function competently as an individual and as a part of multi-disciplinary teams.

6. Good understanding of professional and ethical responsibility

7. Ability to find solutions to engineering problems to cater to the needs of the society.

8. Discharge professional and ethical responsibility considering societal health and safety.

9. Exhibit professionalism by employing modern project management and financial tools.

10. Possess the knowledge of contemporary issues and ability to engage in life-long learning



BLUEPRINT OF SYLLABUS STRUCTURE AND

QUESTION PAPER PATTERN

Blue Print of Syllabus Structure

1. Complete syllabus is prescribed in SIX units as Unit 1, Unit 2, etc.

2. In each unit there is one topic under the heading “Self Learning Exercises” (SLE). These are

the topics to be learnt by the student on their own under the guidance of the course instructors.

Course instructors will inform the students about the depth to which SLE components are to be

studied. Thus there will be six topics in the complete syllabus which will carry questions with a

weightage of 10% in SEE only. No questions will be asked on SLE components in CIE.

Blue Print of Question Paper

1. Question paper will have SEVEN full questions.

One full question each of 15 marks (Question No 1, 2, 3, 4, 5 and 6) will be set from each unit of

the syllabus. Out of these six questions, two questions will have internal choice from the same

unit. The unit from which choices are to be given is left to the discretion of the course instructor.

2. Question No 7 will be set for 10 marks only on those topics prescribed as “Self Learning

Exercises”.



THE NATIONAL INSTITUTE OF ENGINEERING

M.Tech- Nanotechnology

I SEMESTER

Sl.

No.

Subject

Code Title

Teaching Hrs / Week Credits

category L T P Credits

1 APM0401 Applied Mathematics GC 4 0 0 4

2 MNT 0501 Quantum Mechanics C 4 2 0 5

3 MNT0502 Nanoscience & Nanomaterials C 5 0 0 5

4 MNT0515 Synthesis and Characterization of

Nanomaterials

C 4 0 2 5

5 MNT05XX Elective I E 4 2 0 5

6. MNT04XX Elective II E 4 0 0 4

7. MNT0101 Seminar C 0 0 2 1

Total number of Credits 29

Total Teaching Hours 28.5

GC - General Core C - Core E - Elective

Elective I Elective II

MNT0509 Advanced Material Science MNT0402 Nanotechnology for Energy and

Environment

MNT0510 Bio safety And Hazards of Nano Materials MNT0403 Composite Materials And

Applications

MNT0511 Micro and Nano Fluidics MNT0404 Quantum Computing



II SEMESTER

Sl.

No.

Subject

Code Title

Teaching Hrs / Week Credits

category L T P Credits

1 MNT0505 Nano electronics C 4 2 0 5

2 MNT0506 Nanomaterials, Surface Interface and

Catalysis

C

5 0 0 5

3 MNT0411 Carbon Nanostructures and Applications C 4 0 0 4

4 MNT0412 Nano sensors and devices C 4 0 0 4

5 MNT05XX Elective III E 5 0 0 5

6 MNT04XX Elective IV E 4 0 0 4

7 MNT0102 Seminar C 0 0 2 1

8 MNT0103 Course on special topics C 1 0 0 1

Total number of Credits 29

Total Teaching Hours 28.5

GC - General Core C - Core E - Elective

Elective III Elective IV

MNT0513 Entrepreneur Development & Project

Management MNT0413 Additive Manufacturing

MNT0512 Nanotechnology and Industrial

Applications MNT0409 Nano biotechnology

MNT0514 Nanotechnology and Drug Delivery

Systems MNT0410

Nanotechnology in Food and

Agriculture



III SEMESTER

Sl.

No.

Subject

Code Title

Teaching Hrs /

Week Credits

L T P Credits

1 MNT0401

Internship for 8 Weeks duration (At the end of the

internship, students are required to submit a report and

present a seminar)

- - - 4

2 MNT0801

Project Work (preliminary)

(Students have to initiate the project work and at the end

of the semester should present a progress seminar)

- - - 8

3 MNT0201 Seminar 0 0 0 2

SEE - - - 14

IV SEMESTER

Sl.

No.

Subject

Code Title

Teaching

Hrs

L T P Credits

1 MNT2801 Project Work (Students have to submit the final project report

at the end of the semester which will be evaluated followed by

a seminar presentation and viva – voce examination)

- - - 28

SEE - - 28

Credit Structure

Core Courses 37

Elective Courses 18

Seminars/Ind Training/preliminary project 17

Major Project 28

SEE 100



SYALLBUS

APPLIED MATHEMATICS

Sub Code: APM0401 CIE: 50% Marks

Hrs/ Week: 04 SEE: 50% Marks

SEE Hrs.: 03 Exam Marks: 100 Marks

Total hours: 52

Credits: 4.0.0: 4

Course Prerequisites: NIL

Course outcomes:

On successful completion of the course the students will be able to:

1. Recall approximations and errors, apply numerical techniques to estimate the roots of

algebraic and transcendental equations.

2. Compute numerically the values of the derivative and definite integrals, apply it to estimate

the area of the given region.

3. Solve linear homogeneous partial differential equations with constant and variable

coefficients.

4. Apply matrix and iterative methods to solve a system of linear algebraic equations.

5. Compute numerically the eigen values and the corresponding eigen vectors using

diagonalization methods. Also compute the smallest and the largest eigen values.

6. Define vector space, linear transformation, inner product of a vector space and apply the

necessary concepts to compute orthonormal bases.

Numerical Analysis

Unit-1: Approximation & errors, significant figures, accuracy & precision. Round off &

truncation errors. Numerical solution of algebraic equations –Newton Raphson method for

multiple roots. Muller’s method, Horner’s method, Graeffe’s root squaring method.

9 Hours

Self Learning Exercises (SLE): Graphical and Secant methods

Unit-2: Numerical differentiation - Application problems, Numerical Integration – Newton

cote’s quadrature formula. Trapezoidal rule, Boole’s rule, Romberg integration. Numerical

double integration. Gauss quadrature and Gauss Legendre formula.

9 Hours Self Learning Exercises (SLE): Simpson’s one third, three eighth rule, Weddle’s rule,

Partial Differential Equations

Unit-3: Solution of linear homogeneous Partial Differential Equations with constant and variable

coefficients.



8 Hours Self Learning Exercises (SLE): Cauchy’s partial differential equation

Linear Algebra

Unit-4: Solution of system of linear algebraic equations Triangularization method, Cholesky’s

method, Partition method, Gauss Seidel iterative method.

9 Hours

Self Learning Exercises (SLE): Gauss elimination method

Unit-5: Eigen values & Eigen vectors, Bounds on eigen values-Gerschgorin’s circle theorem.

Given’s method, Jacobi’s method for diagonalisation of symmetric matrices, Rutishauser

method for arbitrary matrices, Power method, Inverse power method.

9 Hours

Self Learning Exercises (SLE): Analytical method to obtain eigen values and eigen vectors

Unit-6: Vectors & vector spaces, Linear Transformations - Kernel, Range. Matrix of linear

transformation. Inverse linear transformation, Inner product, Length / Norm. Orthogonality,

orthogonal projections. Orthonormal bases. Gram-Schmidt process. Least square problems.

8 Hours

Self Learning Exercises (SLE): Applications.

Text Books:

1. Introductory Methods of Numerical Analysis – S.S. Sastry, 5th

edition.

2. Numerical Methods in engineering and science – B.S.Grewal, Khanna Publications- 8th

edition, 2009.

3. Higher Engineering Mathematics – Dr. B.V. Ramana, 5th

edition, Tata McGraw – Hill

publications.

4. Linear Algebra – Larson & Falvo (Cengage learning)

5. Numerical Methods for Scientific and Engineering Computation–M.K. Jain, S.R.K. Iyengar,

R.K. Jain, 4th

edition, New Age International Pvt Ltd Publishers,

Assessment Methods:

Written Tests (Test, Mid Semester Exam & Make Up Test) are Evaluated for 25 Marks each.

Mapping of COs to POs:

Course Outcomes Programme Outcomes that are satisfied by the COS

CO 1 PO1, PO2, PO4, PO5 & PO6




CO 5 PO1, PO2, PO5 & PO6

CO 6 PO1, PO2, PO5, & PO6



QUANTUM MECHANICS (4.2.0: 5)

Sub Code: MNT0501 CIE: 50% Marks



Total hours: 52

Credits: 4.0.2: 5


Course outcomes: After the successful completion of this course, the student will be able to:

1. Explain the inadequacy of Classical Mechanics.

2. Make use of Schrodinger equations

3. Distinguish the different types of Operators

4. Discuss the concepts of Perturbation Theory.

Unit-1: Physical basis of quantum mechanics: Experimental background, inadequacy of

classical physics, Planck’s quantum hypothesis, summary of principle experiments, The

Uncertainty principle.

08 Hours Self Learning Exercises (SLE): Wave packets in space and time, and their physical

significance.

Unit-2: Schrodinger wave equation: Time dependent Schrodinger equation, interpretation of

the wave Function, Time-Independent Schrödinger equation.

08 Hours Self Learning Exercises (SLE): normalisation and expectation value.

Unit 3: Quantum mechanics of free particles: square-well potential with rigid walls, Square-

Well Potential with Finite walls, Square Potential barrier.

10 Hours

Self Learning Exercises (SLE): Electron energy bands in solids: conductors, insulators and

semiconductors

Unit-4: General formalism of quantum mechanics

Linear vector space, Hilbert space, Eigen functions and Eigen values, Hermitian operators,

Dirac’s Notation, Equations of Motion.

10 Hours Self Learning Exercises (SLE): operator for Momentum and position co-ordinate

UNIT-5: Time-Independent Perturbation Theory: Basic Concepts, Nondegenerate energy

levels: first-order correction to the energy and wave function, second order correction to the

energy and wave function, Degenerate Energy levels.

08 Hours Self Learning Exercises (SLE): An harmonic oscillator: first-order correction



Unit-6: Theory of scattering: Scattering cross-section, scattering amplitude. Born

approximation, scattering by screened coulomb potential

08Hours Self Learning Exercises (SLE): scattering by an attractive square well potential

Text Books:

1. Text book of Quantum Mechanics: P. M. Mathews and K. Venkateshan (TMH, 1994).

2. Quantum Mechanics: G. Aruldhas, Second edition, PHI publications.

Reference Books:

1. Quantum Physics of Atoms, molecules, solids Nuclei and particles 2nd

Ed by Eisberg,

Robert, Resnick Robert.

2. B. Rogers, S. Pennathur and J. Adams, Nanotechnology: Understanding small systems

CRC press 2008

Assessment Methods:

1. Written Tests (Test, Mid Semester Exam & Make Up Test) are Evaluated for 20 Marks

each

2. Assignment for 10 marks. Students are required to either

a. Deliver a presentation on a topic of significance in the field of Quantum Mechanics.

Or Solve the Problems in Quantum Mechanics.



CO 1 PO1&PO4

CO2 PO1, PO3 &PO8

CO 3 PO1, PO3, PO8,

CO 4 PO1, PO3, PO8



NANOSCIENCE AND NANOMATERIALS (4-0-2-5)




Total hours: 52

Credits: 5-0-0-5


Course Outcomes (CO’s):

After the successful completion of this course, the student will be able to: 1. Recognize the history, background and the nature of the Nanoscience and technology.

2. State the different type of nanostructures and analyze the top down and bottom up approach

for nano-scale device preparation and differentiate the different properties of nanomaterials.

3. Distinguish the functionality of nanostructures and their characteristic evaluation, self

assembly and its application towards controlling the structure.

4. Recognize the surface modification of nanoparticles by surface functionalization and their

application.

5. Appraise the different smart materials like thermos-responsive, piezoelectric electrostrictive

and biometric materials, smart gel, shape memory and their application towards product

formation. UNIT 1: Introduction to nanoscience and nanotechnology, history, background scope and

interdisciplinary nature of nanoscience and nanotechnology, scientific revolutions, nanosized

effects surface to volume ratio, atomic structure, molecules and phases, energy at the nanoscale

molecular and atomic size, quantum effect.

8 Hours

Self Learning Exercise (SLE): Scientific revolutions, Nano-sized effects UNIT 2: Classification of nanostructures - Zero dimensional, one-dimensional and two

dimensional nanostructure materials - semiconductors, ceramics and nanocomposites, size

dependent phenomena, quantum dots, nanowires, nanotubes, nanosheets, nano and mesopores,

misnomers and misconception of nanotechnology.

10 Hours

Self Learning Exercise (SLE): misnomers and misconception of nanotechnology.

UNIT 3: Properties of Nanomaterials: - Mechanical properties - Thermo physical properties

- Electric properties - Electrochemical properties - Magnetic properties - Optical

properties, Catalytic properties, properties of gas permeation and separation membranes.

6 Hours



Self Learning Exercise (SLE) - properties of gas permeation and separation membranes. UNIT 4: Nanostructured design: Functionality of nanostructures and their characteristic

evaluation, Size effect in semiconductor nanoparticles- Particle size, shape density - Melting

point, surface tension, wettability - Specific surface area and pore- assembly of nanoparticles

and functionalization, Self-assembly. Nanoparticle dispersion and aggregation behavior.

10 Hours Self Learning Exercise (SLE) - Nanoparticle dispersion and aggregation behavior UNIT 5: Surface modification of Nanoparticles: Surface modification of inorganic

nanoparticles by organic functional groups, Development of photocatalyst inserted into surface

of porous aluminosilicate - Dispersion control of nanoparticles in solvents - development of

biodegradable PLGA nanospheres and application.

10 Hours

Self Learning Exercise (SLE) - Development of biodegradable PLGA nanospheres and

application

UNIT 6: Smart Materials and Systems: Thermoresponsive materials, piezoelectric materials,

electrostrictive and magnetostrictive materials, ER and MR fluids, biomimetic materials, smart

gel, shape memory alloys.

8 Hours

Self Learning Exercise (SLE) - piezoelectric materials

Text Books

1 . Edward L. Wolf, "Nanophysics and Nanotechnology - An Introduction to Modern

Concepts in Nanoscience" Second Edition, John Wiley & Sons, 2006.

2 . K.W. Kolasinski, ―Surface Science: Foundations of Catalysis and Nanoscience‖, Wiley,

2002.

3 . G.A. Ozin and A.C. Arsenault, ― NAnochemistry : A chemical approach to nanomaterials‖,

Royal Society of Chemistry, 2005.

4 . Nanostrucrues and Nanomaterials synthesis, properties and applications, G. Cao, Imperaial

college press 2004.

References

1. Vladimir P. Torchilin (2006) Nanoparticulates as Drug Carriers, Imperial College Press.

2. M. Reza Mozafari (2007) Nanomaterials and Nanosystems for Biomedical

Applications, Springer.

3. Nanotechnology – Basic Science & Emerging Technologies, Chapman & Hall/CRC

2002

4. Nanomaterials Nanotechnologies and Design: An introduction for Engineers and

architects, Micheal F. Ashby, P.J. Ferreria, D.L.Schodek.



Assessment Methods:

Written Tests (Test, Mid Semester Exam & Make up Test) are evaluated for 25 Marks each.



CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 , PO4

CO 5 PO1, PO3, PO4, PO7



SYNTHESIS AND CHARACTERISATION OF NANOMATERIALS (4.0.2: 5)




Total hours: 52

Credits: 4.0.2: 5


Course Outcomes (CO’s): After the successful completion of this course, the student will be

able to:

1. Judge the ideology for synthesis of nanomaterials by both the approaches as per required

particle size.

2. Synthesize and fabricate nanostructures by physical methods.

3. Discuss various chemical synthesis of nanomaterials and their mechanisms involved.

4. Green synthesize nanomaterials from bio route.

5. Precisely characterize the developed nanostructures and proceed for application part of it.

6. Alter and Pattern the substrates in the nano regime.

Unit 1: Introduction: Fundamentals, Top-Down Approach and Bottom-up approach with

examples. Overview of methods of synthesis.

3 Hours Self Learning Exercises (SLE): Top-Down Approach

Unit2: Physical Methods: Ball milling synthesis, Arc discharge, Plasma arc technique, Inert

gas condensation, electric explosion of wires, Ion sputtering method, Laser pyrolysis, Molecular

beam epitaxy and electrodeposition. Electro spinning, Physical vapor Deposition (PVD),

Chemcial vapours Deposition (CVD) - Atomic layer Deposition (ALD) – Self Assembly- LB

(Langmuir-Blodgett) technique.

10 Hours Self Learning Exercises (SLE): Physical Vapour Deposition

Unit3:Chemical methods: Metal nanocrystals by reduction, Solvothermal synthesis,

Photochemical synthesis, Electrochemical synthesis, Nanocrystals of semiconductors and other

materials by arrested precipitation, Thermolysis routes, Sonochemical routes, Liquid-liquid

interface, VLS growth of Nanowires , Hybrid methods, Solvated metal atom dispersion, Post-

synthetic size-selective processing. Sol- gel, Micelles and microemulsions, Cluster compounds.

8 Hours

Self Learning Exercises (SLE): Microemulsions and reverse micelles



Unit4:Biological methods: Use of bacteria, fungi, Actinomycetes for nanoparticle synthesis,

Magnetotactic bacteria for natural synthesis of magnetic nanoparticles; Mechanism of

formation; Viruses as components for the formation of nanostructured materials; Synthesis

process and application, Role of plants in nanoparticle synthesis.

5 Hours

Self Learning Exercises (SLE): Actinomycetes for nanoparticle synthesis

Unit5:Characterization Techniques: Introduction, XRD - Structural and compositional

characterization-principles and applications of X-ray diffraction , Optical microscope and their

description, Scanning Probe Microscopy, operational principles of Scanning Electron

Microscope (SEM), TEM, X-ray photoelectron spectroscopy, Energy dispersive X-ray analysis,

UV-VIS-IR Spectrophotometers - Principle of operation and application for band gap

measurements, Magnetic and electrical measurements.

10 Hours

Self Learning Exercises (SLE): electrical measurements

Unit6:Lithographic Techniques: AFM based nanolithography and nanomanipulation, E beam

lithography and SEM based nanolithography and nanomanipulation, Ion beam lithography,

oxidation and metallization. Mask and its application, Deep UV lithography, X-ray based

lithography.

6 Hours

Self Learning Exercises (SLE): Deep UV lithography

Lab Workshop: (6 Hours)

1. Synthesis of Gold/Silver nanoparticles by Chemical route

2. A bioroute to Au nanoparticles

3. Thin Film Deposition : Operation of Electrochemical Workstation

4. Thin film fabrication by Sputtering

5. Thin film fabrication by thermal evaporation

6. Characterization by AFM

7. Characterization by XRD

8. Characterization by SEM

9. Characterization by UV-VIS Spectrometer

10. Characterization by FT-IR

Text Books

1. Nanochemistry: A chemical approach to Nanomaterials Roayal Society of Chemistry, Ozin

and Arsenault, Cambridge UK 2005,

2. Nanoparticles: From Theory to Applications, G.Schmidt, Wiley Weinheim 2004.

3. Characterization of Nanostructure materials by XZ.L.Wang

4. Introduction to Nanotechnology - Charles P. Poole Jr. and Franks. J. Qwens



5. Transmission Electron Microscopy: A Textbook for Materials Science (4-Vol Set)- David B.

Williams and C. Barry Carter

References

1. Hari Singh Nalwa - Encyclopedia of Nanotechnology.

2. Novel Nanocrystalline Alloys and Magnetic Nanomaterials- Brian Cantor

3. Nanomaterials Handbook- Yury Gogotsi

4. Springer Handbook of Nanotechnology - Bharat Bhusan

5. Instrumental Methods of Analysis, 7th edition- Willard, Merritt, Dean, Settle

6. Processing & properties of structural naonmaterials by Leon L. Shaw (editor)

7. Chemistry of nanomaterials: Synthesis, properties and applications by CNR Rao et.al.

8. Scanning Probe Microscopy: Analytical Methods (NanoScience and Technology) Rolan

Wiesendanger

9. Advanced X-ray Techniques in Research and Industries - A. K. Singh (Editor)

10. Fabrication of fine pitch gratings by holography, electron beam lithography and nano-imprint

lithography (Proceedings Paper) Author(s): Darren Goodchild; Alexei Bogdanov; Simon

Wingar; Bill Benyon; Nak Kim; Frank Shepherd.

11. Microfabrication and Nanomanufacturing- Mark James Jackson

12. A Three Beam Approach to TEM Preparation Using In-situ Low Voltage Argon Ion Final

Milling in a FIB-SEM Instrument E L Principe, P Gnauck and P Hoffrogge, Microscopy and

Microanalysis (2005), 11: 830-831 Cambridge University Press

Assessment Methods:

1. Written Tests (Test, Mid Semester Exam & Make Up Test) are Evaluated for 20 Marks each

2. Assignment for 10 marks. Students are required to

a. Deliver a presentation on a topic of significance in the relevant field.



CO 1 PO1

CO2 PO1, PO2

CO 3 PO1, PO2, PO3

CO 4 PO3, PO4, PO5

CO5 PO8, PO9, PO10

C06 PO8,PO9



ADVANCED MATERIAL SCIENCE (4.2.0:5)




Total Hours: 52

Credits: 5.0.0:5


Course outcomes:

After the successful completion of this course, the student will be able to:

1. Explain the crystal system and unit cell, reciprocal lattice and X-ray diffraction methods.

2. Elucidate the types of binding, different forces acting on atoms and molecules, quantization

of lattice vibrations and specific heat of lattice.

3. Discuss the formation of energy bands, free electrons in potential well, Fermi energy, point

and plane defects.

4. Discuss the kinds of semiconductors, electrical conductivity, Hall effect and four probe

method.

5. Explain the Boltzmann equation, Electrical conductivity and general transport properties.

6. Define the thermal conductivity, magnetic effects, acoustic and optical scattering by electron.

Unit1: Crystal structure: Crystal systems, Crystal classes, Bravais lattice. Unit cell: Wigner-

Seitz cell, equivalent positions in a unit cell. Notations of planes and directions. Atomic packing:

packing fraction, Co-ordination number. Symmetry operations,

Self Learning Exercise (SLE): point groups and space groups.

08hours Unit2: X-ray diffraction: - X-ray diffraction, Bragg law. Experimental diffraction methods:

Rotating crystal method and Powder method.

Self Learning Exercise (SLE): Concept of reciprocal lattice

8 Hours

Unit3: Crystal binding: Types of binding, Van der Waals-London interaction, Repulsive

interaction. Born’s theory for lattice energy in ionic crystals, Ideas of metallic binding,

Self Learning Exercise (SLE): Hydrogen Bonding

8 Hours

Unit4: Lattice vibrations: - Vibrations of monoatomic lattices. First Brillouin zone.

Quantization of lattice vibrations - Concept of Phonon, Phonon momentum. Specific heat of

lattice (qualitative).

Self Learning Exercise (SLE) - Vibrations of monoatomic lattices. First Brillouin zone

10 Hours

Unit5: Energy bands in solids: Formation of energy bands. Free electron model: free electrons

in one and three dimensional potential wells, electrical conductivity, density of states, concept of

Fermi energy. Defects in solids: Point defects: Schottky and Frenkel defects and their

equilibrium concentrations. Plane defects: grain boundary and stacking faults.



Self Learning Exercise (SLE) – Plane defects: grain boundary and stacking faults

10 Hours

Unit6: Semiconductors: Intrinsic and extrinsic semiconductors, concept of majority and

minority carriers. Statistics of electrons and holes. Experimental determinations of resistivity of

semiconductor by four probe method.

Self Learning Exercise (SLE) – Electrical conductivity. Hall effect

8 Hours

Text Books

1. Introduction to Solid State Physics, C. Kittel, Wiley Eastern

2. A practical approach to X-Ray diffraction analysis by C.Suryanarayana

3. Semiconductor Physics, P. S. Kireev, MIR Publishers.

References

1. Solid State Physics, A. J. Dekkar, Prentice Hall Inc.

2. Introduction to Superconductivity, M. Tinkham, McGraw-Hill, International Editions

3. Elementary Solid State Physics: Principles and applications, M. A. Omar, Addison-Wesley.

Assessment Methods:

Written Tests (Test, Mid Semester Exam & Make Up Test) are Evaluated for 25 Marks each



CO 1 PO1,PO7,PO2

CO 2 PO3, PO4,PO5

CO 3 PO2, PO4, PO7,

CO 4 PO4, PO8, PO6

CO5 PO5, PO2, PO4

CO6 PO3, PO4, PO6



BIOSAFETY AND HAZARDS OF NANO MATERIALS (4.2.0:5)




Total Hours: 52

Credits: 5.0.0:5


Course Outcomes

After the successful completion of this course, the student will be able to

1. Identify different types of nano materials and its applications.

2. Explain problems and issues of Bio nano materials.

3. Understand the patent of research article.

4. Define the safety and handling of nano materials

5. Describe the toxic and hazards of Nanomaterials

6. Discuss the experimental issues of Nano materials.

Unit-1Introduction: Properties of nanomaterials, Interactions between biomolecules and

nanoparticles surface, different types of materials used for the synthesis of hybrid nano-bio

assemblies, applications of nano in biology, nanoprobes for clinical biotechnology.

8 Hours Self Learning Exercise (SLE): Nanomaterials and their applications in agriculture, environment

and medicine.

Unit-2 Bioethics: Introduction to Bioethics. Social and ethical issues in Biotechnology.

Definition of Biosafety. Biosafety for human health and environment. Social and ethical issues.

Use of genetically modified organisms and their release in to the environment.

8 Hours

Self Learning Exercise (SLE): Special procedures for r-DNA based products using

nanomaterials.

Unit-3 Patenting: Invention in context of “prior art”; Patent databases; Searching International

Databases; Country-wise patent searches (USPTO, EPO, India etc.); Analysis and report

formation, International patenting-requirement, procedures and costs; Financial assistance for

patenting-introduction to existing schemes; Publication of patents-gazette of India, status in

Europe and US Patenting by research students, lecturers and scientists-University/organizational

rules in India and abroad, credit sharing by workers, financial incentives.

12 Hours

Self Learning Exercise (SLE):Patent infringement- meaning, scope, litigation, case studies and

examples.



Unit-4 Biosafety: Introduction; Historical Backround; Introduction to Biological Safety

Cabinets; Primary Containment for Biohazards; Biosafety Levels; Biosafety Levels of Specific

Microorganisms; Recommended Biosafety Levels for Infectious Agents and Infected Animals;

Biosafety guidelines - Government of India; Risk management and communication; Overview of

National Regulations and relevant International Agreements including Cartagena Protocol.

Identification of nano specific risks – responding to challenge- human health hazard–risk

reduction-standards–safety–transportation of the nanoparticles–emergency responders. Risk

assessment related to nanotechnology-environmental.

12 Hours

Self Learning Exercise (SLE): policy making – eco toxicity measurement of polychlorinated

biphenyl and intermediates in their degradation.

Unit-5 Nanotoxicology: Inhalation of nano materials–overview. Introduction Inhalation –

deposition and pulmonary clearance of insoluble solids- bio–persistence of Inhaled solid

material. Systemic translocation of inhaled particles .pulmonary effects of SWCNT–pulmonary

inflammatory Reponses to SWCNT. In vivo – interaction of the pulmonary inflammation with

oxidative stress–interactions of SWCNTs with macro phages.

6 Hours

Self Learning Exercise (SLE): Toxicological assessment of nanoparticles: Hazard

identification, hazard characterization, exposure assessment and risk calculation.

Unit-6. Experimental issues: Nano particle exposure and systematic cardiovascular effects –

experimental data–respiratory particulate matter exposure and cardiovascular toxicity, nano

particles–hypothesis and research approaches. SWCNT-experimental data. Toxicity of polymeric

nano particles with respect to and their applications as drug carriers.

6 Hours

Self Learning Exercise (SLE): Particle exposure through the indoor air environment –

Measurement of indoor PM and experimental study.

Text Books

1.J. B Park, “Biomaterials Science and Engineering”, Plenum Press, New York, 1984.

2.P.P. Simeonova, N. Opopol and M.I. Lus ter, “Nanotechnology - Toxicological Issues and

Environmental Safety”, Springer 2006.

3.Vinod Labhasetwar and Diandra L. Leslie, “Biomedical Applications of nanotechnology”, A

John Willyv& son Inc, N.J, USA, 2007 .

References

1.J.J. Davis, Dekker, “Encyclopedia of Nanoscience and nanotechnology”

2.Hutchison, J. E. Green Nanoscience: A Proactive Approach to Advancing Applications and

Reducing Implications of Nanotechnology. ACS Nano 2, (395–402) 2008.

3.Dracy J. Gentleman, Nano and Environment: Boon or Bane? Environmental Science and

technology, 43 (5), P1239, 2009



Assessment Methods:




CO 1 PO1,PO3,PO8

CO2 PO3, PO6,PO7

CO 3 PO2, PO4, PO8

CO 4 PO4, PO2, PO7

CO5 PO2, PO4, PO7

CO6 PO3, PO4, PO2



MICRO AND NANO FLUIDICS (4.2.0:5)




Total Hours: 52

Credits: 5.0.0:5


Course outcomes


1. Understand the basics of Micro and nanofludics.

2. Analyze and apply different techniques such as liquid flows, capillary flow and electro-

Kinetically driven liquid micro flows.

3. Describe the Laminar flow of micro fluidics and case studies.

4. Define the ionic transport of micro fluidic particles.

5. Explain the fabrication techniques of Nano fluidic channels.

6. Identify the Particle moving in flow fields

Unit-1 Introduction: Fundamentals of kinetic theory-molecular models, micro and macroscopic

properties, binary collisions, distribution functions, Boltzmann equation and Maxwellian

distribution functions-Wall slip effects and accommodation coefficients, flow and heat transfer

analysis of microscale Couette flows,

Self Learning Exercises (SLE): Pressure driven gas micro-flows with wall slip effects, heat

transfer in micro-Poiseuille flows, effects of compressibility.

12 Hours

Unit-2 Pressure driven liquid microflow: apparent slip effects, physics of near-wall microscale

liquid flows, capillary flows, electro-kinetically driven liquid micro - flows and electric double

layer (EDL) effects,

Self Learning Exercises (SLE): concepts of electroosmosis, electrophoresis and dielectro-

phoresis.

10Hours

Unit-3 Laminar flow: Hagen-Poiseullie eqn, basic fluid ideas, Special considerations of flow in

small channels, mixing, microvalves & micropumps, Approaches toward combining living cells,

microfluidics and ‘the body’ on a chip, Chemotaxis, cell motility.

Self Learning Exercises (SLE): Case Studies in Microfluidic Devices.

12 Hours

Unit-4 Ionic transport: Polymer transport – microtubule transport in nanotuble channels driven



by Electric Fields and by Kinesin Biomolecular Motors –

Self Learning Exercises (SLE): Electrophoresis of individual nanotubules in microfluidic

channels.

8 Hours

Unit-5 Fabrication techniques for Nanofluidic channels – Biomolecules separation using

Nanochannels - Biomolecules Concentration using Nanochannels – Confinement of

Biomolecules using Nanochannels.

Self Learning Exercises (SLE): Potential Functions in Low Renoylds Number Flow – Arrays of

Obstacles and how particles Move in them: Puzzles and Paradoxes in Low Re Flow.

6 Hours

Unit-6. Hydrodynamics: Particle moving in flow fields – Potential Functions in Low Renoylds

Number Flow – Arrays of Obstacles and how particles Move in them:

Self Learning Exercises (SLE): Puzzles and Paradoxes in Low Re Flow.

6Hours

Text Books

1. Joshua Edel “Nanofluidics” RCS publishing, 2009.

2. Patric Tabeling “Introduction to Microfluids” Oxford U. Press, New York 2005.

3. K. Sarit “Nano Fluids; Science and Technology”, RCS Publishing, 2007.

References

1. M. Madou, Fundamentals of Microfabrication, CRC Press, 1997

2. G. Kovacs, Micromachined Transducers, McGraw-Hill, 1998

3. Steven S Saliterman, Fundamentals of BioMEMS and Medical Microdevices, 2006

Assessment Methods:




CO 1 PO1,PO2,PO6

CO2 PO3, PO4,PO8

CO 3 PO2, PO3, PO7,

CO 4 PO4, PO8, PO9

CO5 PO5, PO3, PO4

CO6 PO3, PO7, PO6



NANOTECHNOLOGY FOR ENERGY AND ENVIRONMENT (4.0.0:4)




Total hours: 52

Credits: 4.0.0: 4



able to:

1. Understand the basic and essential elements of battery materials

2. Explain the mechanism of harnessing solar energy.

3. Discuss the fabrication of solar cell structures.

4. Define and design how hydrogen energy can be stored

5. Describe the working principle of various fuel cells and model it.

6. Analyse the safety and precautionary issues in handling nanomaterials.

Unit - 1: Battery materials and batteries: Lithium Ion based batteries.

4 Hours

Self Learning Exercises (SLE): Types of batteries

Unit - 2: Renewable energy Technology: Energy challenges, nanomaterials and nanostructures

in energy harvesting, developments and implementation of nanotechnology based renewable

energy technologies.

8 Hours

Self Learning Exercises (SLE): Nanostructures in energy harvesting

Unit - 3: Solar cell structures: quantum well and quantum dot solar cells, photo- thermal cells for

solar energy harvesting, Thin film solar cells, CIGS solar cells, Dye sensitized solar cells.

10 Hours Self Learning Exercises (SLE): Dye sensitized solar cells.

Unit – 4: Hydrogen storage Technology: Hydrogen production methods, purification, hydrogen

storage methods. Hydrogen storage materials: metal hydrides and metal-organic framework

materials, volumetric and gravimetric storage capacities, hydriding and dehydriding kinetics,

high enthalphy formations and thermal management during hydriding reaction, multiple catalytic

– degradation of sorption properties, automotive applications.

10 Hours Self Learning Exercises (SLE): Gravimetric storage capacities



Unit – 5: Fuel cell Technology: Fuel cell Principles, types of fuel cells (Alkaline Electrolyte,

Phosphoric acid, Molten Carbonate, solid oxide and direct methanol and Proton exchange fuel

cells), Principle and operation of Proton Exchange Membrane (PEM) fuel cell.

10 Hours Self Learning Exercises (SLE): SOFC

Unit – 6: Environmental and Safety issues: Nanoparticles and environment - Nanoparticles in

atmospheric environment, Indoor environments Industrial processes and nanoparticles ; Safety of

nanoparticles- Problems caused by nanoparticles.

10 Hours Self Learning Exercises (SLE): Health effects on nanoparticles.

Text Books & References

1. Renewable Energy Resources by J. Twidell and T.Weir, E&FN Spon Ltd.

2. Hydrogen from Renewable Energy Source by D.Infield

3. Fundamentals of Industrial Catalytic Process by C.H. Bartholomew and Robert J. Farraoto,

John Wiley & Sons Inc.

4. Fuel storage on Board Hydrogen storage in Carbon Nanostructures by R.A. Shatwell

5. Fuel cell Technology Handbook by Hoogers, CRC Press 6. Hand book of fuel cells: Fuel cell

technology and applications by Vielstich, Wiley:CRC Press

Assessment Methods:






CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4

CO 5 PO1, PO3 & PO4, PO7



COMPOSITE MATERIALS AND APPLICATIONS (4.0.0:4)




Total Hours: 52

Credits: 5.0.0:5


Course Outcomes: After the successful completion of this course, the student will be able to 1. Discuss various properties of nanocomposites and study mechanical properties of super

hard nanocomposites.

2. Gain experimental knowledge on various syntheses of nanocomposites and modelling.

3. Study and replacement of artificial natural composites for biological parts of human body.

4. Understand and develop bio mimetic implant coatings.

5. Apply knowledge of nanocomposites towards commercialization. Unit-1: Introduction to nanocomposites: Advantage of composite materials, mechanical

properties, Thermal, electrical and electronic and optical properties. Super hard

nanocomposites-designing and mechanical properties - stress-strain relationship, toughness,

strength, and plasticity.

7 Hours Self Learning Exercises (SLE): Optical properties of nano composites Unit-2: Ceramic metal nanocompsites: Ceramic based nanoporous composites, metal

matrix nanocomposites, natural nano-bioccomposites, bio-mimetic nanocompostes and

biologically inspired nanocomposites, nanocompsites for hard coatings, DLC coatings, thin

film nanocomposites, modelling of nanocomposites, synthesis of various nanocomposites

materials, sputtering, mechanical alloying.

8 Hours

Self Learning Exercises (SLE): DLC coatings Unit-3: Polymer nanocomposites: Introduction to polymer composites, Processing of

nanoparticles, binding mechanisms in nanoparticles, dispersion of nanoparticles, and

stabilization of nanoparticles. Processing and fabrication of polymer nanocomposites, Melt

blending, solvent casting, In-situ polymerization, solution polymerazation, template synthesis,

high shearmixing. Homogeneous/heterogenous nucleation, plasma promoted nucleation.

Polymer nanocomposites with structural, gas barrier and flame retardant properties, carbon

fiber reinforced polymer composites, elastomer and thermoplastic elastomer nanocompostes for

propulsion systems, water borne fire- retardant nanocompostes, hybrid composites for

cosmetics, protective and decorative coatings.

9 Hours



Self Learning Exercises (SLE): In-situ polymerization. Unit-4: Natural nanocomposite systems: Spider silk, bones, shells; organic –inorganic

nanocomposite formation through self-assembly. Biomimetic synthesis of nanocomposite

material; use of synthetic nanocomposites for bone teeth replacement. Bioactive

nanocomoposites in bone grafting and tissue engineering, inorganic/polymer nanocomposites

for dental restoration and bone replacement applications.

7 Hours Self Learning Exercises (SLE): Bone replacement applications. Unit-5: Bio ceramics for implant coating: Calcium phosphates-hydroxy epilates Ti6Al4V

and other biomedical alloys, implant tissue interfacing-metal organic CVD-use of tricalcium

phosphate-biomimetic and solution based processing- osteo porosis- osteo plastic, regeneration

of bones by using bio compatible ceramics, bioninteractive hydro gels- PEG coating and

surface modifications, PEG hydrogels patterned on surfaces- PEG based hydrogels. Nanobiocomposites: Cell-substrate interaction, types of Nanomaterials for insitu composite

formation, multifunctional namomaterials as biocompatible and bioactive components.

Nanoscaffolds for tissue engineering- types of nanoscaffolds and formation techniques;

advantages over macro/micro-structured surface ssk Nanomaterials for enhanced growth and

differentiation of nerve cells, stem cells and osteoblasts.

14 Hours

Self Learning Exercises (SLE): PEG based hydrogels. Unit-6: Commercial aspects of nanocomposites: Problem related to technological aspects of

nano composites; Difficulty in Fabrication; Limitation; Advantages, properties; Application of

few commercially available nano composites.

7 Hours

Self Learning Exercises (SLE): Limitations in fabrication of nano composites.

Text Books

1. Nanocomposite science and technology by P.M.Ajayan, L.S. Schadler and P.V. Braun,

Wiley-VCH GmbH Co. 2003.

2. Encyclopedia of Nanotechnology by H.S.Nalwa, American Scientific Publishers, 2003.

3. Metalopolymer nanocomposites, Ed A.D. Pomogailo and V.N.Kestelman,\ Springer-

Verlag, 2005. References

1. Biomedical nanostructures by Kenneth E.Gonsalves, Craig R. Halberstadt, Cato T.

Laurencin, Lakshmi S. Nair. John-Wiley & Sons, 2008.

2. Nanobiotechnology II: Edited by Chad A. Mirkin and Christof M. Niemeyer, Wiley- VCH,

2006.



3. Handbook of Biomineralization: Biomimetic and Bioinspired, Chemistry edited by Peter

Behrens, Edmund Bäuerlein John-Wiley Sons, 2006.

Assessment Methods:

Written Tests (Test, Mid Semester Exam & Make Up Test) are Evaluated for 25 Marks each.



CO 1 PO2, PO3

CO2 PO1, PO2

CO 3 PO1, PO4, PO5

CO 4 PO1, PO2, PO3, PO7

CO 5 PO2, PO3, PO 4, PO5



QUANTUM COMPUTING (4.0.0:4)




Total Hours: 52

Credits: 4.0.0:4


Course Outcomes: After the successful completion of this course, the student will be able to

1. Gain facility of some of the many concepts and techniques in second generation

nanotechnology.

2. Understand advanced knowledge on cell repairing and curing using nanotechnology.

3. Use nanoparticles for life extension, quality of life and biostatis requirement.

4. Know the efficient utilization of resources and their limitations.

5. Understand the basic architecture of Engines of Destruction.

6. Should understand foundations of strategies of synthesis for engine survival.

Unit-1: Engines of Construction I : Two styles of technology - Molecular technology today -

Existing protein machines - Designing with protein - Second-generation nanotechnology -

Universal assemblers -Nailing down conclusions - Nanocomputers - Disassemblers - The world

made new - The principles of change - Order from chaos - Evolving molecules -

Explaining order.

Engines of Construction II: Evolving organisms - Another route back - The rise of the

replicators - Evolving technology - The evolution of design - The new replicators - The

creatures of the mind - Selecting ideas - Predicting and projecting - Pitfalls of prophecy

- Science and natural law - Science vs. technology - The lesson of leonardo - The

assembler breakthrough.

13 Hours

Self Learning Exercises (SLE): The rise of the replicators

Unit-2: Engines of abundance and thinking machines -I

Engines of abundance - Clanking replicators - Molecular replicators - Molecules & skyscrapers

- Thinking machines - Machine intelligence - Turing's target - Engines of design - The AI race -

Accelerating the technology race.

Engines of abundance and thinking machines -II :The world beyond earth - The new space

program - Space and advanced technology - Abundance - The positive-sum society -

Engines of healing - Life- Mind and machines - From drugs to cell repair machines - Cell repair

machines - Some cures - Anesthesia plus - From function to structure - From treating disease to



establishing health - A disease called "Aging".

13 Hours

Self Learning Exercises (SLE): Clanking replicators

Unit-3: Long life in an open world and future – I: Cell repair machines - Healing and

protecting the earth - Long life and population pressure - The effects of anticipation -

Progress in life extension. - A door to the future - The requirements for biostasis - Methods

of biostasis - Reversing biostasis.

6 Hours

Self Learning Exercises (SLE): Reversing biostasis

Unit-4: Long life in an open world and future –II: Mind - Body and soul - Reactions &

arguments - Time - Cost and human action - The limits to growth - Thestructure of the vacuum -

Will physics again be upended - The limits to hardware - Entropy - A limit to energy use - The

limits to resources - Malthus - Will someone stop us - Growth within limits - Views of limits.

7 Hours

Self Learning Exercises (SLE): Views of limits

Unit-5: Engines of Destruction: The threat from the machines - Engines of power -Trustworthy

systems - Tactics for the assembler breakthrough - Is success possible - Strategies and survival -

Personal restraint - Local suppression - Global suppression agreements - Global suppression by

force - Unilateral advance - Balance of power.

7 Hours

Self Learning Exercises (SLE): Trustworthy systems

6. Engines of Survival: Cooperative development - A synthesis of strategies - Active

shields vs space weapons - Power - Evil - Incompetence and sloth - Finding the facts -

A mess of experts - From feuds to due process - An approach - Why not due process - Building

due process.

6 Hours

Self Learning Exercises (SLE): Incompetence and sloth

TEXT BOOK

1. Eric Drexler, "Engines of Creation: The Coming Era of Nanotechnology", Reprint

Edition, Anchor, 1987.

Assessment Methods:




CO 1 PO2, PO3

CO2 PO1, PO2

CO 3 PO1, PO2, PO3,

CO 4 PO1, PO2, PO7

CO 5 PO2, PO3, PO8



NANOELECTRONICS (4.2.0:5)




Total Hours: 52

Credits: 5.0.0:5


Course Outcomes


1. Explain the nanoscale Semiconductor materials.

2. Discuss the basics of Plamonics

3. Characterize the Principle and working of Spintronics

4. Describe the fabrication of Photonic crystals.

Unit-1: Semiconductors: Tuning the band gap of nanoscale semiconductors, Quantum

Confinement, Single Electron transistor, the colors and uses of quantum dots, Semiconductor

nanowires- Fabrication strategies, quantum conductance effects in semiconductor nanowires,

fabrication of porous Silicon.

10 Hours

Self Learning Exercises (SLE): Fabrication of Nanobelts

Unit-2: Plasmonics: Introduction, single Emitter Properties, Ideal single photon transistor,

Plasmonic Nano wires, Plasmonic Nano-lithography.

08 Hours

Self Learning Exercises (SLE): Applications of Plasmonics

Unit-3 Spintronics: Introduction, Datta-Das Spin transistor, Johnoson Slisbee Spin Injection

experiment, theory of spin injection through space charge region, spin relaxation in Bulk

Semiconductors.

08 Hours

Self Learning Exercises (SLE): Applications of Spintronic devices.

Unit-4 Photonic crystals: Linear photonics crystals-Maxwell’s equation, Bloch’s theorem,

transmission spectra, Nonlinear Photonic crystals, Fabrication of Photonic crystals (1-D and 2-D)

08 Hours

Self Learning Exercises (SLE): applications of nonlinear photonic crystals devices

Unit-5: Solar energy devices: Solar cell basic working principles, basic principle of HOMO

&LUMO, Bulk Heterojunction polymer solar cells, Dye Senestized Solar cells, working of

quantum dot solar cells.

10 Hours

Self Learning Exercises (SLE): Applications of Solar energy devices



Unit-6: Research topics: Electron Properties of Organic and Inorganic Light Emitting Diodes,

Organic and inorganic Thin film Photovoltaics, Spintronics devices for memory and logic

applications.

08hours

Text Books:

1. Nanotechnology enabled sensors by Kouroush Kalantar – Zadeh, Benjamin Fry, Springer

Verlag New York, (2007)

References

1. W. Ranier, Nano Electronics and Information Technology, Wiley, 2003.

2. K.E. Drexler, Nano systems, Wiley, (1992).

3. M.C. Gupta, J. Ballato The Handbook of Photonics.

Assessment Methods:



a. Deliver a presentation on Research Topics (UNIT-6). A report, supported by technical

publications, of the same topic has to be prepared.



CO 1 PO2,PO5

CO2 PO3, PO8

CO 3 PO3, PO5, PO8,

CO 4 PO1, PO9,



NANOMATERIALS, SURFACE INTERFACE AND CATALYSIS (5.0.0:5)




Total Hours: 52

Credits: 5.0.0:5


Course outcomes (Co’s):


1. Describe the surface-interface concept and its properties especially surface energy and their

states, and surface tension.

2. Explain the binding of molecules to the surface, physio and chemio adsorptions and their

kinetic models, thin films and their properties with epitaxial growth.

3. Demonstrate the surface interface effects, and its characterization, coating surfaces with thin

films.

4. Illustrate the surface segregation and self-assembly of block copolymer, non-lithographic

patterning and micro contact printing.

5. Discuss the Nanostructure catalytic materials like Pt, Pd and Fe, colloidal and porous

materials and applications. Unit-1: Introduction: definitions, Surface energy and surface states, surface tension. Surface,

Interface and Bulk- Surface - Surface electronic structure.

6 Hours Self Learning Exercise (SLE) – Surface energy, surface tension

Unit-2: Surfaces and Interfaces Binding of molecules to the surface, adsorption phenomenon-

chemisorption, and physorptions diffusion, nucleation. Adsorption isotherms, Ideal and real

surface, surface states. Electron spectroscopy. Interaction of particles and radiation with

surfaces, diffraction, secondary emission. Different properties of thin films and bulk, charge

transport through thin films. Epitaxial growth.

10 Hours Self Learning Exercise (SLE) – Different properties of thin and bulk films

Unit-3: Principles of Surface and Interface Chemistry: surface-interface energy and

tension, wetting, characterization of surfaces and interfaces. Techniques for

Manipulating Surfaces: adsorption of surfactants and macromolecules, physical grafting of

macromolecules.

9 Hours

Self Learning Exercise (SLE) – physical grafting of macromolecules



Unit-4: Structured Coatings: surface segregation and self-assembly in films of blends and

copolymers, films by Langmuir-Blodgett. Non-Lithographic Patterning Methods: micro phase

separation in copolymers, dewetting processes, microcontact printing, other uses of self-

assembly for pattern creation.

9 Hours Self Learning Exercise (SLE) – other uses of self-assembly for pattern creation.

Unit-5: Nanostructure & Meosoporous materials & Applications: Nanostructured metals

like Pt, Pd and Fe, nanostructured ceramics like silica, silcate and alumina, pillared clays,

colloids and porous materials. Mesoporous- application with suitable examples, unipore size,

bimodal pore size, supramolecular chemistry.

8 Hours

Self Learning Exercise (SLE) – colloids and porous materials.

Unit-6: Latest Research topics in Surfaces and Interfaces: The topic of interest relating to

the course would be given by course Instructor to each student and they have to demonstrate

their indebt knowledge and presentation skills.

10 Hours

Self Learning Exercise (SLE) – synthesis and application.

Text Books 1 . Handbook of Surface and Interface analysis, J.C. Riviere and S.Myhra, Marcell Decker

Inc., 1998.

2 . Introduction to solid state physics, Charles Kittel, 7th Edition, John Wiley pub, 2000.

3 . Nanstructured catalsysts- SL Scott, CM crudden and CW Jones

References

1. ASM Handbook, Volume 5, Surface Engineering, ASM International Inc., 1998

2. Basic principles in applied catalysis-Mandfredlaerns

3. Nanotechnology in catalysis- Pinzhan

4. Chemistry of Nanomaterials: synthess, Properties and applications, CNR Rao,A Muller

and AK Cheetam.

Assessment Methods:



a. Deliver a presentation on a topic of significance in the field of Surface and Interfaces of

materials and their importance (chapter 6). A report, supported by technical publications,

of the same topic has to be prepared.





CO 1 PO3

CO2 PO1, PO2

CO 3 PO1, PO5, PO3,

CO 4 PO1, PO2, PO9

CO 5 PO2, PO3, PO 5, PO8



CARBON NANOSTRUCTURE AND APPLICATIONS (4.0.0:4)




Total Hours: 52

Credits: 4.0.0:4


Course outcomes (CO’s):

After the successful completion of this course, the student will be able to: 1. Explain the different nanostructures like whiskers, cones and polyhedral crystalsand

their structure properties and application.

2. Describe the type of carbon nanotubes and different synthesis methods and growth

mechanisms.

3. Demonstrate the graphite derivatives, fullerenes and its type, nano-diamond, graphene,

different synthesis methods and their functionalization and applications.

4. Identify the application of carbon nanostructure for different day-to-day applications.

5. Differentiate the nanostructure catalytic materials like Pt, Pd and Fe, colloidal and porous

materials.

Unit-1: Nanostructures: Graphite, Whiskers, Cones, and Polyhedral crystals, structure,

Properties and applications.

6 Hours Self-Learning Exercise (SLE) – Graphite.

Unit-2: Carbon Nanotubes (CNT): Histroy, types of CNTs, synthesis methods, CVD

method, Laser ablation and electric arc processes, growth mechanisms, purification and

characterization methods, solid disordered carbon nanostructures.

8 Hours

Self-Learning Exercise (SLE) – purification and characterization methods.

Unit-3: Properties and applications of CNTs: electrical, vibrational, mechanical, optical

properties and Raman spectroscopy of CNTS, carbon cluseters, decoration of CNT by nano

metals and metal oxides, Applications-Lithium ion battery, fuel cells, sensor applications,

applications to nanoelectronics, nanocomposites.

8 Hours Self-Learning Exercise (SLE) – decoration of CNT by nano metals and metal oxides.

Unit-4: Graphite derivatives: Fullerenes and types, nano-diamond, clusters, metal carbide

derived carbon nanostructures, synthesis and applications. Graphene: - Background, structure,

exfoliation or synthesis methods- physical and methods – micromechanical (scotch t ap e

method), CVD, Chemical approaches -Hammers method, oxidation and reduction of graphite,

solvo-thermal synthesis.



10 Hours Self-Learning Exercise (SLE) – electrochemical synthesis and other methods.

Unit-5: Functionalization of carbon nanostructures: (CNT, Graphene and fullerenes)-

reactivity, covalent functionalization-oxidative purification, defect functionalization,

transformation and modification of carboxylic functionalization like thiolation, halogenations,

hydrogenation, sidewall functionalization through electorphilic addition, non-covavlent

exohedral functionalization, endohedro functionalization.

10 Hours Self-Lear ning Exercise (SLE) – exohedral functionalization, endohedro functionalization.

Unit-6: Carbon nanostructure applications - Lithium ion battery, fuel cells, hydrogen

storage, sensor applications, applications to nano-electronics, nano-composites, nano wires in

drug delivery, polymer reinforcement and as filler materials.

10 Hours Self-Learning Exercise (SLE) – nanowires in drug delivery.

Text Books 1. Carbon N a n o t u b e s : properties a n d a p p l i c a t i o n s -Mchael J . O‘Connell, Taylor &

Francis, 2006

2. Nanotubes and Nanowires-CNR Rao and A Govindaraj RSC publishing

3. Handbook of Carbon, Yury Gagotsi, Taylor & Francis, 2006

Reference

1. Physical properties of carbon nanotube - R. Satio

2. Applied physics of Carbon nanotubes: fundamentals of theory, optics and Transport

Devices - S. Subramoney and S. V. Rotkins

3. Carbon nanotechnology- Liming Dai

Assessment Methods:

Written Tests (Test, Mid Semester Exam & Make up Test) are evaluated for 25 Marks each.



CO 1 PO2, PO3

CO2 PO1, PO2

CO 3 PO1, PO5, PO3,

CO 4 PO2, PO3, PO7

CO 5 PO2, PO8 ,PO9



NANOSENSORS AND DEVICES (4.0.0: 4)




Total hours: 52

Credits: 3.0.2: 4



able to:

1. Understand the basics of a sensor.

2. Study the sensor characterization and modes of packaging.

3. Correlate and record data’s of the medically significant measurands using a bio sensor.

4. Apply the sensing of physical parameters sensed to fabricate appropriate sensors.

5. Understand the processing of input signals of sensors and applying it in electronics.

6. Study the behavior of Quantum structures and apply it in fabricating devices.

Unit-1: Micro and Nano-sensors - Fundamentals of sensors, biosensor, micro fluids, MEMS

and NEMS.

6 Hours

Self Learning Exercises (SLE): Micro fluids

Unit-2: Packaging and characterization of sensors - Methods of packaging at zero level, dye

level and first level, Active and Passive sensors – Static characteristic: Accuracy, offset and

linearity – Dynamic characteristic: First and second order sensors.

8 Hours Self Learning Exercises (SLE): Second order sensors

Unit-3: Biosensors - Medically Significant Measurands, Functional Specifications of Medical

Sensors; Sensor characteristics: linearity, repeatability, hysteresis and drift. Sensor models in the

time & frequency domains, Clinical Diagnostics, generation of biosensors, immobilization,

characteristics, applications, conducting Polymer based sensor, DNA Biosensors, optical sensors.

10 Hours Self Learning Exercises (SLE): Sensor models in the time & frequency domains

Unit-4: Sensor Applications - Sensors for aerospace and defense: Accelerometer, Pressure

Sensor, Night Vision System, Nano tweezers, nano-cutting tools, Integration of sensor with

actuators and electronic circuitry, Sensor for bio-medical applications: Cardiology, Neurology

and as diagnostic tool, For other civil applications: metrology, bridges etc.

10 Hours



Self Learning Exercises (SLE): Nano tweezers

Unit-5: Biochips - Metal Insulator Semiconductor devices, molecular electronics, information

storage, molecular switching, Schottky devices.

8 Hours Self Learning Exercises (SLE): Molecular switching

Unit-6: Quantum Structures and Devices - Quantum layers, wells, dots and wires, Mesoscopic

Devices, Nanoscale Transistors, Single Electron Transistors, MOSFET and NanoFET, Resonant

Tunneling Devices, Carbon Nanotube based logic gates, optical devices, Connection with

quantum dots, quantum wires, and quantum wells.

10 Hours Self Learning Exercises (SLE): Resonant Tunneling Devices

Text Books & References

1. Sensors: Micro & Nanosensors, Sensor Market trends (Part 1&2) by H. Meixner.

2. Between Technology & Science : Exploring an emerging field knowledge flows & networking

on the nanoscale by Martin S. Meyer.

3. Nanoscience & Technology: Novel structure and phenomea by Ping Sheng (Editor)

4. Nano Engineering in Science & Technology: An introduction to the world of nano design by

Michael Rieth.

5. Enabling Technology for MEMS and nano devices -Balles, Brand, Fedder, Hierold.

6. Optimal Synthesis Methods for MEMS- G. K. Ananthasuresh

7. MEMS & MOEMS Technology and Applications- P. Rai Choudhury

8. Processing Technologies- Gandhi

9. From Atom to Transistor- Supriyo Datta

Assessment Methods:






CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4




ENTREPRENEUR DEVELOPMENT & PROJECT MANAGEMENT (5.0.0:5)




Total Hours: 52

Credits: 5.0.0:5



Course Outcomes:

At the end of this course, students will be able to

1. Explain the general working structure and different issues involved of various industries.

2. Interpret the management aspects and organizational control in industry

3. Understand the concepts of financial decisions and accounts management

4. Describe the basics of research methodology and product life cycle

5. Discuss the marketing srtegies of different goods and services

6. Develop an overview of the impacts nanotechnology and its education by nanoengineers

Unit-1: Industry overview: General introduction to Nanotech & Biotech industries. Scope.

Trends and key issues in industry. Organization, financing, policy, trends, problems and issues in

the healthcare, pharmaceutical, Agri and other biotech industries. Overview of cost, quality,

access issues.

8 Hours

Self Learning Exercises (SLE): Overview of Mfg. industries

Unit-2: Organization and Management: Management Concepts and Functions. Development

of Management Theories. The Internal and External Environments of the Organisation. Social

Responsibility and Ethics in Management. Managerial Decision Making. The planning process.

The nature of Organization Structure. Organisational Control. Contemporary issues in

Management. Management in Future. Concepts, structures & functions characterizing

contemporary industries in India and other industrialized nations – model case studies.

Management, Need of Managements, Leadership, Communication Skills for Management;

audience awareness, style, individual and group presentations, conflict resolution. Control of the

movement of goods; coordination of supply and demand and creation and maximization of time

and place utility. Negotiation Strategies.

8 Hours

Self Learning Exercises (SLE): Logistics Systems Management;



Unit-3: Financial Resource management: Mobilization of Financial resources; Bank loans &

Venture capitalism. Concepts and techniques of accounting for planning, control, and

motivation. Factors influencing capital acquisition and allocation. Financial decision making;

Decision making under uncertainty; Current issues in financial management.

6 Hours

Self Learning Exercises (SLE): Positive and normative model

Unit-4: Industrial R&D &Product Development: Research & development. Product

development and project management in Agri, Pharma, Health and other biotech industries.

Overview of issues and techniques involved in conducting & outcome of research. The

multidisciplinary nature of outcomes research: research design and methods, data collection

measurement instruments and clinical endpoints, quality of life issues, behavior change, and

cost-effectiveness. Analysis Transition from R&D to business units, market learning and

transition from R&D. Management of radical innovation technologies vs. stage gate approach in

product development. Case studies.

10 Hours

Self Learning Exercises (SLE): Product development in Mfg industries

Unit-5: Marketing : Introduction to the theory, concepts, skills, and principles of marketing.

Business environment. User-oriented analysis of marketing research process, including problem

definition, design, data collection, data analysis, interpretation, and presentation. Applications of

the theory, concepts, skills, and principles of public relations in marketing. Development of a

marketing management focus, including market analysis, competitive analysis, and decisions in

pricing, product, promotion, and distribution channels. Study of marketing of goods and services

to business, institutions, and government. Marketing strateg for health, pharmaceutical, and other

biotechnology products.

10 Hours

Self Learning Exercises (SLE): Marketing of services to educational institutions

Unit-6: Public Perceptions and Education: Public Interaction Research - Communicating

Nanotechnological Risks - Understanding of Nanotechnology’s Social Impacts -

Nanotechnology in the Media. Educating Undergraduate Nanoengineers - Interactive,

Entertaining, Virtual Learning Environments – Nanotechnology in Education - Education

Opportunities - Human Resources for Nanotechnology. Management of Innovation for

Convergent Technologies – The "Integration/Penetration Model" - Social Impacts of

Nanobiotechnology Issues - Innovation, Legal Risks, and Society.

10 Hours

Self Learning Exercises (SLE): Analogies for Interdisciplinary Research



Assessment Methods:




CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4




NANOTECHNOLOGY AND INDUSTRIAL APPLICATIONS (5.0.0: 5)




Total hours: 52

Credits: 5.0.0: 5



able to:

1. Understand the basic and essential in electronics industry

2. Explain the role and applications of nanotechnology in biomedical and pharmaceutical

industry

3. Discuss the use of nanomaterials for processing in chemical industry

4. Define how nanotechnology can be used in agriculture

5. Apply nanotechnology ideas in textile industry

6. Identify environmental and safety issues in nanomaterials.

UNIT – 1: Nanotechnology In Electrical And Electronics Industry: Advantages of nano

electrical and electronic devices –Electronic circuit chips – Lasers - Micro and Nano-

Electromechanical systems – Sensors, Actuators, Optical switches, Bio-MEMS –Diodes and

Nano-wire Transistors - Data memory –Lighting and Displays – Filters (IR blocking) – Quantum

optical devices – Batteries - Fuel cells and Photo-voltaic cells – Electric double layer capacitors

– Lead-free solder – Nanoparticle coatings for electrical products.

8 hours

Self Learning Exercises (SLE): Nano-wire Transistors.

UNIT – 2: Nanotechnology In Biomedical And Pharmaceutical Industry : Nanoparticles in

bone substitutes and dentistry – Implants and Prosthesis - Reconstructive Intervention and

Surgery – Nanorobotics in Surgery – Photodynamic Therapy - Nanosensors in Diagnosis–

Neuro-electronic Interfaces – Protein Engineering – Drug delivery – Therapeutic applications.

8 hours

Self Learning Exercises (SLE): Protein Engineering

UNIT – 3: Nanotechnology In Chemical Industry : Nanocatalyts – Smart materials –

Heterogenous nanostructures and composites – Nanostructures for Molecular recognition

(Quantum dots, Nanorods, Nanotubes) – Molecular Encapsulation and its applications –

Nanoporous zeolites – Self-assembled Nanoreactors - Organic electroluminescent displays.

8 hours



Self Learning Exercises (SLE): Nanoporous zeolites

UNIT – 4: Nanotechnology In Agriculture And Food Technology : Nanotechnology in

Agriculture -Precision farming, Smart delivery system – Insecticides using nanotechnology –

Potential of nano-fertilizers - Nanotechnology in Food industry - Packaging, Food processing -

Food safety and bio-security – Contaminant detection – Smart packaging.

10 hours

Self Learning Exercises (SLE): Food safety and bio-security

UNIT – 5: Nanotechnology In Textiles And Cosmetics : Nanofibre production -

Electrospinning – Controlling morphologies of nanofibers – Tissue engineering application –

Polymer nanofibers - Nylon-6 nanocomposites from polymerization - Nano-filled polypropylene

fibers - Bionics– Swim-suits with shark-skin-effect, Soil repellence, Lotus effect - Nano

finishing in textiles (UV resistant, antibacterial, hydrophilic, self-cleaning, flame retardant

finishes) – Modern textiles (Lightweight bulletproof vests and shirts, Colour changing property,

Waterproof and Germ proof, Cleaner kids clothes, Wired and Ready to Wear)

Cosmetics – Formulation of Gels, Shampoos, Hair-conditioners (Micellar self-assembly and its

manipulation) – Sun-screen dispersions for UV protection using Titanium oxide – Color

cosmetics.

10 hours

Self Learning Exercises (SLE): Nylon-6 nanocomposites from polymerization

UNIT – 6: Industrial R&D and Product Development

Industrial R&D and product development. Product development and project management in

health and other biotech industries. Analysis Transition from R&D to business units, Overview

of issues and techniques involved in conducting & outcome of research. Product development,

market learning, Case studies.

8 hours

Self Learning Exercises (SLE): Analysis Transition from R&D to business units

Text Books:

1. Mark A. Ratner and Daniel Ratner, Nanotechnology: A Gentle Introduction to the Next Big

Idea, Pearson (2003).

2. Bharat Bhushan, Springer Handbook of Nanotechnology, Barnes & Noble (2004).

3. Neelina H. Malsch (Ed.), Biomedical Nanotechnology, CRC Press (2005)

4. Udo H. Brinker, Jean-Luc Mieusset (Eds.), Molecular Encapsulation: Organic Reactions in

Constrained Systems,Wiley Publishers (2010).

5. Jennifer Kuzma and Peter VerHage, Nanotechnology in agriculture and food production,

Woodrow Wilson International Center, (2006).

6. Lynn J. Frewer, Willehm Norde, R. H. Fischer and W. H. Kampers, Nanotechnology in the

Agri-food sector, Wiley-VCH Verlag, (2011).



7. P. J. Brown and K. Stevens, Nanofibers and Nanotechnology in Textiles, Woodhead

Publishing Limited, Cambridge, (2007).

8. Y-W. Mai,Polymer Nano composites, Woodhead publishing, (2006).

9. W.N. Chang,Nanofibres fabrication, performance and applications, Nova Science Publishers

Inc, (2009).

References:

1. C.W.Turner, T.VanDuzer, Principles of superconductive devices and circuits, 1981

2. Reynolds, M Pomeranty, Electroresponsive molecules and polymeric systems, Skotheim T.

Marcel Dekker, New York, 1991.

3. A.Yariv, Principles of optical electronics, John Wiley, New York, 1984.

4. D.D.C.Bradley, Current opinion in solid state and Materials science vol 1 789 (1996).

Assessment Methods:


each





CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4




NANOTECHNOLOGY AND DRUG DELIVERY SYSTEMS (5.0.0:5)




Total Hours: 52

Credits: 5.0.0:5



1. Knowledge on selectivity and sensitivity of drug delivery and targeting.

2. Select and apply appropriate nanoparticles as drugs and their functionalization.

3. Learn Nanoparticles as drugs to appropriate sites with controlled release of drugs.

4. Give an example and explain the function and potential application of DNA based structures.

5. How nano-assisted technologies compare to conventional medical devices.

6. Descriptive view of how nanotechnology appreciates drug discovery, delivery and its

application.

Unit-1: Principles of drug delivery systems: modes of drug delivery, ADME hypothesis –

controlled drug delivery, site specific drugs , barriers for drug targeting, passive and active

targeting, Strategies for site specific, time and rate controlled delivery of drugs, antibody based

and metabolism-based targeting.

8Hours Self Learning Exercises (SLE): passive and active targeting

Unit-2: Nanoparticles as Drugs: Structure and Preparation, Liposomes, Cubosomes and

Hexosomes, Lipid based Nanoparticles-Liquid nanodispersions- Solid Lipid Nanoparticles

(SLP), Biofunctionalsiation of SLP, Charatcterisation- Nanoparticles for crossing biological

membranes. Fundamentals- Physicochemical Principles of Nanosized Drug Delivery Systems-

Nanotubes, Nanorods, Nanofibers, and Fullerenes for Nanoscale Drug Delivery, Carbon

nanotubes biocompatibility and drug delivery.

9 Hours

Self Learning Exercises (SLE): Fullerenes for Nanoscale Drug Delivery

Unit-3: Targetted Nanoparticles for drug delivery: Nanoparticles surface modification,

bioconjugation, pegylation, antibodies, cell-specific targeting and controlled drug release, Multi-

Functional Gold Nanoparticles for Drug Delivery: Virus Based-nanoparticles.



Dendrimers as Nanoparticular Drug Carriers: Synthesis – Nanoscale containers ––

Naoscafold systems – Gene transfection, Biocompatibility Polymer Micelles as Drug Carriers,

Polymers nanotubes- Magnetic Nanoparticles as Drug Carriers.

12 Hours

Self Learning Exercises (SLE): Virus Based-nanoparticles

Unit-4: Liposomes for drug delivery and targeting: classification and preparation of

liposomal nanoparticles. Liposomes for pharmaceutical and cosmetic applications, Liposomal

Drug Carriers in Cancer Therapy, lipid-DNA complexes, viral gene transfection systems, Lipid

based drug delivery systems for peptide and protein drug delivery, Liposomal anticancer and

antifungal agents.

9 Hours

Self Learning Exercises (SLE): Liposomal Drug Carriers in Cancer Therapy

Unit-5: Nanoparticle and targeted systems for cancer diagnosis and therapy: Targeted

delivery through enhanced permeability and retention. Folate receptors, Targeting through

angiogenesis, Targeting to specific organs or tumor types, Tumor-specific targeting: Breast

cancer, Liver, Targeting tumor vasculature for Imaging, Delivery of specific anticancer agents:

such as Paclitaxel, Doxorubicin,5-Fluorouracil etc.

7 Hours Self Learning Exercises (SLE): Targeting through angiogenesis

Unit-6: Drug Discovery & Delivery: Drug Discovery Using Nanocrystals, Drug Discovery

Using Resonance Light Scattering (RLS) Technology. Benefits of Nano-Imaging Agents,

Nanosensors in Drug Discovery, Drug Delivery using Nanobiosensors, Drug Delivery

Applications, Bioavailability, Suistained and targeted release, Nanorobots, Benefits of Nano-

Drug Delivery. Drug Delivery, Health Risks, and Challenges, Targeting. Drug Delivery

Revenues. Use of microneedles and nanoparticles for local highly controlled drug delivery.

7 Hours Self Learning Exercises (SLE): Drug Delivery Revenues

Text Books

1. Drug Delivery: Engineering Principles for Drug Therapy, M. Salzman,

2. Drug Delivery: Principles and Applications, B. Wang, Wiley Intersceince, 2005.

3. NANOTHERAPEUTICS: Drug Delivery Concepts in Nanoscience edited by Alf Lamprecht

Reference

1. Nanoparticulate Drug Delivery Systems Deepak Thassu, Michel Deleers (Editor), Yashwant

Pathak

2. Drug Delivery and Targetting, A.M.Hillery, CRC Press, 2002.

3. Bio-Applications of Nanoparticles Warren C.W. Chan

4. Lisa Brannon-Peppas, James O. Blanchette Nanoparticle and targeted systems for cancer

therapy Advanced Drug Delivery Reviews 56 (2004) 1649– 1659



Assessment Methods:


each



CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4




Additive Manufacturing (4-0-0:4)




Total Hours: 52

Credits: 4.0.0:4


Course Outcomes:

Upon the successful completion of this course, students will be able to:

1. Explain the importance and growth of Rapid Prototyping Techniques.

2. Differentiate and describe the operation, applications and advantages of Stereo lithography,

selective Laser sintering and fused deposition modeling.

3. Analyze solid ground curing and laminated object manufacturing processes and their working.

4. Able to evaluate different Concept Modelers.

5. Recommend different tooling requirements for Rapid Prototyping.

6. Demonstrate Self learning capability.

Unit-1: Introduction: Need for the compression in product development, Growth of RP

industry, and classification of RP systems.

Stereo Lithography Systems: Principle, Process parameter, Process details, Data preparation.

8 Hours

Self Learning Exercises (SLE): Application of stereo lithography.

Unit-2: Selective Laser Sintering and Fusion Deposition Modeling: Type of machine,

Principle of operation, process parameters, Data preparation for SLS, Applications, Principle of

Fusion deposition modeling, Process parameter.

9 Hours

Self Learning Exercises (SLE): Fused deposition modeling applications.

Unit- 3: Solid Ground Curing: Principle of operation. Laminated Object Manufacturing:

Principle of operation, Process details, Machine details

9Hours Self Learning Exercises (SLE): LOM materials.

UNIT 4: Concepts Modelers: Principle, Thermal jet printer, Sander's model market,. Genisys

Xs printer HP system 5.

8Hours

Self Learning Exercises (SLE): 3-D printer.

UNIT 5: Rapid Tooling: Indirect Rapid tooling -Silicone rubber tooling –Aluminum filled

epoxy tooling Spray metal tooling, 3Q keltool, etc >Direct Rapid Tooling Direct. AIM, Quick

cast process, Copper polyamide, DMILS, Prometal, Sand casting tooling, Laminate tooling.

9Hours



Self Learning Exercises (SLE): soft Tooling vs. hard tooling.

UNIT 6: RP Process Optimization: factors influencing accuracy. Data preparation errors, Part

building errors, Error in finishing.

9Hours

Self Learning Exercises (SLE): Selection of part build orientation for SL and SLS process.

TEXT BOOKS:

1. Pham D.T. & Dimov S.S "Rapid Manufacturing" Springer London 2011.

REFERENCE BOOKS:

1. Terry Wohlers "Wohler's Report 2000" Wohler's Association 2000.

2. Paul F. Jacobs: "Stereo lithography and other RP & M Technologies", SME, NY

1996,Springer

Assessment Methods:



i. Deliver a presentation on a topic of significance in the field Rapid Prototyping. A report,

supported by technical publications, of the same topic has to be prepared.



CO1 PO1, PO3

CO2 PO1, PO2, PO5

CO3 PO3, PO4, PO5 & PO6


CO5 PO1, PO2, PO3, PO4 & PO5




NANOBIOTECHNOLOGY (4.0.0:4)




Total Hours: 52

Credits: 4.0.0:4



1. Understand the basics of Biotechnology

2. Explain the interaction between biomolecules and nanoparticle surface and its applicaitons.

3. Optimise the synthesis of Biocompatibility of Nanomaterials

4. Analyze different types of DNA based Nanostructures

5. Evaluate Implications in Neuro science, tissue engineering and medical applications.

6. Identify the risk assessments involved bio nano materials

Unit-1 Fundamentals of Biotechnology: Basic terms in biotechnology, Biological building

blocks; Sizes of building blocks and comparison with nanostructures. Introduction to Proteins,

lipids, DNA, Membrane structures. PHA, cyanophcin inclusion, magnetosome, alginates,

bacteriophages, bacteriospores,

Self Learning Exercises (SLE): bacterial protein complex, S-layer protein, bacteriorhodpsin.

6 Hours

Unit-2 Interaction between biomolecules and nanoparticle surface: Different types of

inorganic materials used for the synthesis of hybrid nano-bio assemblies, Application of nano in

biology, nanoprobes for Analytical Applications - A new methodology in medical diagnostics

and Biotechnology,

Self Learning Exercises (SLE): Current status of Nanobiotechnology, Future perspectives of

Nanobiology.

08 Hours

Unit-3 Biological synthesis of Nanomaterials: synthesis using microorganisms, synthesis using

plant extracts, synthesis using proteins and DNA templates. Nanoscale magnetic iron minerals in

bacteria, virus & fungi. DNA based Nano structures. Protein based Nano structures.

Introduction-Biocompatibility – anti bacterial activity – principles involved – Applications.

Biomaterial nanocircuitry; Protein based nanocircuitry; Neurons for network formation. DNA

nanostructures for mechanics and computing and DNA based computation; DNA based

nanomechanical devices. Function and application of DNA based nanostructures. In-vitro

laboratory tests on the interaction of nanoparticles with cells.

Self Learning Exercises (SLE): Biomechanical strength properties of Spider silk.



10 Hours

Unit-4 DNA based nanostructures; DNA, structure of DNA, genetic code and protein

synthesis. Topographic and Electrostatic properties of DNA and proteins – Hybrid conjugates of

gold nanoparticles – DNA oligomers – Use of DNA molecules in nanomechanics and

Computing. DNA-protein nanostructures-Methods- Self assembled DNA nanotubes—Nucleic

acid Nanoparticles, DNA as a Biomolecular template-DNA branching-Metallization- Properties.

DNA Origami. Photoinduced Electron Transport in DNA: Toward Electronic Devices Based on

DNA Architecture- DNA Nanowires- Charge Transport- DNA-Based Nanoelectronics-

Electrical Manipulation of DNA on Metal Surfaces,

Self Learning Exercises (SLE): Nanostructured Biocompartments- DNA-Gold nanoconjugates.

10 Hours

Unit-5 Nanomaterials in medical application: Nanomaterials in bone substitutes & Dentistry,

Drug delivery and its applications, Biochips- analytical devices, Biosensors- Natural

nanocomposite systems as spider silk, bones, shells; organic-inorganic nanocomposite formation

through self-assembly. Polymeric nanofibres – Implications in Neuro science, tissue engineering

and cancer therapy. Poly electrolyte multilayers- coated colloids- smart capsules. Colloids and

colloids assembly of bio nanotechnology.

Self Learning Exercises (SLE): Micro emulsions in nanotechnology.

10 Hours

Unit-6 Risk assessment and Nanomaterials: Effects of steric hindrance, inflammatory and

immune based mechanisms – critical variables – exposure and effects through ingestion –

diffusion – endocytosis – exposure and effects through dermal absorption – exposure and effects

through inhalation – mechanism for adsorption and removal – pulmonary toxicology – known

toxicity of nanomaterials. Assessment of the toxic effects of nanoparticles based on in-vitro

laboratory tests.

Self Learning Exercises (SLE): Identification of pathogenic organisms by magnetic

nanoparticle-based techniques.

08 Hours

TEXT BOOKS

1. Nanobiotechnology by Christof M Niemeyer, Chad A Mirkin, Wiley VCH, 2006

2. Jain K.K, Nanobiotechnology in Molecular Diagnostics – Current Techniques and

Applications. Taylor and Francis Publications 2006.

3. Bio-Applications of Nanoparticles BY Warren C.W. Chan, Springer Science+Business Media,

2007

REFERENCE BOOKS

1. Nanotechnology in Drug Delivery by Melgardt M.deVilliers, Pornanong Aramwit, Glen

S.Kwon, Springer-American Association of Pharmaceutical Scientists Press 2009.



2. Bionanotechnology - Global Prospects by David E. Reisner, Taylor & Francis Group, LLC,

2009.

3. Applications of nanoparticles in biology and medicine by Salata O.V. Journal of

Nanobiotechnology, 2:3, 2004.

Assessment Methods:




CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4




NANOTECHNOLGY IN FOOD AND AGRICULTURE (4.0.0:4)




Total Hours: 52

Credits: 4.0.0:4


Course Outcomes:


1. Define intermolecular as well as hydrophilic and hydrophobic interactions, soluble polymers,

self assembly in plant cells.

2. Introduce the nanotechnology in food, food production, antimicrobial functionality,

functional materials in food nanotechnology.

3. Explain the nanotechnology in Agricultural field, different Enzyme and DNA based

biosensors, RFIDs tag, Nano-sensors networks.

4. Define advanced processing techniques for food processing like infrared processing,

dielectric heating, microwave processing, and self-life analysis of food characteristics.

5. Elucidate food quality, safety and security of agricultural product, packaging and

distribution, nanomaterials for food applications.

6. Explain the technology issues, life cycle of nanotechnology food product, food allergy,

impact of nanoscale structures on food product.

Unit-1: Intermolecular Interactions Introduction, Hydrophobic and Hydrophilic Interactions,

Dispersion Interaction, Electrostatic Interactions, Steric Interactions Involving Soluble Polymers.

Self-Assembly, Plant Cells, Organized Self-Assembled Structures.

8 Hours

Self Learning Exercise (SLE) – Organized Self-Assembled Structures

Unit-2: Nanotechnology in Food: Introduction, Food Production, Antimicrobial Functionality,

Visual Indicators, Physics and Structures in Food Bionanotechnology, Information and

Communication Technology, Fibrillar Structures, Plate-Like Structures, Spherically Symmetric

Structures, Bi-continuous Structures in Protein–Polysaccharide Systems, Gastronomy and the

Nanodomain: Molecular Gastronomy, functional materials in food nanotechnology.

10 Hours

Self Learning Exercise (SLE) – Structures in Protein–Polysaccharide Systems

Unit-3: Nanotechnology in Agricultural: Introduction, Biosensors, Enzyme Biosensors and

Diagnostics, DNA-Based Biosensors and Diagnostics, Radiofrequency Identification (RFID),



Integrated Nanosensor Networks: Detection and Response, Precision Agriculture, Potential

Changes in Farming Methods and Sustainable Agriculture.

10 Hours

Self Learning Exercise (SLE) – Precision Agriculture

Unit-4: Advanced Processing Technologies: Introduction, Preservation Methods, Drying

Techniques, Conventional methods and its limitation, Infrared processing, di-electric heating,

microwave processing, batch type and conveyor type systems, shelf-life, analysis of food

characteristics.

8 Hours

Self Learning Exercise (SLE) – shelf-life, analysis of food characteristics

Unit-5: Food Quality, Safety, and Security: Introduction, Improving Quality, Safety, and

Security of Agricultural Production, Food Processing, Packaging and Distribution. Concerns

about using Nanotechnology in Food Production. Reasons to Package Food Products, Physical

Properties of Packaging Materials. Safety Assessment of Oral-Exposure Engineered

Nanomaterials for Food Application. Toxicity aspects of nanofood, modification of nano

materials to avoid toxic effect and commercial aspect.

10 Hours

Self Learning Exercise (SLE) – Toxicity aspects of nanofood

Unit-6: Technology Issues: Life Cycle of Nanotechnology Food Products, Molecules in Foods

Involved in Triggering Allergies, Processing, and Food Allergy, Impact of Nanoscale Structures

on Allergenic Potential of Foods, Innovations in Food and Agriculture Nanotechnology.

6 Hours

Self Learning Exercise (SLE) – Molecules in Foods Involved in Triggering Allergies

Text Books

1. Lynn J. Frewer, Willem Norde, Arnout Fischer, Frans Kampers “Nanotechnology in the

Agri-Food Sector” John Wiley and Sons,2010

2. S.Choudhary, ‘Applied Nanotechnology in Agriculture’, Arise Publication, 2011.

Assessment Methods:




CO 1 PO2, PO3

CO 2 PO1, PO2

CO 3 PO2, PO4, PO7

CO 4 PO2, PO3 & PO4


scheme of teaching, examination & syllabus · trying to strive for academic excellence and...

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