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    Tables

    Table 1. Role of Lipoproteinlipase in Various Tissues

    Tissue Role

    Muscle (cardiac, skeletal) Energy provision

    White adipose tissue Triglyceride storage

    Brown adipose tissue Thermogenesis

    Lactating breast Milk triglyceride synthesis

    Lung ur!actant synthesis"

    Brain #hospholipid and glycolipid synthesis"

    $nknown %drenal, kidney, spleen, !etal liver

    "#utative&

    Table 2. Changes in Body Shape in HIV-infeted !atients Reei"ing !rotease

    Inhibitor Therapy

    #o hange $ild $oderate Se"ere

    Body shape ' *+ - ''

    Loss o! subcutaneous !at + ' + '-

    .ri/ belly 0 - ++ '

    Bu!!alo hump 1- '-

    Table %. &ifferenes Bet'een (asting Syndro)e and Lipodystrophy Syndro)e

    syndro)e

    (asting Lipodystrophy

    Body weight 2ecrease 3ncrease or decrease

    Body !at 2ecrease, all areas#eripheral decrease,

    central increase

    Lean body mass 2ecrease $nchanged

    Total cholesterol 2ecrease 3ncrease

    4L2L cholesterol 2ecrease 3ncrease

    L2L cholesterol 2ecrease 3ncrease

    52L cholesterol 2ecrease 2ecrease

    Triglycerides 3ncrease 3ncrease2iabetes6insulin resistance 7o 8es

    .oronary artery disease 7o 8es

    4L2L, very low9density lipoprotein: L2L, low9density lipoprotein: 52L, high9density lipoprotein&

    Table *. &iagnosti Criteria for HIV Lipodystrophy Syndro)e or $etaboli

    Syndro)e +

    $ain riteria

    534 in!ection#3 therapy

    Loss o! peripheral !at tissue3ncreased central !at tissue

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    (abdominal girth)

    $inor riteria

    4isible subcutaneous veinsLoss o! temple, nasolabial, and

    cheek !at padsBu!!alo hump or bull neck

    Breast hypertrophy

    Enlarged supraclavicular !atpadsBilateral symmetric lipomatosis

    (enlarged a/illary !at pads)2ecreased thigh si;e

    5yperlipidemia (cholesterol,triglycerides)

    ,dunti"e riteria

    2iabetes

    #eripheral insulin resistance5yperinsulinism

    5yperuricemiaLow serum testosterone

    3ncreased . peptide3ncreased !ree !atty acids

    .oronary artery disease,ischemic heart disease

    5ypertension

    Table . The Harris-Benedit /0uation (ith ,dunti"e Calories for Various

    Conditions

    urgical operation 0

    Trauma '- 9 '0

    .omplicated trauma +- 9 0-#eritonitis '0 9 +-

    Minor in!ection 0 9 +-

    evere in!ection *- 9 )

    7%32s (indomethacin, ibupro!en, aspirin) (=educes #? synthesis)

    #E#, phosphoenolpyruvate: c%M#, cyclic adenosine monophosphate: T7>, tumor necrosis !actor: 7%32s,nonsteroidal anti9in!lammatory drugs: #?, prostaglandin: L#, lipopolysaccharide: 3L9', interleukin9'&

    Referenes

    '& Torun B,4iteri >E& #rotein9energy malnutrition& 3n@ hils ME, 8oung 4=, eds& Modern 7utrition in 5ealth and 2isease& thed& #hiladelphia@ Lea A >ebiger: '11@*

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    rancisco %, et al& The magnitude o! body cell mass depletion determines the timing o! death !romwasting in %32& %m .lin 7utr& '1:0-@***9**&

    '%, et al& .orrelation between total body potassium and total body nitrogen in patients withacDuired immunode!iciency syndrome& .lin =es& '':@rancisco& %bstract ThB+-&

    '& .hlebowski =T, ?rosvenor MB, Bernhard 75, et al& 7utritional status, gastrointestinal dys!unction, and survival in patientswith %32& %m ?astroenterol& '1:1*@'+119'+&

    +-& ?ray ?E, ?ray LF& %nthropometric measurements and their interpretations@ principles, practice and problems& %m 2iet%ssoc& '1-:@0*90&

    +'& Blackburn ?., Bistrian B=, Maini B, et al& 7utritional and metabolic assessment o! the hospital patient& #E7& ':'@''9++&

    ++& 2ouglas =?, haw 5>& Metabolic response to sepsis and trauma& Br urg& '1:la: pp& +--9+-0&+1& Brennan M>& $ncomplicated starvation versus cancer cache/ia& .ancer =es& ':@+09+eingold F=& Metabolic disturbances and wasting in the acDuired immunode!iciency syndrome& 7 Engl Med&'+:0@+9&

    -& Wol!e ==, haw 5, 2urkot M& E!!ect o! sepsis on 4L2L kinetics@ responses in basal state and during glucose in!usion& %m #hysiol& '10:+*1@E+9E*-&

    '& >eingold F=, 2oerrler W, 2inarello .%, et al& timulation o! lipolysis in cultured !at cells by tumor necrosis !actor,interleukin9', and the inter!erons is blocked by inhibition o! prostaglandin synthesis& Endocrinology& '+:'-@'-9'eingold F=, %di , taprans 3, et al& 2iet a!!ects the mechanism by which T7> stimulates hepatic triglyceride production&AmJ Physiol.'-:+0@E'9E'1*&

    & ?run!eld .& Mechanisms o! wasting in in!ection and cancer@ an approach to cache/ia in %32& 3n@ Fotler 2#, ed&?astrointestinal and 7utritional Mani!estations o! %32& 7ew 8ork@ =aven #ress: ''@+-9++&

    *& Farmali =%, .hao .., Basu %, Modak M& E!!ect o! n9 and n9< !atty acids on mammary 59ras e/pression and #?E+ levels in2MB%9treated rats& %nticancer =es& '1:@''

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    *+& Nu N, 2e #ergola ?, Borntorp #& The e!!ects o! androgens on the regulation o! lipolysis in adipose precursor cells&Endocrinology& '-:'+01&

    0-& 5engel =L, Watts 7B, Lenno/ L& Benign symmetric lipomatosis associated with protease inhibitors& Lancet& ':0-@'0E, ilver %, Morley E& The e!!ect o! recombinant human growth hormone on malnourished older individuals& %m ?eriatr oc& '':@+09+*-&

    +& Fardinal .?, Loprin;i .L, chaid 2, et al& % controlled trial o! cyproheptadine in cancer patients with anore/ia and6or

    cache/ia& .ancer& '-:

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    0& 4on =oenn 5& Management o! 5349related body weight loss& 2rugs& '*:*(0)@*91&ioravanti M, et al& .ircadian secretory pattern o! growth hormone, insulin9like growth !actor type

    3, cortisol, adrenocorticotropic hormone, thyroid9stimulating hormone, and prolactin during 534 in!ection& %32 =es 5um=etroviruses& ':'*@'+*9'+*&& cevola 2, Bottari ?, Cberto L, et al& Megestrol acetate (M%) and growth hormone (r5?5) as combined therapy !or %32

    cache/ia& 3n@ #rogram and abstracts o! the *th .ongress o! European %ssociation !or #alliative .are: 2ecember ebruary *, ': .hicago& %bstractebruary *, ': .hicago& %bstract