Rice et al, Optics Lett, submitted.

2800 2900 3000Wavenumbers (cm-1)

Abs

orpt

ion

(au)

NanoIR

FTIR

4 5 6 7 8 90

100

200

300

400

Lateral Position (mm)

Hei

ght

(nm

)

160

200

240

280 Opto-acou

(mV

)

AFM

NanoIR

NanoIR

AFM NanoIR

AFM

NanoIR

Nd:YAGPPLN

Quadrant detector

AFM laser

cantilever

sample

Elliptical mirror

Future

• NanoIR Requirements

• Applications - Heterogeneous systems - Bacteria, viruses, cells

• Future developments

NanoIR

Coli bacteria & phage virus

CLIO (2007)Ultramicroscopy, 107, 1194, (2007)

Heavily infected

AFM Ramansingle S.

epidermidis cells

Uninfected

Experimental equipment

Nano flouresence

E

h

E

h

APL, 86, 213103 (2005)

Science, 316, 1153 (2007)

BIO systems

500 nm Science, 312,

1051 (2006)

The Drosophila coiled-coil domainprotein Bruchpilot (BRP)

Future directions

• Requirements - Enables classical microscopy

• Applications - Cells, nanoarchitectures (neurons) - Hybrid systems

• Future developments

Nano Lett., 6, 1502 (2006)

200 nm200 nm

NQD

DNAtemplate

200 nm200 nm

NQD

DNAtemplate

Conclude

• Applying nano-imaging - Cell processes - Nano bio architectures (ex. Neurons)

• Collaboration - College of life sciences - Conway Institute - External centres