relative chd risk by increasing baseline crp plasma levels,* relative to crp
DESCRIPTION
Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRPTRANSCRIPT
![Page 1: Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP](https://reader035.vdocuments.mx/reader035/viewer/2022072013/56812bd6550346895d904153/html5/thumbnails/1.jpg)
Pai JK et al. N Engl J Med 2004; 351:2599-2610.
Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP<1.0 mg/L (RR=1.0)Population CRP 1.0-2.9
mg/L, RR (95% CI)
CRP >3.0 mg/L, RR (95% CI)
p for trend
Women (patients, n=239; controls, n=469)
1.17(0.69-2.00)
1.53(0.89-2.62)
0.09
Men (patients, n=265; controls, n=529)
1.60(1.09-2.34)
1.79(1.14-2.83)
0.03
Men and women 1.44(1.05-1.96)
1.68(1.18-2.38)
0.008
*Adjusted for age, smoking status, month of blood sampling, parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index, diabetes, and hypertension; and in women only, also adjusted for fasting status at time of blood sampling and postmenopausal hormone therapy status.
![Page 2: Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP](https://reader035.vdocuments.mx/reader035/viewer/2022072013/56812bd6550346895d904153/html5/thumbnails/2.jpg)
Relative CHD risk by baseline CRP plasma levels, by quintiles relative to lowest quintile (RR=1.0)
Pai JK et al. N Engl J Med 2004; 351:2599-2610.
Quintiles by sex
Adjusted for case-matching criteria,* RR(95% CI)
Further adjusted for TC:HDL-C, BMI, other risk factors,** RR (95% CI)
Further adjusted for diabetes and hypertension, RR (95% CI)
Women
•Quintile 2 •1.28•(0.74-2.23)
•1.17•(0.64-2.14)
•1.23•(0.66-2.32)
•Quintile 3 •1.03•(0.59-1.81)
•0.81•(0.43-1.52)
•0.89•(0.46-1.72)
•Quintile 4 •1.54•(0.91-2.63)
•1.17•(0.64-2.14)
•1.22•(0.65-2.30)
•Quintile 5 •2.18•(1.30-3.64)
•1.86•(1.00-3.46)
•1.61•(0.84-3.07)
—p for trend <0.001 0.008 0.08*Age, smoking status, month of blood sampling; in women only, also adjusted for fasting status at time of blood sampling.**Parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index (BMI); in women only, also adjusted for postmenopausal hormone therapy status.
![Page 3: Relative CHD risk by increasing baseline CRP plasma levels,* relative to CRP](https://reader035.vdocuments.mx/reader035/viewer/2022072013/56812bd6550346895d904153/html5/thumbnails/3.jpg)
Relative CHD risk by baseline CRP plasma levels, by quintiles relative to lowest quintile (RR=1.0)
Pai JK et al. N Engl J Med 2004; 351:2599-2610.
Quintiles by sex
Adjusted for case-matching criteria,* RR(95% CI)
Further adjusted for TC:HDL-C, BMI, other risk factors,** RR (95% CI)
Further adjusted for diabetes and hypertension, RR (95% CI)
Men
•Quintile 2 •1.81•(1.04-3.17)
•1.75•(0.97-3.14)
•1.75•(0.97-3.16)
•Quintile 3 •2.00•(1.15-3.50)
•1.83•(1.02-3.30)
•1.74•(0.96-3.15)
•Quintile 4 •2.74•(1.59-4.71)
•2.27•(1.26-4.09)
•2.14•(1.18-3.88)
•Quintile 5 •3.29•(1.91-5.65)
•2.73•(1.51-4.96)
•2.55•(1.40-4.65)
—p for trend <0.001 0.007 0.02
*Age, smoking status, month of blood sampling; in women only, also adjusted for fasting status at time of blood sampling.**Parental CHD history, alcohol intake, exercise activity level, total cholesterol/HDL cholesterol ratio, body mass index (BMI); in women only, also adjusted for postmenopausal hormone therapy status.