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    INTRODUCTIONy Red wine is an alcoholic beverage, typically made

    of fermented juice.

    y The natural chemical balance of grapes is suchthat they can ferment without the addition ofsugars, acids, enzymes or other nutrients.

    y Red wine is produced by fermenting crushedgrapes using various types of yeast.

    y Yeasts consumes the sugars found in the grapesand converts them into alcohol.

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    VARIETIES OF RED WINE.y Cabernet sauvignon

    y Argentina malbec wines

    y Chateau margauxy Merlot

    y Nebbiolo

    y Dolcetto

    y Grenache

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    CONSTITUENTS OF RED WINE

    The constituent are divided into two(2) groupsnamely;

    y Biological constituents; This is made up of avariety of grapes which are Vitis viniferd, Vitis

    labrusca, Vitis aestivalis, Vitis rupestris, Vitisrotundifolia and Vitis riparid.

    y Chemical constituents;

    i. Proanthrocyanidins, chemicals rich in

    antioxidantsii. Red wine polyphenols

    iii. Resveratrol

    iv. Sulfur dioxide

    v. Potassium sorbate

    Classification

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    RED WINE TABLE

    NUTRITIONAL VALUE PER 100G

    Energy

    Carbohydrates

    Sugars

    Fat

    Protein

    Alcohol

    355kj (85 kcal)

    2.6g

    0.6g

    0.0g

    0.1g

    10.6g

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    HISTORY

    y Archaeological evidence suggests that the earliestknown production of wine took place in sites in Georgiaand Iran from as early as 600 BC.

    y A 2003 report by archaeologists indicates a possibilitythat grapes were used together with rice to producemixed fermented beverages in china in the early years of7000 BC.

    y The oldest known evidence of wine production inEurope is dated to 4500 BC and comes fromarchaeological sites in Greece.

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    MODE OF PRODUCTION

    y Red wine making can be divided into two generalcategories:

    y Still wine production (without carbonation)

    y

    Sparkling wine production (with carbonation)The science of wine and winemaking is known asOenology.

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    STRUCTURE OF RESVERATROL

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    y The mechanisms of resveratrols action, mimic several ofthe biochemical effects of calorie restriction. Some studiesindicates that resveratrol activates SIRT 1 and PGC -1 and

    improve functioning of the mitochondria.y Resveratrols action in cells creates a fourteen fold increase

    in the action of MnSOD. MnSOD reduces superoxide tohydrogen peroxide and thereby confers resistance to

    mitochondrial dysfunction, permeability transition andapoptotic death in various diseases.

    y MnSOD is increased by the pathway;

    RESV SIRT 1/NAD+ FOXO3a MnSOD

    MECHANISMS OF ACTION OF

    RESVERATROL

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    y Resveratrol has been shown to cause SIRT1 to causemigration of FOXO transcription factors to the nucleus

    which stimulates FOXO3a transcriptional activity andenhance the sirtuin-catalysed deacetylation of FOXO3a.

    y MnSOD is known to be a target of FOXO3a and itsexpression is strongly induced in cells over expressingFOXO3a.

    y Resveratrol interferes with all three stages ofcarcinogenesis; initiation, promotion and progression.

    y Resveratrol exhibit mechanisms in pharmacologicalactivity which include modulation of the transcription

    factor NF-kB, inhibition of the cytochrome P450isoenzyme, alterations in androgenic actions, expressionand activity of cyclooxygenase enzymes.

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    y Resveratrol has been shown to include Fas/Fas ligandmediated apoptosis, cyclins A, B1 and cyclin-dependent kinases 1 and 2.

    y Resveratrol has direct inhibitory action on cardiacfibroblasts and may inhibit the progression of

    cardiac fibrosis.y Resveratrol also significantly increases natural

    testosterone production from being both aselective estrogen receptor modulator and an

    aromatase inhibitor.

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    BENEFICIAL EFFECTS OF RED-

    WINE TO THE TEETHAND BRAINy Red wine when drank in moderation help to ward

    off tooth decay. Such that the most damaging

    bacteria called Streptococcus mutans found in themouth when in contact with the wine are unable tocling to the teeth or saliva.

    y Resveratrol, a potent anti-oxidant in the red

    wine, has been demonstrated to promote theformation of new dendrites in the brain.

    y Resveratrol also helps to protect the brain fromstroke damage.

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    BENEFITS OF REDWINE

    CONTINUEDy Resveratrol and mixed red wine polyphenols can

    be purchased in capsules

    y One capsule of red wine polyphenols isapproximately equal to the polyphenol content ofone bottle of wine.

    y One to two capsules per day is the recommended

    dosage.

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    BENEFITS OF REDWINE

    CONTINUEDy For hypotension (low blood pressure), a generous

    quantity is recommended.

    yFor hypertension, a red wine without tannins isrecommended.

    y A luxurious treatment of anemia is a glass ofchampagne every day or a glass of red wine preferably,

    a Medoc.

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    BENEFITS OF REDWINE

    CONTINUED

    These individual health benefits of red wine havebeen verified:

    y 50% reduced risk of heart disease

    y 50% reduced risk of blood clot-related stroke

    y 58% reduced risk of type two diabetes

    y 56% reduced risk of lung cancer

    y 42%-70% reduced risk of dementiay 59% reduced risk of kidney stories

    y 32% reduced chance of developing cataracts.

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    y Researches have shown that people living in the

    Mediterranean basin tend to live longer.y This is as a result of their kind of meal known as the

    mediterranean diet this encompasses fruits such as;

    y Grapes Cactus pear

    y Figs Persimmony Daily recommended intake: not be more than 125ml a

    day to stay in a good mood and to gain the greatest healthbenefits.

    y It has been recommended that no child or teenager below18 years of age should take it.

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    POSSIBLE SIDE-EFFECTS OF RED

    WINE DRANK IN EXCESSy 52% risk of prostrate cancer

    y Undesirable toxic effect of the alcohol in it

    y

    The body metabolizes the alcohol by converting it toacetaldehyde by the enzyme alcohol dehydrogenase.

    y The acetaldehyde is also converted to acetate byaldehyde dehydrogenase. It is the acetaldehyde thatproduces the undesirable toxic effects.

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    RELIGIOUS VIEW CONCERNING

    WINEIn Christianity, wine is used in a sacred rite calledthe Eucharist.

    y

    In Islam, all alcohol is strictly forbidden widely inIslamic law. It is only permitted for medicinalreasons.

    y In Judaism, wine is an integral part of Jewish laws

    and traditions.

    The Kiddush is a blessing recitedover wine or grape juice to sanctify the Shabbat (AJewish holiday).

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    CONCLUSION

    There has been a lot of interest in the media about thehealth benefits of red wine. It isnt the alcohol in the

    wine that provides a health benefit but the anti-

    oxidants, the red- wine polyphenols,proanthrocyanidins and resveratrol.

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    ReferencesInternet source http://www.devilfinder.com. and

    http://www.google.com

    Robinson, Jancis (2006). The Oxford Companion to wine (3rd ed). Oxford: Oxford University Press.ISBN 0-19-860990-6.

    Johnson, Hugh (2003). Hugh Johnsons WineCompanion (5th ed). Mitchell Beazley. ISBN 978-1840007046.

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    Thanks forlistening.