The EMOTICOM battery: a new paradigm for assessing affective cognition Rebecca Elliott, University of Manchester

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Cognitive impairment: depression

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Affective Cognition: Fundamental to the neurobehavioural pathology of psychiatric disorders.

Developing a battery

• Standardised instrument for:

– Research

– Clinical trials

• Using CANTAB principles

– Reliable, repeatable

– Engaging tasks

– Easy to administer

– Multiple outcome measures

– Neural validity

FACE GO/NOGO TASK

GO! GO! NO GO!

MONETARY INCENTIVE

High Win Low Win Neutral Low Loss High Loss

Well done!

You have won 50p

PRESS! WAIT… REWARD

DELAY DISCOUNTING

SOCIAL INFORMATION TASK

9

ULTIMATUM GAME

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0.2

0.4

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1.0

10 20 30 40 50

% offered

Validation study

• 200 healthy controls

• 100 men, 100 women

• 100 degree educated, 100 not

• Ethnically representative of UK

• Mean age 26.6

• 42 tested twice, 1-2 weeks apart

• Factor analysis

• Test-retest reliability

• Correlations with demographic factors

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Emotional Recognition

Eyes affective bias

Face affective bias

0.63

0.74

Intensity Morphing

Increasing affective bias

Decreasing affective bias

-0.66

0.62

Words affective Go/no-go

Affective bias (RT) 0.49

Reinforcement Learning

Loss learning rate

Win learning rate

-0.77

0.66

Faces affective Go/no-go

Affective bias (RT) -0.74

Ultimatum Game

Risk adjustment 0.78

Delay Discounting

Delay discounting

Probability discounting

-0.60

-0.49

Emotional memory

Retrieval affective bias 0.75

Cambridge Gambling Task

Win RA

Loss RA

0.79

0.82

Monetary incentive reward

Win-neutral RT

Loss-neutral RT

0.87

0.83

Moral Emotions

Guilt rating (agent)

Feeling “bad” rating

-0.87

0.89

Information Preference

Proportion thoughts

Outcome affective bias

-0.70

0.65

Prisoners Dilemma

Steal rate (%) -0.82

Ultimatum Game

Value of offers proposed 0.83

Inference and Integration

Effect of probability

Effect of computer choice

0.96

0.95

Test Factors

Other Results

• Test-retest reliability (N=42)

– 10 measure >0.7

– 10 measures 0.4-0.7

– 5 measures below 0.4

• Demographic factors:

– Face recognition correlated positively with age

– Delay discounting with IQ

– Guilt in moral dilemmas with gender

• Very little redundancy in factor structure

• Moderate to excellent test-retest reliability on most measures

• Limited correlations with age, sex or IQ

• Very well tolerated

• Can be done by children

• Several tasks need refining

• Need to show that tests are sensitive to neuropsychiatric disorders

• Need to show that tests are sensitive to interventions

• Need to consider cross-cultural validity

EMOTICOM team: • Rebecca Elliott (Manchester) • Barbara Sahakian (Cambridge) • Trevor Robbins (Cambridge) • Jon Roiser (UCL) • Mitul Mehta (IoP) • Amy Bland • Thea Schei

COLLABORATORS: • Marcus Munafò, Ian Penton-Voak, • Valerie Voon, Daniel Campbell-Meiklejohn • Essi Viding • Richard Emsley

• CAMBRIDGE COGNITION