rass annual business meeting & reception monday, march 7, 2005 6:00 p.m. – 7:30 p.m. new...
TRANSCRIPT
RASS Annual Business Meeting &
Reception
Monday, March 7, 2005
6:00 p.m. – 7:30 p.m.
New Orleans Convention Center Room 229
Laissez Le Bon Temps Rouler!
Agenda
Accomplishments for 2004-2005 (A. Jarabek) Status of RASS Introduction of new officers
RASS Best Abstract Award (M. Gargas) RASS Best Student Abstract Award (M. Gargas) RASS Best Manuscript Awards (K. Krishnan)
Advancing Risk Assessment Demonstrating Risk Assessment Application
Web page revisions and logo contest (D. Proctor) Next Year: Programs and Activities (K. Krishnan) Open Session for Membership Input
Ideas to better serve RASS membership 2004 nomination of symposia workshops, continuing education, etc.
Concluding comments by Incoming President (K. Krishnan) Panel Discussion: Dose-dependent Transitions in Mechanisms of
Toxicity
Status of RASS: 2005 Annual Meeting
How many members belong: 384 (↑ of 100) Budget (December 2004): $11,645 Members registered to attend meeting as of March 1: ??
Additional revenue: $4,900 (estimate) Annual meeting expenditure: $2000 (estimate)
Sponsored CE Courses: 6 Sponsored Symposia: 6 Secondary endorsements: 26 Precedent set with historical highlight: Vinyl Chloride
RASS 2004-2005 Accomplishments Emphasize the role of specialty sections Monthly Telecon Series – the State of our Science
November: NAS report on use of human studies December: Dose-response assessment: Past & Present
Rory Conolly, CIIT Centers for Health Research January: Dose-response assessment: Future
Rory Conolly and Rusty Thomas, CIIT CHR February: HESI Panel on Dose-dependent transition Coming yet this Spring:
April 13: Bruce Hope, OR DEP on bioterrorism risk assessment May 11: Michael Liebman, Windber Institute: Discovery and
Data mining in health care June 8: Woodrow Setzer, US EPA, NHEERL: OP modeling
Special thanks to Merck for generous offer of telecon system
RASS 2004-2005 Accomplishments
Updated RASS home page User friendly Information sharing Event broadcasting Logo contest
Student membership and SAC liaison Letter soliciting student volunteer sent out Student to be determined ASAP for 2006
Consider a Contemporary Concepts in Toxicology (CCT) workshop
RASS 2005 CCT Workshop
Probabilistic Risk Assessment (PRA) —Bridging Components Along the Exposure-Dose-Response Continuum
Deadline for poster submission is May 12, 2005For more information visit www.toxicology.org
July 25 ─ 27, 2005Omni Shoreham HotelWashington DC
2005-2006 RASS Officers
President Kannan Krishnan Vice President Mike Gargas Vice President-Elect Jennifer Orme-Zavaleta Secretary/Treasurer Lynne Haber Councilor (2 year) Teresa Leavens Councilor (1 year) Deborah Proctor Past President Annie Jarabek
Outgoing Officersto Whom We Owe
Many Thanks…
Councilor Lorenz Rhomberg Secretary/Treasurer Steve DiZio Past President Ed Sargent
Other Grande Gratitude to Jeanne Galbo
CIIT Centers for Health Research
RASS Best Abstract Competition 276 Abstracts with keyword “risk assessment”
reviewed by chair of committee 137 Vetted by Awards Committee
Scored based on criteria: Originality Quality / Clarity Relevance to the risk assessor
No vote for member with conflict of interest on any abstract
RASS 2005 Best AbstractAwards Committee
Mike Gargas, The Sapphire Group, Inc. (Chair) John Christopher, Cal EPA Michael Dourson, TERA, Inc. Annie Jarabek, CIIT CHR / US EPA
RASS 2005Best Abstract“Top Ten” Blue Ribbon Winners 377. A Framework/Approach for Incorporating PBPK Modeling into
Cumulative Risk Assessment of Chemical Mixtures. R. Yang; J. Dennison; J. Lipscomb
381. Risk Assessment in Nephrotoxicology Sensitivity of Renal Tests. P. Potnis; A. Maier; T. Guidotti
402. Incorporation of Trichloroacetic Acid Plasma Binding in Human and Mouse in Trichloroethylene Risk Assessment. D. Keys; M. Lumpkin; J. Bruckner; J. Fisher
404. Monte Carlo Analysis of Sources of Variability in Chloroform‑induced Hepatic Cytolethality and Regenerative Proliferation in B6c3f1 Mice. Y. Tan; R. Conolly
349. An integrated QSAR‑PBPK model for simulating pharmacokinetics of chemicals in mixtures. K. Price; K. Krishnan
847. A Harmonized PBPK Model for Trichloroethylene Risk Assessment. T. Covington; H. Clewell; J. Fisher; D. Keys; C. Hack; J. Zhao
RASS 2005Best Abstract“Top Ten” Blue Ribbon Winners
866. Validation of a Human Physiologically‑Based Pharmacokinetic Model for Vinyl Acetate Against Human Nasal Dosimetry Data. P. Hinderliter; K. Thrall; R. Corley; L. Bloemen; B. Matthew
1096. Assessment of neurotoxicity using zebrafish as a model organism. N. Roy; C. Ton; Y. Lin; C. Parng
1304. A Mechanistic Model of Lifetime Cancer Risk for Inhalation Exposures to Reactive Gases. J. Kimbell; D. Kalisak; R. Conolly; F. Miller; A. Jarabek
1934. Evaluation of Systemic Toxicity in Mixtures of Trichloroethylene (TCE), Heptachlor (HEPT), and Di(2‑ethylhexyl)phthalate (DEHP) Assessed in a 5x5x5 Design. J. Simmons; S. Yeatts; J. Zhao; C. Gennings; A. McDonald; R. MacPhail
2110. Improved Dosimetric Adjustment Factors for Interspecies Extrapolation of Inhaled, Poorly Soluble Particles. B. Asgharian; O. Price; A. Jarabek; F. Miller
RASS 2005Best Abstract Award Winner
Abstract 2110. (Thursday March 10)
Improved Dosimetric Adjustment Factors for Interspecies Extrapolation of Inhaled, Poorly Soluble Particles. B. Asgharian, O. Price, A.M. Jarabek
and F.J. Miller. CIIT Centers for Health Research
RASS 2005 Best Student AbstractCompetition
Submission process Student submits abstract and extended abstract (up to 5
pages) Advisor provides letter of recommendation
Review process – vetted by Award Committee based on criteria:
Originality Clarity Role of Student
Special thanks to Taylor and Francis Burdock Group, Inc.
RASS 2005 Best Student AbstractNominees
62. Decreased Acetaminophen and Bromobenzene-induced Hepatotoxicity and Lethality in Type 2 Diabetic Mice. M. Mitra; S. Sawant; A. Dnyanmote; J. Latendresse; A. Warbritton; H. Mehendale, University of Louisiana.
197. Rat Kidney injury molecule-1 (rKim-1) ELISA: A sensitive assay for early detection of kidney tubular injury in preclinical toxicity studies. V. Vaidya; T. Ichimura; J. Bonventre , Harvard Medical School, Brigham and Women’s Hospital.
259. PBPK modeling of inter-child differences in pharmacokinetics on the basis of subject-specific data on hepatic CYP2E1 levels. A. Nong; D. McCarver; R. Hines; K. Krishnan, University of Montreal.
731. Role of Toxicokinetics in the Bioactivation-mediated Liver Injury of Thioacetamide in Ad Libitum Fed and Diet Restricted Rats. J. Chilakapati; M. Korrapati; H. Mehendale, University of Louisiana.
2095. Characterization of Deltamethrin (Dlt) Metabolism in Adult Male Sprague-dawley Rats. S. Anand; W. Haines; J. Bruckner; J. Fisher; S. Muralidhara; D. Hunter; S. Padilla, University of Georgia.
RASS 2005 Best Student AbstractAward Committee
Mike Gargas, The Sapphire Group, Inc. (Chair) Lisa Sweeney, The Sapphire Group, Inc. Jim McDougal, Wright State University James Holder, US EPA NCEA
RASS 2005 Best Student AbstractWinner
Abstract 197.
Rat Kidney injury molecule‑1 (rKim‑1) ELISA: A sensitive assay for early detection of kidney tubular injury in preclinical toxicity studies. V. Vaidya, T. Ichimura, and J. Bonventre Harvard Medical School, Brigham and Women’s Hospital.
RASS Annual Best Manuscript Competition Nominations by membership Review of relevant journals published in past year
Toxicological Sciences Toxicology & Applied Pharmacology Human & Ecological Risk Assessment Regulatory Toxicology & Pharmacology Risk Analysis
Chosen by Vice-President & Awards Committee “Top ten” fully vetted Scoring criteria: merit, clarity, and impact
No vote on manuscript for committee member if any conflict of interest
RASS 2005 AwardBest Manuscript Advancing Risk Assessment Science
Kannan Krishnan, Univ. Montreal (Chair) Mel Andersen, CIIT CHR Marcy Banton, Lyondell Mike Gargas, The Sapphire Group, Inc. Annie Jarabek, CIIT CHR / US EPA William Slikker, NCTR
Awards Committee
2005 RASS “Top Ten” Papers ADVANCING SCIENCE OF RISK ASSESSMENT
1. Ashani Y and Pistinner S. (2004). Estimation of the upper limit of human butrylchloinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model. Toxicological Sciences 77: 358-367.
2. Conolly RB and Lutz WK. (2004). Nonmonotonic dose response relationships: mechanics basis, kinetic modeling and implications for risk assessment. Toxicological Sciences 77: 153-157.
3. Dorne JL, Walton K, Renwick AG. (2004). Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment. Food Chem. Toxicol. 42(23): 275-98.
4. Englehardt JD (2004) Predictive Bayesian dose-response assessment for appraising absolute health risk from available information. Human and Ecological Risk Assessment 10: 69-78.
5. Gaylor DW and Aylward LL. (2004). An evaluation of benchmark dose methodology for noncancer continuous data health effects in animals due to exposed to dioxin. Regulatory Toxicology and Pharmacology 40: 9-17.
2005 RASS “Top Ten” Papers ADVANCING SCIENCE OF RISK ASSESSMENT
6. Gaylor DW, Lutz WK and Conolly RB. (2004). Statistical analysis of nonmonotonic dose-response relationships: research design and analysis of nasal cell proliferation in rats exposed to formaldehyde. Toxicological Sciences 77: 158-164.
7. Toyoshiba H, Yamanaka T, Sone H, Parham FM, Walker NJ, Martinez J, Portier CJ. (2004). Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta. Environ. Health Perspect. 112(12): 1217-24.
8. Razzaghi M and Kodell R. (2004) Quantitative risk assessment for developmental neurotoxic effects. Risk Analysis 24: 1673.
9. Clark LH, Setzer RW and Barton HA. (2004) Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment. Risk Analysis 24: 1697.
10. Calabrese EJ (2004). Hormesis: from marginalization to mainstream: a case for hormesis as the defaul dose-response model in risk assessment. Toxicol. Appl. Pharmacol. 197: 125-136.
Risk Assessment Specialty Section 2005
Best Paper Advancing the
Science of
Risk Assessment
Toyoshiba H, Yamanaka T, Sone H, Parham FM, Walker NJ, Martinez J, Portier CJ. (2004). Gene interaction network suggests dioxin induces a significant linkage between aryl hydrocarbon receptor and retinoic acid receptor beta. Environ. Health Perspect. 112(12): 1217-24.
RASS 2005 AwardBest manuscript demonstrating application of risk assessment
Kannan Krishnan, Univ. Montreal (Chair) Steve DiZio, Cal EPA Lynne Haber, TERA Deborah Proctor, Exponent Resha Putzrath, EPA Forum Ed Sargent, Merck
Awards Committee
2005 RASS “Top Ten” Papers APPLICATION OF RISK ASSESSMENT
1. Babich MA, Chen SB, Greene MA, Kiss CT, Porter WK, Smith TP, Wind ML, Zamula WW. (2004). Risk assessment of oral exposure to diisononyl phthalate from children’s products. Regul. Toxicol. Pharmacol. 40(2): 151-67.
2. Booze TF, Reinhardt TE, Quiring SJ and Ottmar RD. (2004). A screening level assessment of the health risks of chronic smoke exposure for wildland firefighters. Journal of Occupational and Environmental Hygiene 1: 296-305.
3. Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J and Miller FJ. (2004). Human respiratory tract cancer risks of inhaled formaldehyde: dose response predictions from biologically-motivated computational modeling of as combined rodent and human dataset. Toxicological Sciences 82: 279-296.
4. Farrrow S. (2004). Using risk assessment, benefit-cost analysis, and real options to implement a precautionary principle. Risk Anal. 24(3): 727-35.
5. Himmelstein MW, Carpenter SC, Evans MV, Hinderliter PM, Kenyon EM. (2004). Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis. Toxicol. Sci. 79(1): 28-37.
2005 RASS “Top Ten” Papers APPLICATION OF RISK ASSESSMENT
6. Kirman CR,, Sweeney LM, Teta MJ, Sielken RL, Valdez-Flores C, Albertini RJ and Gargas ML. (2004). Addressing nonlinearity in the exposure-response relationship for a genotoxic carcinogen: cancer potency estimates for ethylene oxide. Risk Analysis 24: 1165.
7. Renwick AG. (2004). Establishing the upper end of the range of adequate and safe intakes for amino acids: a toxicologist’s viewpoint. J. Nutr. 134(6 Suppl): 1617S-1624S.
8. Schoen A, Beck B, Sharma R and Dubé E. (2004) Arsenic toxicity at low doses: epidemiological and model of action considerations. Toxicology and Applied Pharmacology 198: 253-267.
9. Sweeney LM, Andersen ME and Gargas ML. (2004). Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically-based nasal dosimetry model. Toxicological Sciences 79: 394-403.
10. Tsuji JS, Benson Rj, Schoof RA, Hook GC. (2004). Health effect levels for risk assessment of childhood exposure to arsenic. Regul. Toxicol. Pharmacol. 39(2): 99-110.
Risk Assessment Specialty Section 2005
Best Paper Demonstrating the
Application of
Risk Assessment
Kirman CR,, Sweeney LM, Teta MJ, Sielken RL, Valdez-Flores C, Albertini RJ and Gargas ML. (2004). Addressing nonlinearity in the exposure-response relationship for a genotoxic carcinogen: cancer potency estimates for ethylene oxide. Risk Analysis 24: 1165.
RASS Web Page Update
RASS Description, Goals and Activities Links
Monthly Telecons Dates and Downloads
History of RASS Current and Previous Officers and all Presidents Annual Meeting
Best Abstract Awards Best Student Abstracts RASS Endorsed Symposia, etc.
RASS Web Page Update (continued)
Links Annual Meeting
Information regarding reception Information regarding Panel Discussion Tonight
Best Manuscript Awards from 2004 and 2005 Upcoming Events
CCT on Probabilistic Risk Assessment Links to other sites and meetings of interest
Seeking Your Input
Logo Contest History of RASS Feedback on
Web Page Pictures Graphics Send to [email protected]
Logo Contest
Extended for 1 week after SOT (3/17/05) Email Your Entries to Deb Proctor
([email protected]) Computer and drawing skills are not required Prepares will be Anonymous RASS Membership will vote by email Winner by End of March
RASS 2005/06 Program & Activities Submission of symposia and continuing education proposals
Need your input & ideas Evaluate venue attributes that best suit topic:
Symposium Workshop Continuing Education
Provide endorsements: Four primary endorsements Help fully develop proposals
Follow-up Contemporary Concepts in Toxicology (CCT) program PRA proposal Program development and funding formula
RASS 2005/06 Program & Activities (cont.) Post-doc and graduate student memberships in RASS
Risk assessment programs Institutional contacts Enrolment
RASS Newsletter Bi-monthly, electronic Update on activities, hot issues, announcements, opportunities,
… Membership participation
Teleconference presentations Risk assessment tools Topics TBD by YOU — please let us know!
RASS 2005 ReceptionConclusion
Open Forum Panel Discussion: Dose-dependent
transitions in mechanisms of toxicity William Slikker, US FDA NCTR Ray David, Eastman Kodak Rory Conolly, CIIT Centers for Health Research Dale Hattis, Clark University William Farland, US EPA ORD David Jacobson-Kram, US FDA CDER