radiation for science and society · 2019. 1. 10. · 11 4 2nd workshop c2tn: radiation for science...

RADIATION FOR SCIENCE AND SOCIETY

2

2ND WORKSHOP C2TN: RADIATION FOR SCIENCE AND SOCIETY

11TH DECEMBER 2018

Contents

TECHNICAL RECORD ........................................................................................................................................ 4

PREFACE ............................................................................................................................................................... 5

PROGRAMME ....................................................................................................................................................... 6

ORAL PRESENTATIONS .................................................................................................................................... 7

I1 | Quantum Effects In Transport Properties Of Topological Insulators ........................................... 8

I2 | Exemplos De Boas Práticas Em Matéria De Transferência De Conhecimento E

Divulgação Científica No MNA: O “Dia Do Investigador Do MNA” E A Acção Do Laboratório

De Conservação E Restauro ........................................................................................................................ 9

I3 | Voxel-Based Dosimetry For Patient-Specific Liver Radioembolization ..................................... 10

I4 | Advanced Magnetic Nanostructures For Imaging And Theranostic Applications ..................... 11

O1.1 | Radiation Processing For Advanced Macromolecular Materials At C2TN ............................. 12

O1.2 | Thermoelectric Materials For Sustainable Development ....................................................... 14

O2.1 | Is The Air That We Breathe During Sleep Affecting Our Sleep Quality? .............................. 15

O2.2 | Technological Characterisation And Absolute Dating Of Metallurgical Innovations

In Ancient Symbols Of Status ................................................................................................................... 17

O3.1 | Development Of TEM1/Endosialin Targeted Radioimmunoconjugates For Cancer

Theranostics ............................................................................................................................................... 19

O3.2 | Medical Nanodosimetry And Molecular Radiotherapy (MRT): Towards

Personalized And Precision Medicine ..................................................................................................... 21

O4.1 | Groundwater Risks Associated To The Military Activities At Santa Margarida

Military Camp, Based On Environmental Isotopes, Chemical And Enteric Virus Evaluation

...................................................................................................................................................................... 23

O4.2 | Mössbauer Spectroscopy An Invaluable Technique In Materials Science ............................. 25

O4.3 | In-silico Contribution To The Design Of Innovative Molecular Imaging Probes And

Theranostic Agents .................................................................................................................................... 27

POSTER PRESENTATIONS ............................................................................................................................. 28

P01 | C2TN Task Force On Proton Therapy And Research .................................................................. 31

P02 | Targeting The Transporters Of Cationic Amino Acids For Cancer

Radiotheranostics: Experimental And Computational Chemistry Approach .................................... 32

P03 | Membrane Proteins - Development Of New Computational Approaches And Its

Application To G-Protein Coupled Receptors ....................................................................................... 33

P04 | Novel Molecular Imaging Tools For Cystic Fibrosis .................................................................... 34

P05 | Multifunctional Nanoseeds For Chemoradiotherapy Of Glioblastoma ................................... 35

P06 | Radiopharmaceutical Sciences Group ......................................................................................... 37

P07 | Metrology In Health And Industry ................................................................................................ 39

P08 | Environmental Radioactivity And Radioecology ........................................................................ 41

P09.1 | Dosimetry Of The Medical Applications Of Ionizing Radiation ............................................ 43

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P09.2 | Biological Effects Of Radiation ................................................................................................. 45

P10 | Emergency Preparedness And Response In Case Of A Nuclear Or Radiological

Accident In Europe .................................................................................................................................... 47

P11 | Radioactive Waste: Research, Education And Training, Public Perception And

Societal Acceptance .................................................................................................................................. 48

P12 | Uses Of A Nuclear Microprobe Setup (Cultural Heritage Meets Functional

Materials) .................................................................................................................................................... 50

P13 | Production And Use Of Metal In SW Iberian Peninsula From The Chalcolithic To

The Roman Empire .................................................................................................................................... 52

P14 | Applications Of Ionizing Radiation: Why And What For? .......................................................... 54

P15 | Climatic Changes: Isotopic Fingerprints In Aquifers And Marine Mollusk Shells .................. 56

P16 | Polymeric Materials Obtained By -Radiation For Skin Scaffolds And For Roman

Mosaic Preservation .................................................................................................................................. 58

P17 | Development Of Tools To Tackle Air Pollution, Climate Change And Burden Of

Disease In Urban Systems ......................................................................................................................... 60

P18 | Radioactive Local Probe Techniques At The ISOLDE CTN Experimental

Infrastructure, 2018 Achievements ........................................................................................................ 62

P19 | Superheated Liquid Detectors For Science And Society........................................................... 64

P20 | Geochemistry Of Surficial Environments Of Oceanic Volcanic Islands In Arid And

Semi-Arid Climates – A Contribution To Regional Development Planning ....................................... 65

P21 | Nuclear And Radiation-Based Methods As Tools To Cultural Heritage Safeguard ................ 67

P22 | Rare Earth Recovery And Valorisation / Protection Of Environment .................................... 69

P23 | Catalysis (Nano Structures For CO2 Removal And Fuels Production) ..................................... 70

P24 | Non-Aqueous Uranium Coordination Chemistry: Uranium Complexes Supported By

Hydrobis(mercaptoimidazolyl)borates ................................................................................................... 71

P25 | Gas-Phase f-Element Chemistry Studies ..................................................................................... 72

P26 | Ln-Based Compounds: From Magnetism To Optical Sensing .................................................... 73

P27 | Neutrability: Soluble Neutral Materials For Molecular Electronics ........................................ 75

P28 | Thermoelectric Materials For Energy .......................................................................................... 76

P29 | Slow Relaxation Of Magnetization In Molecular Materials ....................................................... 77

P30 | Self Assembled Bilayer Molecular Metals (CNB-EDT-TTF)4X; Polymorphism And

Superconductivity ...................................................................................................................................... 79

P31 | The Importance Of Cation-Anion Interaction In The Spin Crossover Phenomenon:

Structural And Magnetic Correlations In [Fe(nsal2trien)] Salts .......................................................... 81

P32 | Outreach Group Of C2TN: Sharing Science With Society .......................................................... 83

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TECHNICAL RECORD

TITLE: 2nd Workshop C2TN: Radiation for Science and Society – Book Of Abstracts

EDITORS: Dulce Belo, Ana Catarina Antunes, Marta Ferraz Dias, Rita Melo, Ana Belchior,

Rosa Marques, Maria Helena Casimiro and Pedro Valério

PUBLISHER: C2TN, Instituto Superior Técnico, Universidade de Lisboa

DATE: 11th December 2018

Address:

C2TN - Centro de Ciências e Tecnologias Nucleares

Campus Tecnológico e Nuclear

INSTITUTO SUPERIOR TÉCNICO, UNIVERSIDADE DE LISBOA

Estrada Nacional 10, Km 139.7

2695-066 Bobadela LRS, Portugal

© 2018 by Instituto Superior Técnico of Universidade de Lisboa

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11TH DECEMBER 2018

PREFACE

06 December 2018

Dear Participant, Dear Colleague,

Welcome to the 2nd Workshop of C2TN!

The research activities of the C2TN address leading edge, pluridisciplinary and cross-cutting scientific

topics and issues related to the use of Nuclear Sciences and Technologies and of Ionizing Radiation in

multiple sectors, such as Health, Environment, Industry, Energy, Materials Sciences and Cultural

Heritage, among others.

During 2018, the C2TN pursued its strategic objectives encompassing the consolidation of the

internationalization of its activities and the strengthening of its international and national recognition

as a pluridisciplinary research centre of excellence. The first weeks of the year were devoted to the

preparation of C2TN’s Strategic Programme for the period 2019-2022 that was submitted for funding

by the FCT at the beginning of February. The evaluation of the Centre by an international panel of

experts will take place during the coming weeks. Throughout the year, sizable efforts were also

devoted to:

- The successful solution of the Centre’s Human Resources, converting the precarious contractual

links of some of the C2TN younger scientists into research contracts, under the newly approved

legislation;

- The involvement and empowerment of junior researchers as leaders of research activities;

- The submission of research projects to national and international funding programmes, including

Horizon 2020 – researchers from C2TN participated, inter alia, in several consortia that submitted

projects on the Horizon 2020 EURATOM Call, by September 2018, and in a Twinning proposal;

- An acceleration project of outreach and dissemination was launched, promoting the activities of

the Centre and projecting its image, nationally and internationally, with efficiency and intensity;

- The assessment of the societal impact of the C2TN’s activities;

- The organization of several Conferences, Workshops and Training Courses.

By mid-2018, the evaluation of the research projects submitted in 2017 to the FCT was finally

disclosed and turned out to be globally very positive for the Centre. More than 10 projects led by

C2TN researchers were approved for funding and researchers also participated in several tens of

projects led by other institutions and approved for funding.

This Workshop, involved a considerable number of C2TN members and a huge effort in preparing and

setting up its Programme. It aims at summarizing the activities in which the Centre is involved and at

assessing prospectively new research areas and topics where C2TN’s competences, skills, equipment

and infrastructures can be deployed.

Special thanks are due to the members of the Organizing Committee of the Workshop, Dulce Belo

(Coordinator), Ana Catarina Antunes, Marta Ferraz Dias, Rita Melo, Ana Belchior, Rosa Marques, Maria

Helena Casimiro and Pedro Valério for their efforts to make of this initiative a great success.

Enjoy the Workshop!

Pedro Vaz

(President of the Executive Commission of C2TN)

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PROGRAMME

Time Content Speaker

9:30 – 9:45 Welcome Opening Session C2TN 2018 in a snapshot

Dulce Belo Pedro Vaz

C2TN: Radiation for Science and Society vis a vis the UN’ SDG

Advanced Materials Session chair: Manuel Leite de Almeida

09:45 – 10:05 I1. Quantum Effects in Transport Properties of Topological Insulators

José António Paixão Universidade de Coimbra

10:05 – 10:20 O1.1 Radiation Processing for Advanced Macromolecular Materials at C2TN

Maria Helena Casimiro

10:20 – 10:35 O1.2 Thermoelectric materials for sustainable development

António P. Gonçalves

10:35 – 11:00 Coffee Break & Poster Session

Earth Sciences, radioactivity and Cultural Heritage Session chair: M. Isabel Prudêncio

11:00 – 11:20

I2. Exemplos de boas práticas em matéria de transferência de conhecimento e divulgação científica no MNA: o “Dia do Investigador do MNA” e a acção do Laboratório de Conservação e Restauro

António Carvalho Museu Nacional de Arqueologia

11:20 – 11:35 O2.1 Is the air that we breathe during sleep affecting our sleep quality?

Nuno Canha

11:35 – 11:50 O2.2 Technological characterisation and absolute dating of metallurgical innovations in ancient symbols of status

Pedro Valério

Radiopharmaceutical Sciences and Health Physics Session chair: António Rocha Paulo

11:50 – 12:10 I3. Voxel-Based Dosimetry for Patient-Specific Liver Radioembolization

Paulo Ferreira Fundação Champalimaud

12:10 – 12:25 O3.1. Development of TEM1/Endosialin Targeted Radioimmunoconjugates for Cancer Theranostics

Alice D’Onofrio

12:25 – 12:40 O3.2 Medical Nanodosimetry and Molecular Radiotherapy (MRT): Towards Personalized and Precision Medicine

Ana Belchior

12:40 – 12:55 C2TN Family photo

12:55 – 14:15 Lunch Powered by C2TN

C2TN’s leading edge research activities

Ongoing activities Session chair: Fernanda Margaça

14:15 – 14:35 I4. Advanced Magnetic Nanostructures for Imaging and Theranostic Applications

Manuel Bañobre-López Laboratório Ibérico Internacional de Nanotecnologia

14:35 – 14:50

O4.1 Groundwater risks associated to the military activities at Santa Margarida Military Camp, based on environmental isotopes, chemical and enteric virus evaluation

Paula Carreira

14:50 – 15:05 O4.2 Mössbauer spectroscopy an invaluable technique in materials science

João C. Waerenborgh

15:05 – 15:20 O4.3. In-silico contribution to the design of innovative molecular Imaging probes and theranostic agents

João D. G. Correia

15:20 – 15:45 Coffee Break & Poster Session

Prospective views Panel Moderator: Pedro Vaz

15:45 – 16:45

5 min presentations on the following topics: - Biological effects of radiation (Sebastião Rodrigues, Nova Medica School, Universidade Nova de Lisboa) - Protons and ion therapy (Marta F. Dias) - Defence and Security (Pedro Vaz) - Microbioma (Sandra Cabo Verde) - Multifunctional Materials (Manuel Leite de Almeida) Followed by open discussion (30 min)

16:45 – 17:00 Closing Remarks

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ORAL PRESENTATIONS

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11TH DECEMBER 2018

I1 | Quantum Effects In Transport Properties Of Topological Insulators

José António Paixão1,*, Marta Henriques1, Carlotta Micale2, Elsa Branco Lopes2, António Pereira

Gonçalves2

1CFisUc, Department of Physics, University of Coimbra, Rua Larga, Portugal 2CTN, DECN, Instituto Superior Técnico, University of Lisbon, Estrada Nacional 10, 2695-066 Bobadela LRS,

Portugal

*Email of corresponding author: [email protected]

Topological insulators are materials with a peculiar electronic band structure, featuring a gap for bulk

electronic states, but with spin-momentum locked surface states that are symmetry protected from

scattering processes not breaking time-reversal symmetry, thus allowing electric conduction. The

study of such states was originally inspired by the robustness to scattering of conducting edge states

in quantum Hall systems. Bismuth chalcogenides are one of the few materials in this class, that have

been extensively studied as they also perform well as thermoelectric materials. The peculiar

electronic structure of such materials shows up in quantum effects observed in the transport

properties measured at low temperature, such as a strong weak-antilocalisation (WAL) effect in the

longitudinal magnetoresistance or Shubnikov-de Hass (SdH) oscillations. In this talk a brief

introduction to topological insulators and quantum effects in the transport properties in these systems

will be presented. The synthesis, characterization and measurements of the electronic transport

properties will be presented and discussed for single-crystals and nanostructured materials of families

Bi2Se(3-x)Tex and BiSbTe3.

Figure1. Magnetoresistance in Bi2Se3 showing WAL and SdH oscillations at low temperature.

Funding:

This work was supported by funds from FEDER (COMPETE) and from FCT under the projects

UID/FIS/04564/2016, UID/MULTI/ 04349/2013, and PTDC/FIS-NAN/6099/2014

Keywords: Topological Insulators, Bi2Se3, Weak Antilocalisation, Shubnikov–de Haas effect

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I2 | Exemplos De Boas Práticas Em Matéria De Transferência De

Conhecimento E Divulgação Científica No MNA: O “Dia Do Investigador

Do MNA” E A Acção Do Laboratório De Conservação E Restauro

António Carvalho1,2,*

1Museu Nacional de Arqueologia, Praça do Império, 1400-206 – Lisboa 2UNIARQ – Centro de Arqueologia da Universidade de Lisboa, Alameda da Universidade, 1600-214 – Lisboa

*Email of corresponding author: [email protected], [email protected]

O autor apresenta os pressupostos de um projecto pioneiro, iniciado em 2013 no Museu Nacional de

Arqueologia (MNA), em matéria de partilha e transmissão de conhecimento e divulgação científica

nos Museus Nacionais que se encontram no âmbito da Direcção-Geral do Património Cultural e os

principais resultados após 6 edições anuais.

O Dia do Investigador do MNA é uma reunião científica que coloca os investigadores e a sua produção

no centro da reflexão, de forma exclusiva, durante um dia. Até ao presente, traduziu-se no

envolvimento de quase duas centenas de investigadores de Institutos Politécnicos e Universidades,

portuguesas e estrangeiras, mas também de museus, laboratórios, autarquias e outros organismos.

A iniciativa que se apresenta só é possível realizar a partir de um contínuo processo de recenseamento

científico e do desejável diálogo entre os investigadores, a equipa do Museu, a comunidade científica

e o público, sendo portanto uma iniciativa aberta e colaborativa no plano institucional, científico e

pessoal. Com esta iniciativa mede-se também o “músculo científico” do Museu, enquanto plataforma

de produção de conhecimento, e o impacto na comunidade científica, mas não só, das investigações

ali produzidas.

Foi desenhada em função de alguns pressupostos evidentes, mas que importava articular. As vastas

colecções arqueológicas, provenientes de todo o país e que se conservam no Museu, a presença

constante de investigadores há várias décadas, os recorrentes pedidos para se voltar a “olhar” para

“antigas” colecções no quadro da produção de novas pesquisas para a realização de dissertações e

projectos de investigação. Fazendo-se também a ciência da acumulação de dados, o Museu, que

guarda os bens culturais, pretende garantir que o trajecto das investigações e os resultados são

apresentados no âmbito da programação cultural e científica do Museu, de modo a garantir uma

permanente monitorização e um conhecimento cabal dos avanços científicos o que lhe permite,

também, de alguma maneira, incentivar e direccionar a investigação. Explica-se como esta reunião

científica visa congregar e aproximar a comunidade de investigadores do MNA promovendo a partilha

de informação entre pares e a equipa do Museu e, simultaneamente, a divulgação científica dos

diferentes temas junto do público.

A acção do Laboratório de Conservação e Restauro e as respectivas parcerias serão enunciadas.

Acknowledgments:

Agradece-se à equipa do Museu Nacional de Arqueologia, nomeadamente ao Sector de Inventário e de Colecções

e aos investigadores que, sem excepção, respondem sempre favoravelmente aos convites da Direcção para

participar nas sessões.

Keywords: Arqueologia, Museu Nacional de Arqueologia, Dia do Investigador, Laboratório de Conservação e

Restauro, Transmissão de Conhecimento

mailto:[email protected]


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I3 | Voxel-Based Dosimetry For Patient-Specific Liver

Radioembolization

Paulo Ferreira1,2,*, Francisco Oliveira1, Rui Parafita1, Paulo L. Correia2, Pedro S. Girão2, Durval C.

Costa1

1Nuclear Medicine-Radiopharmacology, Champalimaud Centre for the Unknown, Champalimaud Foundation,

Lisbon 2Instituto de Telecomunicações, Instituto Superior Técnico - Universidade de Lisboa


Radioembolization (RE) has emerged as a therapeutic approach to tumors in the liver. Glass or resin

microspheres (MS) loaded with Yttrium-90 (90Y) have been the preferred choice. Soon other options

may be available. Following the European Council Directive 2013/59/EURATOM, the assessment of

the absorbed dose in the planning tumor volume (PTV) and in the normal liver volume (NLV) is the

most important problem to address in all medical exposures during radiotherapeutic applications

(e.g., RE). In clinical practice, the calculation of the 90Y radiation activity to be administered to the

liver follows the MIRD model. This does not consider the specific characteristics of each patient’s

physiology and pathology influencing deposition of MS in the liver. Thus, our research group at the

Champalimaud Centre for the Unknown has tried to overcome this limitation developing a

methodology for personalized estimation of the 3D dose distribution and optimize the activity to be

administered into the patient's liver.

We selected retrospectively sixteen RE treatments. Technetium-99m (99mTc) labelled

macroaggregated albumin (MAA) pre-treatment single-photon emission computed tomography

(SPECT), and 90Y-charged glass MS post-treatment positron emission tomography (PET) images were

available. 3D dose distributions were estimated to investigate the predictive power of SPECT-MAA

when compared with PET-MS. In addition, a computational algorithm based on the -index agreement

test between the SPECT-MAA and PET-MS dose distributions was developed and tested. A

computational algorithm, based on an optimization of the 90Y activity was additionally introduced

using dose thresholds imposed on PTV and NLV voxels.

All this work resulted into a “computational dosimetric system”, which demonstrates that, under well

controlled conditions, the pre-treatment SPECT-MAA predicts the post-treatment PET-MS distribution.

In addition, pre-treatment SPECT-MAA can be used to optimize the 90Y activity.

This “system” proved to be feasible, enabling personalized liver RE treatment. It will, hopefully, be

useful for other radiopharmaceutical therapies, independent of the type of radionuclide emission.

Keywords: radioembolization, albumin macroaggregates, glass microspheres, 3D dose distribution, optimization.

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11TH DECEMBER 2018

I4 | Advanced Magnetic Nanostructures For Imaging And Theranostic

Applications

Lorena García-Hevia1, I. Casafont2, M. L. Fanarraga2, Juan Gallo1 and Manuel Bañobre-López1,*

1Advanced (magnetic) Theranostic Nanostructures Lab, Nanomedicine Group, Department of Life Sciences, INL –

International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal 2Grupo de Nanomedicina-IDIVAL, Universidad de Cantabria, Herrera Oria s/n, CP 39011 Santander, Spain


In this talk, I will highlight the potential of magnetic nanoparticles (MNPs) in the biomedical field. In

particular, I will emphasize the key role of MNPs as building blocks to form more complex

nanostructures with enhanced physico-chemical properties for advanced imaging and theranostic

applications. In particular, examples of application of different types of advanced magnetic hybrids

(organic-inorganic nanoconjugates and nanocomposites) developed by our group will be shown in

these areas, covering from the nanostructure design to the preclinical in vitro and in vivo validation.

In the last years, these structures have gained increasing interest as they combine the functional

properties of the organic part and the intrinsic physico-chemical properties from the magnetic

counterpart, enabling biomedical and pharmaceutical technologies, such as magnetic resonance

imaging, magnetic hyperthermia and induced-drug delivery, and providing a step forward towards

precision and personalized medicine.

Keywords: Cancer; Exposure Biomarkers; Nano- and Microdosimetry; Radiopharmaceuticals; Theranostics


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O1.1 | Radiation Processing For Advanced Macromolecular Materials At

C2TN

Thematic Strands:

Advanced Materials

Earth Systems, Radioactivity and Cultural Heritage

C2TN members: M. Helena Casimiro1,* (IST-ID contract), Fernanda M.A. Margaça1, António N.

Falcão1, Luís C. Alves1, João P. Leal2, Luís M. Ferreira1,*

Students: Alexandra P. Rodrigues1 (PhD)

*Email of corresponding author: [email protected]; [email protected]

Research groups:

1 REI | Radiation, Elements and Isotopes Group, 2 QEf | f-element Chemistry Group

Over the last years the area of Radiation Processing for Advanced Macromolecular Materials integrated

in GREI, gathered a consistent experience in the use of ionizing radiation techniques for the

preparation and/or functionalization of polymeric based materials, targeting an increasing number of

specific applications in different areas. We have been focused mainly on the development and

optimization by gamma irradiation of new functionalized polymeric and hybrid materials, with the

commitment to implement green sustainable techniques.

Concerning polymeric materials, we may refer the development of:

- PE based copolymeric materials, mechanically stable, hydrophilic and biocompatible, that can be

used for biomedical and fine-chemistry industrial applications;

- chitosan based copolymeric membranes, biocompatible and microbiologically safe, that can be used

simultaneously as wound dressing and as support in transdermal drug release systems “ready to use”,

combining matrix modification and microbiological safety in one experimental step;

- PVA supported crosslinked membranes to be used in biodiesel production (pervaporation membrane

reactors) and as catalytic supports for fine-chemistry synthesis (fragrances and food aromas);

Research in hybrid materials has been centered on the preparation and functionalization of

polydimethylsiloxane (PDMS)-based hybrids for biomedical applications, namely as human bone

substitutes.

Figure 1. 3D porous structure of PE-g-HEMA film obtained by -irradiation.

Presently we are particularly involved in the i) preparation of biocompatible and biodegradable

chitosan based 3D matrices as skin substitutes with improved healing and tissue regeneration/repair

capabilities and on ii) the preparation of PDMS-ormosils with biocide content, for conservation of non-

metallic inorganic historical materials, such as the Roman mosaics of Conimbriga.



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The work carried out has been financed by national funds (FCT) and through two Coordinated Research

Projects from IAEA and meets the Sustainable Development Goals G.3 and G.11 of 2030 Agenda,

namely good health and well-being, and sustainable cities and communities.

An overview of the work performed and some relevant data will be presented.

Collaborations:

1 M.H. Gil, FCTUC | Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Coimbra, Portugal

2 J. Vital, A.M. Ramos, M.C. Corvo, FCTUNL | Faculdade de Ciências e Tecnologia, Universidade Nova de

Lisboa, Caparica, Portugal

3 G. Rodrigues, FCUL | Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal

4 D. Casal, NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon,

Portugal

5 V.H. Correia, MMC-MN | Museu Monográfico de Conimbriga – Museu Nacional, Coimbra, Portugal

6 J. Coroado, IPT | Instituto Politécnico de Tomar, Tomar, Portugal

Funding:

FCT - UID/Multi/04349/2013 project; IST-ID/076/2018 contract; PD/BD/114410/2016 grant (in the framework of

PhD Course CORES, FCT-UNL)

IAEA - Research Contract No. 18202 (CRP F23030); Research Contract No. 18982 (CRP F23032)

Keywords: Ionizing radiation, Polymers, Hybrid materials, Bioapplications, CH conservative materials

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O1.2 | Thermoelectric Materials For Sustainable Development

Thematic Strand:

Advanced Materials

C2TN members: António P. Gonçalves*, Elsa B. Lopes

Students: Duarte Moço (PhD), Helena C. M. Ferreira (BSc), Gonçalo Domingos (BSc)


Research group:

ES | Solid State Group

Most of the energy produced by Man is lost, mainly as waste heat. Moreover, innumerous natural heat

sources exist, which makes the use of such energy highly desirable. In 2015, United Nations set 17

global Sustainable Development Goals, with many of them directly related to this problem. An

“Affordable and clean energy” (Goal 7) is needed, that leads to a more “Decent work and economic

growth” (Goal 8) based on sustainable “Industry, Innovation, and Infrastructure” (Goal 9) including

a more “Responsible consumption and production” (Goal 12) with a positive impact in the climate

change (“Climate action”, Goal 13).

There are many systems devoted to the recovery of waste heat, in particular in large industrial

installations, but their prices and complexity are high, making them suitable only for specific

applications. Thermoelectric generators, that directly convert heat into electricity, are able to

recover part of such energy. They are simple solid state equipments with no moving parts, easy to

implement, silent and reliable. Yet, the cost of the energy produced by these equipments is still

excessive due to their low efficiency and high materials and production prices. The work made at

C2TN deals with these challenges, developing new thermoelectric devices with high efficiency and

low price, based on easily available materials with low toxicity. The more recent studies have been

focused on tetrahedrite-based p-type materials, they are copper sulfosalt minerals with good

thermoelectric properties after proper dopping. The final objective is to develop cheap

thermoelectric modules with high efficiency, which is expected to significantly decrease the electrical

energy price produced by this method. The practical application of a prototype in a Portuguese

cement factory, and the corresponding viability study of the employment of thermoelectrics on the

optimization of energy use and decrease of costs, are the next future goals.

Collaborations:

1 Prof. Edgar C. Fernandes, IN+, Dept. Mech. Engineering, Instituto Superior Técnico, Lisbon, Portugal

2 Prof. Pedro M. Amaral, Dept. Mech. Engineering, Instituto Superior Técnico, Lisbon, Portugal

3 Prof. Francisco Brito, Dept. Mech. Engineering, University of Minho, Guimarães, Portugal

4 Dr. Filipe Neves, Unid. de Energias Renováveis e Int. de Sist. de Energia, LNEG, Lisbon,Portugal

5 Prof. Theodora Kyratsi, Dept of Mech. and Manufacturing Engineering, Univ. of Cyprus, Nicosia, Cyprus

6 Prof. Bertrand Lenoir, Institut Jean Lamour, UMR 7198 CNRS, Université de Lorraine, Nancy, France

7 Prof. Judith Monnier, Institut de Chimie et des Matériaux Paris-Est, Université Paris-Est, Thiais, France

Funding:

M-ERA.NET Project, Sustainable Thermoelectric Modules based on Non-toxic Silicides and Sulphides for

Recovery of Waste Heat to Power Generation, THERMOSS, 2017-2020; FCT project “ LocalEnergy”, PTDC/EAM-

PEC/29905/2017

Keywords: Thermoelectrics, Tetrahedrites, Waste energy, Sustainable development


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11TH DECEMBER 2018

O2.1 | Is The Air That We Breathe During Sleep Affecting Our Sleep

Quality?

Thematic Strand:


C2TN members: Nuno Canha* (IST-ID contract), Joana Lage (IST fellowship), Marta Almeida (IST

Contract)

Students: Tiago Faria (PhD)


Research group:

NET | Nuclear Engineering and Techniques Group

People spend around one third of their life sleeping and it is well known that sleep plays a crucial

role in human welfare and performance. However, assessment of indoor air quality (IAQ) during sleep

has been scarcely studied (Canha et al., 2017) and, when it is, usually is only focused on a few

parameters. Moreover, despite the crucial importance of sleep in the daily human welfare, the

assessment of the impact of IAQ on sleep’s quality has not yet been fully studied in order to

understand which environmental factors may affect the quality of sleep.

The present study aimed to fulfil this gap of knowledge:

1) Characterize IAQ, using a multipollutant approach (comfort parameters, carbon dioxide, carbon

monoxide, formaldeyde, microbiological burden (fungi and bacteria), volatile organic compounds and

particulate matter), during the sleep period of 10 couples;

2) Assess the sleep quality of 10 couples using polysomnography; and

3) Try to understand which environmental factors may influence sleep quality.

Results show that, during sleep, individuals are exposed to levels of PM2.5, TVOCs, CO2, bacteria and

fungi above the limit values established by the Portuguese guideline for IAQ. Despite the size of the

studied population, results also showed that there are some evidences that the increase in some

parameters of IAQ (CO, CO2, PM2.5 and PM10) and thermal comfort (T and RH) can be associated to

alterations in cardiovascular and respiratory function during sleep. Further research should increase

the study population to confirm these preliminary results.

This study aims to answer to the following sustainable development goals: 1) Good health and well-

being; 2) sustainable cities and communities; and 3) climate action.

Reference: N. Canha, J. Lage, S. Candeias, C. Alves, S.M. Almeida (2017) Indoor air quality during sleep:

characterisation and variability under different ventilation patterns. Atmospheric Pollution Research 8(6),1132-

1142. DOI: 10.1016/j.apr.2017.05.004

Collaborations:

1 CESAM | Centro de Estudos do Ambiente e do Mar, Departamento de Ambiente, Universidade de Aveiro,

Aveiro, Portugal

2 ESTeSL | Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, Lisboa, Portugal

3 GIAS | Grupo de Investigação em Ambiente e Saúde da ESTeSL - Escola Superior de Tecnologia da Saúde de

Lisboa, Instituto Politécnico de Lisboa, Lisboa, Portugal

4 APCMS | Associação Portuguesa de Cronobiologia e Medicina do Sono, Lisboa, Portugal

5 Sleep Unit - Autonomic Function Lab, Cardiovascular Center of University of Lisbon, Lisboa, Portugal

6 Centro de Investigação em Saúde Pública, Escola Nacional de Saúde Pública, Universidade NOVA de Lisboa,

Portugal


16


11TH DECEMBER 2018

Funding:

FCT, LIFE Programme

Keywords: Indoor air quality; sleep quality; exposure; particulate matter; bedroom

17


11TH DECEMBER 2018

O2.2 | Technological Characterisation And Absolute Dating Of

Metallurgical Innovations In Ancient Symbols Of Status

Thematic Strand:


C2TN members: Pedro Valério*, Maria Fátima Araújo, António Monge Soares


Research group:

REI | Radiation, Elements and Isotopes Group

The lustre of metallic elements has always attracted humankind, the gold being one of the oldest

symbols of status. However, less noble metals also had a degree of prestige among prehistoric

communities due to the novelty factor and exotic nature at the time of its appearance in a certain

region. The research has been establishing the chronology of the introduction of new metals and

alloys in the southern Portuguese territory, in addition to investigate the alloying, joining methods

and decoration techniques used in the manufacture of gold jewellery. The chronology of

archaeological contexts containing artefacts made with innovative metals or alloys was established

by radiocarbon dating of organic materials, such as bone, wood or charcoal, collected in those

contexts. The alloy composition and production techniques of prestige goods were determined with

non-invasive methodologies comprising optical microscopy, micro energy dispersive X-ray

spectrometry and scanning electron microscopy with X-ray microanalysis (Figure 1).

Figure 1. Bronze Age burial at Horta de João Lopes (Vidigueira) containing the oldest lead artefact of the

Iberian Peninsula (left). Gold necklace of Quinta do Castelo 5 (Beja) composed by 3 pendants and 11 spherical

beads with evidences of brazing (right).

The chronological, compositional and microstructural characterization of those ancient symbols of

status has been clarifying the diachrony of novel materials and innovative technologies resulting from

indigenous developments or brought by contacts with people from distant regions such as the Atlantic

or Mediterranean areas. Moreover, the increased knowledge about our Cultural Heritage enhances the

visibility and importance of archaeological sites, in addition to the relevance of archaeological

exhibitions at national and regional museums.

Collaborations:

1 DCR/FCT | Departamento de Conservação e Restauro, Faculdade de Ciências e Tecnologia, Universidade Nova

de Lisboa, Caparica, Portugal

2 Rui J.C. Silva | CENIMAT/i3N | Centro de Investigação em Materiais, Faculdade de Ciências e Tecnologia,

Universidade Nova de Lisboa, Caparica, Portugal


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11TH DECEMBER 2018

3 Lídia Baptista | CEAACP | Centro de Estudos de Arqueologia, Artes e Ciências do Património, Universidade de

Coimbra, Coimbra, Portugal

4 António Faustino Carvalho | Faculdade de Ciências Humanas e Sociais, Universidade do Algarve, Faro, Portugal

5 Pedro Pais Martins | Faculdade de Letras, Universidade do Porto, Porto, Portugal

6 Ever Calvo | ERA Arqueologia | Oeiras, Portugal

Funding:

FCT/UID/Multi/04349/2013 (C2TN)

POCI-01-0145-FEDER-007688, Reference UID/CTM/50025 (CENIMAT/i3N)

Keywords: Archaeometallurgy, Radiocarbon dating, Lead, Silver, Gold

19


11TH DECEMBER 2018

O3.1 | Development Of TEM1/Endosialin Targeted

Radioimmunoconjugates For Cancer Theranostics

Thematic Strand:

Radiopharmaceutical Sciences and Health Physics

C2TN members: L. Gano, F. Mendes, C. Oliveira, A. Paulo*

Students: A. D’Onofrio (PhD)


Research group:

RS | Radiopharmaceutical Sciences Group

The tumour endothelial marker 1 (TEM1/endosialin/CD248) is a receptor widely expressed in several

human solid tumours and silenced in normal adult tissues, representing a suitable and potentially safe

target for radioimmunotherapy of sarcoma1,2. Taking advantage of the very fast in vivo kinetic of the

click reaction between tetrazines (Tz) and trans-cyclooctene (TCO), we want to explore a pre-

targeting approach for in vivo recognition of TEM1 using a single chain fusion protein (scFv-Fc) that

recognizes both the human and the murine TEM1 (Fig. 1).

Fig.1 Pre-targeting approach for in vivo recognition of TEM-1: Step 1. Administration of the scFv-Fc

functionalized with TCO (long biological half-life); Step 2. After the elimination of the unbound scFv-Fc,

administration of the tetrazine radiocomplex (short biological half-life).

Our efforts to optimize the design of the final conjugates using commercially available radioisotopes

(111In and 125I) included:

i) Evaluation of radioiodinated scFv-Fc’s directed towards TEM1

TEM1 scFv-Fc’s were labelled with 125I and biologically evaluated to select the best candidate for pre-

clinical studies. The evaluation comprised the in vitro studies of their uptake and internalization in

TEM1-positive tumor cells (both muTEM1 and huTEM1), the assessment of their binding affinity and

quantification of specific versus nonspecific binding. Once the best scFv-Fc was identified,

biodistribution studies in tumor bearing mice were also performed.

ii) Evaluation of 111In-labelled tetrazine-containing macrocyclic chelators

A small family of macrocyclic chelators carrying tetrazine groups were synthesized and used to obtain

clickable 111In-radiocomplexes for further targeting of TEM1 based on in vivo click chemistry

strategies. Their in vivo stability and pharmacokinetics were studied in normal mice.

The developed research work is expected to provide important insights for the development of TEM1-

targeted radiopharmaceuticals, for which few studies have been reported so far but that can

contribute to the rise of a more personalized approach in cancer treatment.

20


11TH DECEMBER 2018

References: 1. S. Dunn, G. Coukos et al., Oncotarget. 2014; 5: 6994-7012; 2. Y. Guo, G. Coukos et el. Eur J

Cancer. 2018 Feb; 90:111-121

Collaborations:

J. Fierle1, S. Dunn1, D. Viertl2, T. Denoel2, J. Prior2.

1 LAbCore Platform | Ludwig Cancer Research, Lausanne, Switzerland

2 CHUV | University Hospital, Lausanne, Switzerland

Funding:

Marie Skłodowska-Curie Fellowship of the European Commission’s Horizon 2020 Programme under contract

number 642889 MEDICIS-PROMED.

Keywords: Click-Chemistry, Pre-Targeting, scFv-Fc, Endosialin, Theranostics

21


11TH DECEMBER 2018

O3.2 | Medical Nanodosimetry And Molecular Radiotherapy (MRT):

Towards Personalized And Precision Medicine

Thematic Strand:


C2TN members: Ana Belchior2,* (IST-ID contract), António Paulo1, Francisco Silva1(C2TN contract),

Joana F. Guerreiro (C2TN contract)1,2 (C2TN contract), Célia Fernandes1, Elisa Palma (FCT)1, Filipa

Mendes1, Margarida Caldeira2 (IST/LPSR contract), Octávia Monteiro Gil2, Paula Raposinho1, Pedro

Teles2 (IST-ID contract), Pedro Vaz2, Salvatore Di Maria2 (C2TN contract), Yuriy Romanets2

Students: Ana Sá2 (PhD), Carina Coelho2 (PhD), Jorge Borbinha2 (PhD), Mariana Baptista2 (PhD),

Pedro Gomes (PhD), Débora António (MSc), Filipe Pires (MSc), João Canhoto (MSc)


Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS | Radiation Protection and Safety Group

The majority of routinely used medical protocols utilizing ionizing radiation (IR) do not incorporate

factors such as individual sensitivities to IR and, particularly in radiotherapy, still lack selectivity to

target diseased tissues while sparing the adjacent healthy organs and tissues. Precision and

personalized medicine is nowadays at the forefront of research, combining areas of research from

physics (micro-and nanodosimetric calculations at the DNA level), radiopharmaceutical sciences

(development of innovative radiopharmaceuticals using alpha-, beta- and Auger electron emitters)

and radiobiology (validation of diagnostic and treatment biomarkers).

In this field, at C2TN, ongoing research focus on:

i) Assessment of doses and detrimental effects due to IR exposure of the patients and medical staff,

using innovative Monte Carlo calculations coupled with patient-specific voxels phantoms and

measurements in clinical environment to validate the computational models;

ii) Biophysical modelling for targeted cancer therapy, combining computational-nanodosimetric

calculations and cellular experiments;

iii) Development and benchmarking with biological assays, of a nanodosimetric model of complex

double stand breaks production and cell survival probabilities.

iv) Assessment in cellular models of the radiobiological effects due to exposure to external radiation

(protons, alpha particles and gamma photons) and internal emitters (99mTc and 64Cu);

v) Validation of biomarkers to be used as a clinical tool in emerging theranostic applications.

These results contribute for the improvement of the Quality and Safety of patient health care, more

specifically: i) to quantify the risks associated to low dose exposure in the course of a radiotherapy

treatment; ii) to develop personalized medical diagnostic methodologies for patient-specific exams

and protocols; iii) to more accurately deliver the radiation dose in medical procedures, decreasing

patients' morbidity; v) to perform the radiobiological evaluation of targeted radiopharmaceuticals for

imaging and theranostic applications, including the potential side effects in healthy tissues.

Goal: SDG 3- Ensure healthy lives and promote well-being for all at all ages

Collaborations:

International

1 CEA –LIST | Commissariat à l’énergie atomique et aux énergies alternatives, Laboratoire National Henri

Becquerel, Saclay, France

2 Helmholtz Centrum Munique, Munique, Germany

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11TH DECEMBER 2018

3 IRD | Instituto de Radioproteção e Dosimetria, Rio de Janeiro, Brazil

4 IRSN | Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses, France

5 NCI | National Cancer Institute, Maryland, USA

6 PTB | Physikalisch-Technische Bundesanstalt, Braunschweig, Germany

7 SCK-CEN | Belgian Nuclear Research Centre, Mol, Belgium

National

1 CHLN | Centro Hospitalar de Lisboa Norte, EPE , Lisboa

2 CHLC | Centro Hospitalar de Lisboa Central, EPE, Lisboa

3 ESTESC | Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra

4 FC I Fundação Champalimaud, Lisboa

5 FCT-UNL | Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica

6 FCT-UC| Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Coimbra

7 HDL | Hospital da Luz, Lisboa

8 IBEB | Instituto de Biofísica e Engenharia Biomédica, Lisboa

9 IPO Lisboa | Instituto Português de Oncologia de Lisboa, Lisboa

10 IPO Porto | Instituto Português de Oncologia do Porto FG, Porto

Funding:

FCT (1 on-going post-doc fellowship, 2 projects submitted)

EU - FP7-EURATOM, H2020–WIDESPREAD (submitted 1 project), EURAMET-EMPIR

IAEA

OPERRA

Keywords: Radiation Protection, Medical Physics, Monte Carlo Simulations, Micro- and nanodosimetry,

Radiobiology

23


11TH DECEMBER 2018

O4.1 | Groundwater Risks Associated To The Military Activities At

Santa Margarida Military Camp, Based On Environmental Isotopes,

Chemical And Enteric Virus Evaluation

Thematic Strand:


C2TN members: Paula M. Carreira*, Sandra Cabo Verde, Dina Nunes

Students: Joana Madureira (PhD)


Research group:


Groundwater and soils contamination can derive from numerous sources which may carry a distinct

“fingerprint” that allows for identification of the source of contamination or the process which gave

rise to the contamination by a direct and indirect way.

The identification of mixing between different water bodies (superficial and groundwater systems)

can be obtained by environmental isotopes signatures. Also under this aim waterborne viral

contamination of wastewater can be has been studied with a view to optimizing effluent treatment

systems.

The environmental impact ascribed to Santa Margarida Military Camp operation and military training

activities was visible in different approaches:

- chemical contamination of aquifer systems and soils by the use of TNT and DNT associated with

military activities (e.g. conducting real fire);

- accumulation of oils from the washing of military vehicles in surface and groundwater systems and

soils;

- groundwater degradation through the effluents associated to the wastewater treatment plant (after

treatment) to the streams that may contribute to the entry of human enteric viruses such as Norovirus,

Adenovirus and other contaminants.

Through a multidisciplinary approach focused on the risk to human health aspects, water resources

degradation and soil contamination, that are part to outline strategies that allow to anticipate and

correct them, in the medium and short term, as stated in 3rd, 6th, 13th and 15th UN Sustainable

Developmant Goal.

The research started at Santa Margarida Military Camp, is starting point for “Smart Blue Water Camps”

project launched EDA’s energy and environment programme. This programme is centred in defence

sustainability that include water management infrastructure facing pressure due to climatic changes.

Collaborations:

1 Eduardo M. Braga da Cruz Mendes Ferrão – Campo Militar de Santa Margarida, Estado Maior do Exercito,

Ministério da Defesa Nacional

2 Paula Figueiredo |CINAMIL – Academia Militar, Estado Maior do Exercito, Ministério da Defesa Nacional

3 José Manuel Marques; Maria Orquídia Neves | CERENA – Instituto Superior Técnico, Lisboa, Portugal

Funding:

CINAMIL- Projeto RASA - Risks associated with soils and aquifers systems at Santa Margarida Military Field:

chemical and viral evaluation


24


11TH DECEMBER 2018

Keywords: Human health, groundwater and soils contamination, human enteric viruses, waste water treatment

25


11TH DECEMBER 2018

O4.2 | Mössbauer Spectroscopy An Invaluable Technique In Materials

Science

Thematic Strand:

Advanced Materials

C2TN members: João C. Waerenborgh*, Bruno J.C. Vieira (C2TN contract)

Students: Joana Capinha de Matos (PhD)


Research group:


The recoilless gamma ray emission and absorption first observed in 1957 by Rudolf Mossbauer gave

rise to Mössbauer spectroscopy, a versatile technique, used in many areas of science. Measuring

hyperfine effects with heretofore unrealizable accuracy it can give very precise information about

the chemical, structural, magnetic and time-dependent properties of a material, as well as identifying

phases containing the appropriate nuclide.

Examples of Mössbauer spectroscopy studies performed in C2TN contributing to nanotechnology

medicine, molecular magnetism and catalysis, will be presented.

These research fields have significant impact in society:

Superparamagnetic iron oxide nanoparticles (SPIONs) have shown great potential in biomedicine due

to their high intrinsic magnetization behaviour. They are a key component for multifunctional

nanoplatforms capable of accomplishing more sensitive and selective imaging of cancers and

simultaneously performing the delivery of therapeutics to diseased sites (theranostics

nanoplatforms). New synthetic routes for the preparation of more efficient SPIONs are now in

progress.

Magnets are a multi-billion euros business with a multitude of uses. The creation of molecular devices

using one or a few magnetic molecules as well as molecular materials combining conducting (π-type,

delocalized) and magnetic (d-type, localized) electrons have attracted major interest in molecular

science since they can exhibit the coexistence of two distinct physical properties, furnished by two

independent networks, or novel and improved properties when they interact.

2D magnetic materials have remained elusive until recently due to their instability under ambient

conditions and the difficulty to experimentally detect magnetism in the 2D limit. Recently, a less

explored field has emerged with 2D coordination polymers. A new family of these polymers exhibiting

magnetic order even as monoatomic thick layers was obtained. A general strategy for their synthesis

providing an unconventional route to tune at will the surface chemistry of the individual layers is

designed.

Collaborations:

Manuel Almeida, Laura C.J. Pereira, Isabel C. Santos, Vasco da Gama, C2TN, IST, Bobadela, Portugal.

Clara Gonçalves, Centro de Química Estrutural, Departamento de Engenharia Química, IST, Universidade de

Lisboa, Lisboa, Portugal.

José Ramón Galán Mascarós, Cristina Sáenz de Pipaón, Institute of Chemical Research of Catalonia, The Barcelona

Institute of Science and Technology (BIST), Tarragona, Spain.

Eugenio Coronado, Guillermo Mínguez Espallargas, J. López-Cabrelles, Miguel Clemente-León, Alicia Forment-

Aliaga, Instituto de Ciencia Molecular, Universitat de València, C/Catedrático José Beltrán 2, E-46980 Paterna,

Spain.


26


11TH DECEMBER 2018

Imanol de Pedro, Departmento CITIMAC, Facultad de Ciencias, Universidad de Cantabria, 390005 Santander,

Spain.

Narcis Avarvari, Alexandre Abhervé, Laboratoire MOLTECH-Anjou UMR 6200, UFR Sciences, CNRS, Université

d’Angers, France.

Jairton Dupont, Muhammad I. Qadir, Institute of Chemistry, UFRGS, Av. Bento Goncalves, 9500, Porto Alegre

91501-970, Rio Grande do Sul, Brazil.

Funding:

FCT projects (UID/Multi/04349/2013), ChemMat doctoral program (PD/BD/127914/2016), European Institute of

Molecular Magnetism (EIMM), COST ACTION-CA15128 MOLSPIN.

Keywords: Mössbauer spectroscopy, Molecular Magnetism, 2D Magnetism, theranostics nanoplatforms

27


11TH DECEMBER 2018

O4.3 | In-silico Contribution To The Design Of Innovative Molecular

Imaging Probes And Theranostic Agents

Thematic Strand:


C2TN members: João D.G. Correia*, Rita Melo


Research group:


Nowadays, an integrated novel approach of network-based systems biology, molecular docking, and

molecular dynamics became a valuable tool to gain insight into the role played by molecules in vivo,

namely those potentially useful as drugs. These network methodologies are focused on assembling

high-dimensional biological data-sets like chemical molecules and targets, to extract meaningful

information, being the current trend in pharmacology.

Our research group has been engaged in the development of radiolabelled multifunctional target-

specific nanoparticles for cancer theranostics. Profiting from our overall expertise in

radiopharmaceutical sciences, and in order to take a step forward, we are focused in the individual

characterization of molecular systems as well as in the development of innovative key methodologies.

In this way, we will be able to tackle specific problems in the area of structural computational biology

that will contribute to the optimization of the molecular imaging probes and/or theranostics agents.

Thus, a new research line is being developed in the area of data-driven biology computation and will

support and monitor the experimental work paths in RSG-C2TN. Recently, the RSG has been awarded

a FCT project (PTDC/QUI-OUT/32243/2017, PI: Rita Melo) in the computational chemistry field,

highlighting the interest of the scientific community in this methodological approach.

Collaborations:

1 Irina S. Moreira | Center for Neuroscience and Cell Biology , Coimbra, Portugal

2 Alexandre M.J.J. Bonvin | Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University,

Utrecht, The Netherlands

3 Zeynep | Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New

York, USA

Funding:

FCT - PTDC/QUI-OUT/32243/2017 and PTDC/QUI-NUC/30147/2017

Keywords: data-driven biology computation, theranostics, molecular Imaging probes


28


11TH DECEMBER 2018

POSTER PRESENTATIONS

29


11TH DECEMBER 2018

ID Title Presenting Author

P01 C2TN Task Force on Proton Therapy and Research Marta F. Dias Protons Task-force

P02 Targeting the transporters of cationic amino acids for cancer radiotheranostics: Experimental and computational chemistry approach

João D. G. Correia RS

P03 Membrane proteins - development of new computational approaches and its application to G-Protein Coupled Receptors

Rita Melo RS

P04 Novel Molecular Imaging Tools for Cystic Fibrosis Filipa Mendes RS

P05 Multifunctional Nanoseeds for Chemoradiotherapy of Glioblastoma António Paulo RS

P06 Radiopharmaceutical Sciences Group António Paulo RS

P07 Metrology in Health and Industry Margarida Caldeira RPS

P08 Environmental radioactivity and radioecology José Corisco RPS

P09 Innovative dosimetric and radiobiology approaches and leading edge methodologies in the medical uses of ionizing radiation

Salvatore di Maria RPS

P10 Emergency preparedness and response in case of a nuclear or radiological accident in Europe

Octávia Monteiro Gil RPS

P11 Radioactive Waste: Research, Education and Training, Public Perception and Societal Acceptance

Isabel Paiva RPS

P12 Uses of a Nuclear Microprobe setup (Cultural Heritage meets functional materials)

Luis Alves REI

P13 Production and use of metal in SW Iberian Peninsula from the Chalcolithic to the Roman Empire

Maria Fátima Araújo REI

P14 Applications of Ionizing Radiation: Why and What for? Sandra Cabo Verde REI

P15 Climatic Changes: isotopic fingerprints in aquifers and marine mollusk shells Paula Carreira REI

P16 Polymeric materials obtained by -radiation for skin scaffolds and for Roman mosaic preservation

L. M. Ferreira REI

P17 Development of tools to tackle air pollution, climate change and burden of disease in urban systems

Marta Almeida NET

P18 Radioactive Local Probe Techniques at the ISOLDE CTN experimental infrastructure, 2018 achievements

João Correia NET

P19 Superheated Liquid Detectors for Science and Society Ana Fernandes NET

P20 Geochemistry of surficial environments of oceanic volcanic islands in arid and semi-arid climates – a contribution to regional development planning

Rosa Marques NET

P21 Nuclear and radiation-based methods as tool to cultural heritage safeguard Ana Luisa Rodrigues NET

P22 Rare earth recovery and valorisation / Protection of environment José M. Carretas QEf

P23 Catalysis (nano structures for CO2 removal and fuels production) Ana C. Ferreira QEf

P24 Non-aqueous uranium coordination chemistry: uranium complexes supported by hydrobis(mercaptoimidazolyl)borates

Leonor Maria QEf

P25 Gas-Phase f-Element Chemistry Studies Joaquim Marçalo QEf

30


11TH DECEMBER 2018

ID Title Presenting Author

P26 Ln-based Compounds: from Magnetism to Optical Sensing Bernardo Monteiro QEf

P27 Neutrability: Soluble Neutral Materials for Molecular Electronics Dulce Belo ES

P28 Thermoelectric materials for energy Elsa Lopes ES

P29 Slow relaxation of magnetization in molecular materials Laura C. J. Pereira ES

P30 Self Assembled Bilayer Molecular Metals (CNB-EDT-TTF)4X; Polymorphism and Superconductivity

Sandra Rabaça ES

P31 The importance of cation-anion interaction in the spin crossover phenomenon: Structural and magnetic correlations in [Fe(nsal2trien)] salts

Bruno Vieira ES

P32 Outreach Group of C2TN: Sharing Science with Society Dulce Belo GO

31


11TH DECEMBER 2018

P01 | C2TN Task Force On Proton Therapy And Research

Thematic Strand:

Advanced Materials



C2TN members: Ana Belchior2, Ana Fernandes4, António Paulo1, Fernanda Margaça3, Filipa Mendes1,

Joana Guerreiro1,2, Luís M. Ferreira3, Lurdes Gano1, Marta F. Dias5,*, Pedro Santos3, Pedro Teles2,

Pedro Vaz2, Salvatore di Maria2, Sandra Cabo Verde3


Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS | Radiation Protection and Safety Group, 3 REI |

Radiation, Elements and Isotopes Group, 4 NET | Nuclear Engineering and Techniques Group, 5 GO |

Outreach Group

More than one quarter of all deaths in the European Union (EU) are caused by cancer and it has been

estimated that 1 in 3 people in the EU will be diagnosed with cancer in their lifetime. The Portuguese

Minister of Science has officially announced that Portugal is interested in building its first national

charged particle cancer therapy and research centre as means to decrease the number of deaths due

to cancer. This center will be built at the Campus Tecnólogico e Nuclear (CTN) from Instituto Superior

Técnico (IST), where Centro de Ciências e Tecnologias Nucleares (C2TN) is located. Aiming at

developing research of excellence in the field of proton therapy and research, C2TN has assembled a

task force with experienced researchers whose expertise will strengthen the Portuguese know-how

and future scientific output in the field of proton therapy and research. This task force includes C2TN

scientists from different research groups: Radiation, Elements and Isotopes, Radiation Protection and

Safety, Radiopharmaceutical Sciences, and Nuclear Engineering Techniques. Here, we will present

some of the envisaged scientific contributions from C2TN in therapy and research using proton beams.

These foresee research in the fields of Radiation Protection, Medical Physics, Radiation Biology,

Theranostics and multimodal imaging, and Advance Materials. Examples of the possible basic and

applied science projects are, among others:

- Shielding assessment of setups optimized for experiments with the proton beam;

- Neutron detection and dosimetry;

- Nanodosimetry;

- Pulse radiolysis;

- Establishment of animal models suitable for proton therapy preclinical studies;

- Material activation using proton beams;

Activities for network establishment are being pursued, in an effort to create synergies in present

and future international collaborative efforts.

Keywords: Proton, therapy, research, C2TN


32


11TH DECEMBER 2018

P02 | Targeting The Transporters Of Cationic Amino Acids For Cancer

Radiotheranostics: Experimental And Computational Chemistry

Approach

Thematic Strand:


C2TN members: João D.G. Correia*, Filipa F. Mendes, Paula D.G. Raposinho


Research group:


The majority of the cancer cells become auxotrophic for nutrient and energy sources, resulting in

upregulation of membrane transport proteins, namely cationic amino acid (CA) transporters.

Radiotracers targeting those transporters hold potential for non-invasive theranostics of cancer. Such

type of radiotracers is rather unexplored and no radiometal-based molecules have been described,

especially those based on radiometals obtained from widespread commercially available generators.

Combining an experimental approach with computational chemistry, this project aims at addressing

unmet needs in the clinical setting through design of new families of radiometallated CA derivatives

for cancer theranostics. The accomplishment of these goals requires a multidisciplinary team with

experts on Radiopharmaceutical Sciences (C2TN-IST) and on Structural, Computational and Chemical

Biology (CNC-UC). This complementarity will allow the development of the scientific program that

includes the following activities:

Task 1: Synthesis of CA-bearing chelating agents for preparation of radioactive metal complexes (99mTc

or 67Ga);

Task 2: Preparation and characterization of the radiometal complexes;

Task 3: Cell uptake and internalization studies in human cancer cell lines. The ability to cross the

blood brain barrier will be also evaluated;

Task 4: Identification of the entry mechanisms and transporters involved in the uptake;

Task 5: Biodistribution and SPECT-imaging studies of the most promising radiometal complexes in

relevant mice bearing xenografts;

Task 6: Homology modelling and molecular docking, followed by Molecular Dynamics and detailed

characterization of energetics and dynamics of the modelled complexes.

The outcome of the combined experimental and in silico approaches will enable the rationalization

of the overall results and to identify the structural features that influence the affinity of the

(radio)metal complexes for the transporters binding sites. In this way, alterations to the lead

compounds can be proposed, which will ultimately result in the design of metal complexes with

improved CA transporter-recognizing properties and higher potential for cancer theranostics.

Collaborations:

Irina Moreira, Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Coimbra, Portugal.

Funding:

FCT project PTDC/QUI-NUC/30147/2017.

Keywords: Cancer, Computational chemistry, Nuclear imaging, Transporters of cationic amino acids


33


11TH DECEMBER 2018

P03 | Membrane Proteins - Development Of New Computational

Approaches And Its Application To G-Protein Coupled Receptors

Thematic Strand:


C2TN members: Rita Melo*, João D.G. Correia


Research group:


Three-dimensional (3D) structures of protein-protein complexes are fundamental for structural

biology and drug discovery. However, the number of resolved structures is still very low. Docking

algorithms were developed for that purpose, but have limited accuracy in generating native-like

structures and identifying the most correct one, and none was developed for membrane proteins such

as G-protein Coupled Receptors (GPCRs). To deal with these complex systems and overcome current

limitations, we will develop novel computational approaches based on combinations of mature

methodologies, targeted to membrane proteins in general. Particularly, we will focus on developing

software to accurately predict interfacial residues in high-order oligomers and improving search and

scoring algorithms for the docking of membrane proteins, by considering the influence of the cellular

bilayer. This is a relevant and innovative area due to the lipidic environment context that is poorly

addressed in current docking tools. Our new approaches will be applied to the dopamine receptor

type 2 (D2R), a typical member of Class A GPCRs involved in many cognitive, emotional and motor

functions. D2R acts by ligand-dependent signalling through two major systems: G-proteins, and

Arrestin (Arr-s). Ligand preference and selectivity is not yet understood at a molecular level, and this

precludes both the characterization of pathway selectivity and the design of biased ligands. More

importantly, the physiological relevance of oligomerization for this process is still a hot topic. Only

by understanding both the organization and dynamics of receptor interactions will it be possible to

determine the potential of targeting dimers in drug development. This project will yield innovative

methods and approaches to study membrane protein systems and their functional mechanisms,

benefiting the entire research field. It will also provide truly new fundamental knowledge and insights

into the selectivity of D2R signalling by offering mechanistic explanations and experimentally

verifiable hypotheses.

Collaborations:

1 Irina S. Moreira | Center for Neuroscience and Cell Biology, Coimbra, Portugal

2 Alexandre M.J.J. Bonvin | Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University,

Utrecht, The Netherlands

3 José Guilherme Almeida | Center for Neuroscience and Cell Biology, Coimbra, Portugal

4 Harel Weinstein | Weill Medical College of Cornell University, New York, USA

Funding:

FCT - PTDC/QUI-OUT/32243/2017

Keywords: membrane proteins, GPCR, molecular modelling, molecular docking


34


11TH DECEMBER 2018

P04 | Novel Molecular Imaging Tools For Cystic Fibrosis

Thematic Strand:


C2TN members: Filipa Mendes*, João D.G. Correia, Lurdes Gano

Students: Vera F.C. Ferreira (PhD), Mariana A.M. David (Research Fellow)


Research group:


Cystic fibrosis (CF) is a life-shortening genetic disease caused by mutations in the CF Transmembrane

conductance Regulator (CFTR) gene that encodes a chloride channel critical for epithelial ion and

fluid transport. Since the identification of the responsible gene in 1989, our understanding of CF

pathophysiology has improved and ~2000 CFTR mutations are described, being F508del the most

common, occurring in ∼90% of CF patients. Most mutations result in loss of CFTR mediated Cl-

secretion by reduction in the number of CFTR channels or by impairment of the transport ability of

the channel.

Although being one of the most intensively investigated monogenic disorders, symptomatic treatment

remained the bedrock of CF patient care until the beginning of this decade. Recently, novel therapies

based on small organic molecules that target the basic defect in CF have been approved. One of the

therapies combines two molecules to partially restore the trafficking and functional defects of

F508del-CFTR. Despite this exciting development, from the translational medicine perspective there

remains a need to improve disease biomarkers and non-invasive therapeutic endpoints used in clinical

trials.

The aim of this project is to bring forward a novel molecular imaging approach to the managing of

CF. This will be achieved by new imaging biomarkers made available through the development of

specific nuclear medicine probes, based on anti-CFTR-antibody fragments. By allowing CFTR detection

at the membrane of human cells, these probes will have the potential to be transferred as a tool to

assess early therapy response in drug evaluation, thereby facilitating translational research.

The proposed work clearly aligns with the UN Sustainable Development Goal 3 “Ensure healthy lives

and promote well-being for all at all ages”, as it aims to contribute to improve the ability to manage

CF, and ultimately, to translate fundamental research into medical application and health benefit.

Collaborations:

1 BioISI I Instituto de Biosistemas e Ciências Integrativas, Faculdade de Ciências, ULisboa, Portugal

2 iMed I Instituto de Investigação do Medicamento, Faculdade de Farmácia, ULisboa, Portugal

3 ProQr Therapeutics, Leiden, The Netherlands

4 Department of Chemistry, University of Cambrige, Cambridge, UK

5 Case Western Reserve University, Cleveland, Ohio, USA

Funding:

FCT – grants EXPL/BIM-MEC/0115/2012 and PTDC/BTM-TEC/29256/2017

FEBS – Summer Fellowship to V Ferreira

Keywords: Molecular Imaging, Cystic Fibrosis, Rare Disease–ORPHA586, Antibody fragments


35


11TH DECEMBER 2018

P05 | Multifunctional Nanoseeds For Chemoradiotherapy Of

Glioblastoma

Thematic Strand:


C2TN members: Ana Belchior1, António Paulo1,*, Fernanda Marques1, Francisco Silva1, Maria C.

Oliveira1, Maria P.C. Campello1, Paula Raposinho1, Pedro Teles1

Students: Alice D’Onofrio (PhD)


Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS | Radiation Protection and Safety Group

Fully curative therapy remains elusive for many cancers, namely gliomas that correspond to the major

part of brain primary tumours. This is particularly true for glioblastoma multiforme (GBM), which is

by far the most common and malignant glioma subtype. GBM has one of the lowest survival rates and

highest tumour-related average years of life lost among all cancers. Therefore, there is an urgent

need for innovative therapies against GBM to obtain improved outcomes. To tackle this goal, this

project focuses on the design and preclinical evaluation of multifunctional gold nanoparticles (AuNPs)

for image-guided GBM chemoradiotherapy. These multifunctional AuNPs will allow the simultaneous

target-specific delivery of cytotoxic Pt(IV) prodrugs and imaging (111In, 124I) or therapeutic (177Lu, 125I)

radionuclides. To obtain GBM-avid nanoseeds, the AuNPs surface will be decorated with bombesin or

substance P derivatives to target, respectively, the gastrin releasing peptide receptor (GRPr) or

tachykinin NK1 receptors, overexpressed in GBM (Figure 1).

Figure 1. Schematic drawing of the designed multifunctional nanoseeds.

The proposed work comprises the following steps: i) AuNPs chemical modification, i.e, their

functionalization with bioactive peptides and/or linkage of Pt(IV) prodrugs through formation of Au-

S bonds; ii) detailed biophysical characterization of the resulting nanoconjugates to assess the

interaction with plasmatic proteins and binding affinity towards the putative receptors; iii) evaluation

of cellular uptake, cytotoxicity and induced mechanisms of cell death in human glioblastoma cell

lines; iv) biodistribution and PET/SPECT imaging studies in GBM xenografts; v) assessment of

therapeutic effects in a murine GBM orthotopic model, upon intratumoral administration of selected

nanoseeds; vi) dosimetric calculations to rationalize the therapeutic efficacy and eventual side-

effects.

The expected outcomes will provide chemical, radiochemical and biological knowledge useful to

design more efficient and selective therapies with a positive impact in the overall management of

GBM. Therefore, this project might contribute to translate fundamental research discoveries into

medical application and health benefit for the Society.


36


11TH DECEMBER 2018

Collaborations:

Mauro Ravera1, Carla Cruz2, Josué Carvalho2, Tiago Santos2, Nuno Mendes3, Fatima Gartner3, Jordi Llop4

1 Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Alessandria, Italy

2 CICS I Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

3 i3S I Instituto de Investigação e Inovação da Universidade do Porto, Portugal

4 CIC biomaGUNE I Parque Científico y Tecnológico de Gipuzkoa, Gipuzkoa, Spain

Funding:

FCT – EXCL/QEQ-MED/0233/2012 and PTDC/MED-QUI/29649/2017

Keywords: Cancer Theranostics, Glioblastoma, Nanomedicine, Chemoradiotherapy

37


11TH DECEMBER 2018

P06 | Radiopharmaceutical Sciences Group

Thematic Strand:


C2TN members: António Paulo1,*, Célia Fernandes1, Cristina Oliveira1, Elisa Palma1 (FCT), Fernanda

Marques1, Filipa Mendes1, Francisco Silva1 (C2TN contract), Joana F Guerreiro1,2 (C2TN contract),

João DG Correia1, Lurdes Gano1, Paula Campello1, Paula Raposinho1, Rita Melo1 (FCT)

Students: Alice D´Onofrio1 (PhD), Vera Ferreira1 (PhD), João Machado1 (PhD), Mihaela Cudalbeanu1

(PhD), Adriana Cruz1 (MSc), Ana Amendoeira1 (MSc), Ana Inácio1,2 (MSc), Diogo Figueiredo1,2 (MSc),

Sofia Batanete1 (MSc), Mariana David1 (Research fellow), Rúben Silva1 (Research fellow)


Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS I Radiation Protection and Safety Group

The Radiopharmaceutical Sciences Group (RSG) develops research activities on the design and

preclinical evaluation of radioprobes for Positron Emission Tomography (PET) or Single Photon

Emission Computed Tomography (SPECT) imaging and Targeted Radionuclide Therapy (TRT). This

research field has valuable translational potential in the diagnostic and/or treatment of oncological,

cardiovascular and neurodegenerative diseases, and can contribute for the rise of molecular and

personalized medicine. The RSG gathers a multidisciplinary team of scientists with expertise in

chemistry, radiochemistry and biological sciences, who run dedicated facilities for: i) chemical

synthesis (including solid phase peptide synthesis); ii) radiosynthesis; iii) biochemical, molecular

biology and cellular studies; iv) animal housing and biodistribution studies.

The research group is mainly involved in the study of innovative target-specific radiopharmaceuticals,

based on a plethora of imaging or therapeutic radionuclides, to image/interfere with different

disease-associated molecular and biological pathways. The group is a key partner of renowned

national/international institutions involved in radionuclide production, nuclear medicine and

biomedical research, due to its rare combination of radiopharmaceutical chemistry expertise with

preclinical evaluation skills. There is also an active collaboration with research groups engaged in the

discovery and development of novel drugs, as well as technology transfer activities within research

contracts with national/international biotech companies, namely in the field of antibody-based

biopharmaceuticals.

The RSG is also committed to provide advanced training to students and young scientists on

Radiopharmaceutical Sciences and Molecular Imaging, being partner of the ITN “MEDICIS-produced

radioisotope beams for medicine” lead by CERN and the PhD program “ChemMedTrain”. Several

members of RSG teach 2nd and 3rd cycle curricular units and the group also receives undergraduate

and graduate students from different schools of the Universidade de Lisboa and other national and

international universities for laboratory rotations, MSc or PhD thesis.

Collaborations:

International

1 AUN I Assiut University, Assiut, Egypt

2 Cardiff University, Cardiff, UK

3 CERN I European Laboratory for Particle Physics, Geneva, Switzerland

4 CHUV I Centre Hhospitalier Universitaire Vaudois, Lausanne, Switzerland

5 ICMAB I Instituto de Ciencia de Materiales de Barcelona- CSIC, Barcelona, Spain

6 IQFR I Instituto de Química Física Rocasolano - CSIC, Madrid, Espanha


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11TH DECEMBER 2018

7 IQSC-USP I Instituto de Química de São, Carlos, Universidade de São Paulo, São Carlos, Brasil

8 iSm2 I Institut des Sciences Moléculaires de Marseille-CNRS, Marseille, France

9 Ludwig Institute for Cancer Research, Zurich, Switerzland

10 MU I University of Missouri, Columbia, Missouri, USA

11 POLATOM I Nationla Centre for Nuclear Research POLATOM, Otwock, Poland

12 TUM I Technische Universität München, Munich, Germany

13 UAM I Universidad Autónoma de Madrid, Madrid, Spain

14 UdelaR I Universidad de la República, Montevideo, Uruguay

15 UGAL I "Dunarea de Jos" University of Galati, Galati, Romania

16 ULB I Université libre de Bruxelles, Brussels, Belgium

17 Universitat Wien, Vienna, Austria

18 Université de Sherbrooke, Sherbrooke, Canada

19 University of Cambrige, Cambridge, UK

20 UPO I Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Alessandria,Italy

21 UVIGO I Universidad de Vigo, Vigo, Spain

22 UZH I Universitat Zurich, Zurich, Switzerland

National

1 BioISI I Insituto de Biosistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa,

Lisboa

2 CICS I Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Covilhã

3 CIISA I Centro de Investigação Interdisciplinar em Saúde Animal, Faculdade de Medicina Veterinária,

Universidade de Lisboa, Lisboa

4 CNC I Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Coimbra

5 CQE I Centro de Química Estrutural, Universidade de Lisboa, Lisboa

6 FC I Fundação Champalimaud, Lisboa

7 FCT I Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica

8 i3S I Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto

9 ICNAS I Instituto de Ciências Nucleares Aplicadas à Saúde, Universidade de Coimbra, Coimbra

10 iMed I Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa

11 IMM I Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa

Funding:

CRUP, FCT, EU, IAEA, Hovione, ProQr Therapeutics, Technophage

Keywords: Radiopharmaceuticals, Molecular Imaging, Nuclear Medicine, Theranostics, Nanomedicine

39


11TH DECEMBER 2018

P07 | Metrology In Health And Industry

Thematic Strand:


C2TN members: Ana Belchior (IST-ID contract), Carlos Oliveira (retired), Isabel Paiva2 Margarida

Caldeira* (IST contract), Mário Reis, Marta Santos, Pedro Teles (IST-ID contract), Pedro Vaz, Salvatore

Di Maria (IST-ID contract), Yuriy Romanets

Students: Jorge Borbinha (MSc-fellow), Pedro Gomes (PhD)


Research group:

RPS | Radiation Protection and Safety Group

In the last few years, members of the GPSR have been working in metrology related activities, either

by the active participation in metrology research programmes within the framework of EURAMET,

focused on subjects such as Health and Industry, or by the involvement in PhD programmes.

In the industry field, Project MetroNORM established new reference materials and standard sources,

and developed novel in-situ and laboratory measurement instruments and procedures to be used by

the European NORM industry. The outputs of the project were disseminated to metrologists,

stakeholders, regulators and end-users, and led to a significant reduction in uncertainties of NORM

instrument calibration and measurements, leading to cost-effective, accurate and reliable end-user

measurements for NORM industry and increasing safety in NORM production.

As for the health field, the objective of the on-going normative Project RTNorm is to re-calculate the

quality factors used in the IAEA protocol TRS-398 for radiotherapy dosimetry (calculated in the

1990’s), using state-of-the-art Monte-Carlo simulation tools and experimental methods, leading to

the decrease of uncertainties and harmonization of values across hospitals. Validated results will be

incorporated into the upcoming IAEA TRS-398 revision and European hospitals will have reliable

correction factors for the latest ionizing radiation technologies.

The radiation protection of patients is a major metrological concern that starts in the primary

standard definition. To address this question, a homemade graphite cavity chamber for the

measurement of air-kerma in the energy range of 60Co was designed, constructed and characterized,

in agreement with the European pursuit of a more accurate metrological basis for quantities related

to the safe use of ionizing radiation.

An important task for the future is the establishment of procedures for the measurement of micro-

and nanodosimetric quantities, and the respective uncertainty budgets, which need to identify and

quantify all sources of uncertainty associated to the measurement devices as well as those associated

to the track structure simulation codes.

These topics relate to Goals 3 and 9 in the 2030 Agenda for Sustainable Development. The quality of

measurement is a fundamental aspect in our everyday life. If we add ionizing radiation measurements

to the equation, the subject becomes even more challenging, with a direct impact in the community.

Collaborations:

Partners and counterpart institutions from EU countries, international organizations (EMRP, EMPIR)

CEA –LIST | Commissariat à l’énergie atomique et aux énergies alternatives, Laboratoire National Henri

Becquerel, Saclay, France


40


11TH DECEMBER 2018

Funding:

EURAMET (EMRP, EMPIR)

Keywords: EURAMET, NORM, Radiotherapy, Standards, Micro and nano-dosimetry

41


11TH DECEMBER 2018

P08 | Environmental Radioactivity And Radioecology

Thematic Strand:


C2TN members: José Corisco2,*, Mário Reis2, Maria José Madruga2, Eva Andrade2, Marta Santos2,

Célia Fernandes1, Elizabete Ribeiro1, M. Helena Casimiro3 (IST-ID contract), Luís M. Ferreira3, Isabel

Prudêncio4

Post-Doc Contract: Jan Mihalik2


Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS | Radiation Protection and Safety Group,

3 REI | Radiation, Elements and Isotopes Group, 4 NET | Nuclear Engineering and Techniques Group

Indoor radon measurements and exhalation rates in building materials are used to identify areas where

houses have a high probability of exhibiting high radon concentrations. Radon potential maps are used

to show the spatial distribution of radon levels, for its control through planning, building

requirements, and environmental health legislation. Under the frame of the United Nations 2030

Agenda for Sustainable Development, the above mentioned issues are in compliance with goal 3 “Good

health and well-being for people”, since radon in indoor air is a public health issue, and goal 11

“Sustainable cities and communities”, since special attention should be paid to air quality, reducing

the adverse per capita environmental impact of cities. Radium activity concentrations and radon

exhalation rates were measured in several types of building materials, using gamma-ray spectrometry

for 226Ra and a continuous radon monitor and SSNT detectors for 222Rn. The 226Ra activity

concentrations range from 5 to 123 Bq kg-1. The higher radon exhalation rates were measured in

granite samples.

The assessment of the exposure of wild life to inonizing radiation, meets the criterium of the Agenda,

namely on goals 14 “Life below water”, and 15 “Life on land”. Combining this with the environmental

dosimetry approach promoted by ICRP regarding reference widlife forms (ICRP Document 108, 2008),

the assessment of absorbed dose was done in submerged hydrophytes and emergent plants of Tejo

river and in the wild herbaceous vegetation and mosses growing on a phosphogypsum tailing in

Portugal. Monte – Carlo code MCNPX was applied in dose assessment. Results express levels of

background radiation mainly due to 226,228Ra, 210Pb and 40K.

Facing the need to understand the fate of artificial radionuclides on contaminated ground areas after

nuclear accidents, experimental work has been done on the remobilization of 137Cs resulting from the

degradation of contaminated plant biomass in soil. Adsorption and bioavailability from humic acid

(HA)/humic acid like compounds (HALC) and montmorillonite was investigated. Bioavailability

increases when 137Cs reaches the soil associated with newly formed HALC from compost, than when

it is adsorbed on stable HA in soil. Long-term interaction of 137Cs with HALC led to decrease the

fraction adsorbed on montmorillonite and increase its bioavailable fraction. Once this phenomen is

impacting on the bioavailability of 137Cs to terrestrial food chains, the study corresponds well with

the objectives of the above mentioned goal 15 of the Agenda.

These and future activities fulfill the objectives aimed by the European Radioecology ALLIANCE and

the European Radiation Dosimetry Group – EURADOS to which IST is an affiliated member, reinforcing

the commitment of Portugal towards the requirements of Article 35 of EURATOM Treaty.

Collaborations:

1 Conrado Miró | Departamento de Física Aplicada, Universidade da Extremadura

2 Pedro Nogueira | Thünen Institute of Fisheries Ecology Herwigstrasse 31, 27572 Bremerhaven, Germany.


42


11TH DECEMBER 2018

Funding:

FCT ID/Multi/04349/2013 project

Keywords: Radon, absorbed dose, phosphogypsum, 137Cs, bioavailability.

43


11TH DECEMBER 2018

P09.1 | Dosimetry Of The Medical Applications Of Ionizing Radiation

Thematic Strand:


C2TN members: Ana Belchior (IST-ID contract), Pedro Teles (IST-ID contract), Pedro Vaz, Salvatore

Di Maria* (IST-ID contract), Yuriy Romanets

Students: Ana Sá (PhD), Débora António (MSc), Filipe Pires (MSc), Jorge Borbinha (MSc-fellow),

Mariana Baptista (PhD), Maria João Carapinha (PhD), Pedro Gomes (PhD), Mariana Trincão (MSc),

João Canhoto (MSc), Maria José Rodrigues (MSc), Cláudia Gonçalves (MSc)


Research group:


The Radiation Protection and Safety Group is actively involved in some of the most important ionizing

radiation medical applications, both in diagnostic and therapy. The undertaken activities encompass

Monte Carlo (MC) modeling and simulations and measurements in laboratories and Hospitals.

A special effort is devoted to the development of new dosimetric formalisms for Cone Beam CT

(CBCT), in order to easily relate measurable quantities with patient organ doses. Another important

research line is devoted to the use and manipulation of voxel-based phantoms, which play a major

role in the development of personalized-patient dosimetry for several applications such as Digital

Breast Tomosynthesis (DBT) and interventional cardiology. Regarding internal dosimetry activities,

modified biokinetic models have been developed and the determination of specific-absorbed fractions

(SAFs) in organs for paediatric patients in nuclear-medicine examinations have been performed,

including uncertainty analysis. Also, dosimetric studies related to the establishment of diagnostic

reference levels (DRLs) in Portugal are being performed.

In radiotherapy applications, a major effort is devoted to the accurate MC modeling of linear

accelerator in order to assess the out-of-field doses, mainly in peadiatric patients. Concerning new

radiation therapy concepts, studies on radionuclide target therapy are under investigation combining

MC calculations and radiobiological assays, aiming to study the impact of tumor phenotypes

intervariability.

The societal impact of these research and training activities encompasses: i) raising the awareness

about the radiation protection of patients (including paediatric); ii) patient dose and radiological-

cancer and non-cancer risk estimation for better justification of medical procedures; iii) Contributing

to the Quality and Safety of healthcare; iv) education and training of students and health

professionals.

Future activities include dosimetric studies for innovative and challenging techniques (such as ion

therapy), increasing the knowledge about specific patient dosimetry and estimating cancer risk

models for organs. Involvement in previous techniques of radiodiagnostic and Nuclear Medicine exams

will be pursued and furthered.

Collaborations:

International

1 IRSN | Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-aux-Roses , France

2 SCK-CEN | Belgian Nuclear Research Centre, Mol, Belgium

3 IRD | Instituto de Radioproteção e Dosimetria, Rio de Janeiro, Brazil

4 Helmholtz Centrum Munique, Munique, Germany


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11TH DECEMBER 2018

5 PTB | Physikalisch-Technische Bundesanstalt, Braunschweig, Germany

6 NCI | National Cancer Institute, Maryland, USA

7 ENEA |Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile| Lungotevere

Thaon di Revel, 76 , 00196 ROMA Italia

National

1 Fundação Champalimaud, Lisboa, Portugal

2 HDL | Hospital da Luz, Lisboa, Portugal

3 CHLN | Centro Hospitalar de Lisboa Norte, EPE description, Lisboa, Portugal

4 CHLC | Centro Hospitalar de Lisboa Central, EPE description, Lisboa, Portugal

5 IPO Porto | Instituto Português de Oncologia do Porto FG, Porto, Portugal

6 IPO Lisboa | Instituto Português de Oncologia de Lisboa, Lisboa, Portugal

7 ESTESC | Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal

8 IBEB | Instituto de Biofísica e Engenharia Biomédica, Lisboa, Portugal

9 FCT-UNL|Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal

10 FCT-UC| Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Coimbra Portugal

Funding:

FCT

FP7-EURATOM

IAEA

OPERRA (platform)

H2020–WIDESPREAD

EURAMET – EMPIR

Keywords: Radiation Protection, Medical Physics, Radiotherapy, Radiodiagnostics, E&T

45


11TH DECEMBER 2018

P09.2 | Biological Effects Of Radiation

Thematic Strand:


C2TN members: Ana Belchior2,* (IST-ID contract), Joana F. Guerreiro1,2

(C2TN contract), Ana Catarina

Antunes2 (IST-ID contract), António Falcão3, António Rocha Paulo1, Elisa Palma1 (FCT), Filipa Mendes1,

Maria Cristina Oliveira1, Octávia Monteiro Gil2, Paula Raposinho1, Pedro Santos3 (C2TN contract), Pedro

Vaz2

Students: Cristina Pricacaruta2,3 (trainee), Filipe Pires2 (MSc), João Canhoto2 (MSc), Stefan

Spinache2,3 (trainee)


Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS | Radiation Protection and Safety Group, 3 GREI

| Radiation, Elements and Isotopes Group

The biological and molecular consequences of exposure to low doses of ionizing radiation (IR) remain

unclear. With the increasing use of high-precision techniques for radiation therapy, there has been

also an increased requirement for imaging techniques to assist in treatment planning and verification.

Although the dose from these procedures is considered low, the concomitant dose administered to

the patient has been raised as a potential concern, because of an increase in stochastic effects to the

anatomic region subjected to the imaging dose. Additionally, the uncertainty of biological

consequences, at low doses, on the effective repair rate of irradiated blood cells offers a potential

concern.

The search for new diagnostic and therapeutic tools is urgent, with particular interest in

radiopharmaceuticals, which can be used simultaneously for diagnosis and targeted therapy

(theranostics). In this context, obtaining tumour-specific molecular information and assessing the

biological effects of exposure to ionizing radiation in clinically relevant cellular models is essential.

In this context, at C2TN, the ongoing research focus on the:

i) Assessment of the biological effects induced by low doses of IR, in non-tumoral breast cells, using

cytogenetic assays of early and late cellular damage quantification;

ii) Detection of induced and persistent damage in irradiated blood cells, using different doses and

dose-rates of 60Co, determining the dependency between dose and surviving cells;

iii) Assessment of relative biological effectiveness (RBE) after exposure to protons and alpha-radiation

on cancer cells;

iv) Validation of disease and radiation-specific biomarkers;

v) Radiobiological assessment of novel radiolabelled compounds to evaluate their potential for cancer

theranostics.

These results contribute to ensure healthy lives and promote well-being for all at all ages (SDG-3),

more specifically: i) to quantify the risks associated to low dose exposure and ii) to improve the

knowledge of targeted radiopharmaceuticals for imaging and theranostic applications.

Collaborations:

CQE |Centro de Química Estrutural, Instituto Superior Técnico, Lisboa, Portugal

HZM | Helmholtz Zentrum Munique, Munich, Germany

IAEA | International Atomic Energy Agency

ICNAS | Instituto de Cie ncias Nucleares Aplicadas à Saúde, Coimbra, Portugal

NMS | Nova Medical School

PTB | Physikalisch-Technische Bundesanstalt


46


11TH DECEMBER 2018

WHO | World Health Organization

International platforms and networks (MELODI, RENEB, BioDoseNet)

“Alexandru Ioan Cuza” University of Iași (Romania)

Funding:

FCT (Projects ID/Multi/04349/2013 and EXCL/QEQ-MED/0233/2012; Grants SFRH/BPD/80758/2011 and

SFRH/BPD/112654/2015)

Keywords: Cancer; Exposure Biomarkers; Low-dose biological effects; Radiobiology; Theranostics

47


11TH DECEMBER 2018

P10 | Emergency Preparedness And Response In Case Of A Nuclear Or

Radiological Accident In Europe

Thematic Strands:



C2TN members: Octávia Monteiro Gil*, Mário Reis, Isabel Paiva, Maria José Madruga, Ana Catarina

Antunes (IST-ID fellowship), Pedro Teles (IST-ID contract), Pedro Vaz

Students: Mariana Baptista (PhD)


Research group:


The risk of a large-scale radiological event has markedly increased, not only due to possible accidents

in nuclear facilities but also as a result of the threat of terrorist attacks against key facilities or civil

targets in major cities.

Radiation accidents occur under several different potential circumstances that may affect the

environment and people. The nature, extent and intensity of the exposure strongly influence

subsequent medical treatment and the early and late countermeasures to be taken during emergency

and transition phases of an accident. Members of the Radiological Protection and Safety Group works

in the area of dose assessment (total body and thyroid), Monte Carlo simulations, environmental

contamination and countermeasures strategies, decision making support and risk communication.

Members of the Radiological Protection and Safety Group are involved in several EU projects under

FP7 and HORIZON 2020, (RENEB, CAThyMARA, PREPARE, CONFIDENCE) and in the framework of

PT2020, UPCAST, related to nuclear and radiological emergencies.

The social impact is high as it allows: i) to study and estimate Public Health, radioactive

contamination of foodstuffs, feedstuffs and other consumer goods ii) to raise the awareness of public

and decision makers about the importance of allocating adequate resources to manage accidental

situations involving ionizing radiation exposure iii) to provide decision makers and competent

authorities with tools to cope with such situations and iv) to develop the adequate strategies for risk

communication.

Future activities: i) improvement of stakeholders engagement in the preparedness and response in

the transition phase; ii) to identify and reduce the uncertainties in the management of the long-term

exposure situation; iii) to identify social and ethical issues related to uncertainty management in

emergency and post-accident situation; iv) improve communication of uncertainty and reinforce the

decision making process; v) development of new tools to efficiently protect the public and first

responders; vi) education and training.

Funding:

EU (FP7, Horizon2020), Lisboa 2020, PT2020

Keywords: Emergency, Environmental contamination, Biological dosimetry, Uncertainties, Public awareness


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11TH DECEMBER 2018

P11 | Radioactive Waste: Research, Education And Training, Public

Perception And Societal Acceptance

Thematic Strand:


C2TN members: Isabel Paiva1,*, Mário Reis1, Maria José Madruga1, Eva Andrade1, M. Fátima Araújo2,

M. Isabel Dias3, M. Isabel Prudêncio3, Rosa Marques3, Joaquim Marçalo4, João Carlos Waerenborgh5,

Bruno J. C. Vieira5 (C2TN contract), João Paulo Leal4, Marta Santos1, Pedro Valério2, Leonor Maria4

(IST-ID contract), Bernardo Monteiro4 (IST-ID contract), José M. Carretas4, Dulce Russo3, Guilherme

Cardoso3, Catarina Galinha2, José Manuel Bénitez1,3, Fernanda Margaça2, Pedro Vaz1


Research groups:

1 RPS | Radiation Protection and Safety Group, 2 REI | Radiation, Elements and Isotopes Group, 3

NET | Nuclear Engineering and Techniques Group, 4 QEf | f-element Chemistry Group, 5 ES | Solid

State Group

EU Member States acknowledge their responsibility to manage and dispose of radwaste generated in

their territory and to proceed implementation of further research, in line with Council Directive

2009/71/EURATOM and IAEA recommendations. Radwaste produced in Portugal is associated to

health, industry, teaching, R&D activities and with the future decommissioning of the Portuguese

Research Reactor.

Members of the Radiological Protection and Safety Group (GPSR), with other C2TN Groups and

national/international institutions, have been involved in several R&D projects: EURATOM framework,

FCT, ERAMIN and IAEA RER, KADRWaste, ACSEPT, CMET, EAGLE, PETRUS I, II and III, ENVIREE.

The involvement of Portugal in this area of research is of great societal impact towards improving

public perception and societal acceptance of the need to find solutions to better manage radwaste

to reducing the burden on future generations.

GPSR R&D has been focusing on: Studying innovative solutions for radwaste treatment including

recovery of by-products with economical interest (ex.: Rare Earths); Exchanging of experiences with

other Countries; Maintaining and improving the knowledge, skills and competences of future

generations of researchers, producers, operators and regulators; Contribute for the establishment of

a safe culture in the management of radioactive wastes; Engaging other stakeholders in the decision-

making process.

GPSR E&T has been focused on: IST Master Course MPSR; PETRUS MSc and PhD international programs;

Stakeholders communication.

GPSR representation on behalf of IST: IGD-TP, a waste technology platform that promotes research

on all types of radwastes, from nuclear to non-nuclear countries; Art. 37º/EURATOM, IAEA and OSPAR

Convention.

Future activities:

- GPSR is present in the 1st project (EURAD) submitted to the EC under EJP platform on Radwaste and

Knowledge Management, September 2018;

- Identification/characterization of geomaterials suitable for radwaste management, treatment and

disposal; Radionuclide sorption / desorption potential (GPSR & ETN Groups);

- Modelling safety case for radwaste repositories by COMSOL Multiphysics;


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11TH DECEMBER 2018

- Strengthening PETRUS PhD and ECVET methodologies;

- Linking master MPSR to the IAEA radwaste learning project;

- Fostering involvement with experts in communication through social and humanities platforms

(Platenso, Ricomet) for increasing transparency and trust.

Collaborations:

Nélia Soares | AMBIMED, Stericycle Portugal

Lucília Salgado, M.Teresa Rézio | IPOFG Lisboa

Paula Monteiro | CMLisboa

Alfredo Baptista | NOPR/LPSR

António Mateus, Mário Gonçalves |FCUL/CREMINER

F. Maia, P. Santos, A. Lucena, C. Lourenço|Students

Edgar Carvalho, Carlos Rosa | EDM

R. Trindade | IST Retired

Álvaro.F. Tavares, Ana C. Pardal | I.P. Beja

B. Bazargan-Sabet| U Lorraine

C. Ekberg |Uchalmers

M. Palmu | (Posiva Oy)

C. Turcanu | SCK-CEN

F. J. Elorza | UPM

S. Bourg |CEA

A. Pereira |UEstocolmo

Funding:

EURATOM, FCT, IGD-TP, ENEN, IAEA, ERA-Call.

Keywords: Radioactive wastes management, Storage, near-surface and long-term safety disposal, Risk

communication, Societal implications, Education and training.

50


11TH DECEMBER 2018

P12 | Uses Of A Nuclear Microprobe Setup (Cultural Heritage Meets

Functional Materials)

Thematic Strand:


C2TN members: Luís Alves*, Maria Fátima Araújo, Pedro Valério, António Monge Soares

Students: Rui Borges (PhD)


Research group


Ion beam technology has been widely used both for the characterization (through a plethora of ion

beam analytical techniques) or modification (ion implantation, microbeam machining) of materials,

with important applications in the fields of material science and cultural heritage.

A Scanning Nuclear Microprobe adds micrometer spatial resolution and imaging capabilities and was

here used to study samples with: sub-millimeter dimensions; lateral and/or in-depth heterogeneities;

large cultural heritage materials analysis with external microbeam setup.

Under the leadership of FCT an extended work has been carried out on historical glasses, stained

glasses and enamels aiming to path the way from raw materials to glassware, luxury objects or artistic

expression, always questioning their provenance that including the existence of local glass production

centres.

Determination of joining techniques and brazing alloys composition was performed in gold samples

from the National Museum of Archaeology covering a period from the Late Bronze Age to Roman times.

Results obtained allowed to propose the used joining techniques as well as establish late goldsmith

interventions.

A correlation between composition and chronology of 16th to the 17th silver coins was found, clearly

identifying the introduction in Europe of silver originating from the Americas. The database obtained

allows comparison with coeval Portuguese silver jewellery.

Study of advanced materials has also been a goal for the ion beam microprobe as is the case of the

characterization of Schottky-barriers formed in Ga2O3, a wide band-gap semiconductor with high

potential for optic and electronic applications.

The goal of the studies on cultural heritage has been to contribute to the knowledge of ancient

production techniques, together with the raw materials used and their provenance then providing

essential information not only to scholars but also to conservators and museum curators for enriching

the information possible to be provided to the general public in museum collections.

Collaborations:

1 Victoria Corregidor, Marco Peres, IPFN, Instituto de Plasmas e Fusão Nuclear, IST Univ. de Lisboa, Lisboa,

Portugal

2 Márcia Vilarigues, Inês Coutinho, VICARTE, Vidro e Ceramica para as Artes, FCT/UNL, Campus de Caparica,

Caparica, Portugal

3 Alexandra Barreiros, LNEG, Laboratório Nacional de Energia e Geologia, Lisboa, Portugal

4 Katharina Lorenz, INESC, Instituto de Engenharia de Sistemas e Computadores, Lisboa, Portugal

5 Rui Silva, CENIMAT, Centro de Investigação de Materiais, FCT/UNL, Campus de Caparica, Caparica, Portugal

6 Filomena Guerra, CNRS, Centre National de Recherche Scientifique, UMR 8096 CNRS ArchAm, Nanterre, France


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11TH DECEMBER 2018

7 Isabel Tissot, Archeofactu, Arqueologia e Arte, Alfragide, Portugal

8 MNAA, Museu Nacional de Arte Antiga, Lisboa, Portugal

9 MNA, Museu Nacional de Arqueologia, Lisboa, Portugal

Funding:

(FCT UID/Multi/04349/2013; FCT UID/EAT/00729/2013; FCT PTDC/EPH-PAT/3579/2012; IAEA CRP F11021)

Keywords: glass material analysis, ancient joining techniques, nuclear microprobe, Ga2O3, silver coins.

52


11TH DECEMBER 2018

P13 | Production And Use Of Metal In SW Iberian Peninsula From The

Chalcolithic To The Roman Empire

Thematic Strand:


C2TN members: P. Valério, A.M.M. Soares, L.C. Alves, M.F. Araújo*

Students: S.S. Gomes (PhD student), F. Lopes (PhD student), F. Pereira (PhD student)


Research group:


The archaeometallurgical research concerns the different metals and alloys used in ancient times

(copper, bronze, brass, gunmetal, silver, gold and lead) and comprises a large time span ranging from

the 3rd millennium BC to the 4th century AD. The investigation is focused on the distinct metallurgical

steps required to convert a metallic ore into an artefact valued as a tool, weapon or ornament. Hence,

the chronological and cultural features of archaeological materials are crossed with elemental,

isotopic and microstructural data obtained by an array of analytical techniques (ICP-MS, Raman,

micro-EDXRF, micro-PIXE, SEM-EDS, optical microscopy and Vickers hardness testing), which are

selected according to the type of material, e.g. ore, slag, prill, crucible, tuyere, mould, ingot or

artefact (Figure 1).

Figure 1. The array of analytical techniques applied by the REI group in the characterisation of the

different types of metallurgical materials and some of the thematic issues addressed in the

archaeometallurgy field.

The main outcomes concern distinct cultural or chronological phases such as the Bell Beaker Culture

(c. 2650-1800 BC), the beginning of the Bronze Age, the Orientalizing period (c. 800-400 BC) and the

Roman civilization from 100 BC to 400 AD. The research has identified an association between Bell

Beaker archaeological sites and copper-based artefacts richer in arsenic, probably due to the prestige

of the silvery colour of high-arsenical copper alloys. Moreover, the introduction of bronze in

southwestern Iberian Peninsula, in addition to the oldest lead artefact in the Iberian Peninsula, were

attributed to the 2nd quarter of the 2nd millennium BC. Concerning the Orientalizing period, the studies

have been identifying a diversification of copper-based alloys (copper, binary bronze and leaded

bronze), together with innovative techniques in the manufacture and decoration of gold jewellery

such as brazing and filigree. During the Roman Time, the copper-based metallurgy comprises a


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11TH DECEMBER 2018

diversity of alloys without standardised compositions (copper, leaded copper, leaded bronze,

gunmetal and leaded brass), while the recycling becomes quite common in the Empire, suggesting a

technology strongly influenced by economic concerns. In addition, the Iberian Pyrite Belt

(argentiferous jarosite ores) and Sierra Morena and Ossa Morena Zone (galena ores) were identified

as probable sources to the lead production in important urban centres such as Conimbriga, Augusta

Emerita and Mirobriga.

Collaborations:

1 DCR/FCT | Departamento de Conservação e Restauro, Faculdade de Ciências e Tecnologia, Universidade Nova


2 CENIMAT/i3N | Centro de Investigação em Materiais, Faculdade de Ciências e Tecnologia, Universidade Nova


3 CEAACP | Centro de Estudos de Arqueologia, Artes e Ciências do Património, Universidade de Coimbra,

Portugal

3 MMC | Museu Monográfico de Conimbriga, Portugal

4 MDDS | Museu de Arqueologia D. Diogo de Sousa, Portugal

5 Museu Municipal de Santiago do Cacém, Portugal

6 CEAX | Centro de Estudos Arqueológicos de V. Franca de Xira, Portugal

7 Consorcio Ciudad Monumental de Mérida, Spain

8 MAR | Museo Nacional de Arte Romano, Spain

9 Museo Arqueológico Municipal Aroche, Spain

10 Museo Minero de Riotinto, Spain

Funding:

FCT/UID/Multi/04349/2013 (C2TN)

POCI-01-0145-FEDER-007688, Reference UID/CTM/50025 (CENIMAT/i3N)

Keywords: Archaeometallurgy, Provenance, Alloy composition, Manufacture, Joining techniques

54


11TH DECEMBER 2018

P14 | Applications Of Ionizing Radiation: Why And What For?

Thematic Strands:



C2TN members: Sandra Cabo Verde* (Post-Doc), Pedro Santos (Post-Doc), António N. Falcão,

Fernanda M.A. Margaça

Students: Joana Madureira (PhD), Maria Inês Elias (MSc), Joana Roque (MSc), Catarina Palma (MSc),

Andreia Severino (MSc)


Research group:


Ionizing radiation (gamma sources and electron-beam accelerators) is a clean and environmental

friendly technology with the potential to solve most intrinsic problems of conventional methSDG and

an alternative for some of the chemical treatments. In the last years, our R&D was focused on the

development of radiation technologies for different applications.

Food irradiation is a recognized technology to improve the safety and preserve the quality of food

products. The carried out studies in FOOD IRRADIATION intends to evaluate the feasibility of this

process to treat food products with national impact, namely to extend shelf-life of fresh fruits (cherry

tomatoes, sweet cherries, blackberries and raspberries), mushrooms and chestnuts, and to optimize

microbial decontamination treatments for aromatic and medicinal plants. The outcome of these

studies contribute to prevent foodborne outbreaks and improve food quality promoting the good

health and well-being (SDG 3).

Also related to public health protection is the establishment of STERILIZATION processes by ionizing

radiation for industrial products, including pharmaceutical and medical devices, that is being

performed as an add-value service for the industrial sector.

Comprehensive studies were done to assess the use of ionizing radiation to improve water safety and

quality by CHEMICAL AND BIOHAZARD POLLUTANTS DEGRADATION (SDG 6). The degradation of

recalcitrant compounds together with the possible reuse of valuable radiolytic by-products in other

industries is a promising key contributor for the sustainability of life on earth (SDG 12). Regarding

biohazard pollutants, research has been conducted to understand the mechanistic patterns of human

enteric VIRUS INACTIVATION by ionizing radiation to develop efficient mitigation strategies for

waterborne pathogens.

Another recent application has been focused on the olive oil industrial WASTE VALORIZATION due to

its content in valuable bioactive compounds. The extractability of the main phenolic compounds of

olive pomace increased considerably after ionizing radiation treatment and this could outcome on

their incorporation as preservation ingredients in bakery products, upgrading in this way the

technological capabilities of industrial sectors to make them sustainable with increased resource-use

efficiency (SDG 9).

Collaborations:

L. Barros, I. C.F.R. Ferreira, A. L. António, CIMO | Centro de Investigação de Montanha, IPB, Bragança,

Portugal

C. Santos-Buelga, GIP | Grupo de Investigación en Polifenoles, USAL, Salamanca, Spain

M. M. Carolino, DEV | Departamento de Biologia Vegetal, FCUL, Lisboa, Portugal


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11TH DECEMBER 2018

Funding:

FCT, ARIAS - Application of Ionizing Radiation for a Sustainable Environment. RECI/AAG-TEC/0400/2012.

FCT, VRAD - Inactivation patterns of enteric virus by ionizing radiation. EXPL/DTP-SAP/2338/2013.

PRODER, PA 53515, AROMAP – Processamento de plantas aromáticas condimentares.

IAEA, International Research Coordinated Project F23033 - Tracking Enteric Virus Inactivation by E-beam

Irradiation.

IAEA, International Research Coordinated Project D61024 contract no. 19220 - Fostering e-beam food irradiation:

Modelling and Validation.

IAEA, International Research Coordinated Project Contract No. 16513 - Application of Ionizing Radiation on the

Cork Wastewater Treatment.

Keywords: Ionizing radiation, Food irradiation, Wastes valorization, Virucidal action, Sterilization

56


11TH DECEMBER 2018

P15 | Climatic Changes: Isotopic Fingerprints In Aquifers And Marine

Mollusk Shells

Thematic Strand:


C2TN members: Paula M. Carreira*, Dina Nunes, Maria Fátima Araújo, António Monge Soares

Students: Paulo J.C. Portela (MSc)


Research group:


Environmental isotopes content is affected by climatic processes and its quantification may give

access to information that has been recorded since thousands of years ago, in groundwater systems

and in mollusk shells.

The δ18O and the δ13C of inorganically precipitated CaCO3 are a function of the δ18O and the δ13C of

the water in which the CaCO3 is precipitated and also of the salinity, temperature and phase mineral

(calcite and aragonite). The δ18O of biogenic CaCO3 has been extensively used to estimate past

seawater temperatures while the depletion in 12C recorded in marine surface water of some regions

is an excellent proxy of coastal upwelling. The carbonate of foraminifera, fish otoliths and marine

shells has been significantly used in studies concerning palaeoenvironments. Also, speleothems have

been extensively used to reconstruct palaeorainfall, palaeotemperatures and palaeovegetagion based

on stable isotope variations. Under this scenario groundwater isotopic signatures (δ18O and δ2H) is

also an archive of past climates since it will reflect the air temperature when precipitation and

aquifers recharge occurred since it can be compared with modern regional precipitation isotopic

composition.

Past climate can be reconstructed using a combination of different types of proxy records. These

records can then be integrated with observations of Earth's modern climate and placed into a model

to infer past as well as predict future climate. Palaeoenvironmental reconstructions are a unique tool

that leads to a better understanding of imminent climate changes, making it possible to outline

strategies that allow to anticipate and mitigate them, in the medium and long term, as stated in 6th,

13th and 15th UN Sustainable Development Goals.

Ongoing projects focus their studies in Figueira Brava’s Cave, where a Neanderthal occupation left an

important record (mollusk shell midden) and in the Lower Sado Miocene aquifer where environmental

stable and radioactive isotopes were used in the determination of the origins of groundwater

salinization.

Collaborations:

1 Igor Gutièrrez-Zugasti | IIIPC, Cantabria University, Santander, Spain

2 João Zilhão | ICREA, Barcelona University, Barcelona, Spain

3 Pedro Callapez | CITEUC, Coimbra University, Coimbra, Portugal

4 José Manuel Marques | CERENA – Instituto Superior Técnico, Lisboa, Portugal

5 Mohamed Bahir | Ecole Normale Supérieure, Cadi Ayyad University, Marrakesh, Morocco

6 Mariana Nabais | Institute of Archaeology, University College London, England

Funding:

The authors acknowledge the FCT funding under the project UID/Multi/04349/2013.

Paulo J.C. Portela acknowledges the FCT funding under the project PTDC/EPH-ARQ/6485/2014.


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11TH DECEMBER 2018

Keywords: climatic change, palaeoenvironmental reconstructions, environmental isotopes, marine mollusk

shells, groundwater systems.

58


11TH DECEMBER 2018

P16 | Polymeric Materials Obtained By -Radiation For Skin Scaffolds

And For Roman Mosaic Preservation

Thematic Strands:

Advanced Materials


C2TN members: M.H. Casimiro1,* (IST-ID contract), P.M.P. Santos1 (C2TN fellowship), A.N. Falcão1,

L.C. Alves1, F.M.A. Margaça1, J.P. Leal2, L.M. Ferreira1,*

Students: A.P. Rodrigues (PhD); Others: G. Rodrigues (FCUL), D. Casal (NOVA Medical School)

*Email of corresponding author: [email protected], [email protected]

Research groups:

1 REI | Radiation, Elements and Isotopes Group, 2 QEf | f-element Chemistry Group

Polymeric based materials are being successfully prepared/functionalized by ionizing radiation

processing techniques targeting an increasing number of specific applications in different areas. In

particular, the work here reported aims to overcome two distinct problems: one associated with the

difficulty in skin regeneration treatments in patients needing dermal grafts normally resulting from

burned injuries; and the other concerning the preservation of Roman mosaics from Conimbriga ruins,

an important legacy of Roman civilization classified as national cultural heritage and the most

important Portuguese archaeological site.

The present work is part of two Coordinated Research Project from International Atomic Energy

Agency (IAEA) and meets the Sustainable Development Goals G.3 and G.11 of 2030 Agenda, namely

good health and well-being, and sustainable cities and communities.

We have been particularly focused in two reactional systems:

1. Chitosan based copolymeric biocompatible and biodegradable matrices to be used as skin

scaffolds for tissue regeneration processes and,

2. PDMS-Silica ormosils (organically modified silicates) hybrid materials for the consolidation of

ancient Roman mosaics (additive with biocide activity for the composite materials used in

ancient mosaics panels conservation processes).

Figure 1. (A) Chitosan-based skin scaffold and (B) PDMS-TEOS-ZrPO hybrid material obtained by -irradiation.

By different ways, both issues within addressed present high scientific and societal relevance since if

the one can improve the outcome of medical treatment and life quality of patients, and decrease the

need for (sterilized) human donor material in the future, an important and sensitive issue in our

society, the other will allow the preservation of Roman civilization testimonies to the future

generations.

Up to the moment particular attention has been given to the correlation between the different

preparation conditions and the polymeric materials’ properties. Results show that prepared materials

are very promising to be used in each specific application on demand.

(A) (B)



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11TH DECEMBER 2018

Collaborations:

1 FCUL | Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal

2 NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal

3 FCTUNL | Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal

4 MMC-MN | Museu Monográfico de Conínbriga – Museu Nacional, Coimbra, Portugal

5 IPT | Instituto Politécnico de Tomar, Tomar, Portugal

Funding:

FCT - UID/Multi/04349/2013 project; IST-ID/076/2018 contract; PD/BD/114410/2016 grant (in the framework of

PhD Course CORES, FCT-UNL)

IAEA - Research Contract No. 18202 (CRP F23030); Research Contract No. 18982 (CRP F23032)

Keywords: Ionizing radiation, Chitosan, Skin regeneration, PDMS-based hybrid materials, Cultural Heritage

60


11TH DECEMBER 2018

P17 | Development Of Tools To Tackle Air Pollution, Climate Change

And Burden Of Disease In Urban Systems

Thematic Strand:


C2TN members: Susana Marta Almeida2,*, Joana Lage2 (IST Post-Doc fellowship), Vânia Martins2 (IST

Post-Doc fellowship), Nuno Canha2 (IST-ID contract), Joana Coutinho2 (IST Post-Doc fellowship),

Catarina Galinha1,2 (C2TN Post-Doc fellowship), Marina Almeida-Silva2

Students: Tiago Faria (PhD), Vitor Manteigas (PhD), Carolina Correia (MSc), Inês Cunha-Lopes (MSc),

Catarina Nunes (BSc)


Research groups:

1 REI | Radiation, Elements and Isotopes Group, 2 NET | Nuclear Engineering and Techniques Group

Substantial proportion of the European Union’s population remains exposed to high levels of air

pollutants. There is a great deal of improvement with respect to emission control strategies in

European urban areas. However, air quality is still a major problem regarding its detrimental impact

on human health. In the EU-28 and in 2014, the premature deaths attributed to PM2.5, NO2 and O3

exposure were 399.000, 75.000, and 13.600, respectively. The development of innovative and

versatile tools that establish a relation between population exposure to air pollutants, emission

sources and health effects and that identify measures to improve the air quality is an effort

materialized through the projects LIFE Index-Air (www.lifeindexair.net), ClimACT (www.climact.net),

REMEDIO (https://remedio.interreg-med.eu) and ExpoLIS.

LIFE Index-Air assessed the exposure of children to particles chemical species by sampling airborne

particle in 40 homes, 5 schools, 5 transport means and respective outdoors. The sampled particles

were measured by XRF for chemical characterization. The generated data is being used to develop

and validate the LIFE Index-Air decision support tool.

In the scope of ClimACT educational, financial and decision support tools were developed and

implemented to improve the environment and energy performance of 39 schools from Portugal, Spain,

Gibraltar and France.

Within Remedio, C2TN, together with Loures Municipality, installed an air quality monitoring station

in Moscavide to evaluate the environmental impact of a street requalification. Results showed a

reduction of 16% of the vehicles and 7% of PM10 and PM2.5.

ExpoLis aims to develop an air quality exposure sensing system, composed by a network of sensor

nodes, and deploy it on public transportation to obtain the real-time air pollution distribution in urban

areas.

This study answers to the following sustainable development goals: 1) Good health and well-being;

2) sustainable cities and communities; and 3) climate action.

Collaborations:

1 Instituto da Soldadura e da Qualidade (ISQ), Lisbon, Portugal

2 EDIGREEN| EDIGREEN- Soluções energéticas, Lda. , Porto, Portugal

3 ABAE | Associação Bandeira Azul da Europa, Lisbon, Portugal

4 CIEMAT| Centro de Investigaciones Energéticas Medioambientales y Tecnológicas, Madrid, Spain

5 USE| Universidad de Sevilla, Sevilla, Spain


http://www.lifeindexair.net/

http://www.climact.net/

https://remedio.interreg-med.eu/

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11TH DECEMBER 2018

6 ULR|Université de La Rochelle, La Rochelle, France

7 VLR| Ville de La Rochelle, La Rochelle, France

8 UniGIB | University of Gibraltar, Gibraltar

9 ARPA | ARPA Veneto – Regional Agency for Environment Protection in Veneto Region, Veneto, Italy

10 Municipality of Treviso, Veneto, Italy

11 AUTH| Aristotle University of Thessaloniki, Thessaloniki, Greece

12 MDAoTHESNIKI SA| Metropolitan Development Agency Of Thessaloniki S.A., Thessaloniki, Greece

13 SPLIT| City of Split, Split, Croacia

14 CML| Municipality of Loures, Loures, Portugal

15 CESAM-UA | Centro de Estudos do Ambiente e do Mar da Universidade de Aveiro, Aveiro, Portugal

16 NCSR-D | National Center of Scientific Research “Demokritos”, Athens, Greece

17 THL | National Institute for Health and Weldfare, Helsinki, Finland

18 TUC | Technical University of Crete, Chania, Greece

Funding:

European Union through the project LIFE Index-Air LIFE15 ENV/PT/000674

European Regional Development Fund (ERDF) through the Interreg Med project REMEDIO (Ref. 862)

European Regional Development Fund (ERDF) through the Interreg Sudoe project ClimACT (SOE1/P3/P0429)

Fundação para a Ciência e Tecnologia for support the project UID/Multi/04349/2013, IF/01078/2013, and

LISBOA-01-0145-FEDER-032088

Keywords: Air Quality, Aerosol, Source Apportionment, Climate Change, Decision Support Tools

62


11TH DECEMBER 2018

P18 | Radioactive Local Probe Techniques At The ISOLDE CTN

Experimental Infrastructure, 2018 Achievements

Thematic Strand:

Advanced Materials

C2TN members: João Correia*, Ulrich Wahl

Students: Eric Bosne (PhD), Abel Fenta (PhD), Marcelo Barbosa (PhD), Carlos Amorim (PhD),


Research group:


Highlights on:

a) New Lattice site location experiments

a. 11Be in GaN where Be is a potential p-type dopant (optoelectronics).

b. 56Mn: Ge1-xMnxTe identifying and characterizing the lattice displacement of Mn for

different Mn doping concentrations. GMT is a multiferroic material at room

temperature envisaged for Spintronics where the coupling of the magnetic moment

and electric polarization depend on the Mn displacement that we probe.

c. 61Co in diamond for quantum information storage.

b) New Perturbed Angular Correlation experiments

a. 111mCd/Cd: Ca3Mn2O7 and Ca2MnO4 Naturally Layered Multiferroic Perovskites,

observing and characterising new microscopic phase transitions.

b. 199mHg/Hg and 111mCd/Cd di-halide experiments performed in the gas phase HgX2, CdX2

where X = I, Br, Cl. These unique measurements allow determining the quadrupole

moment of the 245keV 5/2 state of 111Cd with unprecedent 2% precision on a state

that is used to calibrate nuclear moments on the Cd isotopes series and isomeric

states, and is used in inumeras PAC hyperfine interactions experiments in material’s

science.

c) R&D and perspectives

a. Draft of EC and PAC R&D on future on-line experiments as well as on laboratory

upgrades and offline experiments running during the next shutdown accelerator

period.

Impact: A unique Portuguese national – inter-institutional and international collaboration.

Applications of radioactive nuclear techniques to nanoscopic research in material science. Synergy

between nuclear physicists and material’s scientists using unique nuclear techniques.

Collaborations:

International

CERN-ISOLDE radioactive ion beam laboratory, IKS-KULeuven, Belgian, University Kwazulu-Natal, South Africa,

Department of Chemistry, University of Copenhagen, Denmark

ILL- Grenoble, France, Talca University, Chile, IPEN, São Paulo, Brazil, Graphene Research Center, National

University of Singapore, Western Michigan University, USA.

National

CICECO, University of Aveiro, IFIMUP, University of Porto, CQ-UTAD, Universiy of Trás-os-Montes e Alto

Douro,Vila-Real, LIP- Laboratory of Instrumentation and Experimental Particles Physics, Lisbon.


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11TH DECEMBER 2018

Funding:

CERN projects, FCT Portugal, ENSAR2 Horizon 2020 Framework, Foreign National Projects

Keywords: Nuclear Radioactive Local Techniques, New Materials, New Properties

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11TH DECEMBER 2018

P19 | Superheated Liquid Detectors For Science And Society

Thematic Strands:

Advanced Materials


C2TN members: Andreas Kling2, José Antunes2, José Marques2, Thomas Girard2, Ana Fernandes2,*

(FCT Investigator), Miguel Felizardo2 (IST contract), Tomoko Morlat1,2 (C2TN contract)

Students: Filipe Soares (MSc), Marta Reis (MSc)


Research groups:

1 RPS | Radiation Protection and Safety Group, 2 NET | Nuclear Engineering and Techniques Group

Our team fabricates and develops radiation detectors based on superheated liquids, namely droplet

detectors and bubble chambers. These devices can be rendered insensitive to minimum ionising

particles yielding an excellent tool for the detection of neutrons, alpha particles and heavy ions at

low intensity levels. The research activity demand-oriented, and is currently focussed on (i) intrinsic

soft error rate assessment in electronic devices using ultra-low activity materials for high reliability

applications; (ii) detection of alpha-emitting contaminants in liquids for emergency response; (iii)

experimental characterisation of neutron environments in massively shielded facilities and for low

dose experiments. In the near future, we envisage to develop novel methods for (a) the early

identification of seismic activity; (b) the detection of solar flares at underground facilities and (c) the

active measurement of galactic radiation fields to be encountered in manned space travel, for which

existing data have gaps in energy and ion type. The connection of the current and foreseen work with

the areas of technology industry and citizen safety convey a relevant societal impact to our activity,

that also addresses the Sustainable Development Goals 3 (Good health and well-being) and 9 (Industry,

innovation and infrastructure) set by the United Nations.

Collaborations:

1 LSBB | Laboratoire Souterrain a Bas Bruit, Rustrel, France

2 Xilinx Inc. | technology company, San Jose CA, USA

Funding:

FCT

Keywords: detector, alpha, neutron, ultralow intensity


65


11TH DECEMBER 2018

P20 | Geochemistry Of Surficial Environments Of Oceanic Volcanic

Islands In Arid And Semi-Arid Climates – A Contribution To Regional

Development Planning

Thematic Strand:


C2TN members: Rosa Marques1,*, Maria Isabel Prudêncio1, João Carlos Waerenborgh2, Bruno José

Cardoso Vieira2 (C2TN contract), Maria Isabel Dias1, Dulce Russo1, Guilherme Cardoso1


Research groups:

1 NET | Nuclear Engineering and Techniques Group, 2 ES | Solid State Group

The geochemical characterization of surficial environments is of extreme importance, especially when

the topsoils are used for agriculture. These studies are of particularly interest in oceanic volcanic

islands where soils are a crucial resource for local economy. Environmental monitoring studies are

essential for the establishment of guidelines for preservation of the environment and for the

identification of potential focus of pollution/contamination of superficial topsoil layers.

A detailed research activity is being performed in Cape Verde archipelago with the main goal of

constructing an environmental atlas of Cape Verde, in collaboration with other national and

international institutions, including the Cape Verde University. Fieldwork, sampling and analyses have

been performed in four islands - Santiago, Fogo, Brava and Sal. Georeferenced volcanic topsoil

samples have been collected in these islands aiming a low sampling-density survey of the geochemistry

of topsoils of the islands, according to the guidelines of the IGCP Project 259 International

Geochemical Mapping.

Nuclear methods, namely instrumental neutron activation analysis (INAA) and Mössbauer spectroscopy

allowed to obtain chemical and crystalchemistry parameters of volcanic soils with good precision and

accuracy.

This research activity is of huge relevance contributing with (a) the establishment of mean values for

volcanic soils worldwide and (b) chemical DATA of topsoils from Cape Verde for the establishment of

the Geochemical Atlas. The evaluation of the chemical elements mobility, availability and

accumulation in soils, particularly in the fine particles where Fe nano-sized oxides exist, accumulation

and translocation in plants, and micropaleontology studies for the identification of biological activity

under an arid to semi-arid climate are also performed. All these studies have a significant

socioeconomic impact, since these volcanic soils are used for agriculture, needing a detailed

investigation for the mitigation of environmental and health issues.

Collaborations:

Fernando Rocha1,2, Eduardo Ferreira da Silva1,2, Marina Cabral Pinto3, Maria Manuela Abreu4, Teresa Silva5,

Francisco Ruiz6, Manuel Abad7

1 UA | Universidade de Averio, Dep. Geociências, Aveiro, Portugal

2 GeoBioTec | GeoBioSciences, GeoTechnologies and GeoEngineering, Aveiro, Portugal

3 INIDA | Instituto Nacional de Investigação e Desenvolvimento Agrícola, Santiago, Cabo Verde

4 Unidade de Investigacão de Química Ambiental | Instituto Superior de Agronomia, Lisboa, Portugal

5 Unidade de Recursos Minerais e Geofísica |Laboratório Nacional de Energia e Geologia, Amadora, Portugal

6 Departamento de Ciencias de la Tierra | Universidad de Huelva, Huelva, Espanha

7 Departamento de Geologia|Universidade de Atacama, Copiapó, Chile


66


11TH DECEMBER 2018

Funding:

Research funded by Fundação para a Ciência e a Tecnologia (FCT, Portugal) through the projects

UID/GEO/04035/2013 and UID/Multi/04349/2013

Support of Ministério da Educação de Cabo Verde (delegação Escolar do Fogo) and City Hall of Vila Nova Sintra

(Brava).

Keywords: Volcanic soils, Geochemistry, Cape Verde, Geochemical Atlas, Nuclear techniques

67


11TH DECEMBER 2018

P21 | Nuclear And Radiation-Based Methods As Tools To Cultural

Heritage Safeguard

Thematic Strand:


C2TN members: Ana Luisa Rodrigues* (FCT Post-Doc), Maria Isabel Dias, Maria Isabel Prudêncio,

Rosa Marques, Guilherme Cardoso, Dulce Russo


Research group:


The C2TN team has been applying nuclear and radiation-based methods for chemical and mineralogical

characterization and absolute dating of cultural heritage. These techniques have been playing an

important role for the study of cultural materials through precise and accurate analyses of

archaeological and historical artefacts (e.g. ceramics, stone, mortars, biomaterials and

geoarchaeological materials) which enable the establishment of provenance, technologies of

production, chronologies and paleoenvironmental reconstruction of human occupation. In the most

of times, the analyses were performed in a non-destructive or micro-invasive way, preserving the

integrity of the studied artefacts. The research has been performed in collaboration with national

and international research institutions, museums, private companies, etc. in the frame of national

and European research projects, and services/contracts. The objectives and the achievements have

as main focus the protection and safeguard of the world’s cultural heritage, contributing to more

sustainable cities and communities (Sustainable Development Goal 11). It is envisage to develop

innovative protocols for luminescence dating, namely an accurate determination of the dose rate in

decontextualized cultural heritage assets, as well as, to increase and improve the compositional

ancient artefacts database, implementing research strategies and networking for European cultural

heritage safeguard.

Collaborations:

Zs. Kasztovszky1, I. Harsányi1, I. Kovács2, Z. Szőkefalvi-Nagy2, Jorge Sanjurjo3, Carlos Odriozola4, Leonardo

García Sanjuán4, Coronada Mora Molina4, Clodoaldo Roldan5, Aleix Eixea6, V. Villaverde6, A. C. Valera6,7, L.

Oosterbeek8, Pedro Flor9, J. Mihaly10, György Káli11, Anísio Franco12, António Carvalho13, M. Antónia Pinto

Matos14, Alicia Medialdea Utande15, Constantin Athanassas16, Nuria Rafel17, Ignacio Soriano18

1 Centre for Energy Research | Hungarian Academy of Sciences, Budapest, Hungary

2 Institute for Particle and Nuclear Physics | Hungarian Academy of Sciences, Budapest, Hungariy

3 University Institute of Geology | Univesity of Coruña, Coruña, Spain

4 Department of Prehistory and Archaeology| University of Seville, Seville, Spain

5 Instituto de Ciencia de los Materiales | University of Valencia, Valencia, Spain

6 Departamento de Prehistoria y Arqueologia | University of Valencia, Valencia, Spain

7 ERA Arqueologia | Núcleo de Investigação Arqueológica, Lisboa, Portugal

8 Instituto Politécnico de Tomar | Campus de Tomar, Tomar, Portugal

9 Inst. História Arte da Fac. Ciências Sociais e Humanas | Univ. Nova de Lisboa, Lisboa, Portugal

10 Research Centre for Natural Sciences, Hungarian Academy of Sciences. Budapest, Hungary

11 Institute for Solid State Physics and Optics, Wigner Research Centre for Physics, Hungarian Academy of

Sciences, Budapest, Hungary.

12 Museu Nacional de Arte Antiga

13 Museu Nacional de Arqueologia

14 Museu Nacional do Azulejo

15 Servicio de Radioisotopos, CITIUS |Universidad de Sevilla, Seville, Spain


68


11TH DECEMBER 2018

16 National Technical University of Athens |Athens, Greece

17 Department of History | University of Lleida, Lleida, Spain

18 Department of Prehistory | Autonomous University of Barcelona, Barcelona, Spain

Funding

Fundação para a Ciência e a Tecnologia (FCT, Portugal) through the projects and fellowships:

- UID/Multi/04349/2013

- PTDC/HIS-HEC/116742/2010 - ROBBIANA - The Della Robbia sculptures in Portugal: History, Art and

Laboratory

- PTDC/EPH-ARQ/0798/2014 - Mobility and interaction in South Portugal Recent Prehistory: the role of

aggregation centers.

- Post-Doctoral fellowship SFRH/BPD/114986/2016

IPERION CH Project H2020:

- VISUAL - SANTA VITÓRIA - UTENSILS AND ORNAMENTS OF AN ENCLOSURE SITE. IPERION CH – FIXLAB

PLATFORM B - NIPS-NORMA and the PGAA facilities of BNC, Budapest Neutron Centre, Wigner Research

Centre for Physics HAS, Centre for Energy Research HAS (2018)

- BRR-527. “Personal ornaments at chalcolithic funerary contexts of SW Iberian Peninsula: The Perdigoes

site” (2017)

- BRR- 484. “Interconnections: archaeological beads and trade in Perdigões during the 3rd millennium

BC” (2016)

Proyectos I+D do Plan Estatal 2013-2016 Excelencia (HAR2013-45149-P) - Naturaleza, Sociedad y

Monumentalidad: Investigaciones Arqueológicas de Alta Resolución del Paisaje Megalítico de Antequera.

Proyectos I+D do Plan Estatal 2014-2017 Excelencia (HAR2014-54012-P) - Mining-metallic resources, trade and

commerce in the Prehistory and Protohistory of the Iberian Peninsula (Catalonia and the northern Valencian

Country). Ministry of the Economy and Competitiveness.

Keywords: Cultural Heritage, Nuclear methods, Luminescence dating, Compositional studies, Provenancing

69


11TH DECEMBER 2018

P22 | Rare Earth Recovery And Valorisation / Protection Of

Environment

Thematic Strand:


C2TN members: José M. Carretas3,*, Adelaide Cruz3, Bernardo Monteiro3 (IST-ID Contract), Catarina

Galinha2 (C2TN Post-doc), Isabel Paiva1, João P. Leal3, Joaquim Marçalo3, Leonor Maria3 (IST-ID

Contract), M. Fátima Araújo2, Susana S. Gomes2 (C2TN Post-doc)

Students: Beatriz Bento (Research Student)


Research groups:

1 RPS | Radiation Protection and Safety Group, 2 REI | Radiation, Elements and Isotopes Group, 3

QEf | f-element Chemistry Group

Rare Earth Elements (REEs; lanthanides (Ln), scandium and yttrium) have become an important raw

material in the industry, playing an essential role in modern electronic technologies, industrial and

medical products and innovative environmental technologies. REEs are considered as being highly

relevant for societal needs but there exists a significant risk of supply for actual demand. Therefore,

the development of selective, efficient, economical and environmentally friendly separation

processes of REEs from different materials is under intense development.(1) This research topic

addresses one of the UN’s Sustainable Development Goals, specifically “Responsible consumption and

production” and we expect to continue contribute to achieve the sustainable management and

efficient use of natural resources.

In our current work, ionic liquids (ILs) with only CHON elements in their composition, both already

existent or newly synthesized, are being used for separation of REEs from other metals, as an

alternative to more traditional methods.(2) Some of the ILs displayed a significant differentiation

between lanthanides and are adequate to selectively extract Ln among them. In certain conditions

an IL was able to separate Ln from other metals. Work is in progress for optimizing a selective

extraction of REEs in the presence of other metals and an effective separation along the lanthanide

series.

References: (1) “Recycling of rare earths: a critical review”, Binnemans K, Jones PT, Blanpain B, Gerven TV,

Yang Y, Walton A, Buchert M (2013) J. Clean. Prod. 51 1-22; (2) “Separation and recovery of critical metal ions

using ionic liquids”, Makanyire T, Sanchez-Segado S, Jha A (2016) Adv. Manuf. 4, 33–46.

Collaborations:

1 Filipe Figueiredo, José P. Sardinha, João C. Bordado | CERENA-IST, Lisboa, Portugal

2 M. Caetano et al | IPMA, Lisboa, Portugal

3 Interecycling | Tondela, Portugal

Funding:

FCT projects ENVIREE (ERA-MIN/0002/2014), REEuse (PTDC/QEQ-EPR/1249/2014) and UID/Multi/04349/2013

PT2020 project RecValTR (03/SI/2017 – I&DT Empresarial project in co-promotion nº 33576)

RNEM – Portuguese Mass Spectrometry Network, ref. LISBOA-01-0145-FEDER-022125, supported by FCT and the

Lisboa Regional Operational Programme (Lisboa2020), under the PT2020 Partnership Agreement, through the

European Regional Development Fund (ERDF)

Keywords: Rare Earth Elements, Ionic Liquids, Metal Extraction, Selective Separation, Mass Spectrometry


70


11TH DECEMBER 2018

P23 | Catalysis (Nano Structures For CO2 Removal And Fuels

Production)

Thematic Strands:

Advanced Materials


C2TN members: Ana C. Ferreira1* (C2TN post doc), Joaquim Branco1, António Pereira Gonçalves2

Students: Pedro de Brito (MEC-Student)


Research groups:

1 QEf | f-Element Chemistry Group, 2 ES | Solid State Group

The main goals of Laboratory of Catalysis covers: i) the production of value-added chemicals and

fuels, such as hydrocarbons, methanol or syngas, using major

gaseous pollutants (e.g. CO2, CH4, N2O) as raw materials; ii)

the development, preparation and characterization of

nanostructured intermetallic compounds containing the f-

block elements (lanthanides, Th and U), bimetallic oxides,

metal borides, pnictides and chalcogenides with specific

functionalities and applications in environment and energy.

For catalytic studies, different heterogeneous systems using

transition metals and f-block elements as massic or supported

(SiO2 or Al2O3) catalysts were tested, either at atmospheric

pressure or under high pressure conditions. On the other hand,

pnictides (e.g. CoSb3) and chalcogenides (e.g. Cu3SbS4 and

Cu12Sb4S13) were prepared using unusual approaches, such as

electrospinning and solvothermal method (Figures).

This work has a strong societal impact since it contributes to

the reduction/removal of major greenhouse gases, namely

CO2, contributing to alleviating global climate changes and

contributing to the development of more clean and efficient

industrial processes, targeting the production of value-added

products (e.g. CH4) that can be used as fuel or fuel

precursors.

New objectives includes the development of new nanoporous/nanofoams f-block element based

catalysts that can economical be competitive when compared to the present state of art used by the

industry.

Collaborations:

1 Nuno Pinhão (IPFN/IST) | Non thermal plasma conversion of methane, Bobadela, Portugal

2 Ana Ferraria and Ana Rego (IST/UL) | Catalysts surface characterization by XPS, Lisbon, Portugal

Funding:

FCT, UID/Multi/04349/2013, Ana C. Ferreira (postdoc grant)

Keywords: f-Block elements, Catalysis, Nanostrutures, Gaseous pollutants, Fuels

0

500

1000

1500

2000

2500

20 30 40 50 60 70 80

Inte

nsi

ty (a.u

.)

2 Theta (degree)

Cu12Sb4S13

0

75

150

225

300

20 30 40 50 60 70 80

Inte

nsi

ty(a

.u.)

2 Theta (degree)

CoSb3


71


11TH DECEMBER 2018

P24 | Non-Aqueous Uranium Coordination Chemistry: Uranium

Complexes Supported By Hydrobis(mercaptoimidazolyl)borates

Thematic Strands:

Advanced Materials


C2TN members: Leonor Maria1,* (IST-ID Contract) Isabel C. Santos2, Adelaide Cruz1, Joaquim

Marçalo1


Research groups:

1 QEf | f-element Chemistry Group, 2 ES | Solid State Group

The oxidation of a metal center is a well-suited reaction to study the influence of the supporting

ligand on reactivity. Since trivalent uranium has a high reducing power, its complexes are extremely

reactive with oxidizing substrates. Studies of U(III) redox chemistry have been reported using diverse

U(III)-ligand systems leading to unprecedented transformations and structures, demonstrating the

chemical potential and unique properties of uranium [1].

Hydrobis(mercaptoimidazolyl)borate ligands are mono-anionic soft chelates, analogues to the [N2]-

donor hydrobis(pyrazolyl)borate ligands, that provide [S2]-donor ligands. Previous results obtained by

us demonstrated that the bis(mercaptoimidazolyl)borate ligands [H(R)B(timMe)2]- are able to stabilize

the cationic uranium(III) complexes [U{3-H,S,S’-H(R)B(timMe)2}2(thf)3][BPh4] (R = H, Ph) [2]. Revisiting

our studies with these [S2]-donor chelators, we verified that the neutral U(III) complexes [U{3-H,S,S’-

H(Ph)B(timMe)2}2I(thf)2] can be used as an U(III) precursor in electron-transfer reactions to access new

tetravalent and hexavalent uranium complexes supported by soft bis(azolyl)borate ligands (Fig. 1),

including the first homoleptic 3- H,S,S’ -based f-element complexes [3].

Figure 1. Reactions of [UIII{3-H,S,S’-H(Ph)B(timMe)2}2I(thf)2] with oxidizing substrates.

These studies have a fundamental nature and do not address UN’s Sustainable Development Goals

directly. Nonetheless, we expect to continue participating in the progress of uranium chemistry and

contribute to the understanding of the structure and bonding in actinide systems and, therefore,

contribute to the resolution of “Environment” concerns.

References: [1] Liddle, S. T. Angew. Chem. Int.Ed., 2015, 54, 8604-864. [2] Maria, L.; Domingos, A; Santos, I.

Inorg. Chem., 2001, 40, 6863-6864. [3] Maria, L.; Santos, I. C.; Santos, I. Dalton Trans. (Invited article: New

Talent: Europe), 2018, 47, 10601-10612.

Funding:

Fundação para a Ciência e a Tecnologia (FCT, Portugal) through the project UID/Multi/04349/2013 and the FCT

Grant SFRH/BPD/101840/2014 (LM).

Keywords: f-Elements, Coordination chemistry, Uranium, Uranyl, Hydrobis(mercaptoimidazolyl)borates


72


11TH DECEMBER 2018

P25 | Gas-Phase f-Element Chemistry Studies

Thematic Strands:

Advanced Materials


C2TN members: Joaquim Marçalo*, Bernardo Monteiro (IST-ID Contract), João P. Leal, Joaquim B.

Branco, José M. Carretas, Leonor Maria (IST-ID Contract)


Research group:

QEf | f-Element Chemistry Group

For some years, we have been using FTICR and QIT mass spectrometry to examine the gas-phase ion

chemistry of the lanthanides from La to Lu (except Pm) and the actinides from Th to Cm. We have

revealed new f-element species, determined thermodynamic properties of neutral and ionic

molecules, and, in the case of the actinides, probed the role of 5f electrons in bonding and the issue

of covalence.

We will present some examples from current studies that comprise: the reactivity of uranium oxide

anionic clusters with methanol, including kinetics and mechanistic studies; the hydrolysis of

lanthanide oxide nitrate anions to probe high oxidation states in the 4f series, namely the access to

uncommon Pr(V); and the activation of small hydrocarbons by lanthanide, thorium and uranium oxide

anions that involve radical oxygens.

These studies have a fundamental nature and do not address UN’s Sustainable Development Goals

directly. Nonetheless, we expect to continue participating in the progress of f-element chemistry

and, therefore, contribute to the resolution of “Energy” and “Environment” concerns.

Collaborations:

1 John K. Gibson | Lawrence Berkeley National Laboratory, Berkeley, USA

2 Nuno A. G. Bandeira | BioISI - FCUL, Lisboa, Portugal

Funding:

FCT projects PTDC/QEQ-QFI/6430/2014 and UID/Multi/04349/2013

FCT grant SFRH/BPD/101840/2014

RNEM – Portuguese Mass Spectrometry Network, ref. LISBOA-01-0145-FEDER-022125, supported by FCT and the

Lisboa Regional Operational Programme (Lisboa2020), under the PT2020 Partnership Agreement, through the

European Regional Development Fund (ERDF)

Keywords: Ion Chemistry, Mass Spectrometry, Uranium Oxide Clusters, Praseodymium(V), Hydrocarbon

Activation


73


11TH DECEMBER 2018

P26 | Ln-Based Compounds: From Magnetism To Optical Sensing

Thematic Strand:

Advanced Materials

C2TN members: Bernardo Monteiro1,* (IST-ID contract), Joaquim Marçalo1, João P. Leal1, Joana T.

Coutinho2, Laura C.J. Pereira2, Manuel Almeida2


Research groups:


Optical Sensor

Based on the interaction of trihexyltetradecylphosphonium cation (P6,6,6,14)+ with a β-diketonate

(1,1,1,2,2,3,3-heptafluoro-7,7-dimethyloctane-4,6-dionate - FOD) of an Europium(III) tetrakis-β-

diketonate complex we present and discuss an equilibrium reaction with pronounced solvent effect

between ethanol and methanol on Eu(III) luminescence, allowing detection and quantification of

methanol in mixtures of both solvents (Figure 1). The developed spectrofluo-rimetric method provides

a faster and low-cost quality test to detect and quantify methanol with limit of detection of 15%

(w/w).

Figure 1. Calibration curve for methanol estimation in ethanol/methanol mixtures. χ molar fraction of

methanol in ethanol

Single Molecule Magnets

Three layered lanthanide hydroxides (LLHs), with the general formula Ln8(OH)20Cl4·nH2O (Ln = Tb (1),

Ho (2), Er (3)), were prepared and magnetically characterized both as pure compounds and diluted

within a yttrium diamagnetic matrix, LYH:xLn, LYH:0.044Tb (1’), LYH:0.045Ho (2’), and LYH:0.065Er

(3’) . This study was complemented with theoretical calculations in order to understand the electronic

configuration and the contributions to the slow relaxation behavior. In the pure compounds dominant

3D ferromagnetic interactions are observed, with a small magnetization hysteresis at 1.8 K for 1,

while the magnetically diluted solid solutions display slow relaxation of the magnetization at low

temperatures.

Molar fraction (χ)

Inte

ns

ity

(a.u

.)

y = 0,0306x + 0,0187

R² = 0,9028

y = 0,0819x + 0,0083

R² = 0,9993LOD= 0,207

0

0,01

0,02

0,03

0,04

0,05

0,06

0,07

0,08

0,09

0,1

0 0,2 0,4 0,6 0,8 1


74


11TH DECEMBER 2018

Figure 2. Experimental and semi-empirical calculations allowed to correlate Ln electronic configurations and

the diversity of different magnetic behaviors of these LLHs.

Collaborations:

Cláudia C.L. Pereira1, Tiago Moreira1, Mani Outis1, César T. Laia1, Filipe A.A. Paz2, Ricardo F. Mendes2, José J.

Baldovi3

1 LAQV-REQUIMTE | Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa, 2829-516 Caparica,

Portugal

2 CICECO | Complexo de Laboratórios Tecnológicos, Campus Universitário de Santiago, 3810-193 Aveiro,

Portugal

3 MPSD | Max Planck Institute for the Structure and Dynamics of Matter, Luruper Chaussee 149, D-22761

Hamburg, Germany

Funding:

We thank the Fundação para a Ciência e a Tecnologia (FCT) for financial support through the

UID/Multi/04349/2013 project (C2TN), UID/QUI/50006/2013 (LAQV-REQUIMTE), grants to J.T.C.

(SFRH/BD/84628/2012) and C.C.L.P. (SFRH/BPD/108959/2015) and contract to BM (contract nº IST-ID/077/2018).

We thank the EU for project “SunStorage- Harvesting and storage of solar energy” (POCI-01-0145-FEDER-016387),

funded by European Regional Development Fund (ERDF) and co-financed by the ERDF under the PT2020

Partnership Agreement (POCI-01-0145-FEDER – 007265), through COMPETE 2020 - Operational Programme for

Competitiveness and Internationalization (OPCI), COST Action CA15128 MOLSPIN and ERC-2014-CoG-647301

DECRESIM) and the Spanish MINECO (Unit of excellence “Maria de Maeztu” MDM-2015-0538). J.J.B. thanks the EU

for a Marie Curie Fellowship (H2020-MSCA-IF-2016-751047).

Keywords: Optical Sensors, Ionic Liquids, Single Molecule Magnets, Lanthanides, Layered Lanthanide Hydroxides

75


11TH DECEMBER 2018

P27 | Neutrability: Soluble Neutral Materials For Molecular Electronics

Thematic Strand:

Advanced Materials

C2TN members: Dulce Belo* (IST-ID contract), Sandra Rabaça (IST-ID contract), Rafaela A.L. Silva

(C2TN fellowship), Isabel C. Santos, Elsa B. Lopes, Laura C.J. Pereira, Manuel Almeida,

Students: Mariana Velho (PhD)


Research group:


The main purpose of this research line, in the scope of C2TN’s Solid State Group activities, is the study

of Single Component Molecular Conductors (SCMC) by designing and preparing new and more soluble

members of this still petite family and persevere in their testing as the base component in electronic

devices. In addition to the multifunctionality, lightness and transparency commonly found in all other

Molecular Materials, SCMC offers the simplicity of involving only a neutral molecule to be designed

and processed. The strategy to overcome the insolubility drawback of SCMC has been their

functionalization with “soluble” substituent group (alkyl, halogen, …). Several processing techniques

have been tested and selected. The starting point of this line off research was the family of neutral

transition metal complexes based on bisthiophenedithiolene ligands, that besides being one of the

families comprising more examples of SCMC, this family also includes the two known successful

attempts to process SCMC: it was showed that thin films, prepared by self-metallizing polycarbonate

films with a SCMC are strain-resistive materials with advanced elastic properties, making them

potentially useful for engineering flexible, lightweight, strain and pressure sensors; another SCMM

proved is ability to be used as conductive ink, with a resistance of ~0.3 kΩ/sq, one order of magnitude

better than commercial carbon based conductive inks. An outline of the research accomplishments

and future work perspectives will be outlined. This line of research has contribute to ODS 3, 4, 9 and

11.

Collaborations:

1 C. Rovira, Marta Mas | ICMAB (CSIC), Bellaterra, Spain

2 D. Simão, M.T. Duarte | CQE-IST, Lisboa, Portugal

3 M. Fourmigué, D. Lorcy | Institut des Sciences Chimiques de Rennes, Rennes, France

4 Helena Alves | CICECO Universidade de Aveiro, Portugal

Funding:

FCT: PTDC/QUI-QIN/29834/2017 and UID/Multi/04349/2013.

Keywords: Single Component Molecular Metals, Synthesis, Transition Metal Bisdithiolates, Molecular Sensors,

Transport Properties, Molecular Designing


76


11TH DECEMBER 2018

P28 | Thermoelectric Materials For Energy

Thematic Strand:

Advanced Materials

C2TN members: Elsa B. Lopes*, António P. Gonçalves

Students: Duarte Moço (PhD), Helena C. M. Ferreira (BSc), Gonçalo Domingos (BSc)


Research group:


Thermoelectric materials are able to convert heat into energy and vice-versa. This allows, for

instance, the recovery of waste heat that can be converted back into energy or the use of these

systems for specific cooling applications. A thermoelectric module is constituted by a number of legs

of both p-type and n-type compatible high zT materials. The search for new thermoelectric materials

continues because the current efficiencies of these materials are still low, they are mostly based in

toxic and non abundant elements and therefore the costs are still high for more disseminated use.

Recently we have focused our attention on the non toxic and cheap promising tetrahedrite-based p-

type materials. Tetrahedrites are copper sulfosalt minerals (Cu12Sb4S13 general formula) with good

thermoelectric properties after proper dopping. We have concentrated our attention in double

substituition the tetrahedrite with a transition metal and Se (M= Co, Mn, Fe, Ni, Zn) Cu12-xMxSb4S13-

ySey using different preparation methods. The best results of these studies will be presented. The

final objective of this work, in collaboration with several other groups, is to develop a cheap “green”

thermoelectric module with high efficiency.

Collaborations:

1 Prof. Edgar C. Fernandes, IN+, Dept. Mech. Engineering, Instituto Superior Técnico, Lisbon, Portugal

2 Prof. Pedro M. Amaral, Dept. Mech. Engineering, Instituto Superior Técnico, Lisbon, Portugal

3 Prof. Francisco Brito, Dept. Mech. Engineering, University of Minho, Guimarães, Portugal

4 Dr. Filipe Neves, Unid. de Energias Renováveis e Int. de Sist. de Energia, LNEG, Lisbon, Portugal

5 Prof. Theodora Kyratsi, Dept of Mech. and Manufacturing Engineering, Univ. of Cyprus, Nicosia, Cyprus

6 Prof. Bertrand Lenoir, Institut Jean Lamour, UMR 7198 CNRS, Université de Lorraine, Nancy, France

7 Prof. Judith Monnier, Institut de Chimie et des Matériaux Paris-Est, Université Paris-Est, Thiais, France

Funding:

M-ERA.NET Project, Sustainable Thermoelectric Modules based on Non-toxic Silicides and Sulphides for

Recovery of Waste Heat to Power Generation, THERMOSS, 2017-2020

FCT project “LocalEnergy”, PTDC/EAM-PEC/29905/2017

Keywords: Thermoelectrics, Tetrahedrites, Waste energy, Sustainable development


77


11TH DECEMBER 2018

P29 | Slow Relaxation Of Magnetization In Molecular Materials

Thematic Strand:

Advanced Materials

C2TN members: Laura C.J. Pereira2,*, Ana C. Cerdeira2 (FCT), Andreia A. Rosatella2 (FCT), Manuel

Almeida2, Joana T. Coutinho2 (PhD), Bernardo Monteiro1 (IST-ID contract)

Students: Maria Susano (PhD); Patrícia Ferreira (PHD)


Research groups:


Over the past decades, progressive research in the Inorganic Chemistry community has allowed the

synthesis of exciting new classes of molecular materials with unique magnetic properties. A

subsequent interdisciplinary effort led this investigation to three main potential candidates to be

developed as nanoswitch or nanomemory devices: spin crossovers, single molecule magnets and single

chain magnets. Single molecule magnets (SMMs) are widely considered the class that shows the most

promising features for remarkable potential applications since they behave as traditional magnets,

although instead of originating in magnetic domains their slow relaxation of the magnetization is of

purely molecular origin. Below a certain temperature, these molecules show slow relaxation of the

magnetization, which arises from the behavior of individual isolated molecules, functioning as

molecular nanomagnets. The intense research on SMMs can be translated in the fast growth of this

class of materials, since they explore the interplay between classic and quantum effects. In

spintronics they can find applicability in ultra-high-density information storage with each bit stored

as the magnetization orientation of an individual molecule, and as quantum bits for quantum

computing.

Driven by this interesting physics, investigations on d and f-SMMs have been carried out allowing to

study their characteristics which depend on the combination of the single-ion anisotropies of the

metal centers involved as well as on the presence of d or f exchange interactions. These surveys rely

on the magnetic characterisation of these compounds and the modelling of these properties by

quantum chemistry calculations. The impact of our research in this area has continued to grow

contributing to elucidate the behaviour of molecular magnets. Its success can be translated in the

scientific collaborations forged with some of the most relevant international groups in the area of

molecular magnetism, as well as through the high impact level of the peer-review publications.

Collaborations:

Manuela Ramos Silva - CFisUC, Departamento de Física, Universidade de Coimbra, Rua Larga, P-3004-516

Coimbra, Portugal

Pedro Teixeira Gomes - Centro de Química Estrutural, Departamento de Engenharia Química, IST, Universidade

de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal

Paulo Nuno Martinho - Centro de Química e Bioquímica, FCUL, Universidade de Lisboa, Campo Grande, 1749-

016 Lisboa Portugal

Hélène Bolvin - Laboratoire de Chimie et Physique Quantiques, Université Toulouse III, 118 route de Narbonne,

31062 Toulouse, France

Pablo Martín-Ramos - EPS, Instituto Universitario de Ciencias Ambientales de Aragón (IUCA), Universidad de

Zaragoza, Carretera de Cuarte s/n, 22071, Huesca, Spain

Stephen Hill and Dorsa Komijani- Department of Physics and National High Magnetic Field Laboratory, 1800 E.

Paul Dirac Drive, Tallhassee, FL 32310, USA


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11TH DECEMBER 2018

William P. Gillin and Peter B. Wyatt - Materials Research Institute and School of Biological and Chemical,

Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK

Eugenio. Coronado - Instituto de Ciencia Molecular, Universitat de València, C/Catedrático José Beltrán 2, E-

46980 Paterna, Spain

J.J. Baldoví - Instituto de Ciencia Molecular, Universitat de València, C/Catedrático José Beltrán 2, E-46980

Paterna, Spain; Max Planck Institute for the Structure and Dynamics of the Matter, Hamburg, Germany

Mauro Perfetti - Dept. Chemistry University of Copenhagen, Universitetparken, 5, 2100 Copenhagen, Denmark

Joris van Slageren and Philipp P. Hallmen - Institut für Physikalische Chemie, Universität Stuttgart

Pfaffenwaldring 55, 70569 Stuttgart, Germany

Amir Hen and Andrei Rogalev - ESRF, The European Synchrotron, Grenoble, France

Funding:

FCT projects (UID/Multi/04349/2013; and grants (ChemMat PD/0045/2013; ChemMat PD/BD/135530/2018; PD

BL57/2018_IST-ID; BL58/2018_IST-ID; SFRH/BD/84628/2012), European Institute of Molecular Magnetism

(EIMM), ECOST-CA15128 MOLSPIN

Keywords: Molecular Magnetism, Anisotropy, Single-Molecule Magnets, Nanomagnetism, Spintronics

79


11TH DECEMBER 2018

P30 | Self Assembled Bilayer Molecular Metals (CNB-EDT-TTF)4X;

Polymorphism And Superconductivity

Thematic Strand:

Advanced Materials

C2TN members: Sandra Rabaça* (IST-ID contract), Vasco Gama, Rafaela. A. L. Silva, Elsa B Lopes,

Isabel C. Santos, Manuel Almeida

Students: Sandrina Oliveira (PhD), Cristina Gonçalves (PhD), Afonso Varatojo (BSc), Gonçalo Lopes


Research group:


A novel type of 2D electronic systems based on radical cation salts with a donor bilayer structure was

recently described by our team in radical cationic salts of an electronic donor asymmetrically

substituted with CN groups (CNB-EDT-TTF). These bilayer systems provide a new model for 2D

electronic systems, intermediate between single layer and 3D solids, exhibiting unique properties

associated with a direct coupling between two adjacent layers of partially oxidised donor molecules

interconnected by relatively weak but direct interactions. These interactions are induced by head-

to-head donor pairing interactions associated with an effective combination of R22(10) and R2

4(10)

synthons of C−N···H interactions [1,2]. Different polymorphs of salts with the 4:1 stoichiometry, (CNB-

EDT-TTF)4X depending on the solvent and crystallization conditions, have been obtained with several

small anions such as X= ClO4-, BF4

-, ReO4-, PF6

-, AsF6-, SbF6

-, I3-, AuI2

-, … [3,4,5]. These 4:1 salts present

2D metallic properties with unusual characteristics derived both from the unusual stoichiometry and

the weak interaction between paired donor layers. Depending on the crystal packing different physical

properties, including superconductivity, can be obtained. However in spite significant exploratory

work already undertaken the different compositions, crystal structures and physical properties of

these bilayer systems remain far from being fully explored and well understood.

The formation of bilayer structures with different anions, including paramagnetic anions, or based on

related dissymmetric donors capable of comparable interactions is currently being explored, and the

study of their physical properties, including the anisotropy and coherenece of electrical transport will

constitute a topic of intensive research during the next few years. The results, due to the originality

of these structures, and uniqueness of these 2D electronic systems, intermediate between single layer

and 3D solids, are expected to have a large impact in the understanding of low dimensional molecular

conductors and superconductors.

References: [1] S. Oliveira, D. Belo, I.C. Santos, S. Rabaça, M. Almeida Beil. J. Organic Chemistry 2015, 11, 951-

956. [2] S. Oliveira, J. Ministro, I.C. Santos, D. Belo, E.B. Lopes, S. Rabaca, E. Canadell, M. Almeida Inorg.

Chem. 2015, 54, 6677−6679. [3] S. Rabaça, S. Oliveira, V. Gama, I.C. Santos, D. Belo, E.B. Lopes, E. Canadell, .

Almeida Inorg. Chem., 2016, 55, 10343-10350. [4] S Rabaça, S. Oliveira, A.C. Gonçalves, V. Gama, I.C. Santos,

D. Belo, M. Almeida Cryst. Growth Design, 2017, 17, 2801−2808. [5] S. Rabaça, S. Oliveira, V. Gama, I.C. Santos,

G.Oliveira, E.B. Lopes, E. Canadell, M. Almeida Crystals 2018, 8, 142.

Collaborations:

1 J.A. Paixão | Departamento de Física-Univ. Coimbra, Coimbra, Portugal

2 E. Canadell | ICMAB (CSIC), Bellaterra, Spain


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11TH DECEMBER 2018

Funding:

FCT through contracts, C494247114-00091874. LISBOA-01-0145-FEDER-029666, ID/MULTI/04349/2013 and

RECI/QEQ-QIN/0189/2012 and grants SFRH/BPD/113344/2015, SFRH/BD/72722/2010 and

SFRH/PD/BD/127804/2016, to S. Rabaça, S. Oliveira and C.Gonçalves, respectively

Keywords: Bilayer Molecular Metals, Dissimetric Organic Donnors, Organic Conductors, Superconductors

81


11TH DECEMBER 2018

P31 | The Importance Of Cation-Anion Interaction In The Spin

Crossover Phenomenon: Structural And Magnetic Correlations In

[Fe(nsal2trien)] Salts

Thematic Strand:

Advanced Materials

C2TN members: Bruno J.C. Vieira* (C2TN contract), Vasco da Gama, Isabel C. Santos, Laura C. J.

Pereira and João C. Waerenborgh


Research group:


The evolution of electronics in the last 50 years has been the backbone of the colossal improvement

in various areas of society, such as health, transportation, agriculture, telecommunications,

education, etc. One of the main challenges of the new era of electronics is to reproduce at a molecular

level spintronic devices, which bring the benefits of smaller component size and a new range of

properties that can be readily tuned. For this purpose, molecular materials containing inexpensive

iron are presently the most studied systems. The spin crossover (SCO) phenomenon is one of the most

spectacular examples of molecular bistability and is quite promising for possible use in molecular

electronics or switches. It has been observed in some octahedral first row transition metal complexes

with electronic configurations from d4 to d7 and takes place when there is an energy difference

between a high-spin (HS) state and a low-spin (LS) state of the order of kT, (k is the Boltzmann

constant). Switching between spin states on a molecular level leads to distinctive changes in colour,

structure and magnetism, which can be driven by changes in temperature, pressure, and in some

cases by light irradiation.

We report the relevance of cation–anion and cation–solvent–anion interactions to the crystal lattice

rigidity and the corresponding effect on the SCO behaviour of six iron(III) complexes with the

hexadentate Schiff base ligand nsal2trien. These compounds were synthesized and structurally and

magnetically characterized by multiple techniques such as single crystal X-Ray diffraction,

magnetometry measurmentes in a SQUID and Mössbauer spectroscopy. In the most rigid structures,

the SCO behaviour is either not allowed or severely hampered. For lower structural connectivity,

incomplete transitions are observed within the 4–300 K temperature range. The most flexible

structure shows a complete transition. The interactions between the cationic units and the anions

were found to be more important than the cation–cation interactions for the SCO phenomenon and

for the overall cooperativity related to the abrupt/gradual character of the transition. Computational

studies were performed in order to determine the crystal splitting gap Δoct. The calculated values

for the HS and LS Δoct are very similar for all compounds suggesting that these parameters have very

little influence on the SCO behaviour. This study allowed to deepen the knowledge of the mechanics

that control the spin transition as well as to approach the creation of guidelines for the intelligent

design of SCO materials.

Collaborations:

Nuno A. G. Bandeira1,2,3

1 Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Spain

2 Centro de Química e Bioquímica – Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal

3 Centro de Química Estrutural – Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal


82


11TH DECEMBER 2018

Funding:

Research funded by Fundação para a Ciência e a Tecnologia (FCT, Portugal) through the project

UID/Multi/04349/2013

Keywords: Magnetic Materials, Iron(III), Spin Crossover, Switchable Materials, Spinctronics

83


11TH DECEMBER 2018

P32 | Outreach Group Of C2TN: Sharing Science With Society

C2TN members: Dulce Belo5,6,* (IST-ID Contract), Ana Catarina Antunes6 (IST-ID Fellowship), Nuno

Canha4,6 (IST-ID Contract), Marta F. Dias6 (IST-ID Fellowship), António N. Falcão3,6, Joana F.

Guerreiro1,2,6 (IST-ID Fellowship), Margarida Oliveira6** (IST-ID Fellowship)


* From June 2017 to May 2018

Research groups:

1 RS | Radiopharmaceutical Sciences Group, 2 RPS | Radiation Protection and Safety Group, 3 REI |

Radiation, Elements and Isotopes Group, 4 NET | Nuclear Engineering and Techniques Group, 5 ES |

Solid State Group, 6 GO | Outreach Group

The C2TN's Outreach Group (GO) was formally created in 2018 with 3 main objectives: (i) to promote

and disseminate the relevance of the research, development and innovation activities and services

provided by C2TN for the society and scientific communities, thus promoting the various aspects of

scientific culture and knowledge; (ii) to increase the visibility of C2TN in national and international

events and in social media; (iii) to encourage collaborative and cooperative links between C2TN and

various stakeholders and actors in the academic, scientific, business, industrial and health fields.

In this communication, an overview of the outreach activities developed in 2018 will be outlined,

highlighting the participation in several events: (a) Loures InSS 2018, (b) Encontro Ciência 2018 and

the (c) Noite Europeia dos Investigadores 2018. Living up to the motto "Radiation for Science and

Society", GO launched the blog "O Alfabeto das Radiações", directed mainly to the non-scientific

communities that are interested in Science and scientific answers. GO was also committed with the

dinamization of many other C2TN's Social Media platforms, such as its official site, Facebook or

LinkedIn. The present communication will also include an outline of the future activities of GO,

namely the "Cientificamente Provável" project which aims to bridge the gap between high schools

and University Research Units. This project intends to motivate young people to pursuit their high

education degrees and the students' interest for science at an initiate level.

Collaborations:

Ciência Viva | Agência Nacional para a Cultura Científica e Tecnológica, Lisboa, Portugal

Agrupamento de Escolas da Bobadela

Escola Secundária Fernão Mendes Pinto – Almada

Funding:

FCT - UID/Multi/04349/

Keywords: Outreach, Social Media, Science for Society, Scientific Culture, Science Promotion


radiation for science and society · 2019. 1. 10. · 11 4 2nd workshop c2tn: radiation for science...

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