Zonerab

Rabeprazole 20mg

Gastric Disorders

Brief Outlook

Gastric Disorders

Some terms• GERD• Heartburn• Duodenal Ulcer• Zollinger-Ellison Syndrome• None Erosive Esophagitis

GERD

• Gastroesophageal reflux disease (GERD) is a chronic digestive disease. GERD occurs when stomach acid or, occasionally, stomach content, flows back into food pipe (esophagus). The backwash (reflux) irritates the lining of esophagus and causes GERD.

Heartburn

• Heartburn is a burning pain in chest, just behind your breastbone. The pain is often worse when lying down. It happens when stomach acid backs up into your esophagus, the tube that carries food from mouth to stomach.

Duodenal ulcers.

• Ulcers that occur in the stomach are called gastric ulcers. Ulcers that occur in the upper area of the small intestine, which is called the duodenum, are called duodenal ulcers.

Ulcers caused by Helicobacter pylori infection

Zollinger-Ellison syndrome

A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach, and the upper portions of the small intestine (the duodenum and jejunum).

Zollinger-Ellison syndrome

Action of Rabeprazole

Rabeprazole is a selective and irreversible proton pump inhibitor. Rabeprazole suppresses gastric acid secretion by specific inhibition of the hydrogen-potassium adenosine triphosphatase (H+, K+-ATPase) enzyme system found at the secretory surface of parietal cells. It inhibits the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen. Since the H+, K +-ATPase enzyme system is regarded as the acid (proton) pump of the gastric mucosa, rabeprazole is known as a gastric acid pump inhibitor.

Facts about Rabeprazole

• Almost 100% inhibition of proton pump within

5 minutes• » Greater antisecretory effect over a 24 hour

period campared to• other PPIs• » Mimimum drug to drug interactions• » Small tablet size for easy swallowing

Zonerab Dosage

• The recommended adult dose of rabeprazole is 20 mg, taken once daily Or as directed by the physician.