PW044 Predictors of in-hospital outcome in takotsubo cardiomyopathy – A multicenter study

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<ul><li><p>POST</p><p>ERABST</p><p>RACTSIntroduction: It has been shown that high intensity training is more effective in treatingpatients with heart failure (HF) however studies havent been evaluated sexual function.Objectives: To compare moderate versus high intensity exercise with regard to sexual andcardiorespiratory function.Methods: Twenty patients with stable HF (aged 53.25 8.87 years), left ventricle ejectionfraction 45%, were randomized to moderate continuous training (MCT) or high-in-tensity interval training (HIT). The subjects underwent 12 weeks of exercise training, threetimes per week, in MCT target zone of heart rate (HR) corresponding to anaerobicthreshold (rst ventilatory threshold) and in HIT the HR corresponding to respiratorycompensation point (second ventilatory threshold) alternating with HR corresponding toanaerobic threshold (recovery period). Patients underwent assessment of sexual function bythe International Index of Erectile Function (IIEF), determination of VO2 peak by car-diopulmonary exercise testing (CPET), determination of distance walk by the six-minutewalk test (6MWT) and assessment of endothelial function by Doppler echocardiography. Instatistical analysis was used Shapiro-Wilk test, Chi-square (x2), Fisher exact test, t test,Mann-Whitney U and paired t test, with signicance level of 5%.Results: Only in HIT was observed increase in erectile function (11 10.46 to 19.55 9.07, p 0.030), desire (from 4.77 2.04 to 6.88 2.08, p 0.034), sexual satisfaction(from 4.00 4.63 to 8.33 5.36, p 0.017) and VO2 peak (from 21.07 4.30 to 23.79 5.26, p 0.021) while in MCT was no signicant changes in these outcomes. Distancewalked in 6MWT increased after MCT (462.63 63.10 to 603.45 67.50, p 0.003)and HIT(456.44 38.51 to 589.66 59, 69, p 0.008). No signicant changes occurredin endothelial function (HIT: +43.6%, p 0.666; MCT:+193%, p 0.214).Conclusion: High-intensity training was superior than MCT for increase sexual andcardiorespiratory function in patients with heart failure.Disclosure of Interest: None Declared</p><p>PW042</p><p>Predictors of Mortality in Patients With Hypertrophic Cardiomyopathy - A HospitalAdmissions Study: 2000-2013</p><p>Niece K. Khouw1, Mohammed Wasim1, Hardeep Uppal2, Suresh Chandran3, Rahul Potluri*41General Medicine, Pennine Acute Hospital NHS Trust, Manchester, 2Coventry andWarwickshire Partnership NHS Trust, Coventry, 3Acute Medicine, Pennine Acute Hospital NHSTrust, Manchester, 4ACALM Study Unit in collaboration with School of Medical Sciences, AstonUniversity, Birmingham, United Kingdom</p><p>Introduction: Hypertrophic Cardiomyopathy (HCM) is a rare condition that can beassoociated with sudden cardiac death. The predictors of mortality in patients with HCMhas not been well studied.Objectives: The aim of this study is to investigate the predictors of mortality in patientswith HCM from a large sample of hospital admissions.Methods: Anonymous information on patients with Hypertrophic Cardiomyopathy, co-morbidities and procedures attending large multi-ethnic general hospitals in Manchester,United Kingdom in the period 2000-2012 was obtained from the local health authoritycomputerised hospital activity analysis register using ICD-10 and OPCS coding systems.Statistical analysis was performed using SPSS version 20.Results: Out of 1,221,216 patients admitted, there were 253 patients with HCM. Themean age of 55.8years18.8(S.D) with 63.2% male patients VS 36.8% female patients. Themain co-morbidities were Hypertension (86;34.0%), Atrial Fibrillation (69;27.3%), HeartFailure (27;10.7%), Type 2 Diabetes Mellitus (24;9.5%), Ventricular Tachycardia(16;6.3%), Debrillator Implant (16;6.3%). A multi-nominal logistic regression modelaccounting for variations in age, sex and ethnic group showed that only Atrial Fibrillation(RR3.8;C.I1.7-8.1) and Heart Failure (RR5.0;C.I1.9-13.5) are signicant predictors ofmortality (p </p></li></ul>


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