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CompanyFil lers catalogue
01
whowe are
Neauvia, present in morethan 70 countries worldwide,
is the main licensor of Matex Lab:the filler and cosmeceutical company headquartered in
Lugano, with subsidiariesin Italy and Poland.
Neauvia has been operating
since 2012 with expertise in
the areas of:
• Injectable, such as dermal fillers and biorevitalizers
• Anti-aging and lenitive creams
• Tissue regeneration systems and healing serums with sterile masks.
Neauvia stands for
innovation and safety and
the high quality standards
are guaranteed by the use
of the highest quality raw
materials and advanced
manufacturing technology.
Fil lers catalogue
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The core business of the company consists of a range of fillers Polyethylene glycol (PEG) crosslinked - an outstanding new technology able to give the products a high safety and tolerability profile.
Each reference of the filler line has a specific rheology, due to the particular chemical geometry and the real polymeric technology, to be effective and perfectly integrated in different anatomical planes.
To complete the treatment with fillers, Neauvia offers a complete range of professional skin care products that prolong the effects of filler therapy.
Thanks to its wide portfolio of products, the brand is able to satisfy the need of the most demanding doctors and patients.
Company
o7o6
vision &MISSION
Company
To create valuefor the science, the society, our team
and our company.
Fil lers catalogue
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Fil lers catalogue
the new 2nd
g e n e r at i o nof ha fillers
Neauvia range of fillers are biomimetic. Thanks to the
PEG-cross-linked technology, they have an high
safety and tolerability profile.
Each Neauvia filler reference is based on a specific
combination of HA and PEG for different indication
and injection planes.
Neauvia fillers bring many benefits:
• High level of biocompatibilty;• Optimal biointegration;• Optimal rheological ratio.
o9
Neauvia fillers are biomimetic.
Company
1110
neauviais highly
biocompatible(1,2)
Neauvia fillers are based onPEG-cross-linked technology.
Biocompatibility depends on how fillers are stabilized. The scientists working on Neauvia
fillers decided to apply not a common molecule, but a new crosslinker: PEG polymer.
Polyethylene glycol is a gold standard of a biocompatible polymer for pharmaceutical,
cosmetic and medical use.
Biocompatibil ity
(1) Zerbinati N, Rauso R, Gonzalez P et al. In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid PEG cross-linked with micromolecules
of calcium hydroxyapatite in low concentration.Journal of biological regulators & homeostatic agents 2017; 31(2): 87-90.
(2) Lam J,Truong NF, Segura T. Design of cell-matrix interactions in Hyaluronic acid hydrogel scaffolds. Acta Biomater. 2014; 10 (4): 1571-1580.02
13
PEG OUTSTANDING ADVANTAGES
FOR SAFETY AND LONGEVITY
PEG is recognized as a
biodegradable low molecular
weight polymer(<400 Da), so
in vivo can be degraded by alcohol dehydrogenase (3,4,5).
Metabolism studies with PEG
have demonstrated that there
is no evidence of ethylene
glycol formation in animals
and humans (6).
metabolismof peg
• Non-toxic (7)
• Reduces the action of the proteolytic
enzymes (e.g. hyaluronidase),
increasing the duration of the implant (8)
• Reduces the immunological response,
the implant is not recognized as a foreign body (7)
• Non-immunogenic polymer (7)
• It has been proven that the products
have not pro-sensitization activity (9)
• Less edema than BDDE (10)
• Lower need to repeat injection
after the first treatment
(3) Webster R, Didier E, Harris P et al. PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies.Drug Metab Dispos 2007; 35: 9-16.
(4) Baumann A, Tuerck D, Prabhu S et al. Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins:quo vadis? Drug Discov. Today 2014; 10: 1623-1631.
(5) Markovsky E, Baabur-Cohen H, Eldar-Boock A et al. Administration, distribution, metabolism and eliminationof polymer therapeutics. J. Control. Release 2012; 161: 446-460.
(6) Fruijtier-Pölloth C. Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. Toxicology 2005. 214; 1-38.
(7) Lam J. Truong Nf, Segura T. Design of cell matrix interation in Hyaluronic Acid hydrogel scaffolds. Acta Biomater. 2014; 10 (4): 1571-1580.
(8) Comparison of the sensitivity of 11 cross-linked Hyaluronic Acid gels to bovine testis hyaluronidase. Ibrahima Sall, Georges Férard. Laboratoire de Biochimie Appliqueé, Faculté de Pharmacie, Université Louis Pasteur, 74 Route du Rhin, BP 60024, F-67401 Illkirch Cedex, France” + data on file
“In vitro evaluation of the sensitivity of Hyaluronic Acid PEG-cross-linked to bovine testes hyaluronidase” UB-Care, Spinoff University of Pavia.
(9) In Vitro Evaluation Of The Pro-Sensitisation Activity Of An Injectable Medical Device (Intense e Intense Flux). UB-Care, Spinoff University of Pavia.
(10) Mechanical Improvement of Hyaluronic Acid (HA) Hydrogels and Incorporation of Polyethylene Glycol (PEG) Ho-Yong Lee, Seol-Ha Jeong,Jae-Uk Baek, Ju-Ha Song, Hyoun-Ee Kim*Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.
Biocompatibil ityFi l lers catalogue
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B IOCOMPAT IB I L I T YOF NEAUVIA F ILLERS IS SCIENT IF ICALLY PROVEN
Test report by UB-Care Spin-off of University Pavia (Italy).
Biocompatibil ity
Cytotoxicity evaluationof an injectable medical device on a cell
culture of human keratinocytes.
Test report MTT/16/ML2P5
Not cytotoxic activitywere observed.
Evaluation of cell morphologyon human keratinocytes cell culture
after treatment with an injectable
medical device.
Test report EE/16/ML2P5
The product does not induce alterations in cell morphology.
Cytotoxicity evaluationof an injectable medical device on a cell
culture of human keratinocytes.
Test report KB/16/ML2P5
Not cytotoxic activitywere observed.
Evaluation of cell viabilityof an injectable medical device on a cell
culture of human keratinocytes through
the live/dead assay.
Test report LAD/16/ML2P5
The product does not determine an alteration of cell viability under the experimental conditions.
Cytotoxicity evaluationof an injectable medical device on a cell
culture of human keratinocytes.
Test report NRU/16/ML2P5
Not cytotoxic activitywere observed.
Measurement of collagen synthesison a cell culture of human fibroblast
after treatment with an injectable
medical device.
Test report CLG/16/ML2P4
The product induced a statistically increase in the collagen production after treatment with the two concentrations tested after 24h treatment in human fibroblasts.
EVALUATIONS Test report OUTCOMES
cohesivityCompression Test
The ability of a gel to stick together and thereby to mantain gel integrity. It depends on the crosslinking used.
elastic modulusFrequency Sweep Test
The tendency of solid material to return to their original shape after being deformed.
viscosous modulusFrequency Sweep Test
It is a measure of resistance to flow in a fluid/semifluid. Adiacent layers move to parallel to eachother with different speeds.
plasticityStrain Sweep Test
The property to undergo permanent deformation under load.
optimalRHEOLOGICAL
RATIO (11,12,13,14)
The most common and most cited values to identify rheological property of an aesthetic hydrogel
are shown in the table below:
The optimal rheological ratio: soft gel for superficial injection layers and stiffer gel for deep injection layers.
17
Rheological ratio
03 (11) La Gatta A, De Rosa M, Frezza AM, Catalano C, Meloni M, Schiraldi c. Biophysical and biological characterization of a new line of hyaluronan-based dermal fillers:A scientific rationale to specific clinical indications . Materials Science and Engineering C 68 (2016) 565–572.
(12) Pierre S, Liew S, and Bernardin A. Basics of Dermal Filler Rheology. Dermatol Surg (2015);41:S120–S126.
(13) La Gatta A, Schiraldi C, Papa A, De Rosa M. Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation. Polymer Degradation and Stability 96 (2011) 630 e 636.
(14) Santoro S, Russo L, Argenzio V, Borzacchiello A. Rheological properties of cross-linked hyaluronic acid dermal fllers. J Appl Biomater Biomech 2011; Vol. 9 no. 2, 127-136.
1918
Strain Sweep Test
Linear Domain Crossover Point
G’(Pa) G”(Pa) tan ð y(%) τ (Pa) G’=G”(Pa)
INTENSE RHEOLOGY
270-320 80-100 0.30-0.40 1690-2070 1750-2150 70-80
INTENSE LIPS
320-380 100-120 0.30-0.40 1880-2200 2100-2500 75-85
INTENSE LV 370-430 110-140 0.30-0.40 1500-1880 1600-1970 70-80
SIMULATE 370-430 110-140 0.30-0.40 1500-1880 1600-1970 70-80
INTENSE 420-480 140-160 0.30-0.40 1940-2380 1600-1970 85-95
INTENSE ROSE
420-480 140-160 0.30-0.40 1940-2380 2300-2850 85-95
INTENSE FLUX
233-276 129-142 0.56-0.51 272-292 390-441 101-106
G*, the complex module, can
be divided into two variables:
G’ (elastic module) and G’’
(viscous module).
Thanks to the high G* and high coesivity of Neauvia products we can obtain many benefits.
Fillers with an high G* allow to achieve a better result using less product.
Fillers with an high G’ and
G’’ allow to obtain an higher
resistance to deformation
when implanted under the
skin while gels remain more
stable in volume: therefore
they have lower migration in the skin allowing much more natural results.
Fillers with high coesivity
allow to obtain a better
resistance to mechanical
chemical degradation and
prevent gel migration: thus
they have a better duration in the skin and maintain the initial shape of gel deposit.
Neauvia Intense for eg. has the highest coesivity compared to the other Neauvia products
besides having an optimal viscoelasticity.
Thanks to PEG features and to a precise techniqueof determining the molecular weight of HA,
Neauvia fillers have an optimal rheological ratio.
Fil lers catalogue
21
Our research team have published several
papers on the evolution over time of Neauvia
implant showing how Neauvia fillers have an
optimal distribution and integration in the
connective tissue of the skin.
Neauvia fillers distribute finely in the interstitial
tissue among constitutive structures of the
hypodermis and dermis, even into the smallest
spaces between collagen fibers, always
preserving the structural integrity of the skin.
Moreover, our research team have demonstrated both in vitro and in vivo the
absence of any adverse reaction.
Inflammatory cells surrounding the implant or closely associated with it have never
been found.
optimal tissue biointegration(15)
Morphological evidences have demonstratedthat Neauvia fillers have a great biointegration.
Figure 1
The common histological stain (H&E) is showing the filler implant (light blue) perfectly integrated in the connective tissue with collagen fibers, adipose tissue and ducts of sweat glands. No immunoreactions are present.
Figure 2
The implant,is clearly visible in the Alcian blue stained preparation. It appears finely distributed in the interstitial tissue, closely associated with dermis and hypodermis structures as gland ducts (encircled) and collagen fibres.
(15) Zerbinati N, D’Este E, Farina A et al. Morphological evidences following PEGylated filler treatment in human skin.Journal of biological regulators & homeostatic agents 2017; 31(S2): 79-85.
Tissue biointegration
04
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2322
The aging process gradually
deprives skin not only of
hyaluronic acid, but also of
collagen.
A solution that really prevents
the aging process is Neauvia
Stimulate: a unique product
which combines pure
hyaluronic acid of probiotic
origin (Bacillus Subtilis) cross-
linked with PEG (poly-ethylen
glycol) and micromolecules (8-12 microns only) of calcium
hydroxyapatite (CaHA), in low
concentration (1%).
The product could be
considered an “hybrid” filler (completely biocompatible
and biodegradable) with both volumizing effect and a
collagenesis activity.
Calcium hydroxyapatite
stimulates the skin self-
production of collage.
Thanks to the small size and low concentration of CaHA
molecules, Neauvia Stimulate fillers are extremely safe.
During the natural degradation
of the product, there is a release
of small particles of CaHA, few at times, that have the right
size to stimulate fibroblasts in producing not only collagen, but also elastin, glycosaminoglycans
and hyaluronic acid (16).
NEAUVIA FILLERS INTEGRATE SO WELL THAT A BIOLOGICAL
SCAFFOLD IS OBTAINED
Using Neauvia Stimulate skin density and elasticity are both improved and, in the meantime, there is a natural, continuous and long-lasting collagen
production thanks to the small size of the particles.
(16) Zerbinati N, Rauso R, Gonzalez P, Cherubino M, D’Este E, Calligaro A, Sommatis S, Maccario C, Mocchi R.In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid PEG cross-linked with micromolecules of calcium hydroxyapatite
in low concentration. J Biol Regul Homeost Agents. 2017 APR-JUN;31(2 Suppl. 2):87-90.
Tissue biointegration
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The maximum size of phagocytes is
around 55 microns, so they can’t eat
CaHA in particle fillers but create a
capsule around the particles. This does
not happen with Stimulate, thanks to its
small size of CaHA.
Moreover, Stimulate makes the CaHA
gradually available in 9 to 12 months,
stimulating collagen production by
signaling, after that phagocytes eat
CaHA particles.
IMAGE ANALYSIS AND COMPUTERIZED MORPHOMETRY
OF THE COLLAGEN PRODUCED
31,66
Control FollowingStimulate
2,18
26,06
10,52
0
5
10
15
20
25
30
35
Old Collagen Newly formed Collagen
ORIGINAL
Follo
win
g s
timul
ate
tre
atm
ent
Co
ntro
l
RED/ORANGE GREEN/YELLOW
Tissue biointegration
Fil lers catalogue
05 27
INTENSE
INTENSE LV
INTENSE Flux
Stimulate
Intense Lips
INTENSE RHEOLOGY
Intense Rose
hydro deluxe
VOLUMIZATION
LIFTING
BIOSTIMULATIONand lifting
shaper
Deep HydratIon
other
Fil lers catalogue
f i l l e rf o r h e r
26
Each reference of Neauvia filler line has a specific
rheology, due to the particular chemical geometry
and the real polymeric technology, to be effective and
perfectly integrated into different anatomical planes.
Thanks to its wide portfolio of products, the brand
is able to satisfy the need of the most demanding
doctors and patients.
Products
28 29
BENEFITS
• High concentration of HA and high viscoelasticity;• It gives fantastic volumetric results shapingthe injected area in the natural way.
CONCENTRATION
26 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Deep tissue restoration of volume & correction.It is suitable especially to deep filling of skin depression (included deep wrinkles and nasolabial folds), cheeks, chin and nose modelling, face contouring, in moderate and strongly aged skin.
BENEFITS
• Slow biodegradation and long lasting results;• Thanks to unique rheological properties,Intense is highly adaptive to the tissue; • Intense gives fantastic lift effect.
CONCENTRATION
28 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Deep tissue restoration of volume & correction.It is suitable especially to deep filling of skin depression (included deep wrinkles and nasolabial folds), cheeks, chin and nose modelling, face contouring and temples, in moderate and strongly aged skin.
EPIDERMAL EPIDERMAL
DERMAL DERMAL
SUBCUTANEOUS SUBCUTANEOUS
PERIOSTEUM PERIOSTEUM
This product contains a high concentration of hyaluronic acid - 26 mg/ml.
This product contains the highest available concentration of hyaluronic acid - 28 mg/ml.
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: SUBCUTANEOUS
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: SUBCUTANEOUS
intense lvintensEHigh viscoelasticity and high modelability. High viscoelasticity and high modelability.
| LIFTING | | LIFTING |
NEEDLE
21 GCANNULA
22 G
NEEDLE
21 GCANNULA
22 G
extrusion force
highextrusion force
medium/high
Fil lers catalogue
Fil lers catalogue Products
30 31
| biostimulation and lifting |
BENEFITS
• Multi task filler: possibility of use in different anatomical areas;• High concentration of HA and low viscoelasticity;• It gives fantastic volumetric results shaping the injected area in the natural way;• Thanks to the balanced crosslinking degree. It is highly adaptive to the tissue which helps to volumize the anatomic area.
CONCENTRATION
26 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Deep tissue restoration of volume in moderate and strongly aged skin. It is suitable for injection into the intradermal layer. Thanks to its viscoelastic properties, this product can correct areas of different consistency.
Intense Flux contains a high concentration of hyaluronic acid - 26 mg/ml.
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DERMAL
NEEDLE
27/30 G
intensE fluxLow viscoelasticity high biointegration.
extrusion force
low
| volumization |
BENEFITS
• Significant improvement in skin density level;• The product immediately fills the tissue deficits giving the desired shape and volume, gradually improving the quality of the skin;• Increment in neocollagenesis;• The neocollagenesis process permits a longer lasting correction.
CONCENTRATION
26 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
1% CaHA; Glycine and L-Proline
INDICATION
Deep filling of skin depression (included deep wrinkles and nasolabial folds), biostimulation and revitalisation.Stimulate is a perfect choice every time a patient is suffering from the lack of volume and density.
stimulateDouble action: combination of filling and biostimulation.
Neauvia Stimulate is a unique product, the only one which offers not only great filling effect but also a long term biostimulation. The 26 mg/ml of hyaluronic acid is complemented with 1% of calcium hydroxyapatite. Calcium hydroxyapatite used in Neauvia fillers has small particle size (8-12 microns) and is well spread in the cluster of the hydrogel. This assures stability of the particles that have no possibility to migrate. The small sizes of CaHA particles do not interfere with phagocytes activities and are gradually released during the degradation of the implant, not all at once. The safe and optimal concentration of CaHA is able to provide excellent results without creating side effects.
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DEEP DERMAL
NEEDLE
21 GCANNULA
22 G
extrusion force
medium/high
Fil lers catalogue Products
3535
BENEFITS
• Optimal amount of HA for natural effectand patient’s comfort;• This dedicate preparation gives special elasticity to the polymer’s chains and permit it to overcome the mechanical stress the lips are submitted to; • This improvement gives a natural touch perception.
CONCENTRATION
24 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Lips augmentation and modelling. Suitable for augmentation, contouring and revitalization of lips.
Intense Lips contains 24 mg/ml of hyaluronic acid to provide optimal results in delicate lips area.
| shaper |
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DEEP DERMAL
NEEDLE
27 G
intensE lipsHighly elastic and resistant.
extrusion force
medium
| SHAPER |
BENEFITS
• Natural correction of superficial and moderate wrinkles;• Specific rheological features to treat specificand difficult areas.
CONCENTRATION
22 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Fine line reduction, lip contouring, orbital area, glabella.It is dedicated to correct the first signs of aging: fine lines and superficial wrinkles especially in young skin. It is also suitable for lip’s barre code correction, light lips correction and hands rejuvenation.
Developed for difficult areas.
Intense Rheology contains 22 mg/ml of hyaluronic acid.
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DERMAL
NEEDLE
27 G
extrusion force
mediumintense rheology
34
Products
3736
BENEFITS
• High concentration of HA and high viscoelasticity level for great volume effects;• Particular rheology to correct lipoatrophy and tissue augmentation.
CONCENTRATION
28 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Soft tissue correction, tissue augmentation, lipodistrofy correction.
It is characterized by the highest amount of hyaluronic acid - 28 mg/ml - and high viscoelasticity of the hydrogel to guarantee 100% satisfaction for the patient.
| other |
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: SUBCUTANEOUS
NEEDLE
22 GCANNULA
21 G
intense roseDelicate and pure.
extrusion force
medium/high hydro deluxeCombination of deep hydration and biostimulation.
BENEFITS
• Specific concentration of HA for great hydration;• Improvement in skin density level thanks to calcium hydroxyapatite.
CONCENTRATION
18 mg/ml of HA, non cross-linked
SYRINGE
2 x 2,5 ml, 2 x 1 ml
CONTAINS
0,01% of CaHA; Glycine and L-Proline
INDICATION
Hydration, revitalization, collagen stimulation.Regeneration, superficial wrinkles correction,hands rejuvenation.
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
Hydro Deluxe contains 18 mg/ml of pure hyaluronic acid, enriched with 0,01% of calcium hydroxyapatite. This unique composition activates and supports natural processes of collagen production, thanks to which skin becomes thicker and firmer. A series of 4 treatments with 3 week intervals between all treatments should be performed to achieve optimal results. At the end of the series, in order to maintain results, it is worth offering to a patient a follow-up treatment scheduled for half a year later.
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: EPIDERMAL
| deep hydration |
NEEDLE
30 G
extrusion force
low
Fil lers catalogue
Products
39
crow’s feet REDUCTIONHydro Deluxe
fine linesIntense Rheology
TEAR TROUGHIntense Rheology
templesIntense
FACE CONTOURS LIFTINGIntense , Stimulate , Intense Flux
NOSE MODELING Intense
cheek MODELING Intense , Stimulate ,
Intense Flux
CHIN MODELINGIntense , Stimulate , Intense Flux
NASO-LABIALFOLDS FILLING
Intense , Stimulate ,Intense Flux , Intense LV
LIPS AUGMENTATIONIntense Lips , Intense Rheology , Intense Flux
ACNE SCARS REDUCTIONStimulate , Intense Rheology
neck and shoulders regenerationHydro Deluxe
skin firmingHydro Deluxe
elbows and knees regenerationHydro Deluxe
strech marks reductionHydro Deluxe
HANDS REJUVENATIONFilling: Stimulate , Intense Rheology Mesotherapy: Hydro Deluxe
modeling of intimate partsIntense Rose
effectivesolutions
Fil lers catalogue
INTENSE MAN
STIMULATE MAN
HYDRO DELUXE MAN
BIOSTIMULATIONand lifting
LIFTING
DEEP HYDRATION
f i l l e rf o r h I M
4140 4140 06
Being aware of the differences in men and women tissue as well as
their subjective expectation from the aesthetic medicine. Neauvia is
proud to present the first and unique product line dedicated to men.
Processes of aging and skin structure of men differs from woman’s
and the results are different with the aging. Their ticker skin lose
volume, density and elasticity of tissue. To reduce the signs of
passing years and keep the young, energetic appearance it is
important to treat it holistic.
Fil lers catalogue
4342
BENEFITS
• High viscoelasticity of the hydrogelfor better adaptation to man’s tissue;• The product immediately fills the tissue deficitsgiving the desired shape and volume graduallyimprovingthe quality of the skin;• Increment in neocollagenesis;• The neocollagenesis process permitsa longer lasting correction.
CONCENTRATION
28 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
1% CaHA; Glycine and L-Proline
INDICATION
Restoration of volume, filling of skin depression (included deep wrinkles and nasolabial folds), collagen stimulation.
BENEFITS
• Slow biodegradation and long lasting results;• Thanks to unique rheological properties, Intense is highly adaptive to the tissue; • Intense gives fantastic lift effect.
CONCENTRATION
28 mg/ml of HA, PEG polymer cross-linked
SYRINGE
1 x 1 ml
CONTAINS
Glycine and L-Proline
INDICATION
Restoration of volume, filling of skin depression (included deep wrinkles, nasolabial folds and temples). Intense Man can be used to add volume in the sagging area and to fill the folds and deep wrinkles.
EPIDERMAL EPIDERMAL
DERMAL DERMAL
SUBCUTANEOUS SUBCUTANEOUS
PERIOSTEUM PERIOSTEUM
A specific formula with the highest concentration of hyaluronic acid (28 mg/ml) and high viscoelasticity of this product suits perfectly for thicker skin and more rapid process of aging.
Stimulate Man is the first filler dedicated to help fighting the time in two ways. 28 mg/ml of hyaluronic acid and high viscoelasticity of the hydrogel fill tissue deficits for a long time. The addition of 1% of calcium hydroxyapatite gives extra stimulation effect by activating fibroblasts to collagen stimulation. Calcium hydroxyapatite used in Neauvia fillers has small particle size (8-12 microns) and is well spread and crosslinked in the hydrogel. This assure stability of the particles that have no possibility to migrate.
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: SUBCUTANEOUS
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DEEP DERMAL
| LIFTING | | BIOSTIMULATION and lifting |
NEEDLE
21 GCANNULA
22 G
NEEDLE
21 GCANNULA
22 G
extrusion force
highextrusion force
medium/highintensE manHigh viscoelasticity and high modelability.
stimulate manDouble action: combination of filling and biostimulation.
ProductsFil lers catalogue
44
BENEFITS
• Specific concentration of HA for great hydration;• Improvement in skin density levelthanks to calcium hydroxyapatite;• Visible results in quality of the skin;• Ultra-safe profile thanks to Bacillus subtilis.
CONCENTRATION
18 mg/ml of HA, non cross-linked
SYRINGE
2 x 2,5 ml, 2 x 1 ml
CONTAINS
0,01% of CaHA; Glycine and L-Proline
INDICATION
Hydration, revitalization, collagen stimulation. Regeneration, superficial wrinkles correction.
Hydro Deluxe Man contains 18 mg/ml of pure hyaluronic acid, enriched with 0,01% of calcium hydroxyapatite. This unique composition activates and supports natural processes of collagen production, thanks to which skin becomes thicker and firmer. A series of 4 treatments with 3 week intervals between all treatments should be performed to achieve optimal results. At the end of the series, in order to maintain results, it is worth offering to a patient a follow-up treatment scheduled for half a year later.
| deep hydration |
EPIDERMAL
DERMAL
SUBCUTANEOUS
PERIOSTEUM
INJECTION PLANENEEDLE ANGLE: 45°DEPTH: EPIDERMAL
NEEDLE
30 G
extrusion force
lowhydro deluxe manCombination of deep hydration and biostimulation.
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47
effectivesolutions
crow’s feet REDUCTION
Hydro Deluxe Man
frown linesIntense Rheology
face revitalisingHydro Deluxe Man
templesIntense Man
filling of skin depressionIntense Man
face volumisingIntense Man , Stimulate Man
nose modellingIntense Man
sagging skinStimulate Man
vertical lips linesIntense Rheology
ProductsFil lers catalogue
4948
intense intenseLV
intenserose
intenseman
stimulateman
hydrodeluxe man
specifications
stimulate intenserheology
LIFTING LIFTINGvolumization shapershaper BIOSTIMULATIONand liftingother deep
Hydration
hydrodeluxe
deepHYdration
intense flux
intenselips
BIOSTIMULATIONand lifting
ProductsFil lers catalogue
1 x 1 ml 1 x 1 ml
hyaluronicacid content
28 mg/ml 26 mg/ml 28 mg/ml 28 mg/ml 28 mg/ml 18 mg/ml
Glycine and L-Proline
Glycine and L-Proline
Glycine and L-Proline
Glycine and L-Proline
1% CaHA,Glycine and
L-Proline
0,01% CaHA,Glycine and
L-Proline
21 G22 G
High
21 G22 G
Medium/High
1 x 1 ml
22 G21 G
Medium/High
1 x 1 ml
21 G22 G
High
1 x 1 ml
21 G22 G
Medium/High
2 x 2,5 ml2 x 1 ml
30 G
Low
Deep tissue restoration
of volume & correction
Deep tissue restoration
of volume & correction
Soft tissuecorrection, tissueaugmentation,
lipodistrofycorrection
Restoration of volume, filling
skin depression
Restoration of volume, filling
skin depression, collagen
stimulation
Hydration, revitalization,
collagenstimulation
amino acidsand calciumhydroxiapatite
syringe
needle/cannula
extrusionforce
indication
Injectionplane
26 mg/ml
1% CaHA,Glycine and
L-Proline
1 x 1 ml
21 G22 G
Medium/High
Deep filling of skin depression, biostimulation
and revitalisation
1 x 1 ml
22 mg/ml
Glycine and L-Proline
27 G
Medium
Fine linereduction,
lip contouring, orbital area,
glabella
18 mg/ml
0,01% CaHA,Glycine and
L-Proline
2 x 2,5 ml2 x 1 ml
30 G
Low
Hydration, revitalization,
collagenstimulation
1 x 1 ml
26 mg/ml
Glycine and L-Proline
27-30 G
Low
Deep tissuerestoration
of volume inmoderate and strongly aged
skin
1 x 1 ml
24 mg/ml
Glycine and L-Proline
27 G
Medium
Lipsaugmentation and modelling
50
before& after
51
before after
LIPS AUGMENTATIONINTENSE LIPS
before after
LIPS AUGMENTATIONINTENSE
before after
Upper Lips augmentationINTENSE RHEOLOGY
before after
BiorevitalizationHYDRO DELUXE
before after
Marionette linesSTIMULATE
before after
Nasolabial foldsINTENSE LV
LIPS ANGULAR FOLDSINTENSE RHEOLOGY
before after
Before & AfterFi l lers catalogue
neauvia meansmany benefits
NeAUvia fillers are BIOMIMETICwith an HIGH TOLERABILITY
AND SAFETY PROFILE
07OPTIMAL
RHEOLOGICAL RATIO
HIGHBIOCOMPATIBILITY
optimalbioINTEGRATION
Key Messages
high biocompatibility
Neauvia fillers are based on PEG-cross-linked technology.
PEG has scientifically proven oustanding advantages
Neauvia preservesthe skin natural integrity
It distributes finely in the interstitial tissue among constitutive structures of the
hypodermis and dermis.
Neauvia does not bring inflammatory cells surrounding the implantor close
Demonstrated both in vitro and in vivo.
It adapts perfectly to the receiving anatomic structures having optimal distribution in the tissue over time.
optimal biointegrationMorphological evidences have demonstratedthat Neauvia fillers have a great biointegration.
Better resultswith less product(HIGH G*)
Neauvia fillersallow natural results (HIGH G’)
Neauvia Fillers have long duration in the skin (HIGH cohesivity)
OPTIMAL RHEOLOGICAL RATIOOptimal gels for each injection plane: soft gel for superficial injection and stiffer gel for deep injection layers.
53
Fil lers catalogue
o57
Products
MATEX LAB SAVia Maggio 1C | CH-6900 Lugano | Switzerland
MATEX LAB S.P.A.Via Carlo Urbani 2 ang. Via Enrico Fermi | 72100 Brindisi | Italy
© Copyright Matex Lab SA. 2018All rights reserved
Concept and design by: Emporio ADV
www.neauvia.com
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