product value sheet dietary supplement vegaplex™ healthy

Product Value Sheet Dietary Supplement

100 Capsules | Code: 30065

**This product information is approved for USA Markets. E. EXCEL USA, LLC www.eexcel.net V.01 E. EXCEL North America – USA

AG

ARICUS BLAZEI MUSHROO

M

ACEROLA CHERRY

BLUEBERRY

M

AITAKE MUSHROOM

At times, even the healthiest vegetarian/vegan diets may lack key nutrients typically found in animal products such as: Vitamin B12 and iron. Vegaplex™ is formulated with vitamin B12 and includes natural wholefood botanical ingredients which are known to contain Vitamin C, iron, antioxidants and polysaccharides to support healthy metabolic functions. Vitamin C has been shown to enhance the absorption of iron. E. EXCEL’s Vegaplex™ wholefood blend capsules are a rich source of Vitamin B12 to support optimal health. This synergistic blend features Agaricus blazei Murill mushrooms (ABM), maitake mushrooms, acerola cherries and blueberries. Vegaplex™ complements healthy plant food choices to support overall health, making it a key part of your healthy lifestyle.*

Primary Structure Function Support: 1. Supports healthy cellular metabolism* 2. Contains 100% of the daily allowance

of Vitamin B12* 3. Promotes oxidative stress reduction* 4. Supports healthy, balanced immune functions* 5. Supports normal anti-inflammatory functions* 6. Helps to promote overall health and wellbeing*

TARGETED BODY SYSTEMS: OVERALL WELLNESS, VEGAN FRIENDLY*

Vegaplex™ Healthy Cellular Metabolic Support and Contains B12*

Other ingredients: Vegetable Capsule, Maltodextrin.

Amount Per Serving % Daily ValueProprietary Blend 1350 mgAgaricus blazei murill fruiting body †Acerola Cherry (Malpighia glabra) fruit †Blueberry (Vaccinium angustifolium) fruit †Grifola frondosa fruiting body †Vitamin B12 100%

† Daily Value not established


THE SCIENCE BEHIND THE INGREDIENTS

**This product information is approved for USA Markets. E. EXCEL USA, LLC www.eexcel.net V.01

The Agaricus blazei Murrill (ABM) mushroom was originally found in Piedade, a small town located in the highland areas of the Atlantic Forest in the municipality of São Paulo, Brazil. It is also known as himematsutake, Mushroom of God, and Mushroom of the Sun. The mushroom became well known in 1960 by a Japanese researcher and grower, Takatoshi Furumoto. ABM mushrooms are rich in polysaccharides. They continue to be used traditionally to support the immune system, combat stress and improve the quality of life for overall good health.*

Acerola cherries grow on small trees or shrubs native to Central America. Just one hundred grams of fresh acerola cherries is known to contain a whopping 2,700% of the body’s daily Vitamin C requirement which helps to protect cells against oxidative damage. What’s more, fresh acerola cherries contain more than 33 times the amount of Vitamin C in orange juice.*

Blueberries may be tiny, but they are known as a popular superfood. They are brimming with health-promoting compounds, which provide delicious support for the heart, immune system, brain, eyes and musculoskeletal system.*

Maitake mushrooms are known in Japan as “the dancing mushroom.” According to a Japanese legend, a group of Buddhist nuns and woodcutters met on a mountain trail, where they discovered a fruiting of maitake mushrooms emerging from the forest floor. Rejoicing at their discovery of this delicious mushroom, they danced to celebrate. Maitake mushrooms are high in polysaccharides, beta-glucans, phospholipids, nucleotides, and unsaturated fatty acids. Because of the high levels of these compounds, maitake mushrooms are said to be one of the most potent immune-stimulants among all mushrooms.*

E. EXCEL North America – USA


What is unique about Vegaplex™?

Vegaplex™ is formulated with vitamin B12 and includes natural wholefood botanical ingredients which are known to contain Vitamin C, iron, and polysaccharides. Research has shown that Vitamin C may enhance the absorption of iron. Vitamin B12 is important for vegans, vegetarians, and those who may not be able to absorb enough vitamin B12 from their diet. These ingredients play a key role in supporting healthy cellular metabolism. Vegaplex™ ingredients include Agaricus blazei and maitake mushrooms, acerola cherries, blueberries and Vitamin B12. Vegaplex™ does not contain animal or animal by-products, gluten, preservatives, or dairy and is suitable for vegans and vegetarians.*


What companion products could I take with Vegaplex™?

O-Seed® and E. EXCEL’s Essential Blend™ are great companion products to Vegaplex™. These products contain essential fatty acids which may be lacking from a vegan/vegetarian diet. O-Seed®’s vegan friendly Ωmega Blend is designed to support the body’s natural health, by providing the essential omega-3 fatty acids. O-Seed® contains chia seed and kiwifruit seed which have two of the best omega-3 to omega-6 fatty acid ratios of any plant source. E. EXCEL’s Essential Blend™ contains omega-3 rich macadamia nut oil and perilla seed oil, when combined has a perfect 1:1 ratio of omega-3 and omega-6 fatty acids your body craves, but cannot produce on its own.*

How quickly can I expect to experience beneficial effects from taking this product?

Please remember that our products are not drugs, nor are they a replacement for drugs and are not meant to treat, cure or prevent disease. Our products contain wholesome food ingredients, which support a safe and gradual but significant change, without drug-related side effects. As part of a healthy lifestyle, the results you desire may occur gradually. We encourage you to use our products together with the four pillars of health taught in the science of Nutritional Immunology, which empowers people to improve their lifestyle by: (1) making balanced wholesome food choices, (2) staying positive and happy, (3) regular exercise, and (4) getting sufficient sleep.*

QUESTIONS & ANSWERS


Will this product interact with any of my medications? Should I take it if pregnant, nursing, or have any health issues?While these products contain wholesome food botanicals and natural ingredients, as with any changes to diet or lifestyle, you should consult your doctor before using. If you are pregnant, breastfeeding, or have any health issues, we encourage you to check with your health care professional before use.


Product Value Sheet

Barbisan, L.F., Scolastici, C., Miyamoto, M., Salvadori, D.M., Ribeiro, L.R., da Eira, A.F., de Camargo, J.L. (2003). “Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine.” Genetics and Molecular Research: GMR;2(3):295–308.

Basu, A., Rhone, M., Lyons, T.J. (2010). “Berries: emerging impact on cardiovascular health.” Nutrition Reviews;68(3):168–177.

Belwal, T., Devkota H.P., Hassan, H.A., Ahluwalia, S., Ramadan, M.F., Mocan, A., Atanasov, A.G. (2018). “Phytopharmacology of Acerola (Malpighia spp.) and its potential as functional food.” Trends in Food Science & Technology; 74:99-106.

Biedroń, R., Tangen, J-M., Maresz, K., Hetland, G. (2012). “Agaricus blazei Murill - immunomodulatory properties and health benefits.” Functional Foods in Health and Disease; 2:428-447.

Borchers, A.T., Stern, J.S., Hackman, R M., Keen, C.L., Gershwin, M.E. (1999). “Mushrooms, tumors, and immunity.” Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.);221(4):281–293.

Carneiro, A.A., Ferreira, I.C., Dueñas, M., Barros, L., da Silva, R., Gomes, E., Santos-Buelga, C. (2013). “Chemical composition and antioxidant activity of dried powder formulations of Agaricus blazei and Lentinus edodes.” Food Chemistry;138(4):2168–2173.

Chen, Jau-Fei. (2004) Enjoying Health & Longevity with Nutritional Immunology, (2015) Nutrition. Immunity. Longevity, (2000) Nutritional Immunology.

Firenzuoli, F., Gori, L., Lombardo, G. (2008). “The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.” Evidence-Based Complementary and Alternative Medicine: eCAM;5(1):3–15.

Fujimiya, Y., Suzuki, Y., Katakura, R., Ebina, T. (1999). “Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill.” Anticancer Research; 19(1A), 113–118.

Ghosh, D., Konishi, T. (2007). “Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function.” Asia Pacific Journal of Clinical Nutrition;16(2):200–208.

Hashimoto, T., Nonaka, Y., Minato, K., et al. (2002). “Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice.” Bioscience, Biotechnology, and Biochemistry;66(7):1610-1614.

Hallberg, L., Brune, M., Rossander, L., (2021). “The role of vitamin C in iron absorption.” Int J Vitam Nutr Res Suppl. 1989,30:103-8, PubMed.gov PMID: 257689

Hong, L., Weiyu, W., Qin, W., Shuzhen, G., lebin, W. (2013). “Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa).” Food and Agricultural Immunology;24(4):409-418.

Kundaković T., Kolundžić M. (2013). “Therapeutic properties of mushrooms in managing adverse effects in the metabolic syndrome.” Current Topics in Medicinal Chemistry;13(21):2734-2744.

Lee, Y.L., Kim, H.J., Lee, M.S., Kim, J.M., Han, J.S., Hong, E.K., Kwon, M.S., Lee, M.J. (2003). “Oral administration of Agaricus blazei (H1 strain)

inhibited tumor growth in a sarcoma 180 inoculation model.” Experimental Animals;52(5):371–375.

Leonov, A., Arlia-Ciommo, A., Piano, A., Svistkova, V., Lutchman, V., Medkour, Y., Titorenko, V.I. (2015). “Longevity extension by phytochemicals.” Molecules (Basel, Switzerland);20(4):6544–6572.

Mizuno, M., Morimoto, M., Minato, K., & Tsuchida, H. (1998). ‘Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.’ Bioscience, Biotechnology, and Biochemistry;62(3):434–437.

Niwa, A., Tajiri, T., Higashino, H. (2011). “Ipomoea batatas and Agarics blazei ameliorate diabetic disorders with therapeutic antioxidant potential in streptozotocin-induced diabetic rats.” Journal of Clinical Biochemistry and Nutrition;48(3):194–202.

Percival, S.S., Findley, B. (2017). “What’s in Your Tropical Fruit?” Food Science and Human Nutrition Department, University of Florida/IFAS Extension.

Popescu, M.L., Costea, T., Gîrd, C.E., Fierăscu, I., Balaci, T.D., Fierăscu, R.C. (2017). “Antioxidant activity of romanian Agaricus blazei murrill and Agaricus bisporus J. E. lange mushrooms.” Farmacia; 65:329-335.

Poucheret, P., Fons, F., Rapior, S. (2006). “Biological and pharmacological activity of higher fungi: 20-year retrospective analysis.” Cryptogamie, Mycologie;27(4):311-333.

Rubin, P.D., Gayer, L.S.Esq., Band, J.M. (2014). “Acerola—Malpighia glabra.” HerbalGram: The Journal of the American Botanical Council; 104:64-69.

Si, H., Liu, D. (2014). “Dietary antiaging phytochemicals and mechanisms associated with prolonged survival.” The Journal of Nutritional Biochemistry; 25(6): 581–591.

Skrovankova, S., Sumczynski, D., Mlcek, J., Jurikova, T., Sochor, J. (2015). “Bioactive Compounds and Antioxidant Activity in Different Types of Berries.” International Journal of Molecular Sciences;16(10):24673–24706.

Takaku, T., Kimura, Y., Okuda, H. (2001). “Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action.” The Journal of Nutrition;131(5):1409–1413.

Vetvicka, V., Vetvickova, J. (2014). “Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts.” Annals of Translational Medicine;2(2):14.

Vincent, M., Philippe, E., Everard, A., Kassis, N., Rouch, C., Denom, J., Takeda, Y., Uchiyama, S., Delzenne, N. M., Cani, P.D., Migrenne, S., Magnan, C. (2013). “Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats.” Obesity (Silver Spring, Md.);21(3):553–561.

Yeh, J.Y., Hsieh, L.H., Wu, K.T., Tsai, C.F. (2011). “Antioxidant properties and antioxidant compounds of various extracts from the edible basidiomycete Grifola frondosa (Maitake).” Molecules (Basel, Switzerland);16(4):3197–3211.

Zhong, M., Tai, A., Yamamoto, I. (2005). “In vitro augmentation of natural killer activity and interferon-gamma production in murine spleen cells with Agaricus blazei fruiting body fractions.” Bioscience, Biotechnology, and Biochemistry; 69(12):2466-2469.

**This information provided is intended for E. EXCEL USA only, and is in compliance with USA guidelines and regulations, pursuant to section 403(r)(6) of the Federal Food, Drug, and Cosmetic Act published by the United States Food and Drug Administration (FDA). We at E. EXCEL North America strive to follow all governing regulations, labeling and testing for the USA following the guidelines from the FDA and FTC, and in Canada following the guidelines from Health Canada. Products and ingredients marketed in North America are currently registered in both Canada and the United States. Structure function claims may vary from country to country to meet each specific country rules and regulations. Therefore, E. EXCEL North America is not responsible for claims made in other countries.

* These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Dietary Supplement

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product value sheet dietary supplement vegaplex™ healthy

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