136 Poster presentations

of syrgery, ASA score, weight loss and BMI were con-sidered. There were statistically significant differencesobserved between SEN and IMEN patients in mortality(p = 0.032) and overall morbidity: complications wereobserved in 72 patients (47.6%) in SEN and 51 (33.55%)in IMEN group (p = 0.016). Infectious complication weremore frequent in SEN patients (39.22 vs 28.3%, p = 0.043).There were no differences in liver and kidney function,treatment tolerance, and visceral protein turnover.Conclusion: The study proved the clinical value ofimmunomodulating enteral nutrition over standard onein patients after major gastrointestinal surgery. Im-munomodulating diets helped to reduce postoperativecomplications.

Disclosure of Interest: None declared

PP289EARLY AND ACTIVE DIETARY COUNSELLING: PATIENTS’USE OF DIETARY ADVICE DURING CHEMOTHERAPY FORCOLORECTAL CANCERI. Besnard1, A. Abakar-Mahamat1, S.M. Schneider1,X. Hebuterne1. 1Pole Digestif, CHU de Nice, Nice, France

Rationale: Ravasco et al. (1) showed the interest ofearly and individualised dietary counselling on nutritionalstatus, quality of life and treatment tolerance in patientsundergoing radiotherapy for colorectal cancer. However,patients’ observance was not assessed. The aim of thisstudy was to assess the use of dietary counselling, itsimpact on body weight at 3 months and its acceptabilityin patients receiving chemotherapy (CT) for digestivecancer.Methods: 68 patients were prospectively included at thestart of CT, when they were given advice for a balancedand enriched diet, adapted to CT side effects, by a RD,with the help of a booklet, and assessed at 3 months(weight + questionnaire). Statistical analyses used Chi-2and Mann-Whitney tests.Results: 97% of patients (n = 66, 38M, 28W, aged 67years [27 85]) answered the questionnaire. Cancer wascolorectal (n = 34), pancreatic (n = 16) or other (n = 16),metastatic in 65%. 62% of patients reportedly changedtheir diet, either varying (42%), balancing (38%), orenriching (33%) it, increasing protein intake (29%), split-ting meals (26%) or excluding specific foods (24%). After3 months, weight was increased/stable/decreased in27%/50%/23% of patients, respectively. Weight evolutionin patients who had balanced their diet was +1.6% ( 27.3%to +10.8%) vs. 1.8% ( 27.7% to +34.6%) (P= 0.006).61% found this counselling useful and 29% essential. Theyconsidered it useful for improving their mental (47%) andphysical (33%) wellbeing, for increasing their weight (44%)or to reduce the side effects of CT (39%).Conclusion: Early dietary counselling before CT fordigestive cancer allows more than 60% of patientsto change their dietary habits. Surprisingly, switchingto a balanced yet not enriched diet is significantlyassociated with a favourable weight evolution. Mostpatients considered this counselling helpful.

References[1] Ravasco et al. J Clin Oncol 2005; 23: 1431 8.

Disclosure of Interest: None declared

PP290PRE-AND POST PRE-AND POST OPERATIVE ENERGYMETABOLISM IN PATIENTS WITH ESOPHAGEALSQUAMOUS CELL CARCINOMA

C. Huang1, J. Wu1, W. Cai1. 1clinical nutrition center,Xinhua Hospital affiliated to Shanghai JiaotongUniversity School of Medicine, Shanghai, China

Rationale: To evaluate the influence of radical procedureon energy metabolism and body composition in patientswith esophageal squamous cell carcinoma.Methods: Nutrition risk was assessed in patients withesophageal squamous cell carcinoma preoperatively andon postoperative day (POD) 1 using NRS2002. Restingenergy metabolism and body composition test weremeasured preoperatively and on POD 10, using indirectcalorimetry and bioelectrical impedance methods respec-tively.Results: 62.5% (25/40) patients were found with nu-trition risk preoperatively, and the ratio was increasedto 82.5% (33/40) on POD1. Patients had lower bodyweight (BW), body mass index (BMI), body fat mass(BFM, 12.92±6.98 vs. 14.67±6.66 kg, P < 0.001), per-cent of body fat (PBF, 21.78±9.79 vs. 23.89±8.40%,P < 0.001) on POD 10 compared with preoperative pe-riod. Measured resting energy expenditure (mREE)was decreased after operation( 1435.4±316.65 vs.1582.63±307.8 kcal/d, P = 0.017). Patients were dividedinto hypermetabolic group (mREE/pREE > 110%, n = 22)and non-hypermetabolic group (n = 18) according to thepre-op measurement. In hypermetabolic group, patientshad lower mREE, pREE, mREE/pREE, RQ after the radicaloperation (P < 0.05), while no difference was found innon-hypermetabolic group.Conclusion: Most of the patients with esophageal squa-mous cell carcinoma had nutritional risk. Resting energyexpenditure was significantly decreased after radicalprocedure, especially in patients with pre-op hypermetabolism; Fat mass loss mainly contribute to thepostoperative weight loss in patients.

Disclosure of Interest: None declared

PP291TAC REGIMEN INDUCED METABOLIC SYNDROME-X INBREAST CANCER PATIENTSD. Hopancı Bıcakli1 , D. Tunali, M. Degirmenci,B. Karaca, B. Karabulut, R. Uslu. 1Medical OncologyDepartment, Ege University Hospital, Izmir, Turkey

Rationale:Docetaxel-doxorubicin-cyclophosphamidecom-bination (TAC) is one of the most common regimens usedfor the treatment of early stage breast cancer. The aimof this prospective study was to determine the effectsof TAC regimen on the metabolic parameters during thetreatment period.Methods: The study was carried out at Medical OncologyDepartment of Ege University Hospital from June 2008to March 2010. The study group consisted of 90 earlystage breast cancer patients. All the patients received6 cycles of TAC regimen. Fasting blood samples andantropometric measurements were done baseline, aftereach cycle and at the end of treatment to determine the