postpartum blood pressure profiles for women with ......postpartum (pp) anti-hypertensive treatment....

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Introduction Conclusion References Results Hypothesis Study Design Hypertension complicates 6-10% of pregnancies worldwide [1]. The incidence of de novo postpartum hypertension or preeclampsia ranges from 0.3-27.5%. [2] Current ACOG recommendations suggest inpatient blood pressure (BP) monitoring through 72 hours postpartum and again at 7-10 days outpatient [3]. It is known that BP in the postpartum period decreases within 48 hours postpartum, but then increases again between 3-6 days postpartum [4]. We hypothesized that blood pressure exacerbation might occur earlier in the postpartum period than 7-10 days postpartum. A secondary analysis of a nonrandomized controlled trial [4]. Inclusion criteria: Women with HDP who delivered at a single midwestern academic center between 3/2017 and 6/2018. BP values of 214 telehealth and 214 control participants were recorded intrapartum through 42 days postpartum using home telehealth BP monitoring. Mean systolic and diastolic BPs were calculated for each day. 1. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol Jul 2000; 183(1):S1– S22. 2. SIBAI BM. Etiology and management of postpartum hypertension-preeclampsia. Am J Obstet Gynecol 2012;206:470-5. 3. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol 2013;122:1122-31. 4. Walters BN, Walters T. Hypertension in the puerperium. Lancet 1987; 2:330. Postpartum hypertension exacerbation is common outpatient and most often before postpartum day 7 (1 st postpartum clinic visit). Postpartum BP increase should be expected on days 3-5 postpartum. Women with chronic hypertension demonstrate more labile postpartum BP profile, which warrants close follow up of all chronic hypertensive women postpartum. Reconsidering of current guidelines in order to provide safe and efficient postpartum care is required. WE RECOMMEND: Daily BP monitoring through the 1 st week postpartum for women with HDP which could be done through the home telehealth with remote BP monitoring OR Scheduling 1 st postpartum clinic visit to the earlier date than 7-10 days postpartum. Figure 1: Blood pressure (BP) profile of women with and without hypertension exacerbation requiring postpartum (PP) anti- hypertensive treatment. A: mean systolic BP values. B: mean diastolic BP values. (*) indicates significant differences between groups, p<.05 (t-test). Figure 2: BP profile of women with chronic hypertension (HTN) vs new onset hypertensive disorder of pregnancy (HDP). A: mean systolic BP values. B: mean diastolic BP values. (*) indicates significant differences between groups, p<.05 (t-test). Mean systolic and diastolic BP values of all women with HDP decreased during the 48 hours postpartum compared to predelivery BP. BP increase after discharge from the hospital most often occurred between postpartum days 3 to 5. The peak BP before delivery demonstrated a similar peak between 3 rd and 7 th days postpartum. Normalization of BP typically occurred by 14 th day postpartum. Women with chronic hypertension regardless of diagnosed pre-eclampsia exhibited exacerbated hypertension. Women with chronic hypertension continued to have labile BP the entire postpartum period. Women with chronic hypertension or HDP requiring postpartum antihypertensive treatment had significantly higher mean BPs at the end point compered to their comparators (p<0.01 for all). Postpartum blood pressure profiles for women with hypertensive disorders of pregnancy Narmin Mukhtarova 1 , Thomas Havighurst 2 , Kara K Hoppe 1 1. Department of Obstetrics & Gynecology, UW Madison School of Medicine and Public Health, Madison, WI, USA 2. Department of Biostatistics & Medical Informatics, UW Madison, Madison, WI, USA Telehealth (N=214) Maternal age (years) 31.4 ± 5.0 Pre-pregnancy BMI (kg/m 2 ) 29.8 (24.4-36.0) HTN classification, n (%) Chronic HTN 20 (9.3) Chronic with SIPE 22 (10.3) Gestational HTN 62 (29.0) Preeclampsia 132 (62.0) Race, n (%) Caucasian 175 (85.4) African American 16 (8.0) American Indian/Alaskan Native 3 (1.4) Asian American 10 (4.0) Other 1 (0.5) BP summary (mmHg) Maximum systolic BP 160 (152-171) Maximum diastolic BP 101 (96.0-110) Discharge systolic BP 131 (124-138) Discharge diastolic BP 78 (72-84) Meds at discharge, n (%) Any antihypertensive 116 (54.0) Labetalol 90 (42.1) Nifedipine 39 (18.2) Data are expressed as mean ± SD or n (%). BMI, body mass index; BP, blood pressure HTN, hypertension; Meds, medications; SIPE, superimposed pre- eclampsia. Table 1: Maternal demographics.

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  • Introduction Conclusion

    References

    Results

    Hypothesis

    Study Design

    • Hypertension complicates 6-10% of pregnancies worldwide [1].

    • The incidence of de novo postpartum

    hypertension or preeclampsia ranges

    from 0.3-27.5%. [2]

    • Current ACOG recommendations

    suggest inpatient blood pressure (BP)

    monitoring through 72 hours

    postpartum and again at 7-10 days

    outpatient [3].

    • It is known that BP in the postpartum

    period decreases within 48 hours

    postpartum, but then increases again

    between 3-6 days postpartum [4].

    • We hypothesized that blood pressure exacerbation might occur earlier in

    the postpartum period than 7-10 days

    postpartum.

    • A secondary analysis of a nonrandomized controlled trial [4].

    • Inclusion criteria: Women with HDP

    who delivered at a single midwestern

    academic center between 3/2017 and

    6/2018.

    • BP values of 214 telehealth and 214 control participants were recorded

    intrapartum through 42 days

    postpartum using home telehealth BP

    monitoring.

    • Mean systolic and diastolic BPs were calculated for each day.

    1. Report of the National High Blood Pressure Education

    Program Working Group on High Blood Pressure in

    Pregnancy. Am J Obstet Gynecol Jul 2000; 183(1):S1–

    S22.

    2. SIBAI BM. Etiology and management of postpartum

    hypertension-preeclampsia. Am J Obstet Gynecol

    2012;206:470-5.

    3. Hypertension in pregnancy. Report of the American

    College of Obstetricians and Gynecologists' Task Force

    on Hypertension in Pregnancy. Obstet Gynecol

    2013;122:1122-31.

    4. Walters BN, Walters T. Hypertension in the

    puerperium. Lancet 1987; 2:330.

    • Postpartum hypertension exacerbation is common outpatient and most often before

    postpartum day 7 (1st postpartum clinic

    visit).

    • Postpartum BP increase should be expected

    on days 3-5 postpartum.

    • Women with chronic hypertension

    demonstrate more labile postpartum BP

    profile, which warrants close follow up of all

    chronic hypertensive women postpartum.

    • Reconsidering of current guidelines in order

    to provide safe and efficient postpartum care

    is required.

    WE RECOMMEND:

    • Daily BP monitoring through the 1st week

    postpartum for women with HDP which

    could be done through the home telehealth

    with remote BP monitoring

    OR

    • Scheduling 1st postpartum clinic visit to the

    earlier date than 7-10 days postpartum.

    Figure 1: Blood pressure

    (BP) profile of women with

    and without hypertension

    exacerbation requiring

    postpartum (PP) anti-

    hypertensive treatment. A:

    mean systolic BP values. B:

    mean diastolic BP values.

    (*) indicates significant

    differences between groups,

    p