post concussion syndrome
DESCRIPTION
a presentation on pcs and featuresTRANSCRIPT
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POST CONCUSSION SYNDROMEC/P : DR.JOHN MATHAIPRESENTER:DR.DAVIN10/08/2011
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INTRODUCTIONPossible outcome of mild
Traumatic Brain Injury(mTBI)(GCS NOT < 13)
Post concussional symptoms seen in 38%-80% of people with mTBI
Post Mortem studies showed Diffuse axonal injury.
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SYNONYMSPostconcussional disorder(DSM
IV)Post traumatic brain
syndrome,nonpsychoticShell shockPosttrauma concussion statePosttrauma syndrome
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HISTORYErichsen(1866)-complaints were
due to trauma induced “molecular disarrangement” of spinal cord.(“railroad spine”)
Rigler(1879)-proposed injuries were due to “compensation neurosis”
Charcot-due to “hysteria and neurasthenia”
World war I – “shell shock”
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HISTORY1939-Coined “posttrauma
concussion state” to avoid epidemic of “shell shock” cases
Disturbance of consciousness with no immediate/obvious pathologic change in the brain
1941- POST CONCUSSION SYNDROME
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Lewis(1942) about PCS“That common dubious
psychopathic condition – the bugbear of the clearminded doctor and lawyer”
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DEFINITION“Rarely Clearly Defined”A condition arising after “head injury”
that produces deficits in 3 areas of CNS functioning:
1) Somatic(neurological-headache,fatigue)
2) Psychological(affective change,lack of motivation,anxiety,emotional lability)
3) Cognitive (impaired memory,attention,concentration)
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EPIDEMIOLOGYIndia - >1 million sustain head
injuries/year80-90% -minor head injuries50% have post concussive
symptoms at 1 month,15% at end of 1 year.
Morbidity – mainly persistent symptoms
Sex-Incidence more in females(US)
Age – 50% between ages 15-34(US)
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ETIOLOGY
A. Brain injuryMicroscopic lesions in brain post
mortem – diffuse axonal injury,microglial clusters,small petechial hemorrhages.
Imaging (Functional with single photon emission CT or PET) show abnormalities – SPECT showed decreased or asymmetric regional blood flow upto 3 years later.
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ETIOLOGYPET scans-reduced metabolic
rate of glucose utilization-documentation for malingering.
Evidence of cerebral dysfunction after mild head injury – a working memory task showed more widespread activation of cerebral cortex though performance was normal
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ETIOLOGY
B. Psychological factorsMostly seen in symptoms lasting
> 1 yearMore likely if patient blames
employerCompensation claims increase
symptoms by about 25%Role is greatest in very mild
injuries and very chronic symptoms
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ETIOLOGYC. Model of interactionProposed by Lishman(1988)Most patients-good recoveryPsychological effects interfere with
normal recovery process – PCS developsAnxiety – patient worries about
symptoms,focuses on them Aggravated – compensation issues and
vulnerability to somatizationVicious circle of disability-anxiety-
symptoms.
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CLINICAL FEATURESEssential FeatureAcquired impairment in cognitive
functioning , with specific neurobehavioural symptoms as a consequence of closed head injury of sufficient severity to produce significant cerebral concussion.
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CLINICAL FEATURESManifestations of concussion
include:1. Loss of consciousness > 5 min2. Posttraumatic amnesia >12 hrs3. New onset/worsening of seizures
within first 6 months
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SOMATIC HeadacheMost common(30-90%)Last longer , occur more frequently than
before the injuryIHS criteria divides into:Acute –within 2 wks,resolve by 2 mthsChronic –within 2 wks ,continue >8 wks85% -steady,aching,tension-typeDue to soft and hard tissue injuriesMigraines –common in
adolescents,sportspeople
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SOMATICDizzinessReported in 50% , 1 yr
prevalence-19-25%Balance uncertainty,LightheadednessSubjective unsteadiness of gaitOlder age correlates for likelihood
of dizzinessDifferentiate from true vertigo
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SOMATICBlurred vision 14%-optical
convergence disorderPhonophobia,photophobia-
10%Decreased smell and taste
~5%Sleep problems – onset and
maintainence
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PSYCHOLOGICALAnxietyNearly 50% report personality
change,irritability,anxiety or depression within 3 months
Anxiety disorders include Generalised anxiety disorder,panic disorder,OCD,PTSD-(11-70%)
Most common-free floating anxiety , fearfulness, intense worry ,social withdrawal
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PSYCHOLOGICALApathyCan be primary(10%) or
secondary to depression(~60%)Neurological damage to
subcortical-frontal region,basal ganglia and thalamus –primary apathy
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PSYCHOLOGICALPsychosisExtremely rare Risk factors – severity of trauma ,
h/o temporal lobe epilepsy , head trauma during adolescence
Atypical antipsychotics better for treatment
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PSYCHOLOGICALPreexisting affective disorders
can result in misdiagnosis of PCS as symptoms of mood change,lability,sleep disturbances,anxiety overlap.
Recall biases – “good old days”phenomenon
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COGNITIVEReductions in information
processing , attention, reaction timeNeuropsychological tests : predict
durationStroop color testProcessing speed testContinuous performance test of
attentionDigit span forwardHopkins verbal learning test
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COGNITIVEVerbal and non verbal memory
impairment –most common(20-79%)
Short term memory deficits – “effortful”> “incidental”
Impaired sustained and divided attention-due to cholinergic dysfunction-impaired sensory gating
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DIAGNOSISDCR 10ICD 10DSM IV
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DCR 10A. The general criteria of F07
must be met.B. History of head trauma with
loss of consciousness, preceding the onset of symptoms by a period of upto four weeks (objective EEG, brain imaging, or oculonystagmographic evidence for brain damage may be lacking).
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DCR 10
C. At least three of the following:(1) Complaints of unpleasant sensations
and pains, such as headache, dizziness (usually lacking the features of true vertigo), general malaise and excessive fatigue. or noise intolerance.
(2) Emotional changes, such as irritability, emotional lability, both easily provoked or exacerbated by emotional excitement or stress, or some degree of depression and/or anxiety.
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DCR 10(3) Subjective complaints of
difficulty in concentration and in performing mental tasks, and of memory complaints, without clear objective evidence (e.g. psychological tests) of marked impairment.
(4) Insomnia.(5) Reduced tolerance to alcohol
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DCR 10(6) Preoccupation with the above
symptoms and fear of permanent brain damage, to the extent of hypochondriacal over-valued ideas and adoption of a sick role.
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ICD - 10F07.2 Postconcussional syndromeOccurs following head
trauma(usually sufficiently severe to result in loss of consciousness)
At least 3 of following symptoms:1. Headache2. Dizziness3. Fatigue4. Irritability
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ICD - 10
5. Difficulty concentrating , performing mental tasks
6. Memory impairment7. Insomnia8. Reduced tolerance to stress
emotional excitement or alcohol
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ICD - 10Feelings of anxiety or depression –loss of
self esteem and fear of permanent brain damage.
Hypochondriacal Nosological status uncertain“Common and distressing to patient”Includes:1. Postcontusional
syndrome(encephalopathy)2. Post-traumatic brain syndrome ,
nonpsychotic
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DSM IV TR
A. A history of head trauma that has caused significant cerebral concussion.
B. Evidence from neuropsychological testing or quantified cognitive assessment of difficulty in attention(concentrating,shifting focus of attention,performing simultaneous tasks) or memory(learning or recalling information).
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DSM IV TR
C. Three (or more) of the following occur shortly after the trauma and last at least 3 months:
1. Becoming fatigued easily2. Disordered sleep3. Headache4. Vertigo or dizziness5. Irritability or aggression on little
or no provocation
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DSM IV TR
6. Anxiety,depression or affective liability
7. Changes in personality(e.g. social or sexual inappropriateness)
8. Apathy or lack of spontaneity.D. The symptoms in criteria B and C
have their onset following head trauma or else represent a substantial worsening of preexisting symptoms.
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DSM IV TR
E. Causes significant impairment in social or occupational functioning and represents a significant decline from a previous level of functioning.
F. Do not meet criteria for Dementia due to Head Trauma and are not better accounted for by another mental disorder.
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DIFFERENTIAL DIAGNOSISMild neurocognitive
disorder(specific etiology and symptoms)
Somatisation disorder,undifferentiated somatoform disorder
Factitious disorder,malingeringPTSDAffective disordersChronic fatigue syndrome
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INVESTIGATIONSCT Scan – to r/o intracranial
abnormalities and skull fractures.Functional MRI,SPECT,PET – more
sensitive for minor head injuriesEEG - epilepsyNeuropsychological testing.
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TREATMENTDepends on specific symptoms
constellationEducate patient and family about
PCS , recovery period Lack of knowledge worsens
psychogenic symptoms and prolongs recovery time
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TREATMENTPersistent headaches-
NSAIDS,migraine prophylactics ( fluoxetine) helpful.
Psychological symptoms-supportive psychotherapy , education, pharmacotherapy for a limited time.
SSRIs are antidepressants of choice –relieve headache,anxiety,tension,depression
Memory deficits-Mild benefits from meds
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TREATMENTAvoid phenytoin , haloperidol,
barbiturates due to significant side effects like
Delayed neuronal recovery,Paradoxical rage,Memory impairmentIndian studies (Deepak et
al ,2007)-Piracetam useful
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COURSE AND PROGNOSISGenerally very good to excellentMost cases –symptoms resolve within
few days to weeksMost are symptom free by 3 months~10 % -symptoms persist more than a
year-leads to persistent PCS(PPCS)Anxiety and depression often the cause
for persisting symptomsRequire multidisciplinary cognitive
therapy programs including vocational training.
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CONTROVERSIESNumerous symptoms in different fields
with no clear association among them-Syndrome?
Each symptom can have specific diagnosis e.g. dizziness-BPPV,headache-migraine
Cause not exactly known-psychogenic or physiogenic
Lishman proposed physiogenic-organic influences and psychogenic –long lasting symptoms
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THANK YOU
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