Comparative Safety of Antimuscarinics in the United States Pediatric Population, 2000-2013. Alan Kinlaw, MSPH, Doctoral Student, Department of Epidemiology, UNC Chapel Hill Gillings School of Global Public HealthDifferential postpartum surveillance for type 2 diabetes in women treated with glyburide versus insulin for gestational diabetes. Suzanne N. Landi, MPH, Doctoral Student, Department of Epidemiology, UNC Chapel Hill Gillings School of Global Public HealthUnderimmunization at discharge from the neonatal intensive care unit. Sudha Raman, PhD, Post Doctoral Associate, Duke Clinical Research InstituteA Feasibility Study of Demand and Supply for Diabetes Prevention Programs (DPP). Tainayah Thomas, MPH, Doctoral Student, Department of Health Behavior, UNC Chapel Hill Gillings School of Global Public HealthThe Monitor Trial: Challenges and Lessons Learned in Successful Engagement of Industry and Health Delivery Network Stakeholders. Laura Young, MD, PhD, Assistant Professor, Endocrinology & Metabolism, UNC School of Medicine

CER SYMPOSIUM

May 13-14, 2015RTP, NC

Building Bridges to Advance CER

1:00 — 2:30 pm

Keynote: Incorporating patient-centered outcomes & diverse stakeholder input in clinical trialsJerry A. Krishnan, MD, PhD Professor of Medicine and Public Health, Associate Vice President for Population Health Sciences, University of Illinois Hospital and Health Sciences System, Chicago, IL.

2:30 — 3:30 pm

Ongoing CER in the Triangle: Presentation of Accepted AbstractsModerator: Janet Freburger, PT, PhD Associate Director of Medical Practice and Prevention Program and Research Fellow at the Cecil G. Sheps Center for Health Services Research, Chapel Hill, NC.

The predictive validity of GRADE concerning the stability of effect estimates was low: a meta-epidemiological studyTammeka Swinson Evans, MOP, Health Services Researcher, RTI International

Controlling for frailty in cancer comparative effectiveness studies of older adultsJennifer Lund, PhD, MSPH Assistant Professor, Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill

Linking an Orthopedic Registry to Medicare Claims DataSudha Raman, PhD Post Doctoral Associate, Duke Clinical Research Institute.

Evidence of recent statin use among ‘new’ statin users in MedicareJessica Young, BA, MSPH/Doctoral Student Department of Epidemiology, UNC Gillings School of Public Health

3:30 — 3:45 pm Closing Address

THURSDAY, MAY 14 (DAY 2) ...cont.

POSTER PRESENTATIONS

Uniform versus all-available look-backs to identify exclusion criteria in observational cohort studies. Mitchell M. Conover, MSPH, Doctoral Student, Department of Epidemiology, UNC Chapel Hill Gillings School of Global Public HealthStandardizing event rates in non-representative data: an applied example. Mitchell M. Conover, MSPH, Doctoral Student, Department of Epidemiology, UNC Chapel Hill Gillings School of Global Public HealthTorsemide vs. Furosemide in Heart Failure Patients: Insights from Duke University Hospital. Adam D. DeVore, MD, Cardiology Fellow, Duke University Medical CenterLessons learned in patient recruitment in a Pragmatic Clinical Trial. Tamara Gregory, BS, Monitor Trial Research Assistant, Cecil G. Sheps Center for Health Services Research, UNC Chapel HillTrends in pharmaceutical comparative effectiveness research in the medical literature, 2004-2013. Laura Hester, ScM, Doctoral Student, Department of Epidemiology, UNC Chapel Hill Gillings School of Global Public HealthComparative Effects of Anti-hypertensive Medications on Colorectal Cancer Risk. Phyo Than Htoo, MD, MPH, Doctoral Student, Department of Epidemiology, UNC Chapel Hill Gillings School of Global Public HealthParent engagement in a comparative effectiveness study examining parent activation and mental health services for Latino children. Mónica Pérez Jolles, PhD, Post Doctoral Research Fellow, Health Policy and Management, Cecil G. Sheps Center for Health Services Research, UNC Chapel Hill Gillings School of Global Public Health

Visit NC TraCS CER at

tracs.unc.edu/cer

12:00 — 1:00 pm Registration / Check-in

1:00 — 1:15 pm Opening Address

1:15 — 2:15 pm

Keynote: Pragmatic trials in health insurance systems: designing and evaluating interventions to increase patient engagement Niteesh Choudhry, MD, PhD Associate Professor, Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA.

2:15 — 3:45 pm

Panel Discussion: Engaging the Patient in CER Moderator: Giselle Corbie Smith, MD, MSc Kenan Distinguished Professor, Social Medicine and Medicine, Director, UNC Center for Health Equity Research UNC School of Medicine; Director, Community Academic Resources for Engaged Scholarship (CARES), NC TraCS Institute, Chapel Hill, NC.

A consolidated model for patient and family engagementMegan Lewis, PhD Director, Patient and Family Engagement Research Program, Center for Communication Science, RTI International, Research Triangle Park, NC.

Katherine Trieman, PhD Senior Scientist, Patient and Family Engagement Research Program, Center for Communication Science, RTI International, Research Triangle Park, NC.

Brittany Zulkiewicz, BS Research Analyst, Patient and Family Engagement Research Program, Center for Communication Science, RTI International, Research Triangle Park, NC.

Advancing Methods for Community Engagement and Outcomes in CERKatrina Donahue, MD, MPH Associate Professor of Family Medicine, UNC School of Medicine; Co-Director, North Carolina Network Consortium (NCNC), Chapel Hill, NC.

Jacquie R. Halladay, MD, MPH Associate Professor, Department of Family Medicine, UNC School of Medicine, Co-Director, North Carolina Network Consortium (NCNC), Chapel Hill, NC.

Gaurav Dave, MD, DrPH, MPH Evaluation Director, NC TraCS Institute, UNC School of Medicine, Chapel Hill, NC.

Patient Reported OutcomesBryce B. Reeve, PhD Associate Professor, Health Policy and Management, UNC Gillings School of Global Public Health, Chapel Hill, NC.

3:45 – 4:00 pm BREAK (coffee, snacks & refreshments served)

4:00 – 5:30 pm

Panel Discussion: Use of ‘Real World’ Data in CERModerator: Til Stürmer, MD, PhD Professor of Epidemiology, Director of the Center for Pharmacoepidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC.

The Realities of Real-World Data: the Mini-Sentinel and PCORnet PerspectivesLesley H. Curtis, PhD Professor of Medicine, Duke University School of Medicine, Director, Center for Pragmatic Health Services Research, Duke Clinical Research Institute, Durham, NC.

CER Across a Large Swath of Practices: EHRs and Opportunity, Chaos, or All of the AboveSamuel Cykert, MD Professor of Medicine and Director of the Program on Health and Clinical Informatics, UNC School of Medicine; Associate Director for Medical Education, NC AHEC Program

Data Linkages, Data Sharing and Data Mining for CERAshok Krishnamurthy, PhD Deputy Director, Renaissance Computing Institute (RENCI), Chapel Hill, NC.

WEDNESDAY, MAY 13 (DAY 1)

7:30 — 8:00 am Continental breakfast (coffee, tea & refreshments served)

8:00 — 8:15 am Opening Address / Housekeeping

8:15 — 9:45 am

Panel Discussion: Engaging Delivery Systems / Industry in CERModerator: Timothy Carey, MD Sarah Graham Kenan Professor of Medicine, Departments of Medicine and Social Medicine, UNC School of Medicine; Adjunct Professor, Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC. The Community Representative Perspective

C. Annette DuBard, MD, MPH Senior Vice President for Informatics and Evaluation, Community Care of North Carolina (CCNC), Raleigh, NC. The Industry Perspective Cindy Girman, DrPH President, CERobs Consulting, LLC, Chapel Hill, NC; Retired Executive Director and Head of Data Analytics & Observational Methods in the Center for Observational & Real World Evidence, Merck Research Laboratories, Research Triangle Park, NC. The Insurance Company Perspective Janet McCauley, MD Senior Medical Director, Blue Cross Blue Shield of North Carolina, Chapel Hill, NC. The Academic Healthcare Delivery System PerspectiveSeth Glickman, MD, MBA Director, Office for Population and Value Care, UNC Health Care System and Associate Professor of Emergency Medicine, UNC School of Medicine, Chapel Hill, NC.

9:45 — 10:00 am BREAK

10:00 am — 12:00 pm

Panel Discussion: CER MethodsModerator: Elizabeth B. Andrews, PhD Vice president of Pharmacoepidemiology and Risk Management, RTI Health Solutions, Research Triangle Park, NC.

Treatment effect heterogeneity: Where should we be looking and how?Michele Jonsson-Funk, PhD Research Associate Professor, Department of Epidemiology, UNC Gillings School of Global Public Health; Director, Methods Core, Center for Women’s Health Research, UNC School of Medicine, Chapel Hill, NC.

Using Qualitative Comparative Analysis to Explore Heterogeneity in Complex InterventionsLeila Kahwati, MD, MPH RTI International, Social, Statistical, & Environmental Sciences, Research Triangle Park, NC.

New methods for conducting rigorous small-sample clinical trials: Toward evidence-based personalized treatmentTy Ridenour, PhD, MPE Division of Behavioral Health and Criminal Justice Research, RTI International, Research Triangle Park, NC.

Using Simulation Models to Inform CER DesignEvan R. Myers, MD, MPH Walter L. Thomas Professor, Department of Obstetrics and Gynecology, Duke University School of Medicine, Evidence Synthesis Group, Duke Clinical Research Institute, Durham, NC.

12:00 — 1:00 pm POSTER WALK (box lunch served)

THURSDAY, MAY 14 (DAY 2)

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