pistoia alliance blockchain webinar 20 june 2017
TRANSCRIPT
June 20, 2017
Is there a role for blockchain
in healthcare?
A Pistoia Alliance Debates Webinar
Moderated by Nick Lynch
This webinar is being recorded
Poll Question 1: What is your familiarity
with blockchain?
A. I am using blockchain
B. I am experimenting with blockchain
C. I am aware of blockchain
D. I know next to nothing about it
Poll Question 2: What is your organization’s
familiarity with blockchain?
A. Actively using blockchain
B. Experimenting with blockchain
C. Aware of blockchain
D. Not sure about my organization
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The Panel
5
Nishan Kulatilaka Associate
Director of applied technology
Merck&Co
Gideon Greenspan, CEO
and Founder Coin
Sciences LTD
Darryl Glover chief clinical
officer iSolve
David Houlding, Director of
Healthcare Privacy & Security,
Intel Health & Life Sciences
Gideon Greenspan, MultiChain
A technical introduction to blockchains
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What is a blockchain?
7
• Shared record of signed transactions, grouped
into timestamped blocks that are chained
together and secured by multiparty consensus.
7
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What’s in the transactions?
8
• Data in cleartext
• Encrypted data
• Hashed data (unique fingerprints)
• Asset transfers (financial, IP, proof of origin)
• Asset exchanges
• General purpose code (“smart contracts”)
• Events which trigger that code
• Public keys for encryption
• Administration / permissioning
8
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Without blockchains
99
AcmeInc
HooliInc
MifflinInc
GlobexInc
Intermediary
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With blockchains
1010
Mifflin
Acme
Globex
HooliTransaction
Blockchain
Ensuring consensus between nodes
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How are blockchains the same?
1111
• Code inside a database
– Stored procedures
• Append-only record
– Only INSERT into database
• Safe asset exchanges
– Atomic transactions in databases
• Robustness
– Distributed databases
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How are blockchains worse?
1212
• Confidentiality
– Blockchains share more
• Transaction immediacy
– Blockchains need consensus
• Code execution speed
– Blockchains need a sandbox
• Throughput scalability
– Blockchains work harder
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Blockchains vs centralized databases
1313
Advantages Disadvantages
Disintermediation Confidentiality
Multiorg robustness Performance
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Half-baked blockchains
1414
• One validator blockchain
– Blocks generated by one party
– Central point of failure
• Shared state blockchain
– Distributed database with blocks on top
– Requires nodes to trust each other
• Centrally hosted blockchain
– Everyone relies on one company
– Why not use a regular database?
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About MultiChain
1515
• Popular open source blockchain platform
• 2+ years in development, now 1.0 beta
• Simple permissions, assets, data streams
• 33 platform partners including:
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David Houlding, Intel
How to identify near term opportunities for
blockchain, and how to manage privacy, security,
and compliance with blockchain.
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Near Term Opportunities for Blockchain
1717
• Opportunities• B2B near term, B2C longer term• Existing networks
• E.g. B2B networks that have an existing trusted intermediary / bottleneck
• E.g. existing use cases with multiple siloed databases across multiple organizations and periodic batch ETL, reporting
• Value• Improved transparency. Real-time visibility• Lower costs. Robustness, avoiding single points of failure• Caveat: depends heavily on what data goes on blockchain
and who has access
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Blockchain Privacy, Security, Compliance
1818
• Protecting CIA: Confidentiality, Integrity, and Availability
• Integrity• Immutable blocks, non-repudiation
• Availability• Ransomware, DDoS and blockchain• Storing data on vs off the blockchain
(with pointers, hashes) and availability ramifications
• Consensus, scalability, and avoiding single / few points of failure
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Blockchain Privacy, Security, Compliance
1919
• Confidentiality and Privacy• Data
• Data on blockchain?• It’s about the use cases• Blockchain is plumbing, what are you going to
do with the data on blockchain?• Risk vs benefit: data and access• Minimal but sufficient (to support use case(s))• Data that is on chain stays on chain (immutability)
• Access • Public, permissioned, private• Encryption• Secure enclaves
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Blockchain Privacy, Security, Compliance
2020
• Compliance
• Data sovereignty, trans-border data flow, compliance
• What data is on blockchain?
• Where physically is the data stored, used? Where are the blockchain nodes, and systems connected to them?
• What are the applicable laws, regulations, standards, privacy principles
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Blockchain Privacy, Security, Compliance
2121
• Security beyond what’s baked into blockchain• Learning from bitcoin hacks /
breaches, and hardening• Administrative, physical, technical• People, process, technology• What is behind the nodes in the
blockchain, how secure?• Assess, identify, remediate weakest
links• Vet security of new organizations
joining the network to ensure adequacy
Holistic
Multi-Layered
DefenseIn Depth
Threat Intelligence
Adequacy
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Poll Question 3: What is the single most
significant hurdle or perceived limitation
that blockchain must overcome before it
is adopted widely in healthcare?
A. Security
B. Privacy
C. Technical
D. Regulatory
E. Other
BLOCKCHAIN AND THE LIFE SCIENCES
Nishan Kulatilaka
Applied Technology
June 20, 2017
Focus on Core Blockchain
Concepts
Definitions from Google 24
Healthcare Use Cases• Supply Chain and Serialization
• Track and trace products through distributors
and other nodes
• Clinical Trials
• Provenance of trial master file
• Study recruitment
• Medical Records
• Paradigms for sharing data
• Granular entitlements
25
Truck: http://www.freeiconspng.com/img/9018Syringe: http://www.iconarchive.com/show/medical-health-icons-by-graphicloads/syringe-injection-icon.htmlChart: https://www.clker.com/clipart-patient-chart-medical-clipboard.html
The Path Forward• Collaboration
• Technology that is strongest with large
ecosystems
• Ideation and Proofs of Concepts
• Build often and build fast
• Integration may seem hard, but prototyping is
easy
• Manage the Hype
• Not a cure-all
• Shiny object syndrome
26Collaboration: https://thenounproject.com/term/collaboration/28324/Lightbulb: http://www.freeiconspng.com/img/835Hype cycle: http://media-s3-us-east-1.ceros.com/gartner/images/2016/09/01/47d42afb4d720e2944314651f1729d36/mini-hype-cycle.png
Poll Question 4: How quickly do you think
blockchain will be adopted in
Pharma/Healthcare?
A. <1 year
B. 1-3 years
C. 3-5 years
D. >5 years
E. never/not sure
Poll Question 5: Where will blockchain
technology have the greatest impact ?
A.Pre-clinical DiscoveryB.ClinicalC.RegulatoryD.Manufacturing and Medicines Supply ChainE.Health Records, inc. Personal Genomics
Daryl Glover, iSolve
The use of Advanced Distributed Ledger
Technology (ADLT) to solve challenges in
medicines supply chain and serialization.
New challenges require New solutions. Today, I will discuss the application of the Advanced Digital Ledger Technology (ADLT™) platform for the Biopharma Industry.The Blockchain provides the following:• Bridge between systems that do not easily communicate with
each other• Immutable, Auditable, and Traceable Record Required• Decentralized Network for Trusted Participants• Complement to Existing Systems and Processes
Overview
Origins of ADLT™2017
1940
Cryptography
First adopted by the US
Navy to decipher foreign
code and trade systems.
1970
Public / Private Keys
Encryption method for
messaging also
leveraging Digital
Signatures
2009
Blockchain
Distributed Ledger used
to support and secure
Digital Currency
transactions.
2014
Blockchain 2.0
The use of Private
Blockchains and Smart
Contracts enhance
Blockchain security and
functionality.
What is ADLT™ ?
ADLT™
DispensersRaw Materials Suppliers
Global Sites
CMOs CPOs
3PLs
Wholesale Distributors
A Secure and Distributed Framework that allows information to be
controlled and passed bilaterally to Trusted Participants.
Manufacturing Supply Chain
Market
Market
Product
Pack
Finished
Goods
A101
A102
A103
B202
B203
B201
E502
E503
E501
C302
C303
C301
D402
D403
D401
E502
E503
E501
A101 B201A101
C301B201
D401C301B201
A101
E501
C301B201A101
A101
D401
ADVANCED DIGITAL LEDGER TECHNOLOGY - BLOCKCHAIN
Production
Drug
Product
Raw
Material
API
Key
IntermediariesBulk API
Logistics Supply Chain
PatientPharmacyWholesaler3PLManufacturers
E501
Batch E501
posted to
Blockchain
E501
Batch E501
received by 3PL
posted to
Blockchain
E501
Batch E501
received by
Wholesaler posted
to Blockchain
E501
Batch E501
received by
Pharmacy posted
to Blockchain
E501
Product from
Batch E501
distributed to
Patient
ADVANCED DIGITAL LEDGER TECHNOLOGY - BLOCKCHAIN
E501 @3PL
@MAN
@PHM
@WHS
@3PL@MAN
E501 @WHS
@3PL
E501
@MAN
E501
ADLT™ - Blockchain
ADLT™ Service LayerThe Blockchain as a Middleware Component
Multi-Site Data entering
the BlockchainThe collection of data for
products and materials that
are Multi-Stage and Multi-Site
Security and ValidationThe management of Data
and Transactions from
Trusted Participants
leveraging Digital Keys
Distributed LedgerADLT™ is Distributed to
Trusted Participants who
have access to view
information
Data Traceability
ADLT™ data is managed
by Blocks which creates
Data Origination and
Provenance
MDM
A101
A102
A103
B101
B102
B103
C101
C102
C103
A101
B101
C101
A102
B102
C102
A103
B103
C103
Product Master Data
Prod A, 20mgB101
API-XYZA101
Prod A, 1x7 BlisterC101
ADLT™ is a Secure and Distributed Framework Data is Secured with Digital Keys and Cryptographic Hashes
Trusted ParticipantOnly Registered and Trusted Participants may enter
or view information..
Immutable RecordsAll records are immutable and can’t be modified. New
records may be added to the same block.
ConsensusThe Trusted Participants of the network must approve
transactions as valid.
Private KeysParticipants must have Private (Digital) Keys in order
to enter or view information..
Decentralized NetworkEach participant of the Blockchain receives a copy of
their own Digital Ledger.
Audience Q&APlease use the Question function in GoToWebinar
The 3rd Annual Pistoia Alliance President’s Challenge is open!
• Annua l compet i t ion to f ind the innovators in l i fe sc ience R&D, o f fe r ing :
• A chance to p i t ch i n the f i na l i n f ron t o f P i s to i a members a t ou r Bos ton con fe rence
• $20000 f o r two w inne rs ($5000 f o r t he runne rs up )
• 6 mon ths men to rsh ip f rom P i s to i a A l l i ance member (s )
• Access to E l sev ie r ’s R&D So lu t i ons po r t fo l i o
• This year we are in te res ted in :• B lockcha in fo r hea l thca re• Rea l Wor l d Da ta• Lab o f the fu tu re• Acce le ra te Ea r l y S tage C l in i ca l Tr ia l s• AI / Deep Lea rn ing
• Find out more a t :• https://goo.gl/vicZu6• or one of the Pistoia Alliance team
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Agenda announced for US Conference 2017 in Boston
Pistoia Alliance Membership Introduction 39
We are pleased to announce the outline agenda for our 2017 US Conference on 10th October 2017 in Boston.“Lab of the Future”.• If you’d like to attend, please register now! The
conference is being held at the Hilton Boston Back Bay. A hotel room block has been made available for the benefit of delegates.
• The distinction between the research laboratory, clinic, ambulatory care and the hospital is diminishing as technology blurs the boundaries.
Major advances are being seen in:• Automation• Connectivity• Machine learning• Augmented reality• Quantum computing• Blockchain
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Innovation Update June 2017
40
ip3.pistoiaalliance.org
• Lab of the Future (LoTF)• Sign up to this community
• RWD• Sign up to this community
• AI/Deep Learning – New community• Sign up to this community
[email protected] @pistoiaalliance www.pistoiaalliance.org