Adding individual patient case data to the

melanoma targeted therapy advisor

Randy GobbelCollabRx Inc.

California, USA

Jeff ShragerStanford and CommerceNet

California, USA

Gregorio ConvertinoXerox Research Center Europe

Grenoble, France

Iman KhaghanifarUniversity of Trento, Italy

Alban MaxhuniCREATE-NET and University

of Trento, Italy

Jovan StevovicCRG - Centro Ricerche GPI

and University of Trento, Italy

Motivation

melanoma is characterized by high variability from patient to patient

treatments need to be specific for each patient

treatment outcomes are of vital importance to others

existing systems do not exploit single case data

Provide targeted therapies

Share therapies

effectiveness

Main Goals

Create patient community

Collect treatment outcomes

● EBM - Evidence Based Medicine: the integration of the literature evidence with clinical trials, early '90s

● Targeted Therapies: specific for each patient based on their current health status (e.g. TTA)

● Social networks: sharing knowledge and experiences among patients (e.g. PatientsLikeMe)

● Mobile: detection of early stage melanoma (e.g. MelApp) or gather and share information from Internet (e.g. TouchOut)

Related Work

TTA[1] – Targeted Therapy Analyzer/AdvisorUses TTD to provide therapy advises

TTD[2] – Targeted Therapy Database of Melanoma Treatments Manually annotated database from literature

Best performing treatments

1. http://www.mmmp.org/MMMP/import.mmmp?page=tta.mmmp2. http://www.mmmp.org/MMMP/import.mmmp?page=targetedtherapydatabase.mmmp

TTA

TTD

Our previous work

New treatment suggestionTreatment outcomes

Treatment administration

Melanoma molecular profile

Patient

Doctor

Treatment approval

PTTA

PTTD

PTTA - Patient or Personal TTA

1

2

34

5

used as treatment selective data

The Melanoma Molecular Profile

Prototype UI

1 2

3

4

5

6

Registration

TR52 Treatment TR66 Treatment

Entire melanoma community

Treatment-centered groups

Treatment-centered Groups

Registration

New treatment notification

Entire melanoma community

Treatment-centered groups

TR52

New Trial Notifications

TR52 Treatment TR66 Treatment

TR52.1 Trial

TR66 Treatment

Registration

TR52.1 Trial

New treatment notification

Entire melanoma community

Treatment-centered groups

TR52Small Groups

Small Groups

TR52 Treatment

1. PTTA exploits the potential of individual treatment outcomes while adding them to a literature-based model of targeted treatments

2. Treatment-based grouping and social interaction can improve:○ patient involvement and motivation ○ self-consciousness about the disease

Thank you!

Summary

Acknowledgments ○ to CommerceNet and Gregorio Convertino for funding project expenses ○ to Konstantinos and Henok for their participation in the project