June 26-28, 2008Leighton AuditoriumRochester, Minnesota

Course Director:Nancy L. Kuntz, M.D.Co-Director, Mayo Pediatric MS ClinicMayo Clinic Rochester

Pediatric Multiple Sclerosis:Acquired Demyelinating Disorders in Children and Adolescents…Symptoms, Evaluation, Treatment and Prognosis

COURSE DESCRIPTIONThis course is intended for primary care providers and specialists who see children and adolescents when they develop acute neurologic dysfunction. These events may be due to acquired demyelinating lesions of the Central Nervous System (CNS). This course will make attendees familiar with clinical findings which should suggest the possibility of acquired CNS demyelination. Typical imaging findings, laboratory diagnostic studies and protocols to differentiate from other neurologic syndromes will be discussed. Treatment of acute episodes and long term disease modifying therapies will be considered. Cognitive impact and social implications for children with acquired CNS demyelinating disorders and their families will be reviewed. Current and future research trends will be presented.

COURSE LEARNING OBJECTIVESUpon conclusion of this program, participants should be able to:• IdentifypresentingclinicalsymptomsofacquiredCNSdemyelinating

disorders in children and adolescents, including acute disseminated encephalomyelitis, clinically isolated syndromes, pediatric multiple sclerosis and neuromyelitis optica.

• DifferentiateacquiredCNSdemyelinatingdisordersinchildrenandadolescents from other disorders which can mimic the same presentation

• Discussappropriateoptionsfortreatmentofacuteclinicaldemyelinatingevents as well as options for disease modifying therapies in children and adolescents

• Identifyneuroimagingchangesthatcharacterizeacquireddemyelinatingdisorders in children and adolescents

• Explaincognitiveandsocialramificationsofacquireddemyelinatingdisorders in children and adolescents as these affect the family unit

• Assess potential for ongoing research to guide development of future therapies

Attendance at this Mayo course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

CONTINUING EDUCATION CREDIT College of Medicine, Mayo Clinic is accredited by the Accreditation Council forContinuingMedicalEducationtoprovidecontinuingmedicaleducationforphysicians.

College of Medicine, Mayo Clinic designates this educational activity for a maximumof11AMA PRA Category 1 Credits™. Physicians should only claim creditcommensuratewiththeextentoftheirparticipationintheactivity.

MayoContinuingNursingEducationisaccreditedasaproviderofcontinuingnursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Participantsattendingtheentirecoursewillreceive11accreditedcontacthours.

INTENDED AUDIENCEThis course is designed for primary care physicians who care for children (pediatricians and family practitioners) and specialists in adult neurology, ophthalmology, neuropsychology and psychiatry.

General Information

EDUCATIONAL GRANTSAt the time of this printing, a complete listing of commercial supporters was not available. Appropriate acknowledgment will be given to all supporters at the time of the meeting.

DATE AND LOCATIONTheDemyelinatingDisordersinChildhoodwillbeheldJune 26-28, 2008. Course headquarters will be located in Leighton Auditorium on the second flooroftheSiebensMedicalEducationBuilding,MayoClinic,100SecondAvenue Southwest, Rochester, Minnesota. Meeting facilities are easily accessible by skyway and pedestrian subway, which connect Mayo Clinic to shops, restaurants, and hotels.

REGISTRATIONTo register online, visit http://www.mayo.edu/cme/jun2008.html, or complete theattachedregistrationformandreturnbymailorfax.Theregistrationfee includes tuition, comprehensive course syllabus, continental breakfasts, break refreshments, lunches, reception, dinner, and tour. Although it is not MayoSchoolofCMEpolicytolimitthenumberofregistrantsforacourse,conference room facilities may necessitate closing of enrollment; therefore, early registration is advised. A letter of confirmation will be sent upon receipt of payment and completed registration form. Please present the confirmation letter when checking in at the meeting registration desk.

CANCELLATION POLICYIfyoucancelyourparticipationinthiscourse,yourregistrationfee,lessa$75administrative fee, will be refunded when written notification is received by MayoSchoolofCMEbeforeJune 11, 2008(fax#:507-284-0532).No refunds will be made after June 11, 2008.

MayoSchoolofCMEreservestherighttocancelorpostponeanycourseduetounforeseencircumstances.IntheunlikelyeventMayoSchoolofCMEmustcancelorpostponethiscourse,MayoSchoolofCMEwillrefundtheregistrationfee,butisnotresponsibleforanyrelatedcosts,charges,orexpensestoparticipants, including fees assessed by airline/travel/lodging agencies.

TRAVELRochester, Minnesota, is a friendly city that greets thousands of visitors from around the world each year. The city is serviced by a modern international airportwithmultipleflightsdailyfromChicago,Detroit,Dallas-FortWorth,and Minneapolis via American or Northwest Airlines. Access to and from the airportisprovidedbytaxi,shuttleservice,andrentalcar.Theairportislocatedapproximately10milesfromtheMayoCliniccampus.

CarlsonWagonlitTravelistheofficialtravelagencyforthisevent.Whenmaking reservations, please indicate that you are traveling to the Mayo Clinic DemyelinatingDisordersinChildhoodmeeting.ContactCarlsonTravelat1-(866)MAYOTVLor(866)629-6885-Chooseprompt#3forGroup/MeetingReservations,thenprompt#1asatravelerattendingthemeeting.Note to Travelers:SeveralcitiesintheUnitedStatesarenamedRochester.When you make airline reservations and check your baggage, be sure that your destination is Rochester, Minnesota (RST) and that your baggage has been properly tagged.

Travel arrangements are the sole responsibility of the individual registrant.

General Information

LODGING ACCOMMODATIONSGuestroomshavebeenreservedforattendeesandtheirguestswithspecialcourseratesateachofthefollowingdowntownRochesterhotels.Inorderto receive the special rate, reservations must be made before the room block isfilledorbeforetheexpirationdateofJune3,2008,whichevercomesfirst. Reservations will be taken following this date based on space and rate availability.PleaseidentifyyourselfasaparticipantoftheDemyelinatingDisordersinChildhoodwhenmakingyourreservation.

Hilton Garden Inn225SouthBroadway800-445-8667507-285-1234$96single/double

Radisson Plaza Hotel150SouthBroadway800-333-3333507-281-8000$104single/double

Rochester Marriott Hotel101FirstAvenueSW877-623-7775507-280-6000$129single/double

The hotels listed above are connected by skyway and pedestrian subway to conferencefacilities,downtownshops,andrestaurants.YoumayalsowishtovisittheRochesterConventionandVisitorsBureauwebsite(www.rochestercvb.org) for additional accommodation options.

Lodging arrangements are the sole responsibility of the individual registrant.

PARKINGParking is available in hotel, city, and Mayo patient/visitor ramps. The cost for parking is not included in the registration fee.

SOCIAL PROGRAMS Welcome Reception – Thursday, June 26, 2008Attendees and their guest(s) are cordially invited to join the course faculty fortheWelcomeReceptiononThursday,June26from6-8p.m.Thiscasualreception welcomes you to Mayo Clinic, officially opens the course, and offersyoutheperfectopportunitytomakeconnectionswithexistingandnewcolleagues.Youmayalsopickupyourcoursematerialsatthisreception.ThereceptionwillbeheldinHageAtriuminthesubwayoftheSiebensBuilding.

Course Dinner and Motivational Speaker – Friday, June 27, 2008Attendees and their guest(s) are invited to a dinner for course attendees and facultyonFriday,June27from6-7:45p.m.Thiscasualdinnerwillfeatureamotivationalspeaker,andwillbeheldintheElizabethanRoomattheKahler.Pre-registrationisrequired.

General Information

OTHER ACTIVITIESThe Mall of Americaisjust80milesnorthwestofRochester. www.mallofamerica.com

RochesterFest–AnnualcelebrationinRochesterwillbeheldJune21-29,2008.Formoreinformationabouteventsandactivities,visitwww.rochesterfest.com.

Wisconsin Dells,Wisconsin–‘TheWaterParkCapitaloftheWorld’isashorttwo-hourdriveintoWisconsin.VisittheWisconsinDellsConvention&Tourism website for more information about this family friendly town. www.wisdells.com

FACULTYCourse DirectorNancy Kuntz, M.D.Co-DirectorMayoPediatricMSClinicMayo Clinic

Mayo Clinic FacultyTanya Brown, Ph.D.Karl Krecke, M.D. Andrew McKeon, M.B.B.Ch.Moses Rodriguez, M.D.Shanu Roemer, M.D.Nathan Young, D.O.

Guest FacultyAnita Belman, M.D.Co-DirectorNationalPediatricMSCenterStateUniversityofNewYorkatStoneyBrook

Pamela M. Captain, L.M.T., N.C.T.MLicensed Massage TherapistRiverseasons

Dorothee Chabas, M.D., Ph.D.Co-DirectorUCSFRegionalPediatricMS ClinicUniversity of California at SanFrancisco

Maria Milazzo, N.P.National Pediatric MS CenterStateUniversityofNewYork– StoneyBrook

Jayne Ness, M.D.DirectorofPediatricMSClinicUniversityofAlabamaatBirmingham

Laurie Lou Smith, Ed.S., N.C.S.P.CenterforPediatricOnsetDemyelinatingDiseaseUniversityofAlabamaatBirmingham

General Information

Guest Faculty - continued

Emmanuelle Waubant, M.D., Ph.D.DirectorUCSFRegionalPediatric MS ClinicUniversityofCaliforniaatSanFrancisco

Bianca Weinstock-Guttman, M.D.DirectorofPediatricMSClinicJacobsNeurologicInstitute,StateUniversityofNewYorkatBuffalo

Anne Yeh, M.D.Co-DirectorPediatricMSClinicJacobsNeurologicInstitute,StateUniversityofNewYorkatBuffalo

Special Evening Session SpeakersKenny Ahern, Performer/ComedianFather Nicklas Mezacapa, Motivational Speaker

FACULTY DISCLOSUREAsaprovideraccreditedbyACCME,CollegeofMedicine,MayoClinic(MayoSchoolofCME)mustensurebalance,independence,objectivityandscientificrigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity.Safeguardsagainstcommercialbiashavebeenputinplace.Facultyalsowilldiscloseanyoff-labeland/orinvestigationaluseofpharmaceuticalsorinstrumentsdiscussedintheirpresentation.Disclosureofthisinformationwill be published in course materials so those participants in the activity may formulate their own judgments regarding the presentation.

General Information

Program Schedule

Thursday June 26th, 20086-8p.m. Registrationand WelcomeReception MarriottBallroom

Friday June 27th, 20087:00a.m. Registration&ContinentalBreakfast LeightonAuditorium,SecondFloorSiebensBuilding

8:00a.m. WelcomeandOpeningRemarks History of Multiple Sclerosis in Children Nancy L. Kuntz, M.D.

9:00a.m. FirstEpisodeofCNSDemyelinationInChildrenorAdolescents: WhatDoYouCallIt? Anne Yeh, M.D.

FatigueManagement,Energy,andLimitSetting (Parent/FamilyBreakoutSession) Maria Milazzo, N.P.

10:00a.m. RefreshmentBreak

10:15a.m. RecurrentCNSDemyelination:WhenIsItMultipleSclerosis? Jayne Ness, M.D., Ph.D.

Travel,Fun,andRecreationforKidswithMS (Parent/FamilyBreakoutSession) Mayo Clinic Physical Therapist

11:15a.m. CaseStudies Anita Belman, M.D.

Parent/FamilyBreakoutSession

12:00p.m. LunchandSpeaker MarriottBallroom

1:00p.m. PathophysiologyofCNSDemyelinatingDisease:MSvsADEM Nathan Young, D.O. and Shanu Roemer, M.D.

Medical Management and Compliance for MS Patients (Parent/FamilyBreakoutSession) Maria Milazzo, N.P.

1:45p.m. LumbarPuncture,EvokedPotentialsandOCT:WhenAreThese HelpfulinEvaluatingCNSDemyelinatingDisease? Bianca Weinstock-Guttman, M.D.

2:00–3:30p.m. Kids–Craft/Activities/Networking (KidsBreakoutSession)

2:30p.m. CurrentStatusandFutureResearchRelatingtoPediatricMS Moses Rodriguez, M.D.

3:00p.m. RefreshmentBreak

3:30p.m. CaseStudies Anita Belman, M.D.

Breakoutsessionsforparents/families/children

Program Schedule

4:30p.m. Adjourn

6:00-7:00pm CourseDinner ElizabethanRoom,KahlerHotel

7:00-7:45p.m. Professionals–Speaker Father Nicklas Mezacapa ElizabethanRoom,KahlerHotel

or

Families–Performer/Comedian Kenny Ahern VikingRoom,KahlerHotel

Saturday June 28th, 20087:30a.m. ContinentalBreakfast LeightonAuditorium,SecondFloorSiebensBuilding

8:00a.m. TheSpectrumofDisordersAssociatedwith NMO-IgGSeropositivityinChildren Andrew McKeon, M.B.B.Ch.

8:30a.m.-12 Kids–Craft/Activities/Networking (KidsBreakoutSession)

8:45a.m. TreatmentofAcuteEpisodesofCNSDemyelinationinChildren Dorothee Chabas, M.D., Ph.D.

9:00a.m. Parents–SchoolAdvocacy–AdvocatingForYourChildAt School(ParentBreakoutSession) Laurie Lou Smith, Ed.S., N.C.S.P.

9:30a.m. UseofDiseaseModifyingTherapyinChildrenandAdolescents with MS Emmanuelle Waubant, M.D., Ph.D. 10:15a.m. RefreshmentBreak

10:30a.m. CognitiveImpactofMSinChildrenandAdolescents Tanya Brown, Ph.D.

11:30a.m. DemonstrationofMind/BodyExercisesinTreatment of Symptoms of MS in Children and Adolescents Pamela M. Captain, L.M.T., N.C.T.M.

12:00p.m. Lunch MarriottBallroom

1:00p.m. MRIFindingsandUtilityofImaginginPediatricMS Karl N. Krecke, M.D.

2:00p.m. CourseEvaluationandSummary

2:30p.m. TourSanfordPediatricOutpatientCenter Tour Mayo Clinic MS Research Laboratories Faculty

4:00p.m. CourseAdjourn

Breakoutsessionsforparents/families/children

Pediatric Multiple Sclerosis: Acquired Demyelinating Disorders in Children and Adolescents…Symptoms, Evaluation, Treatment and Prognosis

June 26–28, 2008 • Rochester, MN

REGISTRATION FORM 2008R881

Mail form and payment to:Mayo Clinic Phone 800-323-2688 or 507-284-2509Plummer 2-60 FAX 507-284-0532200 First Street SW E-mail cme@mayo.edu Rochester, MN 55905 Web site www.mayo.edu/cme

Payment Information

Contact InformationName of Registrant – first name, middle name or initial, and last name Degree – select all that apply

MD PhD DO PA NP

Name of Institution Medical Specialty

Preferred Mailing Address – select one Work/Business Home

Work/Business Address – street address Work Phone – include all country and city/area codes as needed along with complete phone number

City State or Province ZIP or Postal Code Country

Home Address – street address Home Phone – include all country and city/area codes as needed along with complete phone number

City State or Province ZIP or Postal Code Country

E-mail Address FAX – include all country and city/area codes as needed along with complete phone number

FAX Location – select one

Work/Business Home

SPECIALNEEDS

Check is enclosed in the amount shown at right – make checks payable to Mayo Clinic Payment Total

Credit Card – select one

Discover MasterCard VisaAccount Number Exp Date – mm/yy

Name of Cardholder – as it appears on the card Signature of Cardholder – required

X

RegistrationRegistration Fee: Physicians/Scientists . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $ 375 $ ________

Residents, Physician Assistants and Nurse Practitioners . . . . . . . $ 300 $ ________ Families - $25 per adult # of Adults: _________ $ ________ Children 17 and under are free # of children: ________

Total Payment Enclosed $ ________ Scholarships may be available. Contact Paula or Carma at 507-284-6561 for more information. (Families only.)

Other - specify

If you have special assistance needs or dietary restrictions, describe here:

200FirstS

tree

tSW

Roc

hester,M

inne

sota5

5905

Non

-Pro

fit

Org

aniz

atio

nU

.S. P

OST

AGE

PAID

Min

neap

olis

, M

N

Perm

it N

o. 3

395

Pedi

atric

Mul

tiple

Scl

eros

is:

Acqu

ired

Dem

yelin

atin

g D

isor

ders

in

Chi

ldre

n an

d Ad

oles

cent

s…S

ympt

oms,

Ev

alua

tion,

Tre

atm

ent

and

Prog

nosi

s

June

26

-28,

2008

Leig

hton

Aud

itoriu

mR

oche

ster

, M

inne

sota

©20

08,M

ayoPr

ess•Print

edin

USA

M

C80

00-66

M

C80

00-66