© 2017 Bristol-Myers Squibb Company

GLOBALLY, 300,000 CHILDREN AND TEENS UNDERTHE AGE OF 19 ARE DIAGNOSED WITH CANCER EVERY YEAR, AND 80,000 DIE.

PEDIATRIC CANCER BY THE NUMBERSWHILE PROGRESS HAS BEEN MADE IN ADVANCING PEDIATRIC CANCER

RESEARCH, UNMET NEEDS IN CHILDHOOD CANCER STILL EXIST.

THIS INCLUDES BMS SPONSORED CLINICAL TRIALS AS WELL AS SUPPORT OF INDEPENDENT RESEARCH ON CANCERS THAT AFFECT CHILDREN.

Source: WHO IARC Report 2016 Source: Cancer Facts & Figures, 2014

SURGERY CHEMOTHERAPYRADIATION THERAPY

THE MAIN TYPES OF TREATMENT USED FOR CHILDHOOD CANCER ARE:

TREATMENT OPTIONS FOR CHILDREN WITH CANCER ARE LIMITED.

IN THE U.S., APPROX. 1 IN 408 CHILDREN WILL BE DIAGNOSED WITH CANCER BEFORE AGE 15, AND 1 IN 285 CHILDREN WILL BE DIAGNOSED WITH CANCER BEFORE AGE 20 YEARS.

CANCER REMAINS THE FIRST CAUSE OF DEATH BY DISEASE BEYOND ONE YEAR OF AGE.

MOST OF THE ROUTINELY USED TREATMENTS FOR PEDIATRIC CANCERS WERE APPROVED BEFORE 1990 (ABOUT HALF OF THEM BEFORE THE MID-1980S). Source: WHO IARC Report 2016

Source: Multi Stakeholder Proposals, 2016

BRAIN TUMORS AND OTHER CENTRAL NERVOUS SYSTEM (CNS)

TUMORS ARE THE 2ND MOST FREQUENT CHILDHOOD CANCER,

NEARLY 22% OF ALL TUMORS DIAGNOSED UNDER THE AGE OF 15.

LEUKEMIA IS THE MOST COMMON FORM OF CANCER IN CHILDREN ACCOUNTING FOR MORE THAN 30% OF CANCERS DIAGNOSED

UNDER THE AGE OF 15.

Source: Incidence/Prevalence, 2013

THE MOST COMMON CHILDHOOD CANCERS:

LYMPHOMAS RANK 3RD IN THE LIST OF MOST COMMON CHILDHOOD

MALIGNANCIES ACCOUNTING FOR 10% OF CANCERS IN CHILDREN.

NEARLY TWO-THIRDS OF PEDIATRIC LYMPHOMA IS NON-HODGKIN LYMPHOMA 66%75%

5%

20%

APPROX. 75% OF CASES ARE ACUTE LYMPHOCYTIC LEUKEMIA (ALL); 20% ARE ACUTE MYELOID LEUKEMIA (AML); ONLY 5% ARE CHRONIC MYELOID LEUKEMIA (CML).

BRISTOL-MYERS SQUIBB IS COMMITTED TO RESEARCHING ADDITIONAL TREATMENT OPTIONS IN PEDIATRIC CANCERS, SO THAT WE CAN HELP IMPROVE THE LIVES OF CHILDREN AFFECTED BY THE DISEASE.