particulars of appointment - further...ann oncol. 1959-65. doi: 10.1093/annonc/mdw278, 2016) and...

PARTICULARS OF APPOINTMENT

Ref: MI/18/17 Job Title: Postdoctoral Travelling Fellowship - Lung Cancer Early Detection and Early

Disease 1. The Institute invites applications for the above post. 2. Salary will be within the range £30,000 – £39,800 per annum according to relevant

experience and qualifications. 3. Informal enquiries can be made to Professor Caroline Dive CBE via email:

[email protected]. 4. Applications should be returned to the Human Resources Department via email

([email protected]) by the closing date as stipulated in the advert. For applicants who wish to return their application by post, please contact HR department on Tel: (00 44) 0161 306 0840 or via email: [email protected] for further information.

5. To apply for this position please provide a completed CV cover sheet which includes the

names and contact details of three referees, CV and Equal Opportunities Form. A cover letter is optional. No further information will be taken into consideration as part of your application.

6. All applicants should complete an equal opportunities form with their application.

7. If you have not been contacted within four weeks of the closing date you should assume

that, on this occasion, your application has not been successful. We would, however, like to take this opportunity to thank you for your interest in the Cancer Research UK Manchester Institute, and we hope that this will not deter you from applying for other positions in the future.

8. During The Paterson Building's recovery following the fire in April 2017, you may be required to travel between/or be based at any of the following CRUK Manchester Institute locations: Alderley Park, University of Manchester, Manchester Cancer Research Centre, The Christie.

9. The Institute will endeavour to contact shortlisted candidates promptly; however there may

be occasions where a high volume of applications are received therefore applicant’s patience is appreciated.

mailto:[email protected]


COPY OF THE ADVERTISEMENT

The University will actively foster a culture of inclusion and diversity and will seek to achieve true equality of opportunity for all members of its community.

Postdoctoral Travelling Fellowship - Lung Cancer Early Detection and Early Disease

Salary in the range of £30,000 - £39,800 (dependent upon qualifications and experience) Job Ref: MI/18/17 Duration: Four years fixed term contract Located at CRUK Manchester Institute (CRUK MI), UK and Boston University Medical Centre,

USA Subsistence allowance whilst based in the USA

About the role: An opportunity will be available from April 2018 within the Early Detection theme of the CRUK Lung Cancer Centre of Excellence (CoE) at CRUK MI, Manchester and University College London. The successful candidate will initially spend up to 6 months in the biomarker laboratories of Professor Caroline Dive CBE at the CRUK Manchester Institute linking to Dr Philip Crosbie’s respiratory health clinical research at the University Hospital of South Manchester. They will then be hosted in Professor Avrum Spira’s laboratory at Boston University Medical Center in Boston, USA for a period of up to 2.5 years, returning to CRUK MI, Manchester to complete their research. The position is designed to build upon strong collaborations between the CRUK Lung CoE and Prof Spira’s laboratory and to develop the post holder’s career such that they can subsequently apply for a competitive, independent CRUK funded fellowship in the early detection of lung cancer within our CRUK Lung Cancer CoE. Funding for the position will include salary, experimental running costs and a travel allowance. About you: You should have a PhD in cell or molecular biology and have several years’ postdoctoral experience preferably in cancer research and be willing to relocate to Boston, USA for between 18 months and up to 2.5 years. Why choose Cancer Research UK Manchester Institute? The Cancer Research UK Manchester Institute (www.cruk.manchester.ac.uk), an Institute of The University of Manchester (www.manchester.ac.uk), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (www.cancerresearchuk.org), the largest independent cancer research organisation in the world. We are currently situated at the internationally-renowned life sciences campus at Alderley Park in Cheshire England, 15 miles from Manchester, a vibrant and dynamic city surrounded by beautiful countryside. We are partnered with The Christie NHS Foundation Trust (adjacent to the CRUK Manchester Institute, Paterson Building) in South Manchester (www.christie.nhs.uk), one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes. How to apply? To apply for this position please complete an equal opportunities form and submit along with a CV and accompanying CV cover sheet to [email protected]. Please ensure you detail the names of three referees and quote the job reference number above. A cover letter is optional.

http://www.cruk.manchester.ac.uk/

http://www.manchester.ac.uk/

http://www.cancerresearchuk.org/

http://www.christie.nhs.uk/

Informal enquiries can be directed to Professor Caroline Dive CBE via email: [email protected]. Additional Information:

On the 26th April 2017 The Paterson Building, which housed most of the Cancer Research UK (CRUK) Manchester Institute, caught fire resulting in significant damage. We are striving to rebuild our world-class research facilities and we would like to make you aware that in the meantime, the primary place of work for this position whilst at CRUK MI will be at the internationally-renowned life sciences campus at Alderley Park, which has excellent facilities to carry out research. We anticipate that this will be for a few years, after which we will return to our original site in Withington, Manchester, next to The Christie NHS Foundation Trust (Wilmslow Road, M20 4BX).

CANCER RESEARCH UK MANCHESTER INSTITUTE

JOB DESCRIPTION

JOB DETAILS

Job Title: Postdoctoral Travelling Fellowship - Lung Cancer Early Detection and Early

Disease Department: Clinical and Experimental Pharmacology Group (CEP) Division: Cancer Research UK Manchester Institute (CRUK MI)

ORGANISATIONAL ARRANGEMENTS

Accountable to:

Professor Caroline Dive CBE, CEP Group Leader CRUK MI, and Manchester Lead, CRUK Lung Cancer Centre of Excellence.

Dr Philip Crosbie, Senior Lecturer and Early Detection/Early Disease Theme Lead, Faculty of Biology Medicine and Health, University of Manchester.

Professor Avrum Spira, Division of Computational Biomedicine in the Department of Medicine and Director of the Boston University – Boston Medical Center Cancer Center.

Responsible for: Development and delivery of a research project on the early detection of

lung cancer and/or biology of early lung cancers

JOB PURPOSE To gain a thorough scientific training in the early detection of lung cancer and/or biology of early lung cancers. To conduct high quality research overseen by the leaders of the Early Detection/Early Disease themes of the CRUK Lung Cancer Centre of Excellence and by Professor Spira. To agree, develop and deliver a defined and independent research project that complements the research of the Centre and strengthens the existing collaboration with Prof Spira’s laboratory. The post holder will initially spend up to 6 months in the biomarker laboratories of Professor Caroline Dive CBE at the CRUK Manchester Institute linking to Dr Philip Crosbie’s respiratory health clinical research at the University Hospital of South Manchester. They will then be hosted in Professor Avrum Spira’s laboratory at Boston University Medical Center in Boston, USA for a period of up to 2.5 years, returning to CRUK MI, Manchester to complete their research. It is anticipated that the post holder will, by the end of this post, be in a competitive position to establish an independent research program focused on early lung cancer.

BACKGROUND Lung cancer is the most common cause of cancer related death in the world; more than 1.6 million people die of the disease each year. Late clinical presentation is common, with approximately 75% of patients having either locally advanced (stage III) or distant metastatic disease (stage IV) at diagnosis, when treatments are much less effective and survival poor. In the UK ≈100 patients die

from lung cancer every day and only 5% survive 10 years. In Manchester, lung cancer is the single biggest cause of premature death, reflecting high levels of smoking and socio-economic deprivation. Understanding the biology of early stage disease is a critically important component of our strategy to improve outcomes for patients with lung cancer, as this is the area where the greatest impact can be made. The CRUK Lung Cancer of Excellence led by Professor Caroline Dive and Professor Charles Swanton, located in sister sites at Manchester University and University College London, is composed of eight integrated themes including Early Disease and Early Detection, Biomarkers, Basic Research, Tumour Heterogeneity, Immunology, Bioinformatics and Advanced Radiotherapy and Radiobiology and Clinical Trials. Working within the CRUK MI CEP group, led by Professor Dive, this fellowship post will develop a new programme of research in early stage lung cancer biology and/or early detection of lung cancer. The post holder will be able to interact with members of the early disease and early detection theme, led in our Lung Centre by Dr Philip Crosbie at the Manchester University NHS Foundation Trust (MFT) and at UCL by Professor Sam Janes. Early detection of cancer and lung cancer are also strategic foci of the CRUK Manchester Centre. The post holder will benefit from the strong local research environment in Manchester. The CEP group (http://www.cruk.manchester.ac.uk/Research/CEP) and newly-established Manchester Centre for Cancer Biomarker Sciences, led by Professor Dive, will host this fellowship. The group has an international reputation for liquid biopsies, specifically in advanced lung cancer, including circulating tumour cells (CTCs) and circulating DNA (Girotti et al, Cancer Disc. 6(3):286-99, 2016, Gremel et al, Ann Oncol. 1959-65. doi: 10.1093/annonc/mdw278, 2016) and circulating miRNAs with Dr Michela Garofalo at CRUK MI. The CEP group pioneered unique patient CTC derived explant models in mice (CDX) (Hodgkinson et al, Nat Med. 23(1):114-119, 2017) and is developing panels of lung cancer CDX and PDX, together with orthotopic models. They focus predominantly on small cell lung cancer. The CEP group works closely with Thoracic Medical Oncologist Professor Fiona Blackhall at the adjacent The Christie NHS Foundation Trust. The post holder will be strongly encourage to interface with clinical colleagues at MFT, who provide a comprehensive multi-disciplinary thoracic oncology service to the local population and wider Manchester Cancer Network (n=2,200 new lung cancer diagnoses per year). Specialist lung cancer services at MFT include: a RAPID lung cancer diagnostic pathway, standard/advanced bronchoscopy (>2,000 procedures per year) e.g. endobronchial ultrasound (EBUS), based in the UK’s largest purpose built bronchoscopy unit (The Lucis Centre), interventional thoracic radiology services, a survivorship programme and a pleural team. Medical and clinical oncologists deliver adjuvant chemotherapy and treatments for advanced lung cancer and mesothelioma. MFT hosts one of the country’s largest thoracic surgical units, with five dedicated thoracic surgeons who perform >450 primary lung cancer resections a year. Access to lung and tumour tissue for research is facilitated through a well-established collaboration with the Manchester Cancer Research Centre biobank. The service and biobank are supported by a specialist thoracic pathology team. Lung cancer research at MFT is co-ordinated by the Thoracic Oncology Research Hub (TORCH), a collaboration of clinically active investigators that covers the entire patient journey. The Lung Cancer Team at MFT is an academic department with a substantial early detection research portfolio. Screening studies, led by Dr Philip Crosbie, ongoing or upcoming include: 1. The Manchester Early Detection of Lung Disease (MEDLD) Pilot (funded by Macmillan Cancer Support): a community-based lung cancer screening pilot using low dose CT (LDCT), targeted at high-risk (hard-to-reach) smokers in deprived areas of Manchester (n=2,541). 2. The Community Lung Health Study (CLHS) (funded by Cancer Research UK): This study is a collaboration with CEP and the Manchester Collaborative Centre for Inflammation Research (MCCIR)

http://www.cruk.manchester.ac.uk/Research/CEP

with concomitant collection of blood, sputum and nasal samples for discovery of minimally invasive early detection biomarkers. Samples have been collected on ≈600 individuals at high risk of lung cancer (2nd round attendees of the MEDLD pilot). 3. The North Manchester Lung Health Study (NMLHS) (funded by Everest Detection): this study will start in Q3/4 2018 and will screen high risk individuals using annual low dose CT (LDCT) over 2 screening rounds (annual); bloods will be taken from all attendees (n≈5,500) for early detection biomarkers. 4. The Yorkshire Lung Screening Trial (YLST) (funded by Yorkshire Cancer Research): will screen high risk individuals will LDCT over 2 screening rounds (biennial). It is hoped that a biomarker sub-study will run alongside the main study (n≈7,000). Collaboration with world-leading researchers of COPD is also welcomed. Professor Jørgen Vestbo leads the North West Lung Centre (NWLC) at MFT, the largest clinical respiratory department in the UK and an internationally recognised research unit with world leading research in COPD, asthma/allergy, cough and fungal infections. The NWLC includes the Respiratory Theme of the recently awarded NIHR funded Manchester Biomedical Research Centre, which has for years had a dedicated Respiratory and Allergy Clinical Research Facility, and the NWLC is closely linked with the UK’s largest commercial respiratory clinical trials facility, the Medicines Evaluation Unit. In COPD, the academic work focuses on early COPD, exacerbations, biomarkers and, pertinent to this new fellowship, links to lung cancer. The fellow will have the opportunity to interface with the ongoing early detection research within the MCCIR, led by Professor Tracey Hussell (www.mccir.manchester.ac.uk), a unique venture designed to establish a world-leading translational research centre in the UK for inflammatory diseases which affect the joints, lungs, skin, and many other organs in the body. By bringing together the best industrial and academic scientists, the MCCIR enhances our understanding of inflammatory mechanisms and develops ways in which this knowledge can be translated into the identification and clinical development of novel and improved therapies. The fellow will have access to state-of-the-art facilities including 18 colour flow cytometry, CyTOF and the wealth of expertise encompassed in 14 internationally recognised research groupings. Of particular relevance to this position is the interest in novel biomarkers of cleaved receptors and cellular matrix fragments that enable the identification of patients prone to aberrant inflammatory responses, the potential for development of therapy toxicities and more sensitive methods of detecting early disease. Additional opportunities for collaboration will be with Professor Tony Whetton, who leads the Stoller Biomarker Discovery Centre. This is the leading clinical proteomics centre in Europe with the ability to undertake discovery, validation and verification of protein biomarkers in a GCP environment. Work to date in the Centre has identified markers of risk for ovarian cancer and also potential lung cancer biomarkers using discovery proteomics plus mass spectrometry/ELISA validation techniques. Embedded in the Stoller Centre is an MRC funded Pathology Innovation Centre that is charged with developing new tests for clinical usage from findings in the Stoller Centre and elsewhere. Overall the research environment in Manchester provides a wonderful opportunity for the appointed fellow to develop and progress an exciting research programme on early stage lung cancer and/or its earlier detection. Collaborative research within the CRUK Lung Cancer Centre of Excellence At UCL, Professor Sam Janes leads the Early Disease and Early Detection theme within the Lung Cancer Centre, and the post holder will be able to interact and collaborate with the UCL team. Janes’

http://www.mccir.manchester.ac.uk/

research focus is on lung cancer pathogenesis and the development of novel therapies to treat both early and late stage disease. Janes leads the Airway Regeneration and Carcinogenesis Group, with an interest in the mechanisms controlling cell fate decisions and defining whether it is failure of control of these cells that causes early lung cancer lesions. The group’s clinical interest is in monitoring a large cohort of patients with pre-invasive lung cancer lesions. International Collaboration with Professor Avrum Spira Dr. Spira research program at Boston University Medical Campus focuses on the translational study of genomic alterations associated with smoking-related lung disease. His research is based on the paradigm that smoking and other inhaled carcinogens create a ‘field of molecular injury’ in epithelial cells that line the respiratory tract. By sampling these relatively accessible airway cells, Dr. Spira’s lab has developed novel diagnostic and therapeutic biomarkers for lung cancer and COPD as well as a non-invasive approach for measuring the physiological response to a number of inhaled environmental exposures. He leads the DECAMP consortium which is a multicenter study within military and veteran hospitals in the US for developing and validation early detection biomarkers for lung cancer. He also leads a Stand Up To Cancer Dream Team in collaborations with Drs. Swanton and Janes focused on developing new approaches lung cancer interception.

DUTIES AND RESPONSBILITIES The Travelling Fellowship holder will agree and develop a programme of research in early stage lung cancer biology and/or early detection of lung cancer that forms a strong collaborative effort between the CRUK Lung Cancer Centre of Excellence Early Disease & Early detection Theme and Prof Avrum Spira’s laboratory. Key duties of the role include: Research

Planning, performing analysing, interpreting and presenting research studies.

Ensure appropriate experimental design and assist with troubleshooting.

Check data analysis and ensure correct statistical analysis has been performed.

Check scientific rational, study design and for all research protocols to be performed with approval from the appropriate laboratory lead.

Ensure all of the above is in accordance with institute policies. Budget management

Take responsibility for checking budget transactions. Regulatory compliance as appropriate

Take responsibility for compliance with local regulations regarding any in vivo work.

Liaise with biobank staff to ensure appropriate local consent and regulatory compliance for human tissue analysis.

Oversee quality assurance of clinical trial-related work and adherence to GCP or CLIA standards where required.

Other

Meet (in person or by Skype) with Lung Centre Directors and Early Disease/Early Detection theme leads of the Lung Cancer Centre of Excellence and Prof Spira routinely to discuss progress of projects/team members and future planning.

Present at internal and external meetings as required.

To prepare manuscripts for publication; to address referee comments and drive publication output.

To keep up with the scientific literature.

To maintain accurate records of experiments and reagents.

To ensure that all items that are used up during the course of a program of work are replaced immediately by directly ordering the relevant items.

To present work local, national and international meetings.

To attend the CRUK Manchester Institute retreat, space permitting.

To assist supervision of graduate students, visiting scientists and others as necessary.

To conform to Safety, Codes of Practice, and Local and Institutional Rules.

To adhere to the rules and regulations of any facilities, in-house or external, which need to be accessed during the course of the work program.

To perform other functions consistent with the position, nature of the post and as determined by their laboratory head.

6. Become an active member of the CRUK Lung Cancer Centre of Excellence.

STANDARDS OF PERFORMANCE

Work efficiently, cost-effectively and in a flexible manner.

To meet objectives within pre-determined timescales.

Effective communications to be maintained with staff at all levels.

Strict adherence to protocols and Institute policies.

To comply with Health & Safety requirements, including having an awareness of personal responsibilities to maintain a safe working environment.

To contribute to the University’s agenda for social responsibility, including sustainability.

To maintain confidentiality of information in line with data protection requirements and University policy.

Familiarise themselves with the University’s Equality and Diversity policies and to actively support these wherever possible.

Be a team player.

To strive to accomplish high quality of work.

Cancer Research UK Manchester Institute is a Research Institute within The University of Manchester and is core funded by Cancer Research UK

PERSON SPECIFICATION The person specification should set out the qualifications, experience, skills, knowledge, personal competencies and other requirements

which the post holder requires to perform the job to a satisfactory level.

Job Title: Postdoctoral Travelling Fellowship - Lung Cancer Early Detection and Early Disease

ESSENTIAL

The qualities without which a post holder could not be appointed

DESIRABLE Extra qualities which can be used to choose

between candidates who meet all the essential criteria

METHOD OF ASSESSMENT

QUALIFICATIONS

PhD in Cell Biology, Molecular Biology, Genetics or related discipline

Home Office licence if in vivo work is to be conducted in the UK

CV and Presentation of

certificate

EXPERIENCE

Previous Postdoctoral experience

Significant basic, translational or clinical research experience

Significant experience in Lung Cancer Research and/or research on the early development or early detection of cancer

Demonstrable experience managing own work and supervising that of others

Demonstrable experience of project and line management across staff of varying levels of experience

Demonstrable ability to manage time effectively and to deliver a series of concurrent tasks on time within agreed deadlines

Past experience working with clinicians and/or translational researchers

Demonstrated ability to generate high quality, high impact publication(s)

Demonstrated contribution to successful grant applications

Demonstrable success in supervision of junior scientists

Experience of working in multidisciplinary teams

CV, references, publications and

interview


SKILLS

Ability to discuss research strategy effectively with good preparation and in depth knowledge of the research field

A demonstrated ability to perform research and to develop novel ideas

Demonstrable ability to design and plan experiments and interpret results

The ability to plan ahead, to manage time effectively, and to coordinate multiple concurrent projects

The ability to successfully supervise and mentor other team members

Ability to motivate others, strong influencing skills

General management skills

Excellent communication skills, written and verbal

Experience in establishing and coordinating collaborations

Accurate, comprehensive record-keeping

Computer literate, familiarity with MS office package

Effective organisational skills and ability to multi-task

Proven problem solving capabilities, innovative approach to problem solving

To set goals, respond to challenges and take the initiative

Creative thought regarding key scientific issues

Ability to be flexible around staff with clinical commitments

Supervision and coaching scientific staff


interview


KNOWLEDGE

Knowledge of cancer biology

Knowledge of cancer screening approaches

In depth and working knowledge of personalised medicine approaches in cancer

Knowledge of ‘Health & Safety at work’ requirements

Cancer genomics

Clinical trials

Development of biomarkers for early detection of cancer

Tumour pathology and/or immunology

Ability to assimilate information from a variety of sources in order to innovate new research ideas that are beneficial to the research output of the group

A comprehensive understanding on the UK Home Office regulations for research conducted on animals if appropriate to the project

A commitment to the 3Rs in animal research (refine, reduce, replace)


interview

OTHER

Willingness to travel

Willing and able to relocate to Boston, USA for between 18 months and up to 2.5 years

Self-motivated, meticulous, interactive and organised

Ability to work to strict deadlines

Ability to work well within a team framework as well as on an individual project

Technically focused

Willingness to learn new experimental techniques

Willingness to implement new management approaches

To show commitment to equality and fairness and integrity in dealing with others

To be willing to work across organisational boundaries

To seek new knowledge and share ideas

To be open and responsive to change and innovation

Interview,

referees’ comments


THE CITY OF MANCHESTER AND THE REGION Manchester is one of the great European cities and the Cancer Research UK Manchester Institute is located a short distance from the city centre and is serviced by regular public transport to the city centre. The city’s architecture represents one of the high points of Victorian achievement. The modern city is a major centre of banking, commerce and manufacturing. It has a highly cosmopolitan atmosphere and its cultural life is internationally renowned. There are three outstanding professional theatre companies, the halls of the Hallé and BBC Philharmonic orchestras, the Cornerhouse as well as other cinemas, and Europe’s fastest-growing Chinatown. On the way into the city, there is perhaps the best stretch of road in the entire country for Indian and Pakistani food, known as the curry mile in Rusholme. Amongst developments enriching the area’s cultural life have been: the opening of the Lowry Centre and Media City at Salford Quays; the opening of the Bridgewater Concert Hall; the refurbishment of the City Art Gallery; the opening of Urbis in the centre of Manchester and of the Imperial War Museum North, designed by Daniel Libeskind, in Trafford. Trafford, specifically Old Trafford, is known internationally for sport: it is a venue for Test cricket and the home of Manchester United FC. The Commonwealth Games were held in Manchester in 2002 and were highly acclaimed. The Commonwealth Stadium became the home of Manchester City FC in 2003. Housing is varied, plentiful and the price ranges can start moderately priced and are as varied as the requirements. Schooling ranges from world-famous private schools to excellent sixth-form colleges and comprehensives. Manchester is well served by a major international airport, with direct scheduled flights to many destinations in Europe as well as North America and Asia. Manchester Piccadilly railway station has been refurbished and is served by inter-city and other train services – with a direct link to Manchester Airport. The expanding network of Metrolink tram services offers an alternative mode of public transport from certain parts of the conurbation and is currently being expanded to include connections near to the Institute. Some of the most beautiful countryside in Europe is just short of an hour’s drive from the Institute in the Peak District National Park, while the Lake District and Snowdonia are also within easy reach. Manchester offers extensive provision for research. Library facilities include the John Rylands University Library (the major library in the North West and the third largest in the country) and the Manchester Central Reference Library. Facilities for quantitative analysis are provided by Manchester Computing and the Computer Support Unit


ADDITIONAL RECRUITMENT AND SELECTION PARTICULARS: Shortlisted Candidates: 1. We will reimburse reasonable travel expenses. You need to retain all your receipts

as you will need to submit these with your expense claim form. This form will be given to you when you attend your interview.

2. If candidates require accommodation the Institute can arrange this for you. Please

notify the Human Resources Department as soon as possible so that this can be arranged on 0161 306 0840 or email: [email protected]. Please note that reimbursement for accommodation may not apply.

3. If candidates have any additional support needs to enable them to attend an

interview they will be able to request/discuss this with the HR department when arranging the interview.

4. Shortlisted candidates may be expected to complete a presentation as part of the

selection process. Information regarding the duration and title of the presentation will be provided in the invitation to interview correspondence. We supply both laptop and projector for presentations.

5. All dates and times stated in correspondence from the Institute refer to UK GMT

(Greenwich Mean Time). 6. Candidates need to bring along their passport to interview, (a copy of which will be

taken for our records) and where applicable, your visa, when you visit the Institute. If candidates have difficulty in producing their passport, please contact the Human Resources Department prior to the interview on 0161 306 0840 who will be able to advise you.

7. All shortlisted candidates will be requested to complete a Rehabilitation of

Offenders/ Criminal Records declaration form at this stage of the recruitment and selection process. Please note: a criminal record will not necessarily be a bar to obtaining a position.

8. Skype interview with presentation:

Instances may arise when it may not be possible for candidates to travel to the Institute to attend the interview on the given date. In this circumstance, a Skype interview may be used as the first stage of the selection process. The criteria will be consistent with all other candidates. If successful following the Skype interview, candidates will be invited to visit the Institute at a later date. Further information will be provided at that time. 24 hour prior to the interview we will require:

A copy of the presentation emailed to [email protected] Skype name

A contact telephone number




9. Telephone conference with presentation:

As above, instances may arise when it may not be possible for candidates to travel to the Institute to attend the interview on the given date. In this circumstance, and if a Skype interview is not possible, then a telephone conference interview will be arranged as the first stage of the selection process. The criteria will be consistent with all other candidates. 24 hour prior to the interview we will require:

A copy of the presentation emailed to [email protected]

A contact telephone number



POSTDOCTORAL SCIENTIST TERMS AND CONDITIONS The following is a basic summary of the standard terms and conditions applicable to the post you have applied for:

The Postdoctoral Scientist grade is on a Cancer Research UK salary. Starting in the range of £30,000 – £39,800 per annum, dependent upon experience and qualifications.

Your employment will be with The University of Manchester appointed under The Cancer Research UK Manchester Institute terms and conditions.

The position will be located at CRUK Manchester Institute (CRUK MI), UK and Boston University Medical Centre, USA.

Subsistence allowance whilst based in the USA.

Salary is paid monthly.

There are 32 days holiday per year plus Bank Holidays for England.

The duration of the contract is four years.

37 hour week.

There is a probationary period attached to this post of 8 months. It’s standard for many organisations now and consists of two 4-monthly reviews with your line manager.

You are eligible to join the USS pension scheme.

Any offer made by the Cancer Research UK Manchester Institute would require the successful candidate to undergo a medical clearance. This is arranged with Occupational Health department at the University of Manchester prior to starting employment and consists of a basic medical. This is to address and gain clearance for any potential hazards identified for the role on offer.

Offer is subject to receipt of 3 satisfactory references and proof of your highest qualification.

The successful candidate is required to have submitted their thesis prior to their start date. Confirmation from their educational institution will be required by the Institute’s Human Resources Department prior to commencing employment.

Offer is subject to documented evidence of your right to work in the UK under the Home Office UK Border Agency Regulations.

The appointment will be subject to a satisfactory pre-employment security check.


The Institute is promoting a green travel plan and there are staff benefits promoting this including a cycle to work scheme and the use of public transport. There are strong links to bus routes and trains to all CRUK Manchester Institute locations. At the Manchester Cancer Research Centre and The Christie site there are also strong links to tram lines, however, please note: that there are car parking restrictions imposed around these sites.

There are a range of staff benefits. If you require further information at this stage please contact HR department directly.

particulars of appointment - further...ann oncol. 1959-65. doi: 10.1093/annonc/mdw278, 2016) and...

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