parenteral drug administration department of anaesthesia university of glasgow
TRANSCRIPT
Parenteral Drug Parenteral Drug AdministrationAdministration
Department of AnaesthesiaDepartment of Anaesthesia
University of GlasgowUniversity of Glasgow
Parenteral Route in DentistryParenteral Route in Dentistry
• General Dental CouncilGeneral Dental Council– Intravenous sedation drugsIntravenous sedation drugs– Emergency drugs Emergency drugs
Drug AdministrationDrug Administration
Absorbtion
Plasma water
Metabolism
Excretion
Site of ActionTissue
oral intramuscular subcutanous topical intravenous
Parenteral Injection SitesParenteral Injection Sites
subcutanously
intramuscularly
intravenously
Subcutaneous RouteSubcutaneous Route
• Absorption depending on blood flowAbsorption depending on blood flow– Constant & slow absorptionConstant & slow absorption– Prolonged effectProlonged effect
DrugsDrugs– InsulinInsulin– HeparinHeparin
Subcutaneous Injection SitesSubcutaneous Injection Sites
• Abdominal wallAbdominal wall• ThighThigh• Deltoid areaDeltoid area
Intramuscular RouteIntramuscular Route
• Absorption depending on blood flowAbsorption depending on blood flow– Rapid onset & shorter duration Rapid onset & shorter duration – ShockShock
• DrugsDrugs– GlucagonGlucagon– AdrenalineAdrenaline
Intramuscular Injection SitesIntramuscular Injection Sites
Intramuscular Injection SitesIntramuscular Injection Sites
Intramuscular Injection SitesIntramuscular Injection Sites
Intramuscular RouteIntramuscular Route
• LimitationsLimitations– Neurovascular damageNeurovascular damage– Bleeding (eg anticoagulant therapy)Bleeding (eg anticoagulant therapy)– PainPain– InfectionInfection– Delayed absorption in shockDelayed absorption in shock– Interpretation of diagnostic testsInterpretation of diagnostic tests
Intravenous RouteIntravenous Route
• Rapid immediate onsetRapid immediate onset
• Permits titrationPermits titration
• Administer slowlyAdminister slowly
• DrugsDrugs– MidazolamMidazolam
Intravenous Injection SitesIntravenous Injection Sites
• PeripheralPeripheral• CentralCentral
IntravenousIntravenous
• LimitationsLimitations– May be more difficult to obtainMay be more difficult to obtain
– Increased risk of adverse effectsIncreased risk of adverse effects
– Requires intravenous accessRequires intravenous access
– InfectionInfection
– PainPain
AnaphylaxisAnaphylaxis
• DefinitionDefinition– Immunologically mediated reaction to antigen Immunologically mediated reaction to antigen
causing systemic symptomscausing systemic symptoms
• Potentially life threateningPotentially life threatening• Frequent AntigensFrequent Antigens
– AntibioticsAntibiotics
– LatexLatex
– Anaesthetic agents Anaesthetic agents
– Colloid fluidsColloid fluids
AnaphylaxisAnaphylaxis
• DiagnosisDiagnosis– CollapseCollapse
– Difficulty breathingDifficulty breathing
– WheezeWheeze
– Angio-oedemaAngio-oedema
– UrticariaUrticaria
Management AnaphylaxisManagement Anaphylaxis
• PreventionPrevention– Avoid unnecessary drugs particularly ivAvoid unnecessary drugs particularly iv– Take drug historyTake drug history
• Adequate staff training and facilities Adequate staff training and facilities
Immediate Management 1
Remove trigger agent – Stop injection or infusion of
drug – Remove triggering materials
Remember latex allergy Chlorhexidine
– Summon assistance
Immediate Management 2Immediate Management 2
• Basic life supportBasic life support– Check airway, breathing, circulationCheck airway, breathing, circulation– OxygenOxygen
• Give adrenaline (0.5-1mg im) Give adrenaline (0.5-1mg im)
• Elevate legsElevate legs
• (Give intravenous fluids)(Give intravenous fluids)
Subsequent ManagementSubsequent Management
• Antihistamines Antihistamines – Chlorpheniramine ivChlorpheniramine iv
• Steroids Steroids – Hydrocortisone ivHydrocortisone iv
• Intensive care unitIntensive care unit
• Immunological TestingImmunological Testing
SummarySummary
• Parenteral drug administrationParenteral drug administration– SitesSites– Drug availability Drug availability – LimitationsLimitations
• AnaphylaxisAnaphylaxis
Questions ?Questions ?